{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:42:54Z","timestamp":1785404574872,"version":"3.56.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vice-Rectorate for Research (VRIN) of the Universidad Nacional Toribio Rodr\u00edguez de Mendoza de Amazonas","award":["2314496"],"award-info":[{"award-number":["2314496"]}]},{"award":["2314496"],"award-info":[{"award-number":["2314496"]}],"id":[{"id":"https:\/\/ror.org\/0323wfn23","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>This study evaluated the short-term response of the fecal microbiota of wild Cavia tschudii during its transition from natural conditions to captivity under a standardized alfalfa-based diet. Fecal samples were collected over a 21-day period and analyzed using 16S rRNA gene sequencing to assess microbial diversity, community structure, and taxonomic composition. Rarefaction analysis indicated sufficient sequencing coverage; however, samples were normalized to 500 reads per sample, and results should be interpreted cautiously. No significant changes were detected in alpha diversity, beta diversity, or dominant taxonomic composition across sampling time points. The microbiota was consistently dominated by Bacteroidota and Firmicutes, accounting for more than 85% of total relative abundance. Minor taxa such as Methanobacteriales and Spirochaetales were present at low and stable abundances. Despite differences between natural forage and the alfalfa-based diet, microbial community structure showed limited temporal variation during the study period. The absence of detectable parasitic infections further supports that observed patterns reflect host\u2013microbiota dynamics under controlled conditions. Functional predictions suggested variation in metabolic pathways but should be interpreted cautiously due to the limitations of 16S rRNA-based inference. Overall, these findings suggest limited temporal variation in the fecal microbiota of Cavia tschudii during the first three weeks of captivity under the conditions evaluated. However, due to the exploratory nature of the study and its methodological limitations, these results should be interpreted with caution. This study provides baseline insights into limited temporal variation in the fecal microbiota of a wild caviid species and contributes to understanding host\u2013microbiome interactions relevant to conservation and potential domestication processes.<\/jats:p>","DOI":"10.3390\/microorganisms14081629","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:26:23Z","timestamp":1785115583000},"page":"1629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-Term Stability of the Fecal Microbiota in Wild Cavia tschudii During Early Captivity Transition"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-1935","authenticated-orcid":false,"given":"Hugo","family":"Fr\u00edas","sequence":"first","affiliation":[{"name":"Facultad de Ingenier\u00eda Zootecnista, Biotecnolog\u00eda, Agronegocios y Ciencia de Datos (FIZBAC), Universidad Nacional 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Companion Anim. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/vcp.13031","article-title":"Analysis of the gut microbiome in dogs and cats","volume":"50","author":"Suchodolski","year":"2022","journal-title":"Vet. Clin. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","article-title":"Bifidobacterium mechanisms of immune modulation and tolerance","volume":"15","author":"Gavzy","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev-food-061120-014739","article-title":"Gut colonization mechanisms of Lactobacillus and Bifidobacterium: An argument for personalized designs","volume":"12","author":"Xiao","year":"2021","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, W., Dong, H., Chang, X., Chen, Q., Wang, L., Chen, S., Chen, L., Wang, R., Ge, S., and Wang, P. (2024). Bifidobacterium lactis and Lactobacillus plantarum enhance immune function and antioxidant capacity in cats through modulation of the gut microbiota. Antioxidants, 13.","DOI":"10.3390\/antiox13070764"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wei, J., Wei, L., Ullah, A., Geng, M., Zhang, X., Wang, C., Khan, M.Z., Wang, C., and Zhang, Z. (2025). Metagenomic applications to herbivore gut microbiomes: A comprehensive review of microbial diversity and host interactions. Animals, 15.","DOI":"10.3390\/ani15202938"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Belanche, A., Belzecki, G., Hernandez-Sanabria, E., Mart\u00ednez-Fernandez, G., Ramos-Morales, E., and de la Fuente, G. (2025). Editorial: Unravelling the unknown of the rumen microbiome: Implications for animal health, productivity, and beyond. Front. Microbiol., 16.","DOI":"10.3389\/fmicb.2025.1720795"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1126\/science.1155725","article-title":"Evolution of mammals and their gut microbes","volume":"320","author":"Ley","year":"2008","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, S., Luo, S., and Yan, C. (2022). Gut microbiota implications for health and welfare in farm animals: A review. Animals, 12.","DOI":"10.3390\/ani12010093"},{"key":"ref_10","first-page":"1034","article-title":"Exploring bovine fecal bacterial microbiota in the Mapimi Biosphere Reserve, Northern Mexico","volume":"13","author":"Mellado","year":"2022","journal-title":"Rev. Mex. Cienc. Pecu."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e60197","DOI":"10.7554\/eLife.60197","article-title":"Effects of domestication on the gut microbiota parallel those of human industrialization","volume":"10","author":"Reese","year":"2021","journal-title":"eLife"},{"key":"ref_12","unstructured":"Integrated Taxonomic Information System (ITIS) (2025, September 11). Cavia tschudii Fitzinger, Available online: https:\/\/www.itis.gov."},{"key":"ref_13","first-page":"445","article-title":"Genomic characterization and probiotic potential of lactic acid bacteria isolated from feces of guinea pig (Cavia porcellus)","volume":"14","author":"Mialhe","year":"2024","journal-title":"Open Vet. J."},{"key":"ref_14","unstructured":"AOAC International (2016). Official Methods of Analysis of AOAC International, AOAC International. [20th ed.]. Available online: https:\/\/www.aoac.org."},{"key":"ref_15","unstructured":"AOAC International (2019). Official Methods of Analysis of AOAC International, AOAC International. [21st ed.]."},{"key":"ref_16","unstructured":"ANKOM Technology (2021). Analytical Methods for Fiber Analysis, ANKOM Technology. Available online: https:\/\/www.ankom.com."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Straub, D., Blackwell, N., Langarica-Fuentes, A., Peltzer, A., Nahnsen, S., and Kleindienst, S. (2020). Interpretations of Environmental Microbial Community Studies Are Biased by the Selected 16S rRNA (Gene) Amplicon Sequencing Pipeline. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.550420"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nbt.3820","article-title":"Nextflow enables reproducible computational workflows","volume":"35","author":"Chatzou","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_19","unstructured":"Andrews, S. (2010). FastQC: A Quality Control Tool for High Throughput Sequence Data, Babraham Bioinformatics. Available online: https:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: Summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: Improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2: An improved and extensible approach for metagenome inference","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_26","unstructured":"R Core Team (2025). R: A Language and Environment for Statistical Computing, Version 4.5.1, R Foundation for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"fiaa255","DOI":"10.1093\/femsec\/fiaa255","article-title":"Microeco: An R package for data mining in microbial community ecology","volume":"97","author":"Liu","year":"2021","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref_28","first-page":"btac770","article-title":"MicrobiotaProcess: An R package for analysis, visualization and biomarker discovery of microbiome","volume":"39","author":"Xu","year":"2023","journal-title":"Bioinformatics"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"McMurdie, P.J., and Holmes, S. (2013). Phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061217"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2016). ggplot2: Elegant Graphics for Data Analysis, Springer-Verlag. Available online: https:\/\/ggplot2.tidyverse.org.","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"ref_31","unstructured":"Anders, S., Figueroa, C., and Vega, M. (2021). Gut microbiota dynamics in rodents under environmental and dietary shifts. Front. Microbiol., 12."},{"key":"ref_32","first-page":"1012","article-title":"Ecological and evolutionary dynamics of host-microbiota interactions in wild rodents","volume":"34","author":"Viney","year":"2019","journal-title":"Trends Ecol. Evol."},{"key":"ref_33","first-page":"1","article-title":"The Guinea Pig (Cavia porcellus)","volume":"7","author":"Noonan","year":"1994","journal-title":"ANZCCART"},{"key":"ref_34","unstructured":"Figueroa, C., Frias, D., and Anders, S. (2021). Effects of diet and environment on intestinal microbiota of wild rodents. BMC Genom., 22."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kamareddine, L., Najjar, H., Sohail, M.U., Abdulkader, H., and Al-Asmakh, M. (2020). The Microbiota and Gut-Related Disorders: Insights from Animal Models. Cells, 9.","DOI":"10.3390\/cells9112401"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Cantaro Segura, J., C\u00e1ntaro-Segura, H., and Blas, R. (2026). 16S rRNA Metagenomic Profiling Reveals Diet-Induced Shifts in Gut Microbial Diversity and Taxonomic Structure in Guinea Pigs. Appl. Microbiol., 6.","DOI":"10.3390\/applmicrobiol6010018"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cuenca-Condoy, M., Campos-Murillo, N., Quinteros-Rodas, W., and Miranda-Yuquilema, J. (2026). Guinea pigs in balance: Impact of the probiotic diet on the pH, microbiota and productive performance of guinea pigs. Front. Anim. Sci., 6.","DOI":"10.3389\/fanim.2025.1720940"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e30491","DOI":"10.1016\/j.heliyon.2024.e30491","article-title":"Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Frias, H., Murga Valderrama, N.L., Flores Durand, G.J., Cornejo, V.G., Romani, A.C., Bardales, W., Segura, G.T., Polveiro, R.C., Vieira, D.S., and Ramos Sanchez, E.M. (2023). Comparative analysis of fasting effects on the cecum microbiome in three guinea pig breeds: Andina, Inti, and Peru. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1283738"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Volmer, J.G., McRae, H., and Morrison, M. (2023). The evolving role of methanogenic archaea in mammalian microbiomes. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1268451"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cisek, A.A., Szyma\u0144ska, E., Aleksandrzak-Piekarczyk, T., and Cukrowska, B. (2024). The Role of Methanogenic Archaea in Inflammatory Bowel Disease\u2014A Review. J. Pers. Med., 14.","DOI":"10.3390\/jpm14020196"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Thingholm, L.B., Bang, C., R\u00fchlemann, M.C., Starke, A., Sicks, F., Kaspari, V., Jandowsky, A., Fr\u00f6lich, K., Ismer, G., and Bernhard, A. (2021). Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans. BMC Microbiol., 21.","DOI":"10.1186\/s12866-021-02337-5"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"E11996","DOI":"10.1073\/pnas.1810550115","article-title":"Fiber-associated spirochetes are major agents of hemicellulose degradation in the hindgut of wood-feeding higher termites","volume":"115","author":"Tokuda","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12576-023-00869-1","article-title":"The role of gut microbiota on cognitive development in rodents: A meta-analysis","volume":"73","author":"Putri","year":"2023","journal-title":"J. Physiol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"de Miguel, M., de Maria, N., Guevara, M.\u00c1., Diaz, L., S\u00e1ez-Laguna, E., S\u00e1nchez-G\u00f3mez, D., Chancerel, E., Aranda, I., Collada, C., and Plomion, C. (2012). Annotated genetic linkage maps of Pinus pinaster Ait. from a Central Spain population using microsatellite and gene based markers. BMC Genom., 13.","DOI":"10.1186\/1471-2164-13-527"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"131721","DOI":"10.1016\/j.jhazmat.2023.131721","article-title":"Multiomics implicate gut microbiota in low cypermethrin exposure induced multiorgan toxicological effects in pubertal male rats","volume":"458","author":"Yue","year":"2023","journal-title":"J. Hazard. Mater."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/8\/1629\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:38:08Z","timestamp":1785116288000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/8\/1629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,26]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["microorganisms14081629"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms14081629","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,26]]}}}