{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:27:35Z","timestamp":1782325655435,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20CIII-00037"],"award-info":[{"award-number":["PI20CIII-00037"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["TEC-2024\/BIO-66"],"award-info":[{"award-number":["TEC-2024\/BIO-66"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Consejer\u00eda de Educaci\u00f3n, Ciencia y Universidades (Comunidad de Madrid)","award":["PI20CIII-00037"],"award-info":[{"award-number":["PI20CIII-00037"]}]},{"name":"Consejer\u00eda de Educaci\u00f3n, Ciencia y Universidades (Comunidad de Madrid)","award":["TEC-2024\/BIO-66"],"award-info":[{"award-number":["TEC-2024\/BIO-66"]}]},{"name":"ViiV Healthcare Spain","award":["PI20CIII-00037"],"award-info":[{"award-number":["PI20CIII-00037"]}]},{"name":"ViiV Healthcare Spain","award":["TEC-2024\/BIO-66"],"award-info":[{"award-number":["TEC-2024\/BIO-66"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (s.l.) and babesiosis, caused by Babesia divergens and Babesia venatorum, are both transmitted by the ixodid tick Ixodes ricinus. Although these diseases coexist in Spain and other European regions, no studies have been carried out to assess the impact on the health of patients exposed to both causative pathogens. This retrospective study, conducted in Asturias in northwestern Spain between 2015 and 2017, analyzed the possible complications arising from exposure to these pathogens. To this end, the epidemiological, clinical and analytical features of two groups of a cohort of 120 LB patients exposed to one or two of the pathogens were compared. The cohort comprised 73 patients who had only been infected with Bo. burgdorferi s.l. (Bb group) and 47 patients who were seropositive for Ba. divergens\/venatorum in addition to being infected with Bo. burgdorferi s.l. (BbBdv group). The results showed that LB patients who had also been exposed to infection with Babesia spp. (BbBdv group) had significantly more cardiorespiratory symptoms, in particular dyspnea and first- and second-degree atrioventricular (AV) blocks, compared to those who had been infected with Bo. burgdorferi s.l. alone (Bb group). No relevant differences in other symptoms, epidemiological factors or analytical tests were observed between the two groups.<\/jats:p>","DOI":"10.3390\/microorganisms13061383","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T04:06:24Z","timestamp":1750046784000},"page":"1383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological, Clinical and Analytical Features in Lyme Borreliosis Patients Seropositive for Babesia divergens\/venatorum"],"prefix":"10.3390","volume":"13","author":[{"given":"Mar\u00eda","family":"Folgueras","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) Oviedo, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-2450","authenticated-orcid":false,"given":"Luis Miguel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Parasitology Reference and Research Laboratory, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4525-1086","authenticated-orcid":false,"given":"Aitor","family":"Gil","sequence":"additional","affiliation":[{"name":"Parasitology Reference and Research Laboratory, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Collazos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital de Gald\u00e1cano, Labeaga Auzoa, 48960 Gald\u00e1cano, Vizcaya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Rodr\u00edguez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Microbiology Service, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"P\u00e9rez-Is","sequence":"additional","affiliation":[{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) Oviedo, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"D\u00edaz-Arias","sequence":"additional","affiliation":[{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) Oviedo, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Meana","sequence":"additional","affiliation":[{"name":"Internal Medicine Service, Hospital Vital \u00c1lvarez-Buylla, Vistalegre, 2, 33611 Mieres, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Revuelta","sequence":"additional","affiliation":[{"name":"Parasitology Reference and Research Laboratory, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Gray","sequence":"additional","affiliation":[{"name":"UCD School of Biology and Environmental Science, University College Dublin, D04 N2E5 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-960X","authenticated-orcid":false,"given":"Estrella","family":"Montero","sequence":"additional","affiliation":[{"name":"Parasitology Reference and Research Laboratory, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, Majadahonda, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-456X","authenticated-orcid":false,"given":"V\u00edctor","family":"Asensi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"},{"name":"Microbiology and Infectious Diseases Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) Oviedo, Avda Roma s\/n, 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMp1807870","article-title":"Tickborne Diseases\u2014Confronting a growing threat","volume":"379","author":"Paules","year":"2018","journal-title":"N. 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