{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:35:02Z","timestamp":1790094902142,"version":"4.0.1"},"reference-count":66,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Reactive infectious mucocutaneous eruption (RIME) is a rare pediatric condition characterized by severe mucositis, minimal cutaneous involvement, and an infectious rather than drug-induced etiology. Mycoplasma pneumoniae (M. Pneumoniae) represents the most frequently identified trigger, although an increasing number of alternative pathogens have been reported. Its clinical overlap with Stevens\u2013Johnson syndrome (SJS) makes early recognition difficult. We reviewed literature data on the topic and described our center\u2019s experience with three pediatric cases of M. pneumoniae-associated RIME. Medical records, laboratory results, and imaging were systematically analyzed. All patients were male, aged 2 to 12 years and originated from rural communities. Etiologic confirmation was achieved via M. pneumoniae IgM serology and\/or polymerase chain reaction. Clinical exam modifications included multi-site mucositis (oral, ocular, genital) with variable skin involvement: absent in one case, a solitary palm ulcer in another, and widespread rash in the third. One patient required two hospitalizations within a six-month interval, confirming the possible relapsing phenotype of RIME. Another patient developed pneumonia, sepsis, and systemic inflammation. All received macrolide therapy, antifungals, mucosal supportive care, and systemic management as indicated. Recovery occurred within 10\u201321 days, with one patient exhibiting skin hyperpigmentation. These cases illustrate the heterogeneity of RIME, emphasize the importance of prompt recognition, etiology confirmation, and multidisciplinary management. RIME is a rare clinical condition in pediatric population, an uncommon but significant mucocutaneous clinical entity, important to be acknowledged by clinicians as a complication and\/or extra-pulmonary manifestation of M. pneumoniae infection.<\/jats:p>","DOI":"10.3390\/microorganisms14020364","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:02:01Z","timestamp":1770195721000},"page":"364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reactive Infectious Mucocutaneous Eruption (RIME) Associated with Mycoplasma pneumoniae: Clinical and Immunological Insights from Pediatric Cases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5364-4833","authenticated-orcid":false,"given":"David M.","family":"Matea","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"},{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9797","authenticated-orcid":false,"given":"Raluca","family":"Isac","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-1573","authenticated-orcid":false,"given":"Estera","family":"Boeriu","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3870-0768","authenticated-orcid":false,"given":"Patricia","family":"Urtila","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-4034","authenticated-orcid":false,"given":"Gabriela","family":"Doros","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4116-8156","authenticated-orcid":false,"given":"Mihaela","family":"Bataneant","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1829-3159","authenticated-orcid":false,"given":"Andrada L.","family":"Oprisoni","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1918-9322","authenticated-orcid":false,"given":"Smaranda T.","family":"Arghirescu","sequence":"additional","affiliation":[{"name":"Emergency Clinical Hospital for Children \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Department of Pediatrics, University of Medicine and Pharmacy \u201cVictor Babes\u201d, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Elfmann, C., Zhu, B., Pedreira, T., Ho\u00dfbach, B., Lluch-Senar, M., Serrano, L., and St\u00fclke, J. (2022). MycoWiki: Functional Annotation of the Minimal Model Organism Mycoplasma pneumoniae. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.935066"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pereyre, S., Goret, J., and B\u00e9b\u00e9ar, C. (2016). Mycoplasma pneumoniae: Current Knowledge on Macrolide Resistance and Treatment. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00974"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"250046","DOI":"10.1183\/20734735.0046-2025","article-title":"Mycoplasma pneumoniae Respiratory Tract Infections in Children: When and How to Diagnose and Treat","volume":"21","author":"Sharplin","year":"2025","journal-title":"Breathe"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jaad.2014.06.026","article-title":"Mycoplasma pneumoniae\u2013induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme","volume":"72","author":"Canavan","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.5826\/dpc.1503a5083","article-title":"Reactive infectious mucocutaneous eruption (RIME): Narrative review and proposed management algorithm","volume":"15","author":"Sancho","year":"2025","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.5694\/mja2.52434","article-title":"An outbreak of reactive infectious mucocutaneous eruption (RIME) after Mycoplasma pneumoniae infections in Sydney: Retrospective case series","volume":"221","author":"Joseph","year":"2024","journal-title":"Med. J. Aust."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/BOR.0000000000000494","article-title":"Extra-Pulmonary Diseases Related to Mycoplasma pneumoniae in Children: Recent Insights into the Pathogenesis","volume":"30","author":"Poddighe","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.37897\/RJID.2024.1.12","article-title":"Mycoplasma pneumoniae Pneumonia\u2014Challenges Related to Diagnosis and Treatment in Children","volume":"27","author":"Tomsa","year":"2024","journal-title":"Rom. J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ulmeanu, A.I., Ciuparu, G.E., and Matran, E.R. (2025). Characteristics of Mycoplasma pneumoniae pneumonia in Romanian children. Microorganisms, 13.","DOI":"10.20944\/preprints202503.1378.v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/INF.0000000000002291","article-title":"The Clinical Presentation of Pediatric Mycoplasma pneumoniae Infections\u2014A Single-Center Cohort","volume":"38","author":"Gordon","year":"2019","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Biagi, C., Cavallo, A., Rocca, A., Pierantoni, L., Antonazzo, D., Dondi, A., Gabrielli, L., Lazzarotto, T., and Lanari, M. (2021). Pulmonary and Extrapulmonary Manifestations in Hospitalized Children with Mycoplasma pneumoniae Infection. Microorganisms, 9.","DOI":"10.3390\/microorganisms9122553"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"S\u00f8ndergaard, M.J., Friis, M.B., Hansen, D.S., and J\u00f8rgensen, I.M. (2018). Clinical Manifestations in Infants and Children with Mycoplasma pneumoniae Infection. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195288"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1473-3099(24)00805-3","article-title":"Mycoplasma pneumoniae Infection in Adult Inpatients during the 2023\u201324 Outbreak in France (MYCADO): A National, Retrospective, Observational Study","volume":"25","author":"Gavaud","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.amjmed.2024.02.008","article-title":"Mycoplasma pneumoniae\u2013associated reactive infectious mucocutaneous eruption sine rash","volume":"137","author":"Wang","year":"2024","journal-title":"The Am. J. Med."},{"key":"ref_15","first-page":"e186","article-title":"Mucositis secondary to Chlamydia pneumoniae infection: Expanding the Mycoplasma pneumoniae\u2013induced rash and mucositis concept","volume":"34","year":"2017","journal-title":"Pediatr. Dermatol."},{"key":"ref_16","first-page":"5","article-title":"Clinical and microbiological characteristics of reactive infectious mucocutaneous eruption: A case series of five patients","volume":"17","author":"Vassallo","year":"2021","journal-title":"JAAD Case Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pde.15744","article-title":"A severe case of reactive infectious mucocutaneous eruption associated with two possible triggers: Coronavirus and group A streptococcus","volume":"42","author":"Rodriguez","year":"2025","journal-title":"Pediatr. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25284","DOI":"10.51894\/001c.25284","article-title":"Mycoplasma pneumoniae\u2013induced rash and mucositis: A systematic review of the literature","volume":"6","author":"Lofgren","year":"2021","journal-title":"Spartan Med. Res. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/pde.14801","article-title":"Reactive infectious mucocutaneous eruption in children diagnosed with COVID-19","volume":"38","author":"Bowe","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Grama, A.C., Grama, O., M\u0103nescu, M., and Chince\u0219an, M. (2025). More than Mucositis: Pediatric RIME Following Co-Infection with SARS-CoV-2 and Mycoplasma pneumoniae\u2014A Case Report and Mini-Review. Infect. Dis. Rep., 17.","DOI":"10.3390\/idr17050121"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, Y., Jiao, L., Ma, L., Xu, Z., and Liang, Y. (2025). Pediatric Mycoplasma pneumoniae\u2013Induced Rash and Mucositis in China: Clinical Spectrum, Co-Infections and Risk Factors for Recurrence\u2014A Retrospective Cohort Study. Front. Allergy, 6.","DOI":"10.3389\/falgy.2025.1646688"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jdcr.2021.10.007","article-title":"Reactive infectious mucocutaneous eruption secondary to SARS-CoV-2","volume":"18","author":"Ryder","year":"2021","journal-title":"JAAD Case Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/pde.14780","article-title":"Recurrent reactive infectious mucocutaneous eruption (RIME) in two adolescents triggered by several distinct pathogens including SARS-CoV-2 and influenza A","volume":"38","author":"Song","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_24","first-page":"1030","article-title":"Severe reactive infectious mucocutaneous eruption mimicking drug-induced epidermal necrolysis triggered by norovirus","volume":"40","author":"Sanfilippo","year":"2023","journal-title":"Pediatr. Dermatol."},{"key":"ref_25","first-page":"115","article-title":"Reactive infectious mucocutaneous eruption: A case report","volume":"7","author":"Palanisamy","year":"2025","journal-title":"J. Skin Sex. Transm. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamadermatol.2019.3602","article-title":"Frequency and Clinical Presentation of Mucocutaneous Disease Due to Mycoplasma pneumoniae Infection in Children With Community-Acquired Pneumonia","volume":"156","author":"Theiler","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4103\/cdr.cdr_109_23","article-title":"Reactive infectious mucocutaneous eruption with extensive cutaneous involvement","volume":"8","author":"Anderson","year":"2024","journal-title":"Clin. Dermatol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105392","DOI":"10.1016\/j.nurpra.2025.105392","article-title":"Reactive infectious mucocutaneous eruption secondary to Mycoplasma pneumoniae","volume":"21","author":"Merritt","year":"2025","journal-title":"J. Nurse Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e00107-25","DOI":"10.1128\/asmcr.00107-25","article-title":"Reactive infectious mucocutaneous eruption: An increasingly encountered complication during periods of increased Mycoplasma pneumoniae transmission\u2014A case report","volume":"1","author":"Clark","year":"2025","journal-title":"ASM Case Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.4103\/mjdrdypu.mjdrdypu_524_23","article-title":"Let this rash not fox you: Mycoplasma-induced rash and mucositis","volume":"17","author":"Das","year":"2024","journal-title":"Med. J. Dr. D.Y. Patil Vidyapeeth"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1542\/peds.2015-0278","article-title":"Outbreak of Mycoplasma pneumoniae\u2013associated Stevens\u2013Johnson syndrome","volume":"136","author":"Olson","year":"2015","journal-title":"Pediatrics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-4632.2009.04154.x","article-title":"Mycoplasma pneumoniae-induced cutaneous disease","volume":"48","author":"Schalock","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/ced.14404","article-title":"Reactive infectious mucocutaneous eruption: Mycoplasma pneumoniae-induced rash and mucositis and other parainfectious eruptions","volume":"46","author":"Ramien","year":"2021","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/pde.14472","article-title":"Clinical Features of Recurrent Mycoplasma pneumoniae\u2013Induced Rash and Mucositis","volume":"38","author":"Liakos","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1093\/jpids\/piw085","article-title":"Characterization of Children with Recurrent Episodes of Stevens\u2013Johnson Syndrome and Related Mucocutaneous Eruptions","volume":"6","author":"Olson","year":"2017","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/HMO.1000209","article-title":"The importance of distinguishing Mycoplasma pneumoniae-induced rash and mucositis (MIRM) and Stevens-Johnson syndrome in a clinical setting","volume":"5","author":"Pillay","year":"2020","journal-title":"Hematol. Med. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4065\/mcp.2009.0379","article-title":"Clinical, etiologic, and histopathologic features of Stevens\u2013Johnson syndrome during an 8-year period at Mayo Clinic","volume":"85","author":"Wetter","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Frantz, R., Huang, S., Are, A., and Motaparthi, K. (2021). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management. Medicina, 57.","DOI":"10.3390\/medicina57090895"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Harris, V., Jackson, C., and Cooper, A. (2016). Review of toxic epidermal necrolysis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122135"},{"key":"ref_40","unstructured":"Hafsi, W., and Badri, T. (2025). Erythema Multiforme, StatPearls Publishing."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtos.2022.11.007","article-title":"Ocular involvement in Mycoplasma\u2014Induced rash and mucositis: A systematic review of the literature","volume":"28","author":"Haseeb","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_42","unstructured":"Lee, H.Y. (2025, November 18). Stevens\u2013Johnson Syndrome and Toxic Epidermal Necrolysis: Management, Prognosis, and Long-Term Sequelae. UpToDate. Available online: https:\/\/www.uptodate.com\/contents\/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-management-prognosis-and-long-term-sequelae."},{"key":"ref_43","unstructured":"Connor, R.F. (2025, November 18). Reactive Infectious Mucocutaneous Eruption (RIME). UpToDate, Wolters Kluwer. Available online: https:\/\/www.uptodate.com\/contents\/reactive-infectious-mucocutaneous-eruption-rime."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Napi\u00f3rkowska-Baran, K., Darwish, S., Kaczor, J., Treichel, P., Szymczak, B., Szota, M., Koperska, K., and Bartuzi, Z. (2024). Oral Diseases as a Manifestation of Inborn Errors of Immunity. J. Clin. Med., 13.","DOI":"10.3390\/jcm13175079"},{"key":"ref_45","unstructured":"World Health Organization (1979). WHO Handbook for Reporting Results of Cancer Treatment, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/37200."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101300","DOI":"10.1016\/j.disamonth.2021.101300","article-title":"Oral mucositis: Current knowledge and future directions","volume":"68","author":"Shetty","year":"2022","journal-title":"Dis. Mon."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/pde.15826","article-title":"Reactive infectious mucocutaneous eruption associated with Klebsiella pneumoniae","volume":"42","author":"Hamed","year":"2025","journal-title":"Pediatr. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1177\/0022034520925421","article-title":"Oral mucositis: An update on innate immunity and new interventional targets","volume":"99","author":"Chen","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_49","first-page":"63","article-title":"Viral and Fungal Infections of the Oral Mucosa: Predisposing Factors, Clinical Aspects, Diagnostic and Management","volume":"10","author":"Sufaru","year":"2023","journal-title":"ADRE J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Tahmasebi, E., Keshvad, A., Alam, M., Abbasi, K., Rahimi, S., Nouri, F., Yazdanian, M., Tebyaniyan, H., Heboyan, A., and Fernandes, G.V.O. (2023). Current Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology. Life, 13.","DOI":"10.3390\/life13020269"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/jhm.70099","article-title":"Diagnosis and Management of Reactive Infectious Mucocutaneous Eruption","volume":"20","author":"Damari","year":"2025","journal-title":"J. Hosp. Med."},{"key":"ref_52","unstructured":"Connor, R.F. (2025, November 18). Pneumonia Caused by Chlamydia pneumoniae in Children. UpToDate, Wolters Kluwer. Available online: https:\/\/www.uptodate.com\/contents\/pneumonia-caused-by-chlamydia-pneumoniae-in-children."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Isac, R., Cugerian-Ratiu, A.M., Micsescu-Olah, A.M., Bodescu, A.D., Vlad, L.A., Zaroniu, A.M., Gafencu, M., and Doros, G. (2025). Can lung ultrasound act as a diagnosis and monitoring tool in children with community-acquired pneumonia? Correlation with risk factors, clinical indicators and biologic results. J. Clin. Med., 14.","DOI":"10.3390\/jcm14155304"},{"key":"ref_54","unstructured":"(2022). Medical Laboratories\u2014Requirements for Quality and Competence (Standard No. ISO 15189:2022)."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Boeriu, E., Borda, A., Miclea, E., Boeriu, A.I., Vulcanescu, D.D., Bagiu, I.C., Horhat, F.G., Kovacs, A.F., Avram, C.R., and Diaconu, M.M. (2023). Prognosis communication in pediatric oncology: A systematic review. Children, 10.","DOI":"10.3390\/children10060972"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","article-title":"Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"42","author":"Tangye","year":"2022","journal-title":"J. Clin. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Poddighe, D., Demirkaya, E., Sazonov, V., and Romano, M. (2022). Mycoplasma pneumoniae Infections and Primary Immune Deficiencies. Int. J. Clin. Pract., 6343818.","DOI":"10.1155\/2022\/6343818"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Chen, N., and Li, M. (2022). Case Report and Literature Review: Clinical Characteristics of 10 Children With Mycoplasma pneumoniae-Induced Rash and Mucositis. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.823376"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00284-022-03103-0","article-title":"Insight into the Pathogenic Mechanism of Mycoplasma pneumoniae","volume":"80","author":"Hu","year":"2023","journal-title":"Curr. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Prodan-Barbulescu, C., Bratosin, F., Folescu, R., Boeriu, E., Popa, Z.L., Citu, C., Ratiu, A., Rosca, O., and Ilie, A.C. (2024). Analysis of Vaginal Microbiota Variations in the Third Trimester of Pregnancy and Their Correlation with Preterm Birth: A Case-Control Study. Microorganisms, 12.","DOI":"10.3390\/microorganisms12020417"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Jiang, Z., Li, S., Zhu, C., Zhou, R., and Leung, P. (2021). Mycoplasma pneumoniae Infections: Pathogenesis and Vaccine Development. Pathogens, 10.","DOI":"10.3390\/pathogens10020119"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3892\/etm.2021.10399","article-title":"Thrombosis Associated with Mycoplasma pneumoniae Infection","volume":"22","author":"Liu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jdcr.2024.02.013","article-title":"Rash from the past: A case of recurrent reactive infectious mucocutaneous eruption triggered by common coronavirus","volume":"47","author":"Lowell","year":"2024","journal-title":"JAAD Case Rep."},{"key":"ref_64","first-page":"e93698","article-title":"Recurrent Reactive Infectious Mucocutaneous Eruption (RIME) in a Pediatric Patient Triggered by Mycoplasma pneumoniae and Enterovirus Coinfection","volume":"17","author":"Alebaji","year":"2025","journal-title":"Cureus"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Isac, R., Doros, G., Stolojanu, C.A., Steflea, R.M., Stroescu, R.F., Olariu, I.C., Micsescu-Olah, A.M., and Gafencu, M. (2024). General Characteristics and Current State of Antibiotic Resistance in Pediatric Urinary Tract Infection\u2014A Single Center Experience. Antibiotics, 13.","DOI":"10.3390\/antibiotics13080684"},{"key":"ref_66","first-page":"134","article-title":"Pathogenesis of Extrapulmonary Manifestations of Mycoplasma pneumoniae Infection with Special Reference to MIRM","volume":"63","author":"Narita","year":"2020","journal-title":"Clin. Exp. Pediatr."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/2\/364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:13:30Z","timestamp":1770196410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/2\/364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":66,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["microorganisms14020364"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms14020364","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}