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Several studies have implicated human herpesviruses from the Herpesviridae family as primary causes of corneal endotheliitis, including cytomegalovirus (CMV), varicella zoster virus (VZV), and herpes simplex viruses 1 and 2 (HSV-1 and HSV-2). This review critically evaluates the present literature surrounding herpesvirus infections of the corneal endothelium.<\/jats:p>","DOI":"10.3390\/microorganisms13040778","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T13:36:49Z","timestamp":1743169009000},"page":"778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Herpesvirus Infections of the Corneal Endothelium"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4539-3771","authenticated-orcid":false,"given":"Jessie","family":"Wang","sequence":"first","affiliation":[{"name":"Duke Eye Center, Duke University, Durham, NC 27705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4177-1226","authenticated-orcid":false,"given":"Behnam","family":"Rabiee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandani","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"},{"name":"Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, NJ 08084, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansab","family":"Jafri","sequence":"additional","affiliation":[{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad","family":"Hussain","sequence":"additional","affiliation":[{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaila","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtiaz","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Kamoun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nazareth Hospital, Trinity Health Mid-Atlantic, Philadelphia, PA 19152, USA"},{"name":"IC Laser Eye Care, Bensalem, PA 19020, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6091-1989","authenticated-orcid":false,"given":"Lewis","family":"Oh","sequence":"additional","affiliation":[{"name":"Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima I.","family":"Bobat","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The University of Illinois Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-6953","authenticated-orcid":false,"given":"Deepak","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, The University of Illinois Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim V.","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s40123-019-0169-7","article-title":"A review of corneal endotheliitis and endotheliopathy: Differential diagnosis, evaluation, and treatment","volume":"8","author":"Moshirfar","year":"2019","journal-title":"Ophthalmol. 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