{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:07:57Z","timestamp":1777633677039,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Cutaneous nocardiosis is an uncommon bacterial infection caused by Nocardia spp.; Nocardia brasiliensis is the agent involved in most cases. This infection is acquired through the direct traumatic inoculation of soil, plants, or other substrates where the bacteria are found. Clinically, it usually manifests as an erythematous ulcerated nodule. In one-third of cases, nodules or gummas are distributed over the lymphatic pathways that resemble lymphocutaneous sporotrichosis. Its manifestations vary and can present acutely or more frequently with a latent clinical picture over time. Diagnosis is established mainly by Gram staining, biopsy, exudate culture, and molecular biology. Nocardia infections can recur, implying that antimicrobial therapy must be prolonged (between 6 and 12 months) and involve monitoring patients for at least 6 months after the end of treatment. Early diagnosis and targeted treatment may reduce patient mortality rates. We report the case of an 82-year-old woman who presented with four nodules with a lymphangitic spread on her left hand and forearm, one week after the trauma. Molecular identification was performed using 16S rDNA gene sequencing, and Nocardia brasiliensis was identified.<\/jats:p>","DOI":"10.3390\/microorganisms13051022","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:49:36Z","timestamp":1745912976000},"page":"1022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Primary Cutaneous Nocardiosis (Lymphangitic Type) in an Immunocompetent Patient: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"given":"Hilayali","family":"Aguilar-Molina","sequence":"first","affiliation":[{"name":"Servicio de Dermatolog\u00eda, Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-3100","authenticated-orcid":false,"given":"Sonia","family":"Toussaint-Caire","sequence":"additional","affiliation":[{"name":"Servicio de Dermatopatolog\u00eda, Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Arenas","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Micolog\u00eda, Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Tlalpan, Ciudad de Mexico 14080, Mexico"},{"name":"Fundaci\u00f3n Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9973","authenticated-orcid":false,"given":"Juan","family":"Xicohtencatl-Cortes","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda Intestinal, Hospital Infantil de Mexico Dr. Federico G\u00f3mez, Cuauht\u00e9moc, Ciudad de Mexico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-5178","authenticated-orcid":false,"given":"Luary C.","family":"Mart\u00ednez-Chavarr\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Aut\u00f3noma de Mexico, Coyoac\u00e1n, Ciudad de Mexico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-0942","authenticated-orcid":false,"given":"Rigoberto","family":"Hern\u00e1ndez-Castro","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda de Agentes Pat\u00f3genos, Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-0771","authenticated-orcid":false,"given":"Carmen","family":"Rodriguez-Cerdeira","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain"},{"name":"Dermatology Department, Grupo Hospitalario (CMQ Concheiro), Manuel Olivi\u00e9 11, 36203 Vigo, Spain"},{"name":"Department of Health Sciences, University of Vigo, Campus of Vigo, As Lagoas, 36310 Vigo, Spain"},{"name":"European Women\u2019s Dermatologic and Venereologic Society (EWDVS), 36700 Tui, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.mayocp.2011.11.016","article-title":"Nocardiosis: Updates and clinical overview","volume":"87","author":"Wilson","year":"2012","journal-title":"Mayo Clin. 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