{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:58:52Z","timestamp":1760057932835,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Candida infective endocarditis presents therapeutic challenges with high mortality. A complex case of Candida prosthetic valve endocarditis refractory to standard antifungals (anidulafungin and fluconazole) and high-dose caspofungin was successfully treated with heart transplantation. The literature review revealed a few cases of bacterial endocarditis successfully treated with heart transplantation, but with only two transplanted cases of fungal endocarditis. This report explores heart transplantation as a last resort for managing refractory infective endocarditis. The patient is still alive and free of infection, two and a half years after transplantation.<\/jats:p>","DOI":"10.3390\/microorganisms13030580","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T04:58:17Z","timestamp":1741064297000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Heart Transplantation for Refractory Candida tropicalis Endocarditis: A Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1913-6110","authenticated-orcid":false,"given":"Ricardo","family":"El Nouwar","sequence":"first","affiliation":[{"name":"Clinic of Infectious Diseases, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0792-3346","authenticated-orcid":false,"given":"Eva","family":"Larranaga Lapique","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Vanden Eynden","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-7418","authenticated-orcid":false,"given":"Delphine","family":"Martiny","sequence":"additional","affiliation":[{"name":"Laboratoire Hospitalier Universitaire de Bruxelles-Universit\u00e9 Libre de Bruxelles (LHUB-ULB), 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Remmelink","sequence":"additional","affiliation":[{"name":"Anatomy and Pathology Department, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Roussouli\u00e8res","sequence":"additional","affiliation":[{"name":"Department of Cardiology, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Hites","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, H\u00f4pital Universitaire de Bruxelles (HUB), 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Deorukhkar, S.C., Saini, S., and Mathew, S. (2014). Virulence Factors Contributing to Pathogenicity of Candida tropicalis and Its Antifungal Susceptibility Profile. Int. J. Microbiol., 2014.","DOI":"10.1155\/2014\/456878"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis: Developed by the task force on the management of endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_3","unstructured":"Mycology|University of Adelaide [Internet] (2025, February 13). CLSI Break Points. 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