{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:42Z","timestamp":1789500642751,"version":"build-2803163510"},"reference-count":185,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Helicobacter pylori (Hp), a widespread gastric pathogen, has long been studied for its role in upper gastrointestinal disorders. While its involvement in gastritis, peptic ulcer disease, and gastric cancer is well established, its impact on esophageal diseases remains an area of ongoing investigation. Nevertheless, some data indicate that Hp may be involved in the pathogenesis of gastroesophageal reflux disease\u2013Barrett\u2019s esophagus\u2013esophageal adenocarcinoma sequence. Similarly, the Hp-related mast cell activation\u2014an essential immunological event\u2014may also play a crucial role in the progression from gastroesophageal reflux disease to Barrett\u2019s esophagus and esophageal adenocarcinoma. The underlying mechanisms include immune modulation, cytokine cascades, and microbial interactions that collectively shape the esophageal microenvironment. This review provides an in-depth analysis of these pathways, highlighting the potential role of Hp-induced, mast cell-driven inflammation in esophageal disease progression and discussing emerging therapeutic strategies.<\/jats:p>","DOI":"10.3390\/microorganisms13081883","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T15:51:02Z","timestamp":1755013862000},"page":"1883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Potential Role of Helicobacter pylori-Related Mast Cell Activation in the Progression from Gastroesophageal Reflux to Barrett\u2019s Esophagus and Esophageal Adenocarcinoma"],"prefix":"10.3390","volume":"13","author":[{"given":"Evangelos I.","family":"Kazakos","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa University Hospital, 41110 Larissa, Greece"},{"name":"Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymia","family":"Petinaki","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa University Hospital, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-0808","authenticated-orcid":false,"given":"Christos","family":"Liatsos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, 401 General Military Hospital of Athens, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-6168","authenticated-orcid":false,"given":"Ioannis S.","family":"Papanikolaou","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Anastasiadou","sequence":"additional","affiliation":[{"name":"Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannis","family":"Kountouras","sequence":"additional","affiliation":[{"name":"Department of Medicine, Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, 54642 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3748\/wjg.v30.i24.3086","article-title":"Effect and Mechanism of Qingre Huashi Decoction on Drug-Resistant Helicobacter pylori","volume":"30","author":"Lin","year":"2024","journal-title":"World J. 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