{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:45:32Z","timestamp":1791996332160,"version":"4.4.0"},"reference-count":68,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Psychological distress and gut dysbiosis play key roles in IBD. This study investigated whether specific psychopathological and gut microbiota features predict adverse outcomes in UC patients. This retrospective cohort study included 35 UC patients recruited in 2019. Baseline assessments involved clinical interviews, psychiatric evaluations, and stool sampling. In 2024, follow-up interviews and medical record reviews assessed disease progression, including biologic therapy failure, hospitalization, surgery, and diagnosis changes. Disease activity was measured via the Mayo score. Psychological testing included MMPI-2, STAI-Y2, GSES, CD-RISC, and TAS-20. Patients with biological therapy failure showed increased levels of Proteobacteria, Fusobacteria, Enterobacteriaceae, and Trabulsiella, while Firmicutes were less abundant. UC-related hospitalized patients had lower levels of Rikenellaceae, Ruminococcaceae, Faecalibacterium, Lachnospira, Methanobrevibacter, and Phascolarctobacterium compared to non-hospitalized patients. Hospitalized patients scored higher on the Sc clinical scale and the OBS and HEA content scales. Acidaminococcus and Bilophila were more abundant in patients who underwent surgery. PCA revealed differences between patients with and without biological failure. Logistic regression found that Fusobacteria were negatively correlated with the failure of three or more biologics, while Hy and Pd were positively correlated. Pa and Pt were negatively correlated with multifailure. Obsessiveness, health concerns, somatization, and reduced SCFA-producing bacteria may predict UC-related adverse outcomes.<\/jats:p>","DOI":"10.3390\/microorganisms13061208","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:16:22Z","timestamp":1748204182000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of Psychopathology and Gut Microbiota on Disease Progression in Ulcerative Colitis: A Five-Year Follow-Up Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-7541","authenticated-orcid":false,"given":"Franco","family":"Scaldaferri","sequence":"first","affiliation":[{"name":"IBD Unit, Digestive Disease Center (CeMAD), Department of Translational Medicine and Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"CeMAD Translational Research Laboratories, Digestive Disease Center (CeMAD), Department of Medical and Surgical Scences, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d, IRCCS, 44106 Rome, Italy"},{"name":"Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"D\u2019Onofrio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Section of Psychiatry, Universit\u00e0 Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chiera","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-6428","authenticated-orcid":false,"given":"Adrian","family":"Gomez-Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"},{"name":"Digestive Health Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspare Filippo","family":"Ferrajoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Salute Mentale, Ospedale di Latina, ASL Latina, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-7641","authenticated-orcid":false,"given":"Federica","family":"Di Vincenzo","sequence":"additional","affiliation":[{"name":"IBD Unit, Digestive Disease Center (CeMAD), Department of Translational Medicine and Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-1613","authenticated-orcid":false,"given":"Valentina","family":"Petito","sequence":"additional","affiliation":[{"name":"IBD Unit, Digestive Disease Center (CeMAD), Department of Translational Medicine and Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy"},{"name":"CeMAD Translational Research Laboratories, Digestive Disease Center (CeMAD), Department of Medical and Surgical Scences, Fondazione Policlinico Universitario \u201cA. 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Perspect. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","article-title":"Postnatal microbial colonization programs the hypothalamic\u2013pituitary\u2013adrenal system for stress response in mice","volume":"558","author":"Sudo","year":"2004","journal-title":"J. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2102878","DOI":"10.1080\/19490976.2022.2102878","article-title":"Microbiota-derived metabolites as drivers of gut\u2013brain communication","volume":"14","author":"Ahmed","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2613.2011.00767.x","article-title":"Classification and functions of enteroendocrine cells of the lower gastrointestinal tract: Classification and functions of colorectal enteroendocrine cells","volume":"92","author":"Gunawardene","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_5","first-page":"28","article-title":"The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health","volume":"17","author":"Appleton","year":"2018","journal-title":"Integr. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bonaz, B., Bazin, T., and Pellissier, S. (2018). The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00049"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rusch, J.A., Layden, B.T., and Dugas, L.R. (2023). Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1130689"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sterling, K.G., Dodd, G.K., Alhamdi, S., Asimenios, P.G., Dagda, R.K., De Meirleir, K.L., Hudig, D., and Lombardi, V.C. (2022). Mucosal Immunity and the Gut-Microbiota-Brain-Axis in Neuroimmune Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113328"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Masse, K.E., and Lu, V.B. (2023). Short-chain fatty acids, secondary bile acids and indoles: Gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1169624"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1136\/gutjnl-2021-325985","article-title":"Bidirectional brain\u2013gut axis effects influence mood and prognosis in IBD: A systematic review and meta-analysis","volume":"71","author":"Fairbrass","year":"2022","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Peppas, S., Pansieri, C., Piovani, D., Danese, S., Peyrin-Biroulet, L., Tsantes, A.G., Brunetta, E., Tsantes, A.E., and Bonovas, S. (2021). The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030377"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zakerska-Banaszak, O., Tomczak, H., Gabryel, M., Baturo, A., Wolko, L., Michalak, M., Malinska, N., Mankowska-Wierzbicka, D., Eder, P., and Dobrowolska, A. (2021). Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: A pilot study. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-81628-3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e00188-17","DOI":"10.1128\/msystems.00188-17","article-title":"Gut Microbiota Offers Universal Biomarkers across Ethnicity in Inflammatory Bowel Disease Diagnosis and Infliximab Response Prediction","volume":"3","author":"Zhou","year":"2018","journal-title":"mSystems"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S2468-1253(21)00014-5","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: A systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0022-3999(96)00221-8","article-title":"A longitudinal study of alexithymia and psychological distress in inflammatory bowel disease","volume":"41","author":"Porcelli","year":"1996","journal-title":"J. Psychosom. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Vigan\u00f2, C.A., Beltrami, M.M., Bosi, M.F., Zanello, R., Valtorta, M., and Maconi, G. (2018). Alexithymia and Psychopathology in Patients Suffering From Inflammatory Bowel Disease: Arising Differences and Correlations to Tailoring Therapeutic Strategies. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00324"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/ibd\/izad091","article-title":"Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center","volume":"29","author":"Scaldaferri","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.gastro.2023.11.304","article-title":"Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease","volume":"166","author":"Caenepeel","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.chom.2017.04.010","article-title":"Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases","volume":"21","author":"Ananthakrishnan","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ecco-jcc\/jjx008","article-title":"Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders","volume":"11","author":"Magro","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/occmed\/kqn182","article-title":"The Minnesota Multiphasic Personality Inventory-2 (MMPI-2)","volume":"59","author":"Drayton","year":"2009","journal-title":"Occup. Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Friedman, A.F., Bolinskey, P.K., Levak, R.W., and Nichols, D.S. (2014). Psychological Assessment with the MMPI-2\/MMPI-2-RF, Routledge. [3rd ed.].","DOI":"10.4324\/9780203119556"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/00223890701885027","article-title":"The Factor Structure of the State-Trait Anxiety Inventory: An Alternative View","volume":"90","author":"Vigneau","year":"2008","journal-title":"J. Personal. Assess."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2012.04.027","article-title":"State\u2013trait anxiety inventory (STAI) scores during pregnancy following intervention with complementary therapies","volume":"142","author":"Newham","year":"2012","journal-title":"J. Affect. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s11136-020-02467-9","article-title":"Self-esteem in patients with inflammatory bowel disease","volume":"29","author":"Opheim","year":"2020","journal-title":"Qual. Life Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/da.10113","article-title":"Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC)","volume":"18","author":"Connor","year":"2003","journal-title":"Depress. Anxiety"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4306\/pi.2015.12.4.500","article-title":"Psychometric Properties of the 20-Item Toronto Alexithymia Scale in a Group of Italian Younger Adolescents","volume":"12","author":"Craparo","year":"2015","journal-title":"Psychiatry Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/JPER.22-0205","article-title":"Fusobacterium nucleatum aggravates ulcerative colitis through promoting gut microbiota dysbiosis and dysmetabolism","volume":"94","author":"Lin","year":"2023","journal-title":"J. Periodontol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yang, X., Yang, L., Zhang, T., Zhang, H., Chen, H., and Zuo, X. (2023). Causal atlas between inflammatory bowel disease and mental disorders: A bi-directional 2-sample Mendelian randomization study. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1267834"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13643-020-01526-z","article-title":"Detection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer: A systematic review and meta-analysis","volume":"9","author":"Janati","year":"2020","journal-title":"Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lucaf\u00f2, M., Curci, D., Franzin, M., Decorti, G., and Stocco, G. (2021). Inflammatory Bowel Disease and Risk of Colorectal Cancer: An Overview From Pathophysiology to Pharmacological Prevention. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.772101"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/gut.52.1.79","article-title":"Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis","volume":"52","author":"Ohkusa","year":"2003","journal-title":"Gut"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rizzatti, G., Lopetuso, L.R., Gibiino, G., Binda, C., and Gasbarrini, A. (2017). Proteobacteria: A Common Factor in Human Diseases. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/9351507"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1232467","article-title":"Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut","volume":"339","author":"Winter","year":"2013","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"16731","DOI":"10.1073\/pnas.0804812105","article-title":"Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients","volume":"105","author":"Sokol","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1826748","DOI":"10.1080\/19490976.2020.1826748","article-title":"Butyrate mediates anti-inflammatory effects of Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3","volume":"12","author":"Lenoir","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e00300-15","DOI":"10.1128\/mBio.00300-15","article-title":"Identification of Metabolic Signatures Linked to Anti-Inflammatory Effects of Faecalibacterium prausnitzii","volume":"6","author":"Miquel","year":"2015","journal-title":"mBio"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gutjnl-2014-307649","article-title":"Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn\u2019s disease","volume":"65","author":"Maubert","year":"2016","journal-title":"Gut"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.3748\/wjg.v23.i25.4548","article-title":"Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis","volume":"23","author":"Bajer","year":"2017","journal-title":"WJG"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhuang, X., Liu, C., Zhan, S., Tian, Z., Li, N., Mao, R., Zeng, Z., and Chen, M. (2021). Gut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.626232"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12944-024-02203-z","article-title":"Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: A double-blind randomized controlled trial","volume":"23","author":"Firoozi","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Scanu, M., Toto, F., Petito, V., Masi, L., Fidaleo, M., Puca, P., Baldelli, V., Reddel, S., Vernocchi, P., and Pani, G. (2024). An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients. Front. Cell. Infect. Microbiol., 14.","DOI":"10.3389\/fcimb.2024.1366192"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.micpath.2018.01.029","article-title":"Alterations of the human gut Methanobrevibacter smithii as a biomarker for inflammatory bowel diseases","volume":"117","author":"Ghavami","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Feng, Y., Stams, A.J.M., De Vos, W.M., and S\u00e1nchez-Andrea, I. (2017). Enrichment of sulfidogenic bacteria from the human intestinal tract. FEMS Microbiol. Lett., 364.","DOI":"10.1093\/femsle\/fnx028"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/gut.46.1.64","article-title":"The contribution of sulphate reducing bacteria and 5-aminosalicylic acid to faecal sulphide in patients with ulcerative colitis","volume":"46","author":"Pitcher","year":"2000","journal-title":"Gut"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"13419","DOI":"10.1038\/ncomms13419","article-title":"Altered intestinal microbiota\u2013host mitochondria crosstalk in new onset Crohn\u2019s disease","volume":"7","author":"Mottawea","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Stummer, N., Feichtinger, R.G., Weghuber, D., Kofler, B., and Schneider, A.M. (2023). Role of Hydrogen Sulfide in Inflammatory Bowel Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12081570"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/MIB.0000000000000345","article-title":"Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production","volume":"21","author":"Motta","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.dld.2018.11.021","article-title":"Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota","volume":"51","author":"Altomare","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s002030050394","article-title":"Sodium ion-dependent hydrogen production in Acidaminococcus fermentans","volume":"166","author":"Buckel","year":"1996","journal-title":"Arch. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1017\/S0007114520001853","article-title":"Dietary inflammatory potential in relation to the gut microbiome: Results from a cross-sectional study","volume":"124","author":"Zheng","year":"2020","journal-title":"Br. J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Liu, B., Ye, D., Yang, H., Song, J., Sun, X., Mao, Y., and He, Z. (2022). Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn\u2019s Disease. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.921546"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jss.2019.04.032","article-title":"A Distinct Gut Microbiota Exists Within Crohn\u2019s Disease\u2013Related Perianal Fistulae","volume":"242","author":"Haac","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/ecco-jcc\/jjac032","article-title":"A Microbial Signature for Paediatric Perianal Crohn\u2019s Disease","volume":"16","author":"Breton","year":"2022","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_56","first-page":"44","article-title":"Distinction between anxiety state\/trait in general practice: A descriptive study","volume":"25","author":"Jouvent","year":"1999","journal-title":"Encephale"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.3748\/wjg.v20.i13.3552","article-title":"Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease","volume":"20","author":"Filipovic","year":"2014","journal-title":"WJG"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1177\/2050640618804444","article-title":"Fecal SCFAs and SCFA-producing bacteria in gut microbiome of human NAFLD as a putative link to systemic T-cell activation and advanced disease","volume":"6","author":"Rau","year":"2018","journal-title":"UEG J."},{"key":"ref_59","first-page":"1","article-title":"Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)","volume":"66","author":"Ratajczak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Levak, R., Siegel, L., Nichols, D.S., and Stolberg, R. (2011). Therapeutic Feedback with the MMPI-2: A Positive Psychology Approach, Routledge, Taylor & Francis Group.","DOI":"10.4324\/9780203828908"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/apt.14171","article-title":"Systematic review with meta-analysis: The impact of a depressive state on disease course in adult inflammatory bowel disease","volume":"46","author":"Alexakis","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.PSY.0000106907.24881.F2","article-title":"Impact of Depressive Mood on Relapse in Patients With Inflammatory Bowel Disease: A Prospective 18-Month Follow-Up Study","volume":"66","author":"Mittermaier","year":"2004","journal-title":"Psychosom. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1572-0241.2000.02012.x","article-title":"Stress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission","volume":"95","author":"Levenstein","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s00535-022-01902-7","article-title":"The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients","volume":"57","author":"Jordi","year":"2022","journal-title":"J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/ecco-jcc\/jjac145","article-title":"What are the Unmet Needs and Most Relevant Treatment Outcomes According to Patients with Inflammatory Bowel Disease? A Qualitative Patient Preference Study","volume":"17","author":"Schoefs","year":"2023","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"509","DOI":"10.5217\/ir.2018.00074","article-title":"Optimizing the multidimensional aspects of the patient-physician relationship in the management of inflammatory bowel disease","volume":"16","author":"Chew","year":"2018","journal-title":"Intest. Res."},{"key":"ref_67","first-page":"3","article-title":"Obsessive-compulsive and spectrum disorders: Overview and quality of life issues","volume":"57","author":"Hollander","year":"1996","journal-title":"J. Clin. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cgh.2022.07.025","article-title":"High Perceived Stress is Associated With Increased Risk of Ulcerative Colitis Clinical Flares","volume":"21","author":"Sauk","year":"2023","journal-title":"Clin. Gastroenterol. 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