{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:40:23Z","timestamp":1790293223930,"version":"4.1.0"},"reference-count":110,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270919"],"award-info":[{"award-number":["32270919"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470927"],"award-info":[{"award-number":["32470927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32270919"],"award-info":[{"award-number":["32270919"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"award":["32470927"],"award-info":[{"award-number":["32470927"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Jiangsu Innovative and Entrepreneurial Research Team Program","award":["JSSCTD202348"],"award-info":[{"award-number":["JSSCTD202348"]}]},{"name":"Jiangsu Provincial Research Foundation for Basic Research, China","award":["BK20250944"],"award-info":[{"award-number":["BK20250944"]}]},{"DOI":"10.13039\/501100005054","name":"Start-up funds for young scientists of Nantong University","doi-asserted-by":"publisher","award":["03083051"],"award-info":[{"award-number":["03083051"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"award":["03083051"],"award-info":[{"award-number":["03083051"]}],"id":[{"id":"https:\/\/ror.org\/02afcvw97","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["KYCX23_3420"],"award-info":[{"award-number":["KYCX23_3420"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The gut microbiota is increasingly recognized as a dynamic endocrine-like microbial network that exerts systemic effects far beyond the gastrointestinal tract. Emerging evidence supports the existence of a \u201cgut-bone marrow axis\u201d through which gut-derived signals orchestrate hematopoietic homeostasis. However, shifting from correlative observations to causal mechanisms remains a major challenge in defining precise microbial impacts on hematopoietic outcomes. In this review, we systematically synthesize current knowledge on the molecular mechanisms by which microbial products\u2014specifically short-chain fatty acids (SCFAs) and bile acids\u2014translocate into the systemic circulation to modulate hematopoietic stem cell (HSC) function, lineage commitment, and the bone marrow microenvironment. Furthermore, we discuss how gut dysbiosis acts as a driver of hematopoietic dysfunction, contributing to the pathogenesis of anemia, bone marrow failure, and hematologic malignancies such as leukemia. Beyond mechanistic insights, this review critically evaluates the therapeutic promise of emerging microbiota-targeted interventions, including precision probiotics, prebiotics, and FMT, which hold the potential to modulate hematopoietic function and support recovery. Although preclinical evidence is accumulating, these approaches are underpinned by limited yet mechanistically informative clinical evidence. Thus, these emerging interventions require rigorous mechanistic validation and well-designed clinical trials. Herein, by integrating multi-systemic perspectives, we provide a comprehensive framework for future research and clinical strategies aimed at leveraging the microbiota to treat hematologic disorders.<\/jats:p>","DOI":"10.3390\/microorganisms14071446","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:50:37Z","timestamp":1782867037000},"page":"1446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Gut\u2013Bone Marrow Axis: Deciphering the Mechanistic Impact of Microbial Metabolites on Hematopoietic Homeostasis and Disorders"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiaqi","family":"Sun","sequence":"first","affiliation":[{"name":"Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226019, China"},{"name":"Department of Immunology, School of Medicine, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-820X","authenticated-orcid":false,"given":"Liming","family":"Mao","sequence":"additional","affiliation":[{"name":"Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226019, China"},{"name":"Department of Immunology, School of Medicine, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0947-5756","authenticated-orcid":false,"given":"Lingli","family":"Jiang","sequence":"additional","affiliation":[{"name":"Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226019, China"},{"name":"Department of Immunology, School of Medicine, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1007\/s11427-023-2346-1","article-title":"Gut microbiota bridges dietary nutrients and host immunity","volume":"66","author":"Fan","year":"2023","journal-title":"Sci. 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