{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:37Z","timestamp":1790172757679,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Antimicrobial resistance (AMR) constitutes a pressing and intensifying global health crisis, significantly exacerbated by the inappropriate utilization and excessive application of antibiotics in livestock agriculture. The excessive use of antibiotics, including prophylactic and metaphylactic administration as well as growth-promotion applications, exacerbates selective pressures, fostering the proliferation of multidrug-resistant (MDR) bacterial strains. Pathogens such as Escherichia coli, Salmonella spp., and Staphylococcus aureus can be transmitted to humans through direct contact, contaminated food, and environmental pathways, establishing a clear link between livestock farming and human AMR outbreaks. These challenges are particularly pronounced in regions with limited veterinary oversight and weak regulatory frameworks. Addressing these issues requires the implementation of sustainable practices, enhanced antibiotic stewardship, and strengthened interdisciplinary collaboration. This review underscores the critical need for a One Health approach to mitigate AMR, recognizing the interconnectedness of human, animal, and environmental health in safeguarding global public health.<\/jats:p>","DOI":"10.3390\/microorganisms13040779","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T05:21:04Z","timestamp":1743398464000},"page":"779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Antibiotic Use in Livestock Farming: A Driver of Multidrug Resistance?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0048-8911","authenticated-orcid":false,"given":"Andreas","family":"Matheou","sequence":"first","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah","family":"Abousetta","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphrodite Persephone","family":"Pascoe","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demosthenis","family":"Papakostopoulos","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7590-5107","authenticated-orcid":false,"given":"Loukas","family":"Charalambous","sequence":"additional","affiliation":[{"name":"School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0831-3121","authenticated-orcid":false,"given":"Stelios","family":"Panagi","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-5068","authenticated-orcid":false,"given":"Stavros","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"Division of Medical Education, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4286-9284","authenticated-orcid":false,"given":"Andreas","family":"Yiallouris","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9324-1641","authenticated-orcid":false,"given":"Charalampos","family":"Filippou","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0006-5766","authenticated-orcid":false,"given":"Elizabeth O.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Medicine, European University Cyprus, Nicosia 2404, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","unstructured":"(2025, January 03). 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