{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:21:31Z","timestamp":1787739691271,"version":"build-2784847793"},"reference-count":83,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro (FAPERJ)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The increasing prevalence and dissemination of multidrug-resistant bacteria represent a serious concern for public health. Aeromonas caviae is a pathogenic microorganism that causes a wide spectrum of diseases in fish and humans and is often associated with aquatic environments and isolated from foods and animals. Here, we present the isolation and characterization of the V15T strain isolated from a drinking water storage tank in Rio de Janeiro, Brazil. The V15T strain has a genome length of 4,443,347 bp with an average G + C content of 61.78% and a total of 4028 open reading frames. Its genome harbors eight types of antibiotic resistance genes (ARGs) involving resistance to beta-lactamases, macrolides, and quinolones. The presence of blaMOX-6, blaOXA-427\/blaOXA-504, and mutations in parC were detected. In addition, other ARGs (macA, macB, opmH, and qnrA) and multidrug efflux pumps (such as MdtL), along with several resistance determinants and 106 genes encoding virulence factors, including adherence (polar and lateral flagella), secretion (T2SS, T6SS), toxin (hlyA), and stress adaptation (katG) systems, were observed. The genome sequence reported here provides insights into antibiotic resistance, biofilm formation, evolution, and virulence in Aeromonas strains, highlighting the need for more public health attention and the further monitoring of drinking water systems. Also, the results of physiological and phylogenetic data, average nucleotide identity (ANI) calculation, and digital DNA\u2013DNA hybridization (dDDH) analysis support the inclusion of the strain V15T in the genus Aeromonas as a new subspecies with the proposed name Aeromonas caviae subsp. aquatica subsp. nov. (V15T = P53320T). This study highlights the genomic plasticity and pathogenic potential of Aeromonas within household drinking water systems, calling for the revision of water treatment protocols to address biofilm-mediated resistance and the implementation of routine genomic surveillance to mitigate public health risks.<\/jats:p>","DOI":"10.3390\/microorganisms13040897","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:06:51Z","timestamp":1744621611000},"page":"897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aeromonas caviae subsp. aquatica subsp. nov., a New Multidrug-Resistant Subspecies Isolated from a Drinking Water Storage Tank"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-3189","authenticated-orcid":false,"given":"Victor Hugo","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Biology, Rio de Janeiro State University, Rio de Janeiro 20550-013, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-176X","authenticated-orcid":false,"given":"Lidiane Coelho","family":"Berbert","sequence":"additional","affiliation":[{"name":"Department of Biology, Rio de Janeiro State University, Rio de Janeiro 20550-013, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-952X","authenticated-orcid":false,"given":"Ayodele Timilehin","family":"Adesoji","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Federal University, Dutsin-Ma 821101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-4097","authenticated-orcid":false,"given":"Kayo","family":"Bianco","sequence":"additional","affiliation":[{"name":"National Institute for Quality Control in Health, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-7684","authenticated-orcid":false,"given":"Janaina Japiassu Vasconcelos","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Division of Metrology Applied to Life Sciences, National Institute of Metrology, Quality and Technology, Duque de Caxias 25212-435, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via L\u00facia Piffano Costa","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Rio de Janeiro State University, Rio de Janeiro 20550-013, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0643-901X","authenticated-orcid":false,"given":"Rodolpho Mattos","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Rio de Janeiro State University, Rio de Janeiro 20550-013, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa Mandetta","family":"Clementino","sequence":"additional","affiliation":[{"name":"National Institute for Quality Control in Health, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-0232","authenticated-orcid":false,"given":"Alexander Machado","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Biology, Rio de Janeiro State University, Rio de Janeiro 20550-013, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,13]]},"reference":[{"key":"ref_1","unstructured":"WHO (2011). 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