{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:12:42Z","timestamp":1791846762175,"version":"4.3.4"},"reference-count":99,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Antibiotic resistance is increasing at an alarming rate worldwide, in large part due to their misuse and improper disposal. Antibiotics administered to treat human and animal diseases, including feed supplements for the treatment or prevention of disease in farm animals, have contributed greatly to the emergence of a multitude of antibiotic-resistant pathogens. Shewanella is one of many bacteria that have developed antibiotic resistance, and in some species, multiple-antibiotic resistance (MAR). Shewanella is a rod-shaped, Gram-negative, oxidase-positive, and H2S-producing bacterium that is naturally found in the marine environment. In humans, Shewanella spp. can cause skin and soft tissue infections, septicemia, cellulitis, osteomyelitis, and ear and wound infections. Some Shewanella have been shown to be resistant to a variety of antibiotics, including beta-lactams, aminoglycoside, quinolones, third- or fourth-generation cephalosporins, and carbapenems, due to the presence of genes such as the blaOXA-class D beta-lactamase-encoding gene, blaAmpC-class-C beta-lactamase-encoding gene, and the qnr gene. Bacteria can acquire and transmit these genes through different horizontal gene-transmission mechanisms such as transformation, transduction, and conjugation. The genes for antibiotic resistance are present on Shewanella chromosomes and plasmids. Apart from this, heavy metals such as arsenic, mercury, cadmium, and chromium can also increase antibiotic resistance in Shewanella due to co-selection processes such as co-resistance, cross resistance, and co-regulation mechanisms. Antibiotics and drugs enter Shewanella spp. through pores or gates in their cell wall and may be ejected from the bacteria by efflux pumps, which are the first line of bacterial defense against antibiotics. Multiple-drug resistant Shewanella can be particularly difficult to control. This review focuses on the phenotypic and genomic characteristics of Shewanella that are involved in the increase in antimicrobial resistance in this bacterium.<\/jats:p>","DOI":"10.3390\/microorganisms13051115","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:59:26Z","timestamp":1747108766000},"page":"1115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Characterization of Antibiotic Resistance in Shewanella Species: An Emerging Pathogen in Clinical and Environmental Settings"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2765-3269","authenticated-orcid":false,"given":"Shahid","family":"Sher","sequence":"first","affiliation":[{"name":"School of the Environment, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-0874","authenticated-orcid":false,"given":"Gary P.","family":"Richards","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture, Agricultural Research Service, Delaware State University, Dover, DE 19901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-3847","authenticated-orcid":false,"given":"Salina","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and Resource Science, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry N.","family":"Williams","sequence":"additional","affiliation":[{"name":"School of the Environment, Florida A&M University, Tallahassee, FL 32307, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.2147\/IDR.S173867","article-title":"Antibiotic resistance: A rundown of a global crisis","volume":"11","author":"Aslam","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12934-023-02118-x","article-title":"Bioactive compounds and biomedical applications of endophytic fungi: A recent review","volume":"22","author":"Hashem","year":"2023","journal-title":"Microb. Cell Fact."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Nocentini, A., Capasso, C., and Supuran, C.T. (2023). Carbonic anhydrase inhibitors as Novel antibacterials in the era of antibiotic resistance: Where are we now?. Antibiotics, 12.","DOI":"10.3390\/antibiotics12010142"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment\u2014A review\u2014Part I","volume":"75","year":"2009","journal-title":"Chemosphere"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e1418","DOI":"10.1002\/hsr2.1418","article-title":"Collateral sensitivity: An evolutionary trade-off between antibiotic resistance mechanisms, attractive for dealing with drug-resistance crisis","volume":"6","author":"Yekani","year":"2023","journal-title":"Health Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Iu, H.T.V., Fong, P.M., Yam, H.C.B., Gao, P., Yan, B., Lai, P.M., and Ng, K.H.K. (2023). Identification of a small molecule compound active against antibiotic-tolerant Staphylococcus aureus by boosting ATP synthesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076242"},{"key":"ref_7","first-page":"87","article-title":"Antibiotic use pattern of surgical site infection prophylaxis in surgical wards of a teaching hospital in Shiraz, Iran","volume":"9","author":"Mahmoudi","year":"2023","journal-title":"Trends Pharm. Sci."},{"key":"ref_8","first-page":"109","article-title":"History, current situation, and future perspectives on antibiotics and antibiotic Resistance","volume":"Volume 2","author":"Dyary","year":"2023","journal-title":"One Health Triad"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e120102","DOI":"10.1016\/j.envpol.2022.120102","article-title":"Metagenomic analysis reveals the diversity and distribution of antibiotic resistance genes in thermokarst lakes of the Yellow River Source Area","volume":"313","author":"Ren","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Despotovic, M., de Nies, L., Busi, S.B., and Wilmes, P. (2023). Reservoirs of antimicrobial resistance in the context of One Health. Curr. Opin. Microbiol., 73.","DOI":"10.1016\/j.mib.2023.102291"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10096-017-2962-3","article-title":"Current trends of human infections and antibiotic resistance of the genus Shewanella","volume":"36","author":"Yousfi","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Azizi, S.M.M., Haffiez, N., Zakaria, B.S., Elbeshbishy, E., and Dhar, B.R. (2023). Nano-and microplastics as carriers for antibiotics and antibiotic resistance genes. In Curr. Dev. Biotechnol. Bioengin., 361\u2013385.","DOI":"10.1016\/B978-0-323-99908-3.00005-1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Johnson, T., Richards, G.P., Jacobs, J., Townsend, H., Almuhaideb, E., Rosales, D., and Parveen, S. (2025). Prevalence and pathogenic potential of Shewanella species in oysters and seawater collected from the Chesapeake Bay and Maryland Coastal Bays. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1502443"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nguyen, C.C., Hugie, C.N., Kile, M.L., and Nawab-Daneshmand, T. (2019). Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review. Front. Environ. Sci. Eng., 13.","DOI":"10.1007\/s11783-019-1129-0"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhu, Y.G., Zhao, Y., Li, B., Huang, C.L., Zhang, S.Y., Yu, S., and Su, J.Q. (2017). Continental-scale pollution of estuaries with antibiotic resistance genes. Nat. Microbiol., 2.","DOI":"10.1038\/nmicrobiol.2016.270"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.scitotenv.2015.04.101","article-title":"Fate of sulfonamide resistance genes in estuary environment and effect of anthropogenic activities","volume":"527","author":"Lu","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e103505","DOI":"10.1016\/j.etap.2020.103505","article-title":"Effects of low levels of the antibiotic ciprofloxacin on the polychaete Hediste diversicolor: Biochemical and behavioural effects","volume":"80","author":"Nogueira","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1080\/21505594.2022.2117831","article-title":"Shewanella infection in humans: Epidemiology, clinical features and pathogenicity","volume":"13","author":"Yu","year":"2022","journal-title":"Virulence"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/1040841X.2012.726209","article-title":"The genus Shewanella: From the briny depths below to human pathogen","volume":"40","author":"Janda","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/clinids\/22.6.1036","article-title":"Shewanella alga bacteremia in two patients with lower leg ulcers","volume":"22","author":"Dominguez","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1469-0691.2005.01108.x","article-title":"Shewanella algae and Shewanella putrefaciens: Clinical and microbiological characteristics","volume":"11","author":"Holt","year":"2005","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Satomi, M. (2014). The family Shewanellaceae. The Prokaryotes, Springer.","DOI":"10.1007\/978-3-642-38922-1_226"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0723-2020(85)80051-5","article-title":"Phylogeny of the Vibrionaceae, and recommendation for two new genera, Listonella and Shewanella","volume":"6","author":"MacDonell","year":"1985","journal-title":"Syst. Appl. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Nouioui, I., Tarhriz, V., Kim, H.M., Montazersaheb, S., Hejazi, M.A., Jeon, C.O., and Hejazi, M.S. (2022). Shewanella azerbaijanica sp. nov. a novel aquatic species with high bioremediation abilities. Arch. Microbiol., 204.","DOI":"10.1007\/s00203-022-03112-4"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mart\u00edn-Rodr\u00edguez, A.J., and Meier-Kolthoff, J.P. (2022). Whole genome-based taxonomy of Shewanella and Parashewanella. Int. J. Syst. Evol. Microbiol., 72.","DOI":"10.1099\/ijsem.0.005438"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ortega, R.C.M.H., Tabugo, S.R.M., Martinez, J.G.T., Padasas, C.S., and Balc\u00e1zar, J.L. (2023). Occurrence of Aeromonas Species in the Cutaneous Mucus of Barbour\u2019s Seahorses (Hippocampus barbouri) as Revealed by High-Throughput Sequencing. Animals, 13.","DOI":"10.3390\/ani13071241"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.marpolbul.2013.09.025","article-title":"Antibiotic resistance of Shewanella putrefaciens isolated from shellfish collected from the west sea in Korea","volume":"76","author":"Kang","year":"2013","journal-title":"Mar. Pollut. Bull."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"De Marco, G., Cappello, T., and Maisano, M. (2023). Histomorphological changes in fish gut in response to prebiotics and probiotics treatment to improve their health status: A review. Animals, 13.","DOI":"10.3390\/ani13182860"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/jam.15711","article-title":"Marine bacteria and omic approaches: A novel and potential repository for bioremediation assessment","volume":"133","author":"Hassan","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tseng, S.Y., Liu, P.Y., Lee, Y.H., Wu, Z.Y., Huang, C.C., Cheng, C.C., and Tung, K.C. (2018). The pathogenicity of Shewanella algae and ability to tolerate a wide range of temperatures and salinities. Can. J. Infect. Dis. Med. Microbiol., 1.","DOI":"10.1155\/2018\/6976897"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/tcmj.tcmj_69_19","article-title":"Genomic investigation of emerging zoonotic pathogen Shewanella xiamenensis","volume":"32","author":"Wang","year":"2020","journal-title":"Tzu Chi Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3201\/eid1906.121607","article-title":"Shewanella haliotis associated with severe soft tissue infection, Thailand, 2012","volume":"19","author":"Poovorawan","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-018-3354-8","article-title":"Rare Shewanella spp. associated with pulmonary and bloodstream infections of cancer patients, China: A case report","volume":"18","author":"Zhang","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"M\u00fcller, S., von Bonin, S., Schneider, R., Kr\u00fcger, M., Quick, S., and Schr\u00f6ttner, P. (2023). Shewanella putrefaciens, a rare human pathogen: A review from a clinical perspective. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1033639"},{"key":"ref_35","first-page":"1","article-title":"Tail Fan Necrosis in New Zealand Red Rock Lobster, Jasus edwardsii","volume":"33","author":"Pande","year":"2021","journal-title":"MPI Tech. Pap."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gomes, M.P. (2024). The convergence of antibiotic contamination, resistance, and climate dynamics in freshwater ecosystems. Water, 16.","DOI":"10.3390\/w16182606"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.wsee.2023.06.001","article-title":"Growth Regulatory Pattern of Zooplankton in Herbicide and Antibiotic Contaminated Aquatic Ecosystem: An overview","volume":"5","author":"Islam","year":"2023","journal-title":"Watershed Ecol. Environ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e114817","DOI":"10.1016\/j.ecoenv.2023.114817","article-title":"Occurrence, risk assessment, and in vitro and in vivo toxicity of antibiotics in surface water in China","volume":"255","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Liang, J., She, J., Fu, J., Wang, J., Ye, Y., Yang, B., and Tao, H. (2023). Advances in natural products from the marine-sponge-associated microorganisms with antimicrobial activity in the last decade. Mar. Drugs, 21.","DOI":"10.3390\/md21040236"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5184","DOI":"10.1016\/j.jmb.2020.04.022","article-title":"Lipid A phosphoethanolamine transferase: Regulation, structure and immune response","volume":"432","author":"Samantha","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1128\/AEM.00060-08","article-title":"Shewanella and Photobacterium spp. in oysters and seawater from the Delaware Bay","volume":"74","author":"Richards","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yousfi, K., Touati, A., and Bekal, S. (2016). Complete genome sequence of an extensively drug-resistant Shewanella xiamenensis strain isolated from Algerian hospital effluents. Genome Announc., 4.","DOI":"10.1128\/genomeA.01236-16"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1099\/ijs.0.02392-0","article-title":"Shewanella marinintestina sp. nov., Shewanella schlegeliana sp. nov. and Shewanella sairae sp. nov., novel eicosapentaenoic-acid-producing marine bacteria isolated from sea-animal intestines","volume":"53","author":"Satomi","year":"2003","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yu, K., Huang, Z., Li, Y., Fu, Q., Lin, L., Wu, S., and Lan, R. (2021). Establishment and application of matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry for detection of Shewanella genus. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.625821"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mateos, G., Bonilla, A.M., de Francisco de Polanco, S., Mart\u00ednez, J.M., Escudero, C., Rodr\u00edguez, N., and Amils, R. (2022). Shewanella sp. T2. 3D-1.1 a novel microorganism sustaining the iron cycle in the deep subsurface of the Iberian Pyrite Belt. Microorganisms, 10.","DOI":"10.3390\/microorganisms10081585"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e119326","DOI":"10.1016\/j.envpol.2022.119326","article-title":"Effects of heavy metals pollution on the co-selection of metal and antibiotic resistance in urban rivers in UK and India","volume":"306","author":"Gupta","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/raq.12639","article-title":"Interactions and associated resistance development mechanisms between microplastics, antibiotics and heavy metals in the aquaculture environment","volume":"14","author":"Li","year":"2022","journal-title":"Rev. Aquacult."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31605","DOI":"10.1007\/s11356-022-24015-3","article-title":"Metal-and antibiotic-resistant heterotrophic plate count bacteria from a gold mine impacted river: The Mooi River system, South Africa","volume":"30","author":"Bosch","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1111\/1462-2920.15865","article-title":"Low occurrence of multi-antimicrobial and heavy metal resistance in Salmonella enterica from wild birds in the United States","volume":"24","author":"Fu","year":"2022","journal-title":"Environ. Microbiol."},{"key":"ref_50","unstructured":"Dao, T.D., Takemura, T., Kasuga, I., Hirabayashi, A., Nga, N.T., Anh, P.H.Q., and Shibayama, K. (2015). Emergence of plasmid-mediated RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis in a water environment. bioRxiv."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Huang, L., Wu, C., Gao, H., Xu, C., Dai, M., Huang, L., and Cheng, G. (2022). Bacterial multidrug efflux pumps at the frontline of antimicrobial resistance: An overview. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040520"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Blanco, P., Hernando-Amado, S., Reales-Calderon, J.A., Corona, F., Lira, F., Alcalde-Rico, M., and Martinez, J.L. (2016). Bacterial multidrug efflux pumps: Much more than antibiotic resistance determinants. Microorganisms, 4.","DOI":"10.3390\/microorganisms4010014"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Athar, M., Gervasoni, S., Catte, A., Basciu, A., Malloci, G., Ruggerone, P., and Vargiu, A.V. (2023). Tripartite efflux pumps of the RND superfamily: What did we learn from computational studies?. Microbiology, 169.","DOI":"10.1099\/mic.0.001307"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.marpolbul.2018.07.051","article-title":"Whole genome sequences to assess the link between antibiotic and metal resistance in three coastal marine bacteria isolated from the mummichog gastrointestinal tract","volume":"135","author":"Lloyd","year":"2018","journal-title":"Mar. Pollut. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e130260","DOI":"10.1016\/j.jhazmat.2022.130260","article-title":"Association of antibiotics and heavy metal arsenic to horizontal gene transfer from multidrug-resistant clinical strains to antibiotic-sensitive environmental strains","volume":"443","author":"Kothari","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_56","first-page":"303","article-title":"Topic: Shewanella Species: Case Series on a Rare Emerging Pathogen","volume":"6","author":"Prasad","year":"2019","journal-title":"Indian J. Microbiol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Madrid, N.Y., Mejia, L.F., and Urrego, J.F.G. (2023). Left knee septic monoarthritis in a pediatric patient due to Shewanella putrefaciens: Case report and literature review. Clin. Microbiol. Antimicrob., 23.","DOI":"10.21203\/rs.3.rs-3375940\/v1"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zago, V., Veschetti, L., Patuzzo, C., Malerba, G., and Lleo, M.M. (2020). Resistome, mobilome and virulome analysis of Shewanella algae and Vibrio spp. strains isolated in italian aquaculture centers. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040572"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1586\/14787210.2016.1106936","article-title":"Whole genome sequence to decipher the resistome of Shewanella algae, a multidrug-resistant bacterium responsible for pneumonia, Marseille, France","volume":"14","author":"Cimmino","year":"2016","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2478\/jvetres-2019-0046","article-title":"Phenotypic diversity and potential virulence factors of the Shewanella putrefaciens group isolated from freshwater fish","volume":"63","author":"Wasyl","year":"2019","journal-title":"J. Vet. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Jousset, A.B., Dabos, L., Bonnin, R.A., Girlich, D., Potron, A., Cabanel, N., and Naas, T. (2018). CTX-M-15-producing Shewanella species clinical isolate expressing OXA-535, a chromosome-encoded OXA-48 variant, putative progenitor of the plasmid-encoded OXA-436. Antimicrob. Agents Chemother., 62.","DOI":"10.1128\/AAC.01879-17"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1286","DOI":"10.1097\/IPC.0000000000001286","article-title":"Shewanella algae, an emerging pathogen, causing skin and soft tissue infections","volume":"31","author":"Kalathuru","year":"2023","journal-title":"Infect. Dis. Clin. Pract."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3109\/23744235.2016.1169554","article-title":"Epidemiological and clinical characteristics of Shewanella spp. infections in a tertiary hospital in Madrid","volume":"48","author":"Chaves","year":"2016","journal-title":"Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ng, W.W.S., Shum, H.P., To, K.K.W., and Sridhar, S. (2022). Emerging infections due to Shewanella spp.: A case series of 128 cases over 10 years. Front. Med., 9.","DOI":"10.3389\/fmed.2022.850938"},{"key":"ref_65","first-page":"e005131","article-title":"Shewanella spp. infections in Gran Canaria, Spain: Retrospective analysis of 31 cases and a literature review","volume":"4","year":"2017","journal-title":"JMM Case Rep."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Li, Y., Qi, R., Yang, H., Zhang, X.L., Wu, Y., Huang, B.H., Zhao, Q., and Gu, Y.F. (2024). Analysis of clinical characteristics of infections caused by Shewanella species. Indian J. Med. Microbiol., 49.","DOI":"10.1016\/j.ijmmb.2024.100574"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10482-023-01829-w","article-title":"Shewanella subflava sp. nov., a novel multi-resistant bacterium, isolated from the estuary of the Fenhe River into the Yellow River","volume":"116","author":"Luo","year":"2023","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_68","unstructured":"Wahid, J. (2025, March 31). Study of the Distribution of Antimicrobial Resistance in Organic Crops and Their Environment. Available online: https:\/\/riunet.upv.es\/handle\/10251\/197455."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.ijantimicag.2015.09.001","article-title":"Functional genomics to discover antibiotic resistance genes: The paradigm of resistance to colistin mediated by ethanolamine phosphotransferase in Shewanella algae MARS 14","volume":"46","author":"Telke","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1111\/1462-2920.16107","article-title":"Polar flagellar wrapping and lateral flagella jointly contribute to Shewanella putrefaciens environmental spreading","volume":"24","author":"Edelmann","year":"2022","journal-title":"Environ. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ghotbi, M., Kelting, O., Bl\u00fcmel, M., and Tasdemir, D. (2012). Gut and gill-associated microbiota of the flatfish European plaice (Pleuronectes platessa): Diversity, metabolome and bioactivity against human and aquaculture pathogens. Mar. Drugs., 20.","DOI":"10.3390\/md20090573"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/CMR.00043-12","article-title":"Adaptive and mutational resistance: Role of porins and efflux pumps in drug resistance","volume":"25","author":"Hancock","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhou, G., Wang, Q., Wang, Y., Wen, X., Peng, H., Peng, R., Shi, Q., Xie, X., and Li, L. (2023). Outer membrane porins contribute to antimicrobial resistance in gram-negative bacteria. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071690"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Gao, T., Ju, L., Yin, J., and Gao, H. (2015). Positive regulation of the Shewanella oneidensis OmpS38, a major porin facilitating anaerobic respiration, by Crp and Fur. Sci. Rep., 5.","DOI":"10.1038\/srep14263"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Huang, Y.T., and Liu, P.Y. (2024). Emergence of carbapenem resistance in persistent Shewanella algae bacteremia: The role of pdsS G547W mutation in adaptive subpopulation dynamics. Ann. Clin. Microbiol. Antimicrob., 23.","DOI":"10.1186\/s12941-024-00759-3"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/AAC.49.8.3523-3525.2005","article-title":"Origin of plasmid-mediated quinolone resistance determinant QnrA","volume":"49","author":"Poirel","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.addr.2005.04.003","article-title":"Bacterial resistance to antibiotics: Modified target sites","volume":"57","author":"Lambert","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jmii.2020.04.019","article-title":"Detection of S83V GyrA mutation in quinolone-resistant Shewanella algae using comparative genomics","volume":"54","author":"Tseng","year":"2021","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/trstmh\/traa041","article-title":"Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: Review and update","volume":"114","author":"Azargun","year":"2020","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ijantimicag.2017.05.014","article-title":"Shewanella species as the origin of blaOXA-48 genes: Insights into gene diversity, associated phenotypes and possible transfer mechanisms","volume":"51","author":"Araujo","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1128\/AAC.48.1.348-351.2004","article-title":"Chromosome-encoded Ambler class D \u03b2-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase","volume":"48","author":"Poirel","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1128\/AAC.00681-11","article-title":"Origin of OXA-181, an emerging carbapenem-hydrolyzing oxacillinase, as a chromosomal gene in Shewanella xiamenensis","volume":"55","author":"Potron","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Yin, J., Sun, L., Dong, Y., Chi, X., Zhu, W., Qi, S.H., and Gao, H. (2013). Expression of blaA underlies unexpected ampicillin-induced cell lysis of Shewanella oneidensis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060460"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Liu, L., Wang, W., Wu, S., and Gao, H. (2022). Recent advances in the siderophore biology of Shewanella. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.823758"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e131545","DOI":"10.1016\/j.jhazmat.2023.131545","article-title":"Effectively facilitating the degradation of chloramphenicol by the synergism of Shewanella oneidensis MR-1 and the metal-organic framework","volume":"454","author":"Li","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Van Hoek, A.H., Mevius, D., Guerra, B., Mullany, P., Roberts, A.P., and Aarts, H.J. (2011). Acquired antibiotic resistance genes: An overview Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00203"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1128\/JB.00926-06","article-title":"Anaerobic central metabolic pathways in Shewanella oneidensis MR-1 reinterpreted in the light of isotopic metabolite labeling","volume":"189","author":"Tang","year":"2007","journal-title":"J. Bacteriol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Xue, Y., Xue, B., and Zhang, L. (2024). Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the development and lifespan of marine nematode litoditis marina. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25169111"},{"key":"ref_89","first-page":"1","article-title":"Pangenome analysis of Shewanella xiamenensis revealed important genetic traits concerning genetic diversity, pathogenicity and antibiotic resistance","volume":"25","author":"Wang","year":"2024","journal-title":"BMC Genom."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.plasmid.2015.07.001","article-title":"Transformation of Shewanella baltica with ColE1-like and P1 plasmids and their maintenance during bacterial growth in cultures","volume":"81","author":"Milewska","year":"2015","journal-title":"Plasmid"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lopez-Perez, M., Haro-Moreno, J.M., Gonzalez-Serrano, R., Parras-Molto, M., and Rodriguez-Valera, F. (2017). Genome diversity of marine phages recovered from Mediterranean metagenomes: Size matters. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1007018"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wang, H., Zheng, K., Wang, M., Ma, K., Ren, L., Guo, R., Ma, L., Zhang, H., Liu, Y., and Xiong, Y. (2024). Shewanella phage encoding a putative anti-CRISPR-like gene represents a novel potential viral family. Microbiol. Spectrum., 12.","DOI":"10.1128\/spectrum.03367-23"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Fang, Y., Wang, Y., Li, Z., Liu, Z., Li, X., Diao, B., Kan, B., and Wang, D. (2018). Distribution and genetic characteristics of SXT\/R391 integrative conjugative elements in Shewanella spp. from China. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00920"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Amirfard, K.D., Moriyama, M., Suzuki, S., and Sano, D. (2024). Effect of environmental factors on conjugative transfer of antibiotic resistance genes in aquatic settings, J. Appl. Microbiol., 135.","DOI":"10.1093\/jambio\/lxae129"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Zhao, J.Y., Mu, X.D., Zhu, Y.Q., Xi, L., and Xiao, Z. (2015). Identification of an integron containing the quinolone resistance gene qnrA1 in Shewanella xiamenensis. FEMS Microbiol. Lett., 362.","DOI":"10.1093\/femsle\/fnv146"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.marpolbul.2016.08.033","article-title":"Antibiotic and heavy metal resistance in Shewanella putrefaciens strains isolated from shellfishes collected from West Sea, Korea","volume":"112","author":"Kang","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1472-765X.2004.01650.x","article-title":"Copper amendment of agricultural soil selects for bacterial antibiotic resistance in the field","volume":"40","author":"Berg","year":"2005","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijantimicag.2007.03.012","article-title":"Antibiotic and heavy metal resistance in motile Aeromonads and Pseudomonads from rainbow trout (Oncorhynchus mykiss) farms in Australia","volume":"30","author":"Akinbowale","year":"2007","journal-title":"Int. J. Antimicrob. Agents."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e137099","DOI":"10.1016\/j.chemosphere.2022.137099","article-title":"A comprehensive review on bio-stimulation and bio-enhancement towards remediation of heavy metals degeneration","volume":"312","author":"Nivetha","year":"2022","journal-title":"Chemosphere"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/5\/1115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:31:33Z","timestamp":1760031093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/5\/1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":99,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["microorganisms13051115"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms13051115","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]}}}