{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:33:18Z","timestamp":1785407598621,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573384"],"award-info":[{"award-number":["32573384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32573384"],"award-info":[{"award-number":["32573384"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Key Research and Development Project of Shaanxi Province","award":["2025SF-YBXM-506"],"award-info":[{"award-number":["2025SF-YBXM-506"]}]},{"name":"Young Talent Program of Xi\u2019an Jiaotong University","award":["YX6J027"],"award-info":[{"award-number":["YX6J027"]}]},{"award":["YX6J027"],"award-info":[{"award-number":["YX6J027"]}],"id":[{"id":"https:\/\/ror.org\/017zhmm22","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities of Xi\u2019an Jiaotong University","award":["xzy012025170"],"award-info":[{"award-number":["xzy012025170"]}]},{"award":["xzy012025170"],"award-info":[{"award-number":["xzy012025170"]}],"id":[{"id":"https:\/\/ror.org\/017zhmm22","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Infectious laryngotracheitis virus (ILTV), formally known as Gallid alphaherpesvirus 1, represents a prominent alphaherpesvirus that poses a significant threat to the global poultry industry. Current routine vaccination strategies fail to eliminate latent infection. Host\u2013pathogen interaction networks have become a key focus in antiviral research. Our previous study demonstrated that activation of the MEK\/ERK signaling pathway upon ILTV infection restricts host cellular metabolic activity to mount protective host antiviral responses, yet the underlying molecular mechanism remains unclear. The present work systematically dissects the contribution of MEK\/ERK signaling to intrinsic host defense against ILTV. The results show that ILTV infection activates the MEK\/ERK pathway, which in turn promotes the expression, activation, and nuclear translocation of the transcription factor Fos. As a core transcriptional regulator, Fos represses host metabolic gene expression, thereby restricting viral replication and proliferation. Integrated multi-omics analyses further demonstrate that the MEK\/ERK-Fos-metabolic regulatory axis operates uniformly during infection with avian, human, and porcine alphaherpesviruses, suggesting a broadly conserved host antiviral mechanism. This consistent cross species signaling pattern points toward an evolutionarily conserved host antiviral strategy and provides potential molecular targets for the development of broad-spectrum antiviral strategies against alphaherpesviruses.<\/jats:p>","DOI":"10.3390\/microorganisms14071492","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:27:23Z","timestamp":1783520843000},"page":"1492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MEK\/ERK-Mediated Transcriptional Repression of Metabolic Genes Confers Host Defense Against Gallid alphaherpesvirus 1 Infection via Modulating Fos Nuclear Translocation"],"prefix":"10.3390","volume":"14","author":[{"given":"Lu","family":"Cui","sequence":"first","affiliation":[{"name":"National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"MOE Key Laboratory of 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Li","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"MOE Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwang","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin 150069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-2097","authenticated-orcid":false,"given":"Hai","family":"Li","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Translational Medicine Institute, Xi\u2019an Jiaotong University Health Science Center, Xi\u2019an 710061, China"},{"name":"MOE Key Laboratory of Environment and Genes Related to Diseases, Xi\u2019an Jiaotong University, Xi\u2019an 710061, China"},{"name":"Key Laboratory for ImmunoHealth of Shaanxi Province, Xi\u2019an 710061, 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