{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:31:49Z","timestamp":1760711509461,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ICMR-National Institute of Virology","award":["EVI 2401"],"award-info":[{"award-number":["EVI 2401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Echovirus 30 (E-30), a member of the Enterovirus B species, is frequently linked to neurological illnesses such as aseptic meningitis, encephalitis, and hand, foot, and mouth disease. In this study, we present the complete-genome analysis of an Echovirus 30 strain isolated from cerebrospinal fluid (CSF) and stool samples of a pediatric encephalitis case in Kerala, India, during 2023. A comparative genomic investigation was carried out using a dataset of 111 human E-30 isolates, encompassing 116,991 mutation records. This analysis revealed six distinct non-synonymous amino acid substitutions uniquely present in the isolate PQ472410.1, which may be associated with pathogenicity and\/or neurotropic behavior. To the best of our knowledge, this represents the first complete-genome sequence report of E-30 from an encephalitis case in India. These findings contribute valuable information to the understanding of E-30\u2019s molecular epidemiology and evolution and offer vital data for enhancing surveillance and response strategies against enteroviral infections.<\/jats:p>","DOI":"10.3390\/microorganisms13071580","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:20:11Z","timestamp":1751628011000},"page":"1580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Complete-Genome Analysis of Echovirus-30 Isolated from an Encephalitis Case in India Revealed Distinct Mutations"],"prefix":"10.3390","volume":"13","author":[{"given":"Rishabh","family":"Waghchaure","sequence":"first","affiliation":[{"name":"Enteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jithin","family":"Kunjumon","sequence":"additional","affiliation":[{"name":"Enteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-9660","authenticated-orcid":false,"given":"Alfia Fathima","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0337-4177","authenticated-orcid":false,"given":"Ranjana Mariyam","family":"Raju","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-3703","authenticated-orcid":false,"given":"Anita","family":"Shete","sequence":"additional","affiliation":[{"name":"Maximum Containment Laboratory, ICMR-National Institute of Virology, Sus Road, Pashan, Pune 411021, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Cherian","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-9313","authenticated-orcid":false,"given":"Mallika","family":"Lavania","sequence":"additional","affiliation":[{"name":"Enteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3201\/eid2706.203096","article-title":"Molecular epidemiology and evolutionary trajectory of emerging Echovirus 30, Europe","volume":"27","author":"Benschop","year":"2021","journal-title":"Emerg. 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