{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:03:56Z","timestamp":1777644236317,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources","award":["2020-ZJ-Y04"],"award-info":[{"award-number":["2020-ZJ-Y04"]}]},{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources","award":["1003-005024011"],"award-info":[{"award-number":["1003-005024011"]}]},{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources","award":["2023-ZJ-908M"],"award-info":[{"award-number":["2023-ZJ-908M"]}]},{"name":"Qinghai Province \u201cKunlun Talents High end Innovation and Entrepreneurship Talents\u201d Program (Leading Talents) Project","award":["2020-ZJ-Y04"],"award-info":[{"award-number":["2020-ZJ-Y04"]}]},{"name":"Qinghai Province \u201cKunlun Talents High end Innovation and Entrepreneurship Talents\u201d Program (Leading Talents) Project","award":["1003-005024011"],"award-info":[{"award-number":["1003-005024011"]}]},{"name":"Qinghai Province \u201cKunlun Talents High end Innovation and Entrepreneurship Talents\u201d Program (Leading Talents) Project","award":["2023-ZJ-908M"],"award-info":[{"award-number":["2023-ZJ-908M"]}]},{"name":"Classification and Identification Methods of Tibetan Willow and Genetic Background of Wild Germplasm Resources","award":["2020-ZJ-Y04"],"award-info":[{"award-number":["2020-ZJ-Y04"]}]},{"name":"Classification and Identification Methods of Tibetan Willow and Genetic Background of Wild Germplasm Resources","award":["1003-005024011"],"award-info":[{"award-number":["1003-005024011"]}]},{"name":"Classification and Identification Methods of Tibetan Willow and Genetic Background of Wild Germplasm Resources","award":["2023-ZJ-908M"],"award-info":[{"award-number":["2023-ZJ-908M"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Phlomoides rotata, a traditional medicinal plant, always grows on the Tibetan Plateau at a high altitude of 3100\u20135200 m. The major active ingredients in P. rotata were used in medicines due to their diverse pharmacological effects, including hemostatic, anti-inflammatory, antitumor, immuno-modulatory, and antioxidant activities. This study screened 15 top endophytic genus through the analysis of OTUs and the top 30 metabolites with relatively high content in P. rotata roots from four different habitats (HN, GL, YS, and CD regions) in Qinghai Province. Twelve physicochemical indicators were measured and analyzed in the rhizosphere soils of P. rotata habitats. The results indicated that the top 30 metabolites compounds included 7 amino acids, 5 sugars and alcohols, 4 phenylpropanoids, 3 Organic acids, and 3 Alkaloids. Four endophytic bacteria (Acidibacter, Sphingomonas, Variovorax, and Sphingobium) and three endophytic fungi (Tetracladium, Cadophora, and Minimelanolocus) were dominant genera in P. rotata roots from four habitats. There were 109 positive significant correlations and 57 negative correlations between OTUs of endophytic bacteria and contents of top 30 metabolites, and 59 positive significant correlations and 58 negative correlations between OTUs of endophytic fungus and contents of top 30 metabolites. The OTUs of Acidibacter were significantly positively correlated with the content of 5 soil physicochemical indicators (total phosphorus, amylase, sucrase, total potassium, or soil organic carbon) and significantly negatively correlated with the content of acid protease. OTUs of Tetracladium or Cadophora showed a positive correlation with the content of total phosphorus and a negative correlation with that of alkaline phosphatase. This study provides a theoretical basis for the study of the correlation between endophytes and metabolites in P. rotata roots.<\/jats:p>","DOI":"10.3390\/microorganisms13030503","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T03:40:12Z","timestamp":1740454812000},"page":"503","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diversity and Correlation Analysis of Endophytes and Top Metabolites in Phlomoides rotata Roots from High-Altitude Habitats"],"prefix":"10.3390","volume":"13","author":[{"given":"Zuxia","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichun","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"},{"name":"Academy of Plateau Science and Sustainability, Qinghai Normal University, Xining 810008, China"},{"name":"Qinghai South of Qilian Mountain Forest Ecosystem Observation and Research Station, Huzhu 810500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guigong","family":"Geng","sequence":"additional","affiliation":[{"name":"Qinghai South of Qilian Mountain Forest Ecosystem Observation and Research Station, Huzhu 810500, China"},{"name":"Academy of Agricultural and Forestry Sciences, Qinghai University, Xining 810016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9351-3311","authenticated-orcid":false,"given":"Chongxin","family":"Yin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhuo","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxia","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Su","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3122-1522","authenticated-orcid":false,"given":"Feng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tibetan Plateau Medicinal Plant and Animal Resources, School of Life Sciences, Qinghai Normal University, Xining 810008, China"},{"name":"Academy of Plateau Science and Sustainability, Qinghai Normal University, Xining 810008, China"},{"name":"Qinghai South of Qilian Mountain Forest Ecosystem Observation and Research Station, Huzhu 810500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1104\/pp.20.00433","article-title":"Plant Secondary Metabolites as Defenses, Regulators, and Primary Metabolites: The Blurred Functional Trichotomy","volume":"184","author":"Erb","year":"2020","journal-title":"Plant Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ebu, S.M., Adem, M.A., Dekebo, A., and Olani, A. (2023). Isolation and Identification of Endophytic Bacterial Isolates from the Leaves, Roots, and Stems Parts of Artemisia Annua, Moringa Oleifera, and Ocimum Lamiifolium Plants. Curr. Microbiol., 80.","DOI":"10.1007\/s00284-023-03513-8"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, D., Cai, J., He, H., Yang, S., Chater, C.C.C., and Yu, F. (2022). Anemochore Seeds Harbor Distinct Fungal and Bacterial Abundance, Composition, and Functional Profiles. J. Fungi, 8.","DOI":"10.3390\/jof8010089"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Liu, T.-H., Zhang, X.-M., Tian, S.-Z., Chen, L.-G., and Yuan, J.-L. (2020). Bioinformatics Analysis of Endophytic Bacteria Related to Berberine in the Chinese Medicinal Plant Coptis teeta Wall. Biotech, 10.","DOI":"10.1007\/s13205-020-2084-y"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dang, H., Zhang, T., Wang, Z., Li, G., Zhao, W., Lv, X., and Zhuang, L. (2021). Succession of Endophytic Fungi and Arbuscular Mycorrhizal Fungi Associated with the Growth of Plant and Their Correlation with Secondary Metabolites in the Roots of Plants. BMC Plant Biol., 21.","DOI":"10.1186\/s12870-021-02942-6"},{"key":"ref_6","first-page":"190","article-title":"Effects of Plants-Associated Microbiota on Cultivation and Quality of Chinese Herbal Medicines","volume":"16","author":"Ouyang","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Feng, J., Rana, S., Liu, Z., Wang, Y., Cai, Q., Geng, X., Zhou, H., Zhang, T., Wang, S., and Xue, X. (2022). Diversity Analysis of Leaf Nutrient Endophytes and Metabolites in Dioecious Idesia Polycarpa Maxim Leaves during Reproductive Stages. Life, 12.","DOI":"10.3390\/life12122041"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1021\/acs.jafc.9b00467","article-title":"Correlation in Chemical Metabolome and Endophytic Mycobiome in Cynomorium Songaricum from Different Desert Locations in China","volume":"67","author":"Cui","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e8510","DOI":"10.7717\/peerj.8510","article-title":"Niche Differentiation in the Rhizosphere and Endosphere Fungal Microbiome of Wild Paris Polyphylla Sm","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Akram, S., Ahmed, A., He, P., He, P., Liu, Y., Wu, Y., Munir, S., and He, Y. (2023). Uniting the Role of Endophytic Fungi against Plant Pathogens and Their Interaction. J. Fungi, 9.","DOI":"10.3390\/jof9010072"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Zhou, Z.Y., Liu, X., Cui, J.L., Wang, J.H., Wang, M.-L., and Zhang, G. (2022). Endophytic Fungi and Their Bioactive Secondary Metabolites in Medicinal Leguminosae Plants: Nearly Untapped Medical Resources. FEMS Microbiol. Lett., 369.","DOI":"10.1093\/femsle\/fnac052"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"wrae235","DOI":"10.1093\/ismejo\/wrae235","article-title":"Trophic modulation of endophytes by rhizosphere protists","volume":"18","author":"Asiloglu","year":"2024","journal-title":"ISME J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Li, J., Li, L., Arif, M., Ding, D., Hu, X., Zheng, J., Yuan, Z., and Li, C. (2021). Artificial Plantation Responses to Periodic Submergence in Massive Dam and Reservoir Riparian Zones: Changes in Soil Properties and Bacterial Community Characteristics. Biology, 10.","DOI":"10.3390\/biology10080819"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sainju, U.M., Liptzin, D., and Jabro, J.D. (2022). Relating Soil Physical Properties to Other Soil Properties and Crop Yields. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-26619-8"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhu, J., Ma, J., Wang, S., Zuo, L., and Yang, Z. (2024). Close Correlation between Sugarcane Ratoon Decline and Rhizosphere Ecological Factors. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-70613-1"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13808","DOI":"10.7717\/peerj.13808","article-title":"Zanthoxylum bungeanum root-rot associated shifts in microbiomes of root endosphere, rhizosphere, and soil","volume":"10","author":"Liao","year":"2022","journal-title":"PeerJ"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rana, A.K., Vyas, P., Sharma, S., and Sardana, V. (2023). Groundnut harbours non-nodulating non-rhizobial plant growth-promoting bacterial endophytes. 3 Biotech, 13.","DOI":"10.1007\/s13205-023-03837-z"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Das, G., and Dhal, P.K. (2022). Salinity Influences Endophytic Bacterial Communities in Rice Roots from the Indian Sundarban Area. Curr. Microbiol., 79.","DOI":"10.1007\/s00284-022-02936-z"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wulandari, A.P., Triani, E., Sari, K., Prasetyani, M., Nurzaman, M., Purwati, R.D., Ermawar, R.A., and Nuraini, A. (2022). Endophytic Microbiome of Boehmeria Nivea and Their Antagonism against Latent Fungal Pathogens in Plants. BMC Microbiol., 22.","DOI":"10.1186\/s12866-022-02737-1"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-4939-8724-5_3","article-title":"Analysis of Secondary Metabolites from Plant Endophytic Fungi","volume":"1848","author":"Liu","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154043","DOI":"10.1016\/j.jplph.2023.154043","article-title":"Flavonoid Synthesis in Lamiophlomis Rotata from Qinghai-Tibet Plateau Is Influenced by Soil Properties, Microbial Community, and Gene Expression","volume":"287","author":"Qiao","year":"2023","journal-title":"J. Plant Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, F., Zheng, T.-T., Shi, L., Zhang, Z.-G., Niu, T.-M., Wang, Q.-Y., Zhao, D.-S., Li, W., and Zhao, P. (2021). Lamiophlomis Herba: A Comprehensive Overview of Its Chemical Constituents, Pharmacology, Clinical Applications, and Quality Control. Biomed. Pharmacother. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112299"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"113953","DOI":"10.1016\/j.jep.2021.113953","article-title":"Systems Pharmacology-Based Dissection of Mechanisms of Tibetan Medicinal Compound Ruteng as an Effective Treatment for Collagen-Induced Arthritis Rats","volume":"272","author":"Huang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11463","DOI":"10.1039\/D0RA01050B","article-title":"Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Lamiophlomis Rotata (Benth.) Kudo: A Review","volume":"10","author":"Cui","year":"2020","journal-title":"RSC Adv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1099\/ijsem.0.004161","article-title":"Nocardioides Dongxiaopingii Sp. Nov., Isolated from Leaves of Lamiophlomis Rotata on the Qinghai-Tibet Plateau","volume":"70","author":"Zhang","year":"2020","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Song, Y., Liang, Y., Zeng, R., Li, R., Zhou, Y., Huang, S., Li, X., Zhang, N., Xu, M., and Xiong, K. (2023). Qualitative and Quantitative Analyses of Chemical Constituents in Vitro and in Vivo and Systematic Evaluation of the Pharmacological Effects of Tibetan Medicine Zhixue Zhentong Capsules. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1204947"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lian, C., Zhang, B., Yang, J., Lan, J., Yang, H., Guo, K., Li, J., and Chen, S. (2022). Validation of Suitable Reference Genes by Various Algorithms for Gene Expression Analysis in Isodon Rubescens under Different Abiotic Stresses. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-22397-5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1039\/D2MO00247G","article-title":"Lamiophlomis Rotata Attenuates Rheumatoid Arthritis by Regulating Sphingolipid and Steroid Hormone Metabolism","volume":"19","author":"Zhou","year":"2023","journal-title":"Mol. Omics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116850","DOI":"10.1016\/j.jep.2023.116850","article-title":"Exploring the Pharmacological Mechanisms and Key Active Ingredients of Total Flavonoids from Lamiophlomis Rotata (Benth.) Kudo against Rheumatoid Arthritis Based on Multi-Technology Integrated Network Pharmacology","volume":"317","author":"Zhan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1039\/C7RA10143K","article-title":"The Similarity and Variability of the Iridoid Glycoside Profile and Antioxidant Capacity of Aerial and Underground Parts of Lamiophlomis Rotata According to UPLC-TOF-MS and Multivariate Analyses","volume":"8","author":"Zhang","year":"2018","journal-title":"RSC Adv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000527262","article-title":"Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury","volume":"108","author":"Peng","year":"2023","journal-title":"Pharmacology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1389557522666220602141142","article-title":"An Insight into the Hepatoprotective Activity and Structure-Activity Relationships of Flavonoids","volume":"23","author":"Majee","year":"2023","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.2174\/0929867326666190916144709","article-title":"Bioactive Secondary Metabolites from Endophytic Fungi","volume":"27","author":"Ancheeva","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-Resolution Sample Inference from Illumina Amplicon Data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-4939-8728-3_8","article-title":"16S rRNA Gene Analysis with QIIME2","volume":"1849","author":"Hall","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yu, C., Wang, P., Ding, H., Hu, Y., Wang, F., Chen, H., Chen, L., and Liu, Y. (2024). Effects of the Epiphytic Patterns on Endophytes and Metabolites of Dendrobium Nobile Lindl. Front. Plant Sci., 15.","DOI":"10.3389\/fpls.2024.1326998"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"110850","DOI":"10.1016\/j.ygeno.2024.110850","article-title":"Metabolomic and Transcriptomic Reveal Flavonoid Biosynthesis and Regulation Mechanism in Phlomoides Rotata from Different Habitats","volume":"116","author":"Li","year":"2024","journal-title":"Genomics"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yang, P., Luo, Y., Gao, Y., Gao, X., Gao, J., Wang, P., and Feng, B. (2020). Soil properties, bacterial and fungal community compositions and the key factors after 5-year continuous monocropping of three minor crops. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0237164"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wippel, K. (2023). Plant and Microbial Features Governing an Endophytic Lifestyle. Curr. Opin. Plant Biol., 76.","DOI":"10.1016\/j.pbi.2023.102483"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Shimasaki, T., Masuda, S., Garrido-Oter, R., Kawasaki, T., Aoki, Y., Shibata, A., Suda, W., Shirasu, K., Yazaki, K., and Nakano, R.T. (2021). Tobacco Root Endophytic Arthrobacter Harbors Genomic Features Enabling the Catabolism of Host-Specific Plant Specialized Metabolites. mBio, 12.","DOI":"10.1128\/mBio.00846-21"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cotes, B., Th\u00f6ming, G., Amaya-G\u00f3mez, C.V., Nov\u00e1k, O., and Nansen, C. (2020). Root-Associated Entomopathogenic Fungi Manipulate Host Plants to Attract Herbivorous Insects. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-80123-5"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Waqar, S., Bhat, A.A., and Khan, A.A. (2024). Endophytic Fungi: Unravelling Plant-Endophyte Interaction and the Multifaceted Role of Fungal Endophytes in Stress Amelioration. Plant Physiol. Biochem. PPB, 206.","DOI":"10.1016\/j.plaphy.2023.108174"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00203-020-01882-3","article-title":"Analysis of Endophytic and Rhizosphere Bacterial Diversity and Function in the Endangered Plant Paeonia Ludlowii","volume":"202","author":"Lu","year":"2020","journal-title":"Arch. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Gluck-Thaler, E., and Slot, J.C. (2015). Dimensions of Horizontal Gene Transfer in Eukaryotic Microbial Pathogens. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005156"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ban, Y., Yang, H., Jiang, J., Wang, C., Lv, B., and Feng, Y. (2024). A \u03b1-L-Rhamnosidase from Echinacea Purpurea Endophyte Simplicillium Sinense EFF1 and Its Application in Production of Calceorioside B. Int. J. Biol. Macromol., 270.","DOI":"10.1016\/j.ijbiomac.2024.132090"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, R., Duan, W., Ran, Z., Chen, X., Yu, H., Fang, L., Guo, L., and Zhou, J. (2023). Diversity and Correlation Analysis of Endophytes and Metabolites of Panax Quinquefolius L. in Various Tissues. BMC Plant Biol., 23.","DOI":"10.1186\/s12870-023-04282-z"},{"key":"ref_47","unstructured":"(2024, July 05). Comprehensive Microbiome and Metabolome Analyses Reveal the Medicinal Components of Paeonia Lactiflora, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/37111836\/."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, W., Li, D., Qiu, X., Yang, J., Liu, L., Wang, E., and Yuan, H. (2024). Selective regulation of endophytic bacteria and gene expression in soybean by water-soluble humic materials. Environ. Microbiome, 19.","DOI":"10.1186\/s40793-023-00546-1"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3852\/08-192","article-title":"Tetracladium nainitalense sp. nov., a root endophyte from Kumaun Himalaya, India","volume":"101","author":"Sati","year":"2009","journal-title":"Mycologia"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"135524","DOI":"10.1016\/j.foodchem.2023.135524","article-title":"Detection and classification of volatile compounds emitted by three fungi-infected citrus fruit using gas chromatography-mass spectrometry","volume":"412","author":"Wu","year":"2023","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1080\/09593330.2020.1818833","article-title":"Isolation of endophytic bacteria from the medicinal, forestal and ornamental tree Handroanthus impetiginosus","volume":"43","author":"Yarte","year":"2022","journal-title":"Environ. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1139\/cjm-2022-0171","article-title":"New insights into the composition and diversity of endophytic bacteria in cultivated Huperzia serrata","volume":"69","author":"Pan","year":"2023","journal-title":"Can. J. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.14715\/cmb\/2021.67.3.33","article-title":"Antibacterial and antioxidant activities of endophytic fungi and nettle (Urtica dioica L.) leaves as their host","volume":"67","author":"Salmi","year":"2021","journal-title":"Cell. Mol. Biol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/3\/503\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:41:51Z","timestamp":1760028111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/3\/503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["microorganisms13030503"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms13030503","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]}}}