{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:56:58Z","timestamp":1793235418682,"version":"4.5.0"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Periprosthetic joint infection (PJI) is a complex complication of total joint arthroplasty, with microbiological profiles varying across centers worldwide. However, most studies are limited to single-center or intra-country multicenter analyses, often including mixed cohorts of primary and revision PJI cases, with limited data regarding global antibiotic resistance patterns. This study compared the microbiological characteristics, polymicrobial culture rates, prevalence of culture-negative infections, and antibiotic resistance patterns in PJI cases across five referral centers from five continents. A total of 717 patients with primary hip and knee PJI were included from centers in Argentina, Canada, Turkey, England, and New Zealand. Staphylococcus aureus and Staphylococcus epidermidis were the most common pathogens (48.5%, p &lt; 0.01). Culture-negative infection rates varied significantly, ranging from 4.2% (England) to 24.6% (Turkey) (p &lt; 0.01). Polymicrobial infections were the most frequent in Canada (8.9%) and the least frequent in England (1.1%) (p &lt; 0.01). Gram-negative bacteria comprised 13.1% of culture-positive cases, with no significant intercountry difference. Multidrug resistance was observed in all centers, ranging from 23.7% (Argentina) to 43.1% (Turkey), with no statistical significance. Vancomycin resistance was detected in England (2.3%) and Canada (1.2%) but absent in Turkey, New Zealand, and Argentina. These findings underscore significant intercontinental variability, emphasizing the need for regional considerations in regards to empiric antibiotic selection and PJI management.<\/jats:p>","DOI":"10.3390\/microorganisms13071505","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T03:54:28Z","timestamp":1751255668000},"page":"1505","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Microbiological Profiles of Primary Hip and Knee Peri-Prosthetic Joint Infections Treated at Specialist Centers Around the World"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2050-9499","authenticated-orcid":false,"given":"Emin Suha","family":"Dedeogullari","sequence":"first","affiliation":[{"name":"Hacettepe University Hospital, Hacettepe, A.Adnan Saygun Cd., 06230 Altindag, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-075X","authenticated-orcid":false,"given":"Pablo","family":"Slullitel","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Per\u00f3n 4190, CABA, Buenos Aires 1199, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Horton","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-0642","authenticated-orcid":false,"given":"Bulent","family":"Atilla","sequence":"additional","affiliation":[{"name":"Hacettepe University Hospital, Hacettepe, A.Adnan Saygun Cd., 06230 Altindag, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-6978","authenticated-orcid":false,"given":"Saif","family":"Salih","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Monk","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, 2 Park Road, Grafton, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Mazhar","family":"Tokgozoglu","sequence":"additional","affiliation":[{"name":"Hacettepe University Hospital, Hacettepe, A.Adnan Saygun Cd., 06230 Altindag, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-5309","authenticated-orcid":false,"given":"Michael","family":"Goplen","sequence":"additional","affiliation":[{"name":"Auckland City Hospital, 2 Park Road, Grafton, Auckland 1023, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8784-0836","authenticated-orcid":false,"given":"Bonita","family":"Tsang","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Buljubasich","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Per\u00f3n 4190, CABA, Buenos Aires 1199, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-0775","authenticated-orcid":false,"given":"Hesham","family":"Abdelbary","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Garceau","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-9498","authenticated-orcid":false,"given":"George","family":"Grammatopoulos","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, 501 Smyth Rd., Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2340457","DOI":"10.1001\/jamanetworkopen.2023.40457","article-title":"Incidence, Microbiological Studies, and Factors Associated With Prosthetic Joint Infection After Total Knee Arthroplasty","volume":"6","author":"Weinstein","year":"2023","journal-title":"JAMA Netw. 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