{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:04:29Z","timestamp":1790888669624,"version":"4.1.0"},"reference-count":183,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R21AI183094"],"award-info":[{"award-number":["R21AI183094"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI190438"],"award-info":[{"award-number":["R01AI190438"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The gut microbiota, a complex community of trillions of microorganisms residing in the gastrointestinal tract, plays a vital role in maintaining host health and regulating a wide range of physiological functions. Advances in molecular biology have greatly expanded our understanding of the dynamic interactions between the gut microbiome and the immune system. Disruption of this microbial community, known as dysbiosis, can compromise epithelial barrier integrity, trigger aberrant immune activation, and lead to the production of proinflammatory metabolites. These changes are increasingly recognized as contributing factors in the pathogenesis of chronic inflammatory diseases. Emerging research highlights the gut microbiota as a key modulator of immune homeostasis, influencing both local and systemic inflammatory processes during the initiation and progression of these diseases. Understanding the mechanisms underlying gut microbiota-immune interactions will offer new avenues for therapeutic interventions. This review focuses on six representative chronic inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, systemic lupus erythematosus, asthma, and vasculitis, all of which are characterized by dysregulated immune responses and persistent inflammation. Our goal is to synthesize the recent research on the role of gut microbiome in the pathogenesis of the diseases listed above and provide insights into the development of microbiota-based therapies, particularly fecal microbiota transplant, dietary modifications, prebiotic and probiotic interventions, for their treatment.<\/jats:p>","DOI":"10.3390\/microorganisms13112516","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:55:22Z","timestamp":1762178122000},"page":"2516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities"],"prefix":"10.3390","volume":"13","author":[{"given":"Jefferson J.","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"},{"name":"Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil R.","family":"Maddirala","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"},{"name":"Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Saint Fleur","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9354-8611","authenticated-orcid":false,"given":"Di","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8594-4232","authenticated-orcid":false,"given":"Yongrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wilkins, L.J., Monga, M., and Miller, A.W. (2019). Defining Dysbiosis for a Cluster of Chronic Diseases. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-49452-y"},{"key":"ref_2","first-page":"33","article-title":"Influence of Commensal Microbiota in Barrier Function of Intestinal Mucosal Epithelium","volume":"1","author":"Michie","year":"2019","journal-title":"Adv. Res. Endocrinol. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mostafavi Abdolmaleky, H., and Zhou, J.R. (2024). Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic Alterations in Metabolic Diseases. Antioxidants, 13.","DOI":"10.3390\/antiox13080985"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/intimm\/dxaa079","article-title":"Gut microbiota and systemic immunity in health and disease","volume":"33","author":"Lo","year":"2021","journal-title":"Int. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s44324-025-00066-1","article-title":"Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes","volume":"3","author":"Dey","year":"2025","journal-title":"npj Metab. Health Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/JCN.0000000000000166","article-title":"20 things you didn\u2019t know about the human gut microbiome","volume":"29","author":"Ferranti","year":"2014","journal-title":"J. Cardiovasc. Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Krishnamurthy, K.H., Pereira, M., Bosco, J., George, J., Jayaraman, V., Krishna, K., Wang, T., Bei, K., and Rajasekaran, J.J. (2023). Gut commensals and their metabolites in health and disease. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2023.1244293"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2052698","DOI":"10.1080\/19490976.2022.2052698","article-title":"The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota","volume":"14","author":"Zhang","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41423-021-00661-4","article-title":"Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases","volume":"18","author":"Yang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Maciel-Fiuza, M.F., Muller, G.C., Campos, D.M.S., Costa, P.D.S.S., Peruzzo, J., Bonamigo, R.R., Veit, T., and Vianna, F.S.L. (2023). Role of gut microbiota in infectious and inflammatory diseases. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1098386"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/infdis\/jir748","article-title":"Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models","volume":"205","author":"Steele","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.aad0135","article-title":"A gut-vascular barrier controls the systemic dissemination of bacteria","volume":"350","author":"Spadoni","year":"2015","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","article-title":"Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development","volume":"71","author":"Mouries","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Segui-Perez, C., Huang, L.Z.X., Paganelli, F.L., Lievens, E., and Strijbis, K. (2025). Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-92125-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3920\/BM2018.0071","article-title":"Lactobacillus rhamnosus GG can protect malnourished children","volume":"10","author":"Kara","year":"2019","journal-title":"Benef. Microbes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Reytor, D., Puebla, C., Karahanian, E., and Garc\u00eda, K. (2021). Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins. Front. Physiol., 12.","DOI":"10.3389\/fphys.2021.650313"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Hansen, N.W., and Sams, A. (2018). The Microbiotic Highway to Health-New Perspective on Food Structure, Gut Microbiota, and Host Inflammation. Nutrients, 10.","DOI":"10.3390\/nu10111590"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e02766-16","DOI":"10.1128\/AEM.02766-16","article-title":"Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice","volume":"83","author":"Hindryckx","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/19490976.2019.1629235","article-title":"Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner","volume":"11","author":"Stephens","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1038\/s41467-025-58553-4","article-title":"Gut commensal Bifidobacterium-derived extracellular vesicles modulate the therapeutic effects of anti-PD-1 in lung cancer","volume":"16","author":"Preet","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"113972","DOI":"10.1016\/j.jconrel.2025.113972","article-title":"Engineered bacterial extracellular vesicles for gastrointestinal diseases","volume":"385","author":"Nie","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s44149-024-00125-y","article-title":"Lactobacillus alleviates intestinal epithelial barrier dysfunction through GPR43-mediated M2 macrophage polarization","volume":"4","author":"Yao","year":"2024","journal-title":"Anim. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2377567","DOI":"10.1080\/19490976.2024.2377567","article-title":"Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate","volume":"16","author":"Zhao","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s12016-024-08999-z","article-title":"Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections","volume":"66","author":"Xie","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gaskarth, D.A., Fan, S., Highton, A.J., and Kemp, R.A. (2025). The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1577906"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clim.2010.04.018","article-title":"Histone\/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs","volume":"136","author":"Akimova","year":"2010","journal-title":"Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1038\/s41467-021-24331-1","article-title":"Microbial short-chain fatty acids modulate CD8(+) T cell responses and improve adoptive immunotherapy for cancer","volume":"12","author":"Luu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/JLB.1MR0321-660R","article-title":"Gut microbiota shape B cell in health and disease settings","volume":"110","author":"Yu","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.12189","article-title":"Intestinal IgA production and its role in host-microbe interaction","volume":"260","author":"Gutzeit","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/mi.2013.13","article-title":"The role of pattern recognition receptors in intestinal inflammation","volume":"6","author":"Fukata","year":"2013","journal-title":"Mucosal Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12964-025-02149-4","article-title":"An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein-protein interactions","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"527696","DOI":"10.1155\/2015\/527696","article-title":"Toll-like receptor mediated modulation of T cell response by commensal intestinal microbiota as a trigger for autoimmune arthritis","volume":"2015","author":"Rogier","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1128\/IAI.01506-06","article-title":"How flagellin and toll-like receptor 5 contribute to enteric infection","volume":"75","author":"Steiner","year":"2007","journal-title":"Infect. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.2147\/JIR.S407521","article-title":"TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity","volume":"16","author":"Feng","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Oliviera-Nascimento, L., Massari, P., and Wetzler, L.M. (2012). The Role of TLR2 in Infection and Immunity. Front. Immunol., 3.","DOI":"10.3389\/fimmu.2012.00079"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"McClure, R., and Massari, P. (2014). TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens. Front. Immunol., 5.","DOI":"10.3389\/fimmu.2014.00386"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.4110\/in.2021.21.e18","article-title":"Toll-like Receptor 2 in Autoimmune Inflammation","volume":"21","author":"Marks","year":"2021","journal-title":"Immune Netw."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hug, H., Mohajeri, M.H., and La Fata, G. (2018). Toll-Like Receptors: Regulators of the Immune Response in the Human Gut. Nutrients, 10.","DOI":"10.3390\/nu10020203"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaci.2005.03.036","article-title":"Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin","volume":"115","author":"Smits","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2018.05.003","article-title":"Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells","volume":"831","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wysocki, T., Olesi\u0144ska, M., and Paradowska-Gorycka, A. (2020). Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice. Cells, 9.","DOI":"10.3390\/cells9051127"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/ard.2008.091355","article-title":"Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: Association with HLA-DRB1 alleles","volume":"68","author":"Snir","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1093\/rheumatology\/keaa232","article-title":"The genetics of rheumatoid arthritis","volume":"59","author":"Dedmon","year":"2020","journal-title":"Rheumatolog"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021","volume":"5","author":"Black","year":"2023","journal-title":"Lancet Rheumatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ferro, M., Charneca, S., Dourado, E., Guerreiro, C.S., and Fonseca, J.E. (2021). Probiotic Supplementation for Rheumatoid Arthritis: A Promising Adjuvant Therapy in the Gut Microbiome Era. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.711788"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e33357","DOI":"10.1097\/MD.0000000000033357","article-title":"Dietary fiber intake associated with risk of rheumatoid arthritis among U.S. adults: NHANES 2010\u20132020","volume":"102","author":"Liu","year":"2023","journal-title":"Medicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/ccr3.3677","article-title":"Fecal microbiota transplantation for rheumatoid arthritis: A case report","volume":"9","author":"Zeng","year":"2021","journal-title":"Clin. Case Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e065186","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: A systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40291-023-00678-7","article-title":"The Genetics of Inflammatory Bowel Disease","volume":"28","author":"Schreiner","year":"2024","journal-title":"Mol. Diagn. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.gastro.2015.04.001","article-title":"Fecal Microbiota Transplantation Induces Remission in Patients with Active Ulcerative Colitis in a Randomized Controlled Trial","volume":"149","author":"Moayyedi","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/MIB.0000000000001132","article-title":"Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis","volume":"23","author":"Jacob","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lu, G., Zhang, S., Wang, R., Wu, X., Chen, Y., Wen, Q., Cui, B., Zhang, F., and Li, P. (2025). Fecal microbiota transplantation improves bile acid malabsorption in patients with inflammatory bowel disease: Results of microbiota and metabolites from two cohort studies. BMC Med., 23.","DOI":"10.1186\/s12916-025-04353-y"},{"key":"ref_56","unstructured":"World Health Organization (2025, October 28). Global Report on Psoriasis. World Health Organization, Available online: https:\/\/iris.who.int\/handle\/10665\/204417."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"100286","DOI":"10.1016\/j.jtauto.2025.100286","article-title":"Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes","volume":"10","author":"Yan","year":"2025","journal-title":"J. Transl. Autoimmun."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Patel, H.A., Revankar, R.R., Pedroza, S.T., Graham, S., and Feldman, S.R. (2023). The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to Our Treatment Options. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202306.1290.v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard-2022-223035","article-title":"Global epidemiology of systemic lupus erythematosus: A comprehensive systematic analysis and modelling study","volume":"82","author":"Tian","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102844","DOI":"10.1016\/j.jaut.2022.102844","article-title":"Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial","volume":"130","author":"Huang","year":"2022","journal-title":"J. Autoimmun."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Widhani, A., Djauzi, S., Suyatna, F.D., and Dewi, B.E. (2022). Changes in Gut Microbiota and Systemic Inflammation after Synbiotic Supplementation in Patients with Systemic Lupus Erythematosus: A Randomized, Double-Blind, Placebo-Controlled Trial. Cells, 11.","DOI":"10.3390\/cells11213419"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Guarino, M.P.L., Altomare, A., Emerenziani, S., Di Rosa, C., Ribolsi, M., Balestrieri, P., Iovino, P., Rocchi, G., and Cicala, M. (2020). Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults. Nutrients, 12.","DOI":"10.3390\/nu12041037"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s10067-024-07046-8","article-title":"Genetic polymorphisms in genes involved in the type I interferon system (STAT4 and IRF5): Association with Asian SLE patients","volume":"43","author":"Liu","year":"2024","journal-title":"Clin. Rheumatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S2213-2600(25)00003-7","article-title":"Global, regional, and national burden of asthma and atopic dermatitis, 1990\u20132021, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021","volume":"13","author":"Oh","year":"2025","journal-title":"Lancet Respir. Med."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ntontsi, P., Photiades, A., Zervas, E., Xanthou, G., and Samitas, K. (2021). Genetics and Epigenetics in Asthma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052412"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41584-021-00718-8","article-title":"Global epidemiology of vasculitis","volume":"18","author":"Watts","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/1756-185X.13218","article-title":"The genetics of Kawasaki disease","volume":"21","author":"Onouchi","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8055","DOI":"10.1002\/jcp.27576","article-title":"Beh\u00e7et\u2019s disease: An immunogenetic perspective","volume":"234","author":"Salmaninejad","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13073-016-0299-7","article-title":"An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis","volume":"8","author":"Chen","year":"2016","journal-title":"Genome Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Romero-Figueroa, M.D.S., Ram\u00edrez-Dur\u00e1n, N., Montiel-Jarqu\u00edn, A.J., and Horta-Baas, G. (2023). Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1092118"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Maresz, K.J., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Koziel, J., Gawron, K., Mizgalska, D., A Marcinska, K., and Benedyk, M. (2013). Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003627"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e01202","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"eLife"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"eabn5166","DOI":"10.1126\/scitranslmed.abn5166","article-title":"Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum","volume":"14","author":"Chriswell","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"24705470221076390","DOI":"10.1177\/24705470221076390","article-title":"The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation","volume":"6","author":"Page","year":"2022","journal-title":"Chronic Stress"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/nu7010017","article-title":"The impact of diet and lifestyle on gut microbiota and human health","volume":"7","author":"Conlon","year":"2014","journal-title":"Nutrients"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7546047","DOI":"10.1155\/2019\/7546047","article-title":"The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases","volume":"2019","author":"Xu","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2022.11.006","article-title":"Subdoligranulum chews up joints: How a gut pathobiont can instigate arthritis","volume":"44","author":"Kriegel","year":"2023","journal-title":"Trends Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Takahashi, D., Hoshina, N., Kabumoto, Y., Maeda, Y., Suzuki, A., Tanabe, H., Isobe, J., Yamada, T., Muroi, K., and Yanagisawa, Y. (2020). Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine, 58.","DOI":"10.1016\/j.ebiom.2020.102913"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/1756-185X.12333","article-title":"Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: A randomized double-blind clinical trial","volume":"17","author":"Alipour","year":"2014","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13073-021-00957-0","article-title":"Gut microbial determinants of clinically important improvement in patients with rheumatoid arthritis","volume":"13","author":"Gupta","year":"2021","journal-title":"Genome Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ibd.21403","article-title":"Importance of disrupted intestinal barrier in inflammatory bowel diseases","volume":"17","author":"Salim","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00281-014-0454-4","article-title":"The gut microbiota and inflammatory bowel disease","volume":"37","author":"Matsuoka","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Kittana, H., Gomes-Neto, J.C., Heck, K., Geis, A.L., Mu\u00f1oz, R.R.S., Cody, L.A., Schmaltz, R.J., Bindels, L.B., Sinha, R., and Hostetter, J.M. (2018). Commensal Escherichia coli strains can promote intestinal inflammation via differential interleukin-6 production. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02318"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/femsre\/fux048","article-title":"The role of toxins in Clostridium difficile infection","volume":"41","author":"Chandrasekaran","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/MIB.0000000000000750","article-title":"Current Understanding of Dysbiosis in Disease in Human and Animal Models","volume":"22","author":"DeGruttola","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Arze","year":"2019","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Bretin, A., Lucas, C., Larabi, A., Dalmasso, G., Billard, E., Barnich, N., Bonnet, R., and Nguyen, H.T.T. (2018). AIEC infection triggers modification of gut microbiota composition in genetically predisposed mice, contributing to intestinal inflammation. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30055-y"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4291\/wjgp.v5.i3.213","article-title":"Escherichia coli in chronic inflammatory bowel diseases: An update on adherent invasive Escherichia coli pathogenicity","volume":"5","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3748\/wjg.v17.i5.557","article-title":"Intestinal microbiota in inflammatory bowel disease: Friend of foe?","volume":"17","author":"Fava","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1600129","DOI":"10.1002\/mnfr.201600129","article-title":"Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases","volume":"61","author":"Dolan","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_92","first-page":"CD005573","article-title":"Probiotics for induction of remission in ulcerative colitis","volume":"3","author":"Kaur","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8428","DOI":"10.1038\/s41467-024-52722-7","article-title":"Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication","volume":"15","author":"Cao","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1039\/D2FO00546H","article-title":"The role of functional oligosaccharides as prebiotics in ulcerative colitis","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Bueno-Hernandez, N., Yamamoto-Furusho, J.K., and Mendoza-Mart\u00ednez, V.M. (2025). Nutrition in Inflammatory Bowel Disease: Strategies to Improve Prognosis and New Therapeutic Approaches. Diseases, 13.","DOI":"10.3390\/diseases13050139"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Wang, C., Gu, Y., Chu, Q., Wang, X., Ding, Y., Qin, X., Liu, T., Wang, S., Liu, X., and Wang, B. (2024). Gut microbiota and metabolites as predictors of biologics response in inflammatory bowel disease: A comprehensive systematic review. Microbiol. Res., 282.","DOI":"10.1016\/j.micres.2024.127660"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Tokuyama, M., and Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207488"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Li, Y., Chen, G., Hu, X., Bao, Y., Wu, C., Zeng, N., and Jiang, F. (2024). Assessing causal relationships between gut microbiota and psoriasis: Evidence from two sample Mendelian randomization analysis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-59603-5"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4168\/aair.2018.10.4.354","article-title":"Microbiome in the Gut-Skin Axis in Atopic Dermatitis","volume":"10","author":"Lee","year":"2018","journal-title":"Allergy Asthma Immunol Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Polak, K., Bergler-Czop, B., Szczepanek, M., Wojciechowska, K., Fr\u0105tczak, A., and Kiss, N. (2021). Psoriasis and Gut Microbiome-Current State of Art. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094529"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Benhadou, F., Mintoff, D., Schnebert, B., and Thio, H.B. (2018). Psoriasis and Microbiota: A Systematic Review. Diseases, 6.","DOI":"10.3390\/diseases6020047"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Buha\u0219, M.C., Gavrila\u0219, L.I., Candrea, R., C\u0103tinean, A., Mocan, A., Miere, D., and T\u0103taru, A. (2022). Gut Microbiota in Psoriasis. Nutrients, 14.","DOI":"10.3390\/nu14142970"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5114\/ada.2024.142394","article-title":"Study of gut microbiome alterations in plaque psoriasis patients compared to healthy individuals","volume":"41","author":"Polak","year":"2024","journal-title":"Postep. Dermatol Alergol"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Yunusbayev, B., Bogdanova, A., Nadyrchenko, N., Danilov, L., Bogdanov, V., Sergeev, G., Altinbaev, R., Bilalov, F., and Yunusbaeva, M. (2025). Gut dysbiosis narrative in psoriasis: Matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin. Microbiol. Spectr., 13.","DOI":"10.1128\/spectrum.01382-24"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Yegorov, S., Babenko, D., Kozhakhmetov, S., Akhmaltdinova, L., Kadyrova, I., Nurgozhina, A., Nurgaziyev, M., Good, S.V., Hortelano, G.H., and Yermekbayeva, B. (2020). Psoriasis Is Associated with Elevated Gut IL-1\u03b1 and Intestinal Microbiome Alterations. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.571319"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"114196","DOI":"10.1016\/j.intimp.2025.114196","article-title":"Modulation of gut propionate and intestinal mucosal protection by Bifidobacterium longum: Mitigating methotrexate side effects without compromising the efficacy of psoriasis therapy","volume":"149","author":"Mao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Tan, J., Taitz, J., Nanan, R., Grau, G., and Macia, L. (2023). Dysbiotic Gut Microbiota-Derived Metabolites and Their Role in Non-Communicable Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015256"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Chen, Y.J., Ho, H.J., Tseng, C.H., Chen, Y.F., Wang, S.T., Shieh, J.J., and Wu, C.Y. (2024). Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: A metagenomic association analysis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-67325-x"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4161\/gmic.25487","article-title":"Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut","volume":"4","author":"Groeger","year":"2013","journal-title":"Gut Microbes"},{"key":"ref_110","first-page":"1078","article-title":"Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial","volume":"99","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Buha\u0219, M.C., Candrea, R., Gavrila\u0219, L.I., Miere, D., T\u0103taru, A., Boca, A., and C\u0103tinean, A. (2023). Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311225"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Roach, L.A., Meyer, B.J., Fitton, J.H., and Winberg, P. (2023). Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences. Mar. Drugs, 21.","DOI":"10.3390\/md21070379"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s00403-023-02553-1","article-title":"Efficacy of an adjuvant Lactobacillus rhamnosus formula in improving skin lesions as assessed by PASI in patients with plaque psoriasis from a university-affiliated, tertiary-referral hospital in S\u00e3o Paulo (Brazil): A parallel, double-blind, randomized clinical trial","volume":"315","author":"Suriano","year":"2023","journal-title":"Arch. Dermatol. Res."},{"key":"ref_114","first-page":"782","article-title":"Fecal microbiota transplantation as a novel therapy for severe psoriasis","volume":"58","author":"Yin","year":"2019","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.2147\/JIR.S337031","article-title":"Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice","volume":"14","author":"Chen","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Tang, B., Zheng, X., Luo, Q., Li, X., Yang, Y., Bi, Y., Chen, Y., Han, L., Chen, H., and Lu, C. (2024). Network pharmacology and gut microbiota insights: Unraveling Shenling Baizhu powder\u2019s role in psoriasis treatment. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1362161"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/ard-2022-223741","article-title":"Pathogenesis of systemic lupus erythematosus: Risks, mechanisms and therapeutic targets","volume":"82","author":"Crow","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/0961203314530488","article-title":"Ultraviolet radiation and systemic lupus erythematosus","volume":"23","author":"Barbhaiya","year":"2014","journal-title":"Lupus"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/BOR.0000000000000318","article-title":"Environmental exposures and the development of systemic lupus erythematosus","volume":"28","author":"Barbhaiya","year":"2016","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41584-020-0480-7","article-title":"New insights into the role of antinuclear antibodies in systemic lupus erythematosus","volume":"16","author":"Pisetsky","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Dema, B., and Charles, N. (2016). Autoantibodies in SLE: Specificities, Isotypes and Receptors. Antibodies, 5.","DOI":"10.3390\/antib5010002"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00006416-200603000-00013","article-title":"The pathogenesis of systemic lupus erythematosus","volume":"25","author":"Childs","year":"2006","journal-title":"Orthop. Nurs."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.coi.2019.08.007","article-title":"Systemic Lupus Erythematosus and dysbiosis in the microbiome: Cause or effect or both?","volume":"61","author":"Silverman","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2016.06.009","article-title":"A clinical update on the significance of the gut microbiota in systemic autoimmunity","volume":"74","author":"Rosser","year":"2016","journal-title":"J. Autoimmun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1073\/pnas.1904099116","article-title":"Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn\u2019s disease, produces an inflammatory polysaccharide","volume":"116","author":"Henke","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Pan, Q., Guo, F., Huang, Y., Li, A., Chen, S., Chen, J., Chen, J., Liu, H.-F., and Pan, Q. (2021). Gut Microbiota Dysbiosis in Systemic Lupus Erythematosus: Novel Insights into Mechanisms and Promising Therapeutic Strategies. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.799788"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/imr.12567","article-title":"Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease","volume":"279","author":"Pickard","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/09612033241281891","article-title":"Alterations of the microbiome across body sites in systemic lupus erythematosus: A systematic review and meta-analysis","volume":"33","author":"Wang","year":"2024","journal-title":"Lupus"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e22044","DOI":"10.1096\/fj.202100851RR","article-title":"The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH","volume":"35","author":"Xing","year":"2021","journal-title":"FASEB J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e610","DOI":"10.1002\/mco2.610","article-title":"Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11-Gasdermin D pathway in systemic lupus erythematosus","volume":"5","author":"Xin","year":"2024","journal-title":"MedComm"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.aar7201","article-title":"Translocation of a gut pathobiont drives autoimmunity in mice and humans","volume":"359","author":"Vieira","year":"2018","journal-title":"Science"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.chom.2018.11.009","article-title":"A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity","volume":"25","author":"Ruff","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13099-025-00683-7","article-title":"Gut microbiota dysbiosis and associated immune response in systemic lupus erythematosus: Impact of disease and treatment","volume":"17","author":"Ali","year":"2025","journal-title":"Gut Pathog."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Park, J.K., Lee, Y.J., Park, J.S., Lee, E.B., and Song, Y.W. (2021). CD47 Potentiates Inflammatory Response in Systemic Lupus Erythematosus. Cells, 10.","DOI":"10.3390\/cells10051151"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Parodi, E., Novi, M., Bottino, P., La Porta, E., Merlotti, G., Castello, L.M., Gotta, F., Rocchetti, A., and Quaglia, M. (2025). The Complex Role of Gut Microbiota in Systemic Lupus Erythematosus and Lupus Nephritis: From Pathogenetic Factor to Therapeutic Target. Microorganisms, 13.","DOI":"10.3390\/microorganisms13020445"},{"key":"ref_136","first-page":"292","article-title":"The Effect of Probiotic Yogurt Containing Lactobacillus rhamnosus and Bifidobacterium bifidum on Disease Activity and Disability in Patients with Systemic Lupus Erythematosus: A Randomized Controlled Trial","volume":"24","author":"Banaki","year":"2025","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Dai, X., and Shen, L. (2022). Advances and Trends in Omics Technology Development. Front. Med., 9.","DOI":"10.3389\/fmed.2022.911861"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Frati, F., Salvatori, C., Incorvaia, C., Bellucci, A., Di Cara, G., Marcucci, F., and Esposito, S. (2018). The Role of the Microbiome in Asthma: The Gut(-)Lung Axis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20010123"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaci.2019.02.032","article-title":"Integrative analysis of the intestinal metabolome of childhood asthma","volume":"144","author":"Kelly","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41467-018-03157-4","article-title":"Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation","volume":"9","author":"Durack","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.chom.2025.05.014","article-title":"Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming","volume":"33","author":"Zhernakova","year":"2025","journal-title":"Cell Host Microbe"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ozcan, E., and Sela, D.A. (2018). Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00046"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3345\/kjp.2017.60.5.145","article-title":"Clostridium difficile colonization and\/or infection during infancy and the risk of childhood allergic diseases","volume":"60","author":"Lee","year":"2017","journal-title":"Korean J. Pediatr."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Enaud, R., Prevel, R., Ciarlo, E., Beaufils, F., Wie\u00ebrs, G., Guery, B., and Delhaes, L. (2020). The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00009"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"100163","DOI":"10.1016\/j.jacig.2023.100163","article-title":"Short-chain fatty acids ameliorate allergic airway inflammation via sequential induction of PMN-MDSCs and Treg cells","volume":"2","author":"Huang","year":"2023","journal-title":"J. Allergy Clin. Immunol. Glob."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbrc.2017.03.071","article-title":"Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-\u03b1-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells","volume":"486","author":"Kobayashi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/cea.13119","article-title":"Short-chain fatty acids induce tissue plasminogen activator in airway epithelial cells via GPR41&43","volume":"48","author":"Imoto","year":"2018","journal-title":"Clin. Exp. Allergy"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Huang, J., Zhou, X., Dong, B., Tan, H., Li, Q., Zhang, J., Su, H., and Sun, X. (2023). Obesity-related asthma and its relationship with microbiota. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1303899"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Cheng, Z.X., Wu, Y.-X., Jie, Z.-J., Li, X.-J., and Zhang, J. (2023). Genetic evidence on the causality between gut microbiota and various asthma phenotypes: A two-sample Mendelian randomization study. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1270067"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Yan, T., Bao, Y., Cao, S., Jiang, P., Zhang, Z., Li, L., Kang, Y., and Wu, Q. (2024). The investigation of the role of oral-originated Prevotella-induced inflammation in childhood asthma. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1400079"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3892\/etm.2024.12445","article-title":"Antibiotic administration aggravates asthma by disrupting gut microbiota and the intestinal mucosal barrier in an asthma mouse model","volume":"27","author":"Xu","year":"2024","journal-title":"Exp. Ther. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.2001304","article-title":"Gut Microbiota Regulate Gut-Lung Axis Inflammatory Responses by Mediating ILC2 Compartmental Migration","volume":"207","author":"Pu","year":"2021","journal-title":"J. Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.jaci.2024.07.023","article-title":"Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2-B1 cell-innate IgE axis","volume":"154","author":"Kabil","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ebiom.2019.07.048","article-title":"Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial","volume":"46","author":"McLoughlin","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"e20163000","DOI":"10.1542\/peds.2016-3000","article-title":"Early Probiotic Supplementation for Eczema and Asthma Prevention: A Randomized Controlled Trial","volume":"140","author":"Cabana","year":"2017","journal-title":"Pediatrics"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.anai.2016.09.004","article-title":"Lactobacillus reuteri DSM 17938 plus vitamin D3 as ancillary treatment in allergic children with asthma","volume":"117","author":"Maiello","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e14004","DOI":"10.1111\/pai.14004","article-title":"Maternal fish oil and\/or probiotics intervention: Allergic diseases in children up to two years old","volume":"34","author":"Komulainen","year":"2023","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Huang, C.F., Chie, W.-C., and Wang, I.-J. (2018). Efficacy of Lactobacillus Administration in School-Age Children with Asthma: A Randomized, Placebo-Controlled Trial. Nutrients, 10.","DOI":"10.3390\/nu10111678"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3837418","DOI":"10.1155\/2022\/3837418","article-title":"The Probiotics in Pediatric Asthma Management (PROPAM) Study in the Primary Care Setting: A Randomized, Controlled, Double-Blind Trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706)","volume":"2022","author":"Drago","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Liu, A., Ma, T., Xu, N., Jin, H., Zhao, F., Kwok, L.-Y., Zhang, H., Zhang, S., and Sun, Z. (2021). Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome. Microbiol. Spectr., 9.","DOI":"10.1128\/Spectrum.00859-21"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Liao, H., Tao, L., Zhao, J., Qin, J., Zeng, G.-C., Cai, S.-W., Li, Y., Zhang, J., and Chen, H.-G. (2016). Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients. Sci. Rep., 6.","DOI":"10.1038\/srep20481"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"106853","DOI":"10.1016\/j.imlet.2024.106853","article-title":"Saccharomyces boulardii alleviates allergic asthma by restoring gut microbiota and metabolic homeostasis via up-regulation of METTL3 in an m6A-dependent manner","volume":"267","author":"Liu","year":"2024","journal-title":"Immunol. Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/cea.13976","article-title":"Limosilactobacillus reuteri DSM-17938 for preventing cough in adults with mild allergic asthma: A double-blind randomized placebo-controlled cross-over study","volume":"51","author":"Satia","year":"2021","journal-title":"Clin. Exp. Allergy"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1007\/s10753-024-02233-w","article-title":"Fecal Microbiota Transplantation Alleviates Airway Inflammation in Asthmatic Rats by Increasing the Level of Short-Chain Fatty Acids in the Intestine","volume":"48","author":"Lai","year":"2025","journal-title":"Inflammation"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Sun, B., He, X., and Zhang, W. (2022). Findings on the Relationship Between Intestinal Microbiome and Vasculitis. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.908352"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Chen, S., Nie, R., Wang, C., Luan, H., Ma, X., Gui, Y., Zeng, X., and Yuan, H. (2024). A two sample mendelian randomization analysis investigates causal effects between gut microbiome and immune related Vasculitis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-68205-0"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Wang, J.K., Yan, B., Zhao, J.-M., and Yuan, L.-P. (2021). Effect of gut microbiota from Henoch-Schonlein Purpura patients on acid-sensitive ion channel 3 expression and intestinal motility in germ-free rats. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-03013-3"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/BOR.0000000000000574","article-title":"The microbiome in systemic autoimmune disease: Mechanistic insights from recent studies","volume":"31","author":"Dehner","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Li, M., Wang, X., Lin, X., Bian, X., Jing, R., Frelinger, A., and Zhang, A. (2021). Comparison and Analysis of Gut Microbiota in Children with IgA Vasculitis with Different Clinical Symptoms. Front. Pediatr., 9.","DOI":"10.3389\/fped.2021.800677"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2217\/fmb-2019-0301","article-title":"Correlation of gut microbial compositions to the development of kawasaki disease vasculitis in children","volume":"15","author":"Khan","year":"2020","journal-title":"Future Microbiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1161\/CIRCRESAHA.124.325079","article-title":"Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice","volume":"136","author":"Jena","year":"2025","journal-title":"Circ. Res."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Liang, Y., Zhao, C., Zhao, L., Sheng, D., Chen, B., Zhao, G., Wang, Q., and Zhang, L. (2024). Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers. Front. Pediatr., 12.","DOI":"10.3389\/fped.2024.1356529"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hu, X., Fan, R., Song, W., Qing, J., Yan, X., Li, Y., Duan, Q., and Li, Y. (2022). Landscape of intestinal microbiota in patients with IgA nephropathy, IgA vasculitis and Kawasaki disease. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.1061629"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s10067-018-04419-8","article-title":"Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet\u2019s disease (210 characters)","volume":"38","author":"Shimizu","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12950-023-00360-z","article-title":"Advances in the study of macrophage polarization in inflammatory immune skin diseases","volume":"20","author":"Xia","year":"2023","journal-title":"J. Inflamm."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"E47","DOI":"10.3314\/mmj.16-00014","article-title":"Effects of Natural and Chemically Defined Nutrients on Candida albicans Water-soluble Fraction (CAWS) Vasculitis in Mice","volume":"58","author":"Sato","year":"2017","journal-title":"Med. Mycol. J."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Islam, S.M.S., Ryu, H.-M., Sayeed, H.M., Byun, H.-O., Jung, J.-Y., Kim, H.-A., Suh, C.-H., and Sohn, S. (2021). Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.712312"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Wang, F., Qian, F., Zhang, Q., Zhao, J., Cen, J., Zhang, J., Zhou, J., Luo, M., Jia, C., and Rong, X. (2023). The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1124118"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Saravanan, C., Gopinath, N.K., Ganesan, R., and Thirumurugan, D. (2025). Challenges and limitations in using bacterial metabolites as immunomodulators. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1535394"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s13063-020-04444-6","article-title":"Modulation of gut microbiota through nutritional interventions in Beh\u00e7et\u2019s syndrome patients (the MAMBA study): Study protocol for a randomized controlled trial","volume":"21","author":"Pagliai","year":"2020","journal-title":"Trials"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e1342","DOI":"10.1002\/cti2.1342","article-title":"Metagenomic profiling reveals dominance of gram-positive bacteria in the gut microbiome shifts associated with immunoglobulin A vasculitis (Henoch-Schonlein Purpura)","volume":"10","author":"Cao","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Hafler","year":"2018","journal-title":"Nat. Immunol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1007\/s12015-023-10522-4","article-title":"Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity","volume":"19","author":"Bu","year":"2023","journal-title":"Stem Cell Rev. Rep."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/11\/2516\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T05:42:46Z","timestamp":1762234966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/13\/11\/2516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":183,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["microorganisms13112516"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms13112516","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]}}}