{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:00:07Z","timestamp":1790193607921,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Winthrop P. Rockefeller Cancer Institute New Faculty Start-up Fund","award":["NIH R21AI186566"],"award-info":[{"award-number":["NIH R21AI186566"]}]},{"name":"Winthrop P. Rockefeller Cancer Institute New Faculty Start-up Fund","award":["R03DE034653"],"award-info":[{"award-number":["R03DE034653"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Kaposi\u2019s Sarcoma-associated herpesvirus (KSHV) has been etiologically linked to several human cancers, including Kaposi\u2019s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman\u2019s disease (MCD). However, recent studies suggest that KSHV infection may also be associated with the development of other diseases or increased risks, such as KSHV inflammatory cytokine syndrome (KICS), diabetes, malaria, heart disease, and other cancers. In this review, we summarize these findings from clinical observations, epidemiological studies or laboratory research, though more studies are needed in these emerging areas. We believe that this work will enhance our understanding of the molecular mechanisms underlying KSHV pathogenesis and contribute to improving treatments for related human diseases.<\/jats:p>","DOI":"10.3390\/microorganisms14030637","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:12:24Z","timestamp":1773321144000},"page":"637","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KSHV and Human Diseases: Beyond KS, PEL and MCD"],"prefix":"10.3390","volume":"14","author":[{"given":"Caroline Grace","family":"Firmin","sequence":"first","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-1275","authenticated-orcid":false,"given":"Zhiqiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12250-019-00114-3","article-title":"Towards Better Understanding of KSHV Life Cycle: From Transcription and Posttranscriptional Regulations to Pathogenesis","volume":"34","author":"Yan","year":"2019","journal-title":"Virol. Sin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chakraborty, S., Veettil, M.V., and Chandran, B. (2012). Kaposi\u2019s Sarcoma Associated Herpesvirus Entry into Target Cells. Front. Microbiol., 3.","DOI":"10.3389\/fmicb.2012.00006"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Broussard, G., and Damania, B. (2020). Regulation of KSHV Latency and Lytic Reactivation. 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