{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:39:15Z","timestamp":1777765155223,"version":"3.51.4"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QC084"],"award-info":[{"award-number":["ZR2022QC084"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Agricultural Major Technology Collaborative Promotion Plan","award":["SDNYXTTG-2025-43"],"award-info":[{"award-number":["SDNYXTTG-2025-43"]}]},{"name":"Key Research and Development Programs of Shandong Province","award":["2024TZXD027"],"award-info":[{"award-number":["2024TZXD027"]}]},{"name":"Agriculture Research System in Shandong Province","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]},{"name":"Daizong Talent Project for Innovation and Entrepreneurship","award":["DZRC202311"],"award-info":[{"award-number":["DZRC202311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Glucose oxidase (GOD) is a natural enzyme with antioxidant and antimicrobial properties but its effects on sows remain insufficient. This study investigated the effects of dietary GOD supplementation during gestation on inflammatory response, antioxidant capacity, immune function, and gut microbiota of farrowing sows. Twenty-four primiparous sows were randomly assigned to two groups and fed a basal diet or a basal diet supplemented with GOD (300 mg\/kg diet) from gestation day 30 to farrowing. GOD supplementation significantly increased triglyceride, superoxide dismutase, and immunoglobulin M levels (p &lt; 0.05), and significantly decreased alanine aminotransferase and interleukin-6 levels in serum (p &lt; 0.05); significantly reduced placental interleukin-1\u03b2, malondialdehyde and tumor necrosis factor-\u03b1 concentrations and NF-\u03baB gene expression (p &lt; 0.05), and elevated glutathione peroxidase activity and relative mRNA expressions of Nrf2, HO-1, GPX1 and SOD2 (p &lt; 0.05). Moreover, GOD supplementation altered the fecal microbial community structure (p &lt; 0.05), significantly reducing Clostridium, dgaA-11_gut_group, Bacteroides, and Prevotellaceae_NK3B31_group abundance (p &lt; 0.05), while enriching Lachnospira, unclassified_f_Erysipelotrichiaceae, and Anaerostipes (p &lt; 0.05). Collectively, 300 mg\/kg glucose oxidase supplementation during mid-to-late gestation improved the health status of farrowing sows by improving nutrient utilization, immune function and antioxidant capacity, and altering fecal microbial structure and relative abundances.<\/jats:p>","DOI":"10.3390\/microorganisms14051005","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:01:18Z","timestamp":1777474878000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Glucose Oxidase Supplementation During Gestation Improves Health Status by Affecting Antioxidant Capacity, Immune Function, and Gut Microbiota of Farrowing Sows"],"prefix":"10.3390","volume":"14","author":[{"given":"Shuning","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Hemeihua Biotechnology Co., Ltd., Jinan 250104, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Lonct Enzymes Co., Ltd., Linyi 276400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Kong","sequence":"additional","affiliation":[{"name":"Shandong Provincial Animal Husbandry General Station (Shandong Provincial Quality Testing Station for Breeding Livestock and Poultry), Jinan 250109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuemeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-0322","authenticated-orcid":false,"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-1259","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Panhe Street 7, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2049-1891-4-26","article-title":"Improving efficiency of sow productivity: Nutrition and health","volume":"4","author":"Kim","year":"2013","journal-title":"J. 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