{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:28:20Z","timestamp":1785403700547,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82020108022"],"award-info":[{"award-number":["NSFC82020108022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["NSFC82020108022"],"award-info":[{"award-number":["NSFC82020108022"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Ulcerative colitis (UC) is a type of inflammatory bowel disease without curative therapeutics. Recent studies demonstrate that Akkermansia muciniphila exerts mitigating effects on UC, but the underlying mechanisms remain unclear. In this study, we isolated a strain of A. muciniphila, designated NND9, from the feces of DSS-induced ulcerative colitis model mice and investigated its effects on UC of the mouse model. NND9 significantly alleviated UC severity in the mice by restoring gut barrier integrity through improving colonic mucus layer thickness, mitigating goblet cell depletion, and halting epithelial cell death. Mechanistically, NND9 suppressed the expression of the Tnfrsf10b gene encoding death receptor 5 (DR5) on the surface of colonic epithelial cells. Additionally, NND9 inhibited the phosphorylation of kinase 3 (RIPK3) and the pseudokinase mixed-lineage kinase domain-like protein (MLKL) associated with the necrotic apoptosis pathway, thereby reducing gut epithelial cell death. NND9 also markedly ameliorated the gut microbiome of the colitis mice. Untargeted metabolomics analysis demonstrated that NND9 modulated both tryptophan and bile acid metabolism. In conclusion, NND9 exhibits curative effects on UC by resolving inflammatory reactions of the gut mucosa through the DR5-RIPK3\/p-RIPK3-MLKL\/p-MLKL pathway and redressing gut dysbiosis. This study provides valuable information for the development of innovative therapeutic strategies for the treatment of UC.<\/jats:p>","DOI":"10.3390\/microorganisms14051002","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:31:56Z","timestamp":1777465916000},"page":"1002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Akkermansia muciniphila NND9 Mitigates Ulcerative Colitis by Ameliorating the Gut Barrier via Suppressing DR5 Expression in a Mouse Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Xin-Yu","family":"Gao","sequence":"first","affiliation":[{"name":"Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, and State-Province Key Laboratory of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin 150081, China"},{"name":"National Key Laboratory of Frigid Zone 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J. Gastroenterol. J. Can. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","article-title":"Inflammatory bowel disease: Cause and immunobiology","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/gutjnl-2011-300430","article-title":"Ulcerative colitis as a sole mucosal disease: Another misunderstanding?","volume":"61","author":"Torres","year":"2012","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1001\/jama.2023.23814","article-title":"What Is Ulcerative Colitis?","volume":"331","author":"Voelker","year":"2024","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","article-title":"Immunopathogenesis of IBD: Current state of the art","volume":"13","author":"Fiocchi","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1038\/d41586-018-07276-2","article-title":"Ulcerative colitis: Towards remission","volume":"563","author":"Eisenstein","year":"2018","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: Causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1826746","DOI":"10.1080\/19490976.2020.1826746","article-title":"B. adolescentis ameliorates chronic colitis by regulating Treg\/Th2 response and gut microbiota remodeling","volume":"13","author":"Fan","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.chom.2024.04.020","article-title":"Enterococcus-derived tyramine hijacks alpha(2A)-adrenergic receptor in intestinal stem cells to exacerbate colitis","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host Microbe"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","article-title":"Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium","volume":"54","author":"Derrien","year":"2004","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s40168-024-01995-7","article-title":"Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice","volume":"12","author":"Liu","year":"2024","journal-title":"Microbiome"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e0073021","DOI":"10.1128\/Spectrum.00730-21","article-title":"Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation","volume":"9","author":"Qu","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4632","DOI":"10.1039\/D2FO03493J","article-title":"The effects of live and pasteurized Akkermansia muciniphila on DSS-induced ulcerative colitis, gut microbiota, and metabolomics in mice","volume":"14","author":"Xue","year":"2023","journal-title":"Food Funct."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s12276-022-00911-z","article-title":"Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases","volume":"55","author":"Wang","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ordas","year":"2012","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15683","DOI":"10.1038\/s41598-019-51878-3","article-title":"The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis","volume":"9","author":"Earley","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1892441","DOI":"10.1080\/19490976.2021.1892441","article-title":"Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development","volume":"13","author":"Kim","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1038\/sj.onc.1207232","article-title":"TRAIL and apoptosis induction by TNF-family death receptors","volume":"22","author":"Wang","year":"2003","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2019.02.001","article-title":"Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling","volume":"176","author":"Pan","year":"2019","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/cdd.2013.28","article-title":"Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: Discord in the death receptor family","volume":"20","author":"Azijli","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Guerrache, A., and Micheau, O. (2024). TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling. Cells, 13.","DOI":"10.3390\/cells13060521"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.4049\/jimmunol.141.8.2629","article-title":"Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis","volume":"141","author":"Laster","year":"1988","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","article-title":"The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death","volume":"84","author":"Ai","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1128\/AEM.01477-07","article-title":"Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly","volume":"73","author":"Collado","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.aay7367","article-title":"Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota","volume":"370","author":"Bergstrom","year":"2020","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-021-03967-5","article-title":"A single sulfatase is required to access colonic mucin by a gut bacterium","volume":"598","author":"Luis","year":"2021","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3748\/wjg.v22.i11.3117","article-title":"Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer","volume":"22","author":"Landy","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bhat, A.A., Uppada, S., Achkar, I.W., Hashem, S., Yadav, S.K., Shanmugakonar, M., Al-Naemi, H.A., Haris, M., and Uddin, S. (2018). Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01942"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e2334","DOI":"10.1038\/cddis.2016.234","article-title":"Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation","volume":"7","author":"Chen","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41556-021-00708-8","article-title":"E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis","volume":"23","author":"Patankar","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/gutjnl-2011-301364","article-title":"Apoptosis, necrosis and necroptosis: Cell death regulation in the intestinal epithelium","volume":"62","author":"Gunther","year":"2013","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and Strukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1038\/s41467-023-42788-0","article-title":"Microbiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts","volume":"14","author":"Ning","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fu, Y., Lyu, J., and Wang, S. (2023). The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1277102"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Iyer, N., and Corr, S.C. (2021). Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease. Nutrients, 13.","DOI":"10.3390\/nu13124259"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1080\/10408398.2019.1598334","article-title":"Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)","volume":"60","author":"Sun","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"126158","DOI":"10.1016\/j.ijpharm.2025.126158","article-title":"Enteric delivery of indole-3-carboxylic acid unlocks therapeutic potential of postbiotic metabolite cascade","volume":"684","author":"Puccetti","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev-med-042320-021020","article-title":"The Gut Microbiome and Inflammatory Bowel Diseases","volume":"73","author":"Shan","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s13238-020-00745-3","article-title":"The microbiome in inflammatory bowel diseases: From pathogenesis to therapy","volume":"12","author":"Liu","year":"2021","journal-title":"Protein Cell"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bian, X., Wu, W., Yang, L., Lv, L., Wang, Q., Li, Y., Ye, J., Fang, D., Wu, J., and Jiang, X. (2019). Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.02259"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e0085825","DOI":"10.1128\/spectrum.00858-25","article-title":"Streptomyces sp. BI87 from human gut: Potent anticancer activities and divergence from known Streptomyces lineages","volume":"13","author":"Wang","year":"2025","journal-title":"Microbiol. Spectr."},{"key":"ref_47","unstructured":"Liu, S.L. (2022). Pursuing the Origin of Pathogenic Bacterial Species, Cambridge Scholars Publishing Ltd."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1136\/gutjnl-2020-322260","article-title":"Mucus barrier, mucins and gut microbiota: The expected slimy partners?","volume":"69","author":"Paone","year":"2020","journal-title":"Gut"},{"key":"ref_49","first-page":"O161","article-title":"Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis","volume":"16","author":"Lennon","year":"2014","journal-title":"Color. Dis. Off. J. Assoc. Coloproctol. Great Br. Irel."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/gut.2007.147595","article-title":"Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse","volume":"58","author":"Dawson","year":"2009","journal-title":"Gut"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2377576","DOI":"10.1080\/19490976.2024.2377576","article-title":"Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation","volume":"16","author":"Li","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1053\/j.gastro.2020.11.008","article-title":"A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity","volume":"160","author":"Kumar","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/j.molcel.2025.06.005","article-title":"MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction","volume":"85","author":"Ding","year":"2025","journal-title":"Mol. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e2307395120","DOI":"10.1073\/pnas.2307395120","article-title":"Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation","volume":"121","author":"Yang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.canlet.2019.05.034","article-title":"MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses","volume":"459","author":"Zhao","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lee, K.I., Jo, Y., Yuk, H.J., Kim, S.Y., Kim, H., Kim, H.J., Hwang, S.K., and Park, K.S. (2024). Potential Phytotherapy of DSS-Induced Colitis: Ameliorating Reactive Oxygen Species-Mediated Necroptosis and Gut Dysbiosis with a New Crataegus pinnatifida Bunge Variety-Daehong. Antioxidants, 13.","DOI":"10.3390\/antiox13030340"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41419-019-1580-7","article-title":"Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2003.025403","article-title":"Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease","volume":"53","author":"Ott","year":"2004","journal-title":"Gut"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Chen, B., Zhang, X., Akbar, M.T., Wu, T., Zhang, Y., Zhi, L., and Shen, Q. (2024). Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function. Nutrients, 16.","DOI":"10.3390\/nu16162660"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1136\/gutjnl-2023-329969","article-title":"Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases","volume":"73","author":"Zhang","year":"2024","journal-title":"Gut"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41586-020-2047-9","article-title":"Global chemical effects of the microbiome include new bile-acid conjugations","volume":"579","author":"Quinn","year":"2020","journal-title":"Nature"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/5\/1002\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:15:20Z","timestamp":1777468520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/5\/1002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["microorganisms14051002"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms14051002","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}