{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:50:13Z","timestamp":1791244213651,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Lactiplantibacillus plantarum is one of the most studied probiotic organisms due to its adaptability, gastrointestinal tolerance, antimicrobial activity, and health-promoting properties. However, the survival and efficacy of this probiotic can be significantly reduced during processing, storage, and gastrointestinal transit, limiting its effectiveness in food, nutraceutical, and pharmaceutical products. Synbiotic formulations, which are prepared by combining probiotics with prebiotics, have emerged as a promising approach to enhance the survival and efficacy of probiotics. In this context, encapsulation technologies play a crucial role in protecting probiotic cells from environmental and physiological stresses and in enabling controlled release at targeted sites within the gastrointestinal tract. This review describes recent developments in encapsulation strategies for L. plantarum-based synbiotic formulations, including traditional methods such as spray drying, freeze drying, extrusion and emulsion-based systems, as well as emerging methods such as nanoencapsulation and hydrogel-based delivery systems. The properties of commonly used encapsulating materials, and functional applications in food, nutraceutical and pharmaceutical products are also described. Furthermore, current challenges and future prospects are also highlighted. Overall, encapsulation represents an effective strategy to improve the stability, delivery and therapeutic potential of L. plantarum-based synbiotic formulations.<\/jats:p>","DOI":"10.3390\/microorganisms14081621","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:53:26Z","timestamp":1784901206000},"page":"1621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recent Advances in Encapsulation Strategies for Synbiotic Formulation Containing Lactiplantibacillus plantarum"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3179-9460","authenticated-orcid":false,"given":"Kairat Saparkhanovich","family":"Zhakipbekov","sequence":"first","affiliation":[{"name":"School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole Bi Str., 050012 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-0224","authenticated-orcid":false,"given":"Murat Zulpidinovich","family":"Ashirov","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole Bi Str., 050012 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baurzhan Kalzhanovich","family":"Makhatov","sequence":"additional","affiliation":[{"name":"LLC \u201cCenter for Continuous Professional Development\u201d, 8, Tashenova Str., 160011 Shymkent, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlygash Manapovna","family":"Akpayeva","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Astana Medical University, 49A, Beybitshilik Str., Saryarka District, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-5783","authenticated-orcid":false,"given":"Aziza Mukataikyzy","family":"Omari","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Astana Medical University, 49A, Beybitshilik Str., Saryarka District, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakatzhan Duisenbekuly","family":"Abdikalykov","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Astana Medical University, 49A, Beybitshilik Str., Saryarka District, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanar Kasymbekovna","family":"Shimirova","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, South Kazakhstan Medical Academy, Al-Farabi Square, 1, 160019 Shymkent, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-0713","authenticated-orcid":false,"given":"Gulmira Marsovna","family":"Abdrakhmanova","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Karaganda Medical University, 40, Gogol Str., 100000 Karaganda, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-5963","authenticated-orcid":false,"given":"Yerbolat Abibillayevich","family":"Tulebayev","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Disciplines, \u201cBolashaq\u201d Academy, 16\/6, Yerubayev Str., 100012 Karaganda, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabit Bekseitovich","family":"Pazilov","sequence":"additional","affiliation":[{"name":"City Polyclinic No. 10, Microdistrict Aksai-4, 17, 050063 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-3135","authenticated-orcid":false,"given":"Bazarkhan","family":"Imangaliyeva","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Food Technology, K.Zhubanov Aktobe Regional State University, 34, A. Moldagulova Ave., 030000 Aktobe, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzhan","family":"Bauyrzhan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kazakh-Russian Medical University, Abylai Khan Str. 51\/53, 050004 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bauyrzhan Kuanishbekovich","family":"Toizhanov","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole Bi Str., 050012 Almaty, Kazakhstan"},{"name":"Masgut Aikimbayev National Scientific Center for Especially Dangerous Infections, 14, Zhahanger Str., 050054 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-9460","authenticated-orcid":false,"given":"Zhanat Sadebekovna","family":"Toxanbayeva","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, South Kazakhstan Medical Academy, Al-Farabi Square, 1, 160019 Shymkent, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulushash Dauletiyarkyzy","family":"Butanbayeva","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Asfendiyarov Kazakh National Medical University, 94, Tole Bi Str., 050012 Almaty, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the Human Gut Microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. 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