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Allergic contact dermatitis (ACD), a common skin disorder affecting one in four people worldwide, can be accompanied by intestinal disturbances. To explore this, we used an experimental model of ACD to investigate the intestinal changes induced by the disease. Parameters assessed included intestinal microbiota, short-chain fatty acids (SCFAs), gene expression related to intestinal permeability, inflammatory cytokines, and mucus production. To evaluate potential therapeutic interventions, the probiotic Bifidobacterium longum strain BB536 was administered via gavage, starting 10 days before dermatitis induction and continuing until the last day of disease induction. ACD caused alterations in the composition of intestinal microbiota compared to na\u00efve mice but did not affect SCFA production. The probiotic altered microbiota composition and increased acetate production in dermatitis-induced mice. ACD decreased the gene expression of TjP1, ATHO1, and MUC2, while probiotic treatment restored TjP1 and ATHO1 to normal levels. The cytokine IL-6 increased in the ACD group compared to na\u00efve mice, whereas IL-10 decreased; probiotic treatment also restored these levels. Intestinal mucus production, affected by ACD, was partially restored by probiotic treatment. The findings suggest that probiotics could be a therapeutic strategy to prevent intestinal issues caused by skin diseases.<\/jats:p>","DOI":"10.3390\/microorganisms13051082","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:20:26Z","timestamp":1746591626000},"page":"1082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-1245","authenticated-orcid":false,"given":"Eduardo","family":"Mendes","sequence":"first","affiliation":[{"name":"Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de S\u00e3o Paulo, Diadema 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-9012","authenticated-orcid":false,"given":"Evelyn Roxana Perez","family":"Umana","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de S\u00e3o Paulo, Diadema 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-9780","authenticated-orcid":false,"given":"Daniel","family":"Di Pace Soares Penna","sequence":"additional","affiliation":[{"name":"Division of Microbial Resources, Multidisciplinary Center for Chemical, Biological and Agricultural Research (CPQBA), State University of Campinas (UNICAMP), Paul\u00ednia 13148-218, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-6940","authenticated-orcid":false,"given":"Fernando Augusto","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neurobiology Laboratory (LaNeC), Center of Mathematics, Computing and Cognition (CMCC), Federal University of ABC, S\u00e3o Bernardo do Campo 09280-560, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-568X","authenticated-orcid":false,"given":"Leandro Nascimento","family":"Lemos","sequence":"additional","affiliation":[{"name":"Ilum School of Science, Brazilian Center for Research in Energy and Materials (CNPEM), Campinas 13083-100, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-956X","authenticated-orcid":false,"given":"Willian Rodrigues","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de S\u00e3o Paulo, Diadema 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-0369","authenticated-orcid":false,"given":"Mateus Barbosa","family":"Casaro","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de S\u00e3o Paulo, Diadema 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-7583","authenticated-orcid":false,"given":"Mariana","family":"Lazarini","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemistry and Pharmaceutical Sciences, Department of Pharmaceutics Sciences, University Federal de S\u00e3o Paulo, Diadema 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-4758","authenticated-orcid":false,"given":"Val\u00e9ria 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