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The development of drugs aimed at maintaining intestinal health is a key area of biotechnology. Algae-based prebiotics are one such drug. The aim of this study was to conduct a comparative analysis of the fecal microbiota of Mus musculus with and without a prebiotic supplement. We studied the effects of enzymatically processed Laminaria digitata and Fucus vesiculosus seaweeds on the gut microbiome of mice with induced inflammation using DNBSEQ-G50 sequencing. The results showed that these prebiotic supplements can reduce the impact of inflammation on the intestine. An increase in the relative abundance of Anaerostipes rhamnosivorans, Dysosmobacter welbionis, Akkermansia muciniphila, Flavonifractor plautii, and a decrease in Longicatena caecimuris relative to the LPS group were observed. Furthermore, enzymatically processed algae were found to increase the relative abundance of gut bacterial metabolic pathways responsible for glucose breakdown. Thus, both enzymatically processed and unprocessed algae-based prebiotic supplements restored gut microbiome composition and gut morphology in LPS-exposed mice, as confirmed by microbiome analysis and histological examination.<\/jats:p>","DOI":"10.3390\/microorganisms14030592","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:05:44Z","timestamp":1772795144000},"page":"592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of a Combination of Prebiotic Supplements Based on Fucus and Kelp on the Gut Microbiome of Mice with Induced Inflammation"],"prefix":"10.3390","volume":"14","author":[{"given":"Anatoly A.","family":"Khitrov","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-0845","authenticated-orcid":false,"given":"Inna Yu.","family":"Burakova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-1804","authenticated-orcid":false,"given":"Yuliya D.","family":"Smirnova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7924-8027","authenticated-orcid":false,"given":"Svetlana V.","family":"Pogorelova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0021-6408","authenticated-orcid":false,"given":"Egor A.","family":"Chirkin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0075-9170","authenticated-orcid":false,"given":"Polina D.","family":"Morozova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil A.","family":"Garmonov","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chemistry and Standardization, Tver State Technical University, Nikitina Street, 22, Tver 170026, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Ozhimkova","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chemistry and Standardization, Tver State Technical University, Nikitina Street, 22, Tver 170026, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail Yu.","family":"Syromyatnikov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"},{"name":"Department of Genetics, Cytology and Bioengineering, Voronezh State University, 1 Universitetskaya Sq., Voronezh 394018, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-0771","authenticated-orcid":false,"given":"Olga S.","family":"Korneeva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Voronezh State University of Engineering Technologies, 19 Revolutsii Prospect, Voronezh 394036, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Shannon, E., Conlon, M., and Hayes, M. 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