{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:53:08Z","timestamp":1789023188426,"version":"build-2803163510"},"reference-count":177,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J197"],"award-info":[{"award-number":["2022J197"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"publisher","award":["T2023101"],"award-info":[{"award-number":["T2023101"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Ningbo Natural Science Foundation","doi-asserted-by":"publisher","award":["2025-5"],"award-info":[{"award-number":["2025-5"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Agricultural Science and Technology Innovation Project","award":["2022J197"],"award-info":[{"award-number":["2022J197"]}]},{"name":"Shanghai Agricultural Science and Technology Innovation Project","award":["T2023101"],"award-info":[{"award-number":["T2023101"]}]},{"name":"Shanghai Agricultural Science and Technology Innovation Project","award":["2025-5"],"award-info":[{"award-number":["2025-5"]}]},{"name":"Industrial Technology Projects of Department of Agriculture and Rural Affairs of Zhejiang Province","award":["2022J197"],"award-info":[{"award-number":["2022J197"]}]},{"name":"Industrial Technology Projects of Department of Agriculture and Rural Affairs of Zhejiang Province","award":["T2023101"],"award-info":[{"award-number":["T2023101"]}]},{"name":"Industrial Technology Projects of Department of Agriculture and Rural Affairs of Zhejiang Province","award":["2025-5"],"award-info":[{"award-number":["2025-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Gram-negative Burkholderia bacteria are known for causing diseases in humans, animals, and plants, and high intrinsic resistance to antibiotics. Phage therapy is a promising alternative to control multidrug-resistant bacterial pathogens. Here, we present an overview of Burkholderia phage characteristics, host specificity, genomic classification, and therapeutic potentials across medical, veterinary, and agricultural systems. We evaluate the efficacy and limitations of current phage candidates, the biological and environmental barriers of phage applications, and the phage cocktail strategy. We highlight the innovations on the development of targeted phage delivery systems and the transition from the exploration of clinical phage therapy to plant disease management, advocating integrated disease control strategies.<\/jats:p>","DOI":"10.3390\/microorganisms13081873","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T17:22:07Z","timestamp":1754932927000},"page":"1873","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Burkholderia Phages and Control of Burkholderia-Associated Human, Animal, and Plant Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Bingjie","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plant Quarantine, Shanghai Extension and Service Center of Agriculture Technology, Shanghai 201103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munazza","family":"Ijaz","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2019an","family":"Bi","sequence":"additional","affiliation":[{"name":"Crop Institute, Ningbo Academy of Agricultural Sciences, Ningbo 315040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8649-1263","authenticated-orcid":false,"given":"Chenhao","family":"Li","sequence":"additional","affiliation":[{"name":"Station for the Plant Protection & Quarantine and Control of Agrochemicals Zhejiang Province, Hangzhou 310004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daixing","family":"Dong","sequence":"additional","affiliation":[{"name":"Fuyang District Agricultural Technology Extension Center, Hangzhou 311400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hangzhou Agricultural Technology Extension Center (Hangzhou Plant Protection and Quarantine Center), Hangzhou 310020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-4775","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agriculture and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Zhejiang Engineering Research Center for Biological Control of Crop Pathogens and Insect Pests, Institute of Biotechnology, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Plant Quarantine, Shanghai Extension and Service Center of Agriculture Technology, Shanghai 201103, 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