{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:05:05Z","timestamp":1784624705982,"version":"3.55.0"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Guidance on Local Science and Technology Development Fund of Shanxi Province","award":["YDZJSX20231A003"],"award-info":[{"award-number":["YDZJSX20231A003"]}]},{"name":"\u201cUncovering the top leadership\u201d project of Taiyuan bureau of science and technology","award":["2024TYJB0147"],"award-info":[{"award-number":["2024TYJB0147"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health burden. Host genetic factors play a critical role in TB susceptibility, but the underlying mechanisms are not fully understood. Genome-wide association studies have identified DUSP14 as a TB susceptibility gene, and the single nucleotide polymorphism (SNP) rs1051838 in DUSP14 seems to be associated with TB risk. Using in vitro models including THP-1-derived macrophages, A549 cells, and HEK293T cells, we investigated how rs1051838 regulates DUSP14 expression and modulates macrophage responses to Mtb infection. We found that the G allele of rs1051838 exhibits higher transcriptional activity than the A allele in reporter assays. The G allele creates a CpG dinucleotide that is subject to methylation-mediated repression. Mtb infection reduced CpG methylation across this region to upregulate DUSP14, leading to suppressed JNK phosphorylation via its phosphatase activity, reduced pro-inflammatory cytokine production, and promoted intracellular bacterial survival. Knockdown of DUSP14 decreases bacterial burden and increases cytokine secretion. These findings reveal a functional link between genetic variation and immune response in TB and point to DUSP14 as a potential target for host directed therapy, although further validation in primary cells or using virulent strains and in vivo models is needed.<\/jats:p>","DOI":"10.3390\/microorganisms14071588","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:14:27Z","timestamp":1784621667000},"page":"1588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["rs1051838 Promotes Intracellular Survival of Mycobacterium tuberculosis H37Ra by Regulating DUSP14 Expression"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-2031","authenticated-orcid":false,"given":"Jiao","family":"Feng","sequence":"first","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Meng","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runru","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Cui","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-2667","authenticated-orcid":false,"given":"Zhiqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-3459","authenticated-orcid":false,"given":"Li","family":"Xing","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-1662","authenticated-orcid":false,"given":"Changxin","family":"Wu","sequence":"additional","affiliation":[{"name":"Biomedicine and Health Laboratory in Shanxi Province, Institute of Biomedical Sciences, Shanxi University, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"ref_1","unstructured":"WHO (2025). 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