{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:33:53Z","timestamp":1790879633767,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brasil","award":["#2014\/50315-0"],"award-info":[{"award-number":["#2014\/50315-0"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brasil","award":["#88887.649146\/2021-00"],"award-info":[{"award-number":["#88887.649146\/2021-00"]}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["#2014\/50315-0"],"award-info":[{"award-number":["#2014\/50315-0"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["#88887.649146\/2021-00"],"award-info":[{"award-number":["#88887.649146\/2021-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nucleus of Tropical Medicine of Federal University of Par\u00e1 State, Brazil","award":["#2014\/50315-0"],"award-info":[{"award-number":["#2014\/50315-0"]}]},{"name":"Nucleus of Tropical Medicine of Federal University of Par\u00e1 State, Brazil","award":["#88887.649146\/2021-00"],"award-info":[{"award-number":["#88887.649146\/2021-00"]}]},{"name":"Secretary of Health and Environment Surveillance of Ministry of Health, Brazil","award":["#2014\/50315-0"],"award-info":[{"award-number":["#2014\/50315-0"]}]},{"name":"Secretary of Health and Environment Surveillance of Ministry of Health, Brazil","award":["#88887.649146\/2021-00"],"award-info":[{"award-number":["#88887.649146\/2021-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>American cutaneous leishmaniasis (ACL), caused by Leishmania (Leishmania) amazonensis and L. (Viannia) braziliensis, presents a wide spectrum of clinical and immunopathological manifestations, ranging from localized cutaneous leishmaniasis (LCL) to severe forms like anergic diffuse cutaneous (ADCL) and mucocutaneous leishmaniasis (MCL). Despite evidence of the immune response\u2019s complexity, the role of inflammasomes in disease severity and parasite persistence remains unclear. We investigated the transcriptomic and immunopathological profiles of inflammasome components in patient lesions across the clinical spectrum. Genes such as NLRP3, AIM2, NLRP12, NLRC4, CASP1, CASP5, GSDMD, and IL1B and all evaluated proteins, showed higher expression in ACL compared to healthy controls. Distinct inflammasome activation patterns were observed: MCL, the hyperreactive form, showed elevated NLRP3, AIM2, and IL-1\u03b2, indicating an intensified inflammatory environment. ADCL, the hyporeactive form, displayed increased NLRP12 and NLRC4 expression with reduced GSDMD. Localized forms showed transitional profiles, highlighting ACL\u2019s multifactorial pathogenesis. These findings advance our understanding of inflammasome mechanisms in ACL, identifying potential therapeutic targets to modulate inflammation and improve management.<\/jats:p>","DOI":"10.3390\/microorganisms13050980","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:44:52Z","timestamp":1745495092000},"page":"980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptomic and Immunopathological Profiles of Inflammasomes in Different Clinical Forms of American Cutaneous Leishmaniasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Larissa dos Santos","family":"Alc\u00e2ntara","sequence":"first","affiliation":[{"name":"Laboratorio de Patologia de Mol\u00e9stias Infecciosas\u2014LIM-50 Departamento de Patologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-8765","authenticated-orcid":false,"given":"Marliane Batista","family":"Campos","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas, Departamento de Parasitologia, Bel\u00e9m 70300-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Stocco","family":"Lima","sequence":"additional","affiliation":[{"name":"Instituto Evandro Chagas, Departamento de Parasitologia, Bel\u00e9m 70300-000, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pontillo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica, Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paolo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla Batista da Silva","family":"Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica, Departamento de Imunologia, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade de S\u00e3o Paulo, Sao Paolo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea Favero","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratorio de Patologia de Mol\u00e9stias Infecciosas\u2014LIM-50 Departamento de Patologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Pires","family":"Camargo","sequence":"additional","affiliation":[{"name":"Laboratorio de Microcirurgia\u2014Cirurgia Pl\u00e1stica\u2014LIM-04 Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-5973","authenticated-orcid":false,"given":"Sueli Mieko","family":"Oba-Shinjo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular e Molecular\u2014LIM-15 Departamento de Neurologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-2440","authenticated-orcid":false,"given":"M\u00e1rcia Dalastra","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Laboratorio de Patologia de Mol\u00e9stias Infecciosas\u2014LIM-50 Departamento de Patologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo Pereira","family":"Corbett","sequence":"additional","affiliation":[{"name":"Laboratorio de Patologia de Mol\u00e9stias Infecciosas\u2014LIM-50 Departamento de Patologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, Sao Paolo 01246-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-6121","authenticated-orcid":false,"given":"Vania L. 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