{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:03:29Z","timestamp":1791597809365,"version":"4.3.4"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BS0050"],"award-info":[{"award-number":["BS0050"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Provincial Traditional Chinese Medicine Research Project","award":["ZHY2025-084"],"award-info":[{"award-number":["ZHY2025-084"]}]},{"name":"Fundamental Research Funds in Universities of Heilongjiang Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Cinnamon essential oil (CEO), a safe, medicinal, and edible Traditional Chinese Medicine (TCM) component, was investigated for its anti-Candida albicans property and ability to relieve intestinal inflammation. The anti-Candida albicans ability of CEO was evaluated by Minimum Inhibitory Concentration (MIC), 2,3-Bis-(2-Methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT), and Scanning Electron Microscope (SEM) methods. By constructing ulcerative colitis (UC) mice intestinally colonized by C. albicans, the CEO effects on the regulation of flora, the relief of intestinal inflammation, and possible related signal pathway were discussed. The results showed that CEO has a significant effect on inhibiting C. albicans, where the MIC80 value was 265 \u03bcg\/mL, and the Sessile Minimum Inhibitory Concentration (SMIC)80 value was 530 \u03bcg\/mL. SEM showed the CEO could inhibit C. albicans mycelium growth and biofilm formation. CEO can regulate the flora disturbance, reduce inflammatory factors level, and play a protective role in intestinal mucosal damage. Network pharmacology predicts CEO may be associated with Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway. It was proved that CEO had an inhibitory effect on the JAK-STAT pathway by qPCR determination. These findings suggest CEO may have therapeutic potential for C. albicans\u2013associated UC.<\/jats:p>","DOI":"10.3390\/microorganisms13122724","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:03:13Z","timestamp":1764687793000},"page":"2724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of Cinnamon Essential Oil on Intestinal Flora Regulation of Ulcerative Colitis Mice Colonized by Candida albicans"],"prefix":"10.3390","volume":"13","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhe","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9213-5298","authenticated-orcid":false,"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9792-9992","authenticated-orcid":false,"given":"Yuyang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zesen","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghan","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and Pathogenesis of Ulcerative Colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. 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