{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:09:29Z","timestamp":1778501369419,"version":"3.51.4"},"reference-count":79,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DGAPA-PAPIIT UNAM project","award":["IN200524"],"award-info":[{"award-number":["IN200524"]}]},{"name":"SECIHTI (Formerly CONAHCYT) project","award":["CF-2023-G370"],"award-info":[{"award-number":["CF-2023-G370"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa and the causative agent of toxoplasmosis, a disease with a worldwide distribution that causes serious consequences in immunocompromised patients and during pregnancy. Current pharmacological treatments have significant limitations, including their toxicity, lack of efficacy against the chronic phase of the parasite, and low selectivity, highlighting the need to develop new therapeutic targets. One of the most promising targets is the fatty acid synthesis pathway II (FASII), a metabolic pathway located in the parasite\u2019s apicoplast and absent in mammalian hosts. This review synthesizes the available evidence on FASII pathway inhibitors described to date, as well as their potential impact on the viability and development of T. gondii. Overall, the reviewed studies support the FASII pathway as an attractive therapeutic target for the development of more selective and effective treatments against toxoplasmosis.<\/jats:p>","DOI":"10.3390\/microorganisms14051072","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:50:52Z","timestamp":1778496652000},"page":"1072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibitors of the FASII Metabolic Pathway in Toxoplasma gondii: Advances and Therapeutic Perspectives"],"prefix":"10.3390","volume":"14","author":[{"given":"Claudia Jessica","family":"Castillo-Villanueva","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Biol\u00f3gicas, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"},{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6538-9788","authenticated-orcid":false,"given":"Jhony","family":"Anacleto-Santos","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2225-7686","authenticated-orcid":false,"given":"Teresa de Jes\u00fas","family":"L\u00f3pez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-0658","authenticated-orcid":false,"given":"Brenda","family":"Casarrubias-Tabarez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3507-1365","authenticated-orcid":false,"given":"Teresa I.","family":"Fortoul","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Rojas-Lemus","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0525-1074","authenticated-orcid":false,"given":"Nelly","family":"L\u00f3pez-Valdez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Tisular, Facultad de Medicina, Ciudad Universitaria, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Vega-\u00c1vila","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Salud, Universidad Aut\u00f3noma Metropolitana Iztapalapa, Ciudad de M\u00e9xico 09340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-5988","authenticated-orcid":false,"given":"Fernando","family":"Calzada","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Farmacolog\u00eda, Unidad M\u00e9dica de Alta Especialidad, Hospital de Especialidades Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Col. Doctores, Cuauhtemoc 06725, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1093-757X","authenticated-orcid":false,"given":"Perla Yolanda","family":"L\u00f3pez-Camacho","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Naturales, Unidad Cuajimalpa, Universidad Aut\u00f3noma Metropolitana (UAM), Col. 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