{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:28:51Z","timestamp":1789417731601,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170102"],"award-info":[{"award-number":["32170102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024NITFID401"],"award-info":[{"award-number":["2024NITFID401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["63253191"],"award-info":[{"award-number":["63253191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","award":["32170102"],"award-info":[{"award-number":["32170102"]}]},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","award":["2024NITFID401"],"award-info":[{"award-number":["2024NITFID401"]}]},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","award":["63253191"],"award-info":[{"award-number":["63253191"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["32170102"],"award-info":[{"award-number":["32170102"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["2024NITFID401"],"award-info":[{"award-number":["2024NITFID401"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["63253191"],"award-info":[{"award-number":["63253191"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Acute inflammation is frequently triggered by pathogen infections and contributes to host mortality. In this study, a new exopolysaccharide (ObEPS) was isolated from the moss endophyte Ovatospora brasiliensis and characterized for its structure and biological activity. Monosaccharide composition analysis revealed that ObEPS was mainly composed of galactose, glucose, mannose, and glucuronic acid. Multi-angle light scattering and conformation analysis showed a molar mass of 105\u2013106 Da and a compact chain conformation. In vitro experiments showed that ObEPS markedly inhibited nitric oxide production and reduced pro-inflammatory cytokine expression in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In a systemic Candida albicans infection model, ObEPS combined with fluconazole significantly reduced fungal colony-forming units (CFUs)\/g kidney from 3.8 \u00d7 105 to 0.1 \u00d7 105, with the reduction of pro-inflammatory cytokine levels and tissue damage compared with the EPS-free groups suffering from C. albicans infection. Overall, these findings indicate that ObEPS has potent anti-inflammatory activity and may serve as a promising natural adjunct for mitigating infection-associated inflammatory damage.<\/jats:p>","DOI":"10.3390\/microorganisms13092037","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T13:27:44Z","timestamp":1756733264000},"page":"2037","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Inflammatory Potential of Extracellular Polysaccharide from the Moss Endophyte Ovatospora brasiliensis During Pathogen Infection"],"prefix":"10.3390","volume":"13","author":[{"given":"Jiayue","family":"Yang","sequence":"first","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5326-2332","authenticated-orcid":false,"given":"Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchun","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-5111","authenticated-orcid":false,"given":"Qilin","family":"Yu","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, College of Life Sciences, Nankai University, Tianjin 300071, China"},{"name":"Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hebecker, B., Vlaic, S., Conrad, T., Bauer, M., Brunke, S., Kapitan, M., Linde, J., Hube, B., and Jacobsen, I.D. 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