{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:26:39Z","timestamp":1787030799710,"version":"build-2736575974"},"reference-count":73,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["305003\/2022-4"],"award-info":[{"award-number":["305003\/2022-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Science and Technology in Human Pathogenic Fungi","award":["FUNVIR\u2014405934\/2022-0"],"award-info":[{"award-number":["FUNVIR\u2014405934\/2022-0"]}]},{"DOI":"10.13039\/501100005283","name":"Cearense Foundation for the Support of Scientific and Technological Development","doi-asserted-by":"crossref","award":["PVS-0215 00099.01.00\/23"],"award-info":[{"award-number":["PVS-0215 00099.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Antimicrobial peptides (AMPs) occur naturally in living organisms and play an essential role in defense against pathogens. Consequently, these peptides are significant in public health research as alternatives in addressing microbial resistance. Here, we present the proteomic profile of Cryptococcus neoformans treated with RcAlb-PepII, an AMP derived from the 2S albumin of Ricinus communis seed cake. This research is noteworthy, as C. neoformans is an emerging fungal pathogen classified by the World Health Organization (WHO) as a critical threat. Proteomic analysis revealed depletion of proteins involved in DNA and RNA metabolism, reduced protein biosynthesis, and mitochondrial damage-associated proteins in C. neoformans following RcAlb-PepII treatment. These findings advance the understanding of the therapeutic profile of AMPs and underscore their importance in combating critical pathogens.<\/jats:p>","DOI":"10.3390\/microorganisms14081800","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:05:41Z","timestamp":1786953941000},"page":"1800","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RcAlb-PepII Perturbs the Proteomic Profile of Cryptococcus neoformans, Shutting Down Proteins Involved in Fungal Survival"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3989-1573","authenticated-orcid":false,"given":"Nicholas Silva dos Santos","family":"Filho","sequence":"first","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6786-4360","authenticated-orcid":false,"given":"Lua","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Cear\u00e1, Fortaleza 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana de Aguiar","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Graduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Cear\u00e1, Fortaleza 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5581-1808","authenticated-orcid":false,"given":"Patr\u00edcia Gomes","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"},{"name":"National Institute of Science and Technology INCT Bioinspir\u2014Bioinspired Molecules as Innovative Solutions for Agricultural Challenges, Mato Grosso do Sul 79117-900, Brazil"},{"name":"National Institute of Science and Technology in Human Pathogenic Fungi (FunVir), Ribeir\u00e3o Preto 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton Araripe dos Santos","family":"Neto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Molecular Pathology, Darcy Ribeiro Campus, University of Bras\u00edlia, Bras\u00edlia 70910-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Victor da Rocha","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"},{"name":"Graduate Program in Medical Microbiology, Group of Applied Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Cear\u00e1, Fortaleza 60430-160, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7699-7332","authenticated-orcid":false,"given":"Francisco Italo Rodrigues","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3714-4178","authenticated-orcid":false,"given":"Jo\u00e3o Lucas Timb\u00f3","family":"Moror\u00f3","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 H\u00e9lio de Ara\u00fajo","family":"Filho","sequence":"additional","affiliation":[{"name":"Biological Science Department, State University of Rio Grande do Norte, Mossor\u00f3 59607-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Pantoja","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"},{"name":"National Institute of Science and Technology INCT Bioinspir\u2014Bioinspired Molecules as Innovative Solutions for Agricultural Challenges, Mato Grosso do Sul 79117-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2524-4434","authenticated-orcid":false,"given":"Pedro Filho Noronha","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics Applied to Human Health, Center for Drug Research and Development (NPDM), Federal University of Cear\u00e1, Fortaleza 60355-636, Brazil"},{"name":"National Institute of Science and Technology INCT Bioinspir\u2014Bioinspired Molecules as Innovative Solutions for Agricultural Challenges, Mato Grosso do Sul 79117-900, Brazil"},{"name":"National Institute of Science and Technology in Human Pathogenic Fungi (FunVir), Ribeir\u00e3o Preto 14040-903, Brazil"},{"name":"Visiting Researcher at the Cearense Foundation to Support Scientific and Technological Development, Fortaleza 60325-452, Brazil"},{"name":"S-Inova Biotech, Graduate Program in Biotechnology, Dom Bosco Catholic University, Campo Grande 79117-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s42770-020-00348-4","article-title":"Quinolines Derivatives as Promising New Antifungal Candidates for the Treatment of Candidiasis and Dermatophytosis","volume":"51","author":"Diedrich","year":"2020","journal-title":"Braz. J. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/mmi.14565","article-title":"Combatting the Evolution of Antifungal Resistance in Cryptococcus Neoformans","volume":"114","author":"Bermas","year":"2020","journal-title":"Mol. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104731","DOI":"10.1016\/j.meegid.2021.104731","article-title":"Cryptococcus Neoformans: Sex, Morphogenesis, and Virulence","volume":"89","author":"Zhao","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e00156-22","DOI":"10.1128\/cmr.00156-22","article-title":"Diagnosis and Management of Cryptococcal Meningitis in HIV-Infected Adults","volume":"36","author":"McHale","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_5","first-page":"49","article-title":"Cryptococcus Neoformans: Import\u00e2ncia No Diagn\u00f3stico Cl\u00ednico Das Formas Polim\u00f3rficas","volume":"24","author":"Oliveira","year":"2014","journal-title":"Bol. Inst. Adolfo Lutz-BIAL"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Aguiar, T.K.B., Mesquita, F.P., Neto, N.A.S., Gomes, F.\u00cd.R., Freitas, C.D.T., Carneiro, R.F., Nagano, C.S., Alencar, L.M.R., Santos-Oliveira, R., and Oliveira, J.T.A. (2023). No Chance to Survive: Mo-CBP3-PepII Synthetic Peptide Acts on Cryptococcus Neoformans by Multiple Mechanisms of Action. Antibiotics, 12.","DOI":"10.20944\/preprints202301.0373.v1"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40249-023-01073-4","article-title":"Cryptococcus Neoformans, a Global Threat to Human Health","volume":"12","author":"Zhao","year":"2023","journal-title":"Infect. Dis. Poverty"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118803","DOI":"10.1016\/j.lfs.2020.118803","article-title":"Synthetic Peptides against Trichophyton Mentagrophytes and T. Rubrum: Mechanisms of Action and Efficiency Compared to Griseofulvin and Itraconazole","volume":"265","author":"Lima","year":"2020","journal-title":"Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Aguiar, T.K.B., Neto, N.A.S., Freitas, C.D.T., Silva, A.F.B., Bezerra, L.P., Malveira, E.A., Branco, L.A.C., Mesquita, F.P., Goldman, G.H., and Alencar, L.M.R. (2022). Antifungal Potential of Synthetic Peptides against Cryptococcus Neoformans: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane\u2013Pore Formation, DNA Degradation, and Apoptosis. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081678"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Branco, L.A.C., Souza, P.F.N., Neto, N.A.S., Aguiar, T.K.B., Silva, A.F.B., Carneiro, R.F., Nagano, C.S., Mesquita, F.P., Lima, L.B., and Freitas, C.D.T. (2022). New Insights into the Mechanism of Antibacterial Action of Synthetic Peptide Mo-CBP3-PepI against Klebsiella Pneumoniae. Antibiotics, 11.","DOI":"10.3390\/antibiotics11121753"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41374-022-00830-7","article-title":"High-Throughput Proteomics: A Methodological Mini-Review","volume":"102","author":"Cui","year":"2022","journal-title":"Lab. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Steele, J.F.C., Hughes, R.K., and Banfield, M.J. (2019). Structural and Biochemical Studies of an NB-ARC Domain from a Plant NLR Immune Receptor. PLoS ONE, 14.","DOI":"10.1101\/557280"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Slack, J.M.W. (2020). Molecular Biology of the Cell. Princ. Tissue Eng., 65\u201378.","DOI":"10.1016\/B978-0-12-818422-6.00005-8"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhang, C., Huang, H., Deng, W., and Li, T. (2019). Genome-Wide Analysis of the Zn(II)2Cys6 Zinc Cluster-Encoding Gene Family in Tolypocladium Guangdongense and Its Light-Induced Expression. Genes, 10.","DOI":"10.3390\/genes10030179"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gellon, L., Razidlo, D.F., Gleeson, O., Verra, L., Schulz, D., Lahue, R.S., and Freudenreich, C.H. (2011). New Functions of Ctf18-RFC in Preserving Genome Stability Outside Its Role in Sister Chromatid Cohesion. PLoS Genet., 7.","DOI":"10.1371\/journal.pgen.1001298"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ng.3080","article-title":"The Scc2\u2013Scc4 Complex Acts in Sister Chromatid Cohesion and Transcriptional Regulation by Maintaining Nucleosome-Free Regions","volume":"46","author":"Kelly","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"EMBJ2021108290","DOI":"10.15252\/embj.2021108290","article-title":"Metabolic Remodeling Maintains a Reducing Environment for Rapid Activation of the Yeast DNA Replication Checkpoint","volume":"41","author":"Li","year":"2022","journal-title":"EMBO J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e12961","DOI":"10.1111\/cmi.12961","article-title":"Role of Clathrin-Mediated Endocytosis in the Use of Heme and Hemoglobin by the Fungal Pathogen Cryptococcus neoformans","volume":"21","author":"Bairwa","year":"2018","journal-title":"Cell. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20552","DOI":"10.1016\/S0021-9258(19)47098-1","article-title":"Cloning and Sequencing of the Nuclear Gene MIP1 Encoding the Catalytic Subunit of the Yeast Mitochondrial DNA Polymerase","volume":"264","author":"Foury","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Varassas, S.P., Amillis, S., Pappas, K.M., and Kouvelis, V.N. (2024). The Identification of the Mitochondrial DNA Polymerase \u03b3 (Mip1) of the Entomopathogenic Fungus Metarhizium Brunneum. Microorganisms, 12.","DOI":"10.3390\/microorganisms12061052"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1093\/nar\/gkf392","article-title":"The Mitochondrial DNA Polymerase as a Target of Oxidative Damage","volume":"30","author":"Graziewicz","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"jkac066","DOI":"10.1093\/g3journal\/jkac066","article-title":"Dual Targeting of Saccharomyces Cerevisiae Pso2 to Mitochondria and the Nucleus, and Its Functional Relevance in the Repair of DNA Interstrand Crosslinks","volume":"12","author":"Somashekara","year":"2022","journal-title":"G3 Genes Genomes Genet."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Marini, V., Nikulenkov, F., Samadder, P., Juul, S., Knudsen, B.R., and Krejci, L. (2023). MUS81 Cleaves TOP1-Derived Lesions and Other DNA\u2013Protein Cross-Links. BMC Biol., 21.","DOI":"10.1186\/s12915-023-01614-1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e01167-21","DOI":"10.1128\/Spectrum.01167-21","article-title":"RNase Z Oxidative Degradation Impedes TRNA Maturation and Is Involved in Streptococcal Translation Regulation in Response to Oxidative Stress","volume":"9","author":"Dong","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1128\/MCB.25.12.5196-5204.2005","article-title":"Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces Cerevisiae","volume":"25","author":"Doudican","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sleiman, S., and Dragon, F. (2019). Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33\/NAT10. Cells, 8.","DOI":"10.3390\/cells8091035"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1038\/ncomms7757","article-title":"Systematic Functional Profiling of Transcription Factor Networks in Cryptococcus Neoformans","volume":"6","author":"Jung","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1110\/ps.12801","article-title":"Sequence-Structure Analysis of FAD-Containing Proteins","volume":"10","author":"Dym","year":"2001","journal-title":"Protein Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Silva, M.G., Schrank, A., Fl\u00e1via, E., Bail\u00e3o, A.M., Borges, C.L., Staats, C.C., Parente, J.A., Pereira, M., Salem-Izacc, S.M., and Jos\u00e9, M. (2011). The Homeostasis of Iron, Copper, and Zinc in Paracoccidioides Brasiliensis, Cryptococcus Neoformans Var. Grubii, and Cryptococcus Gattii: A Comparative Analysis. Front. Microbiol., 2.","DOI":"10.3389\/fmicb.2011.00049"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1097-2765(02)00696-2","article-title":"The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum","volume":"10","author":"Tu","year":"2002","journal-title":"Mol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"21749","DOI":"10.1074\/jbc.M312267200","article-title":"Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress","volume":"279","author":"Cumming","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1039\/C9OB00562E","article-title":"Melleolides Impact Fungal Translation via Elongation Factor 2","volume":"17","author":"Heine","year":"2019","journal-title":"Org. Biomol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S1286-4579(02)00006-0","article-title":"Phenotypic Switching in Cryptococcus Neoformans","volume":"4","author":"Fries","year":"2002","journal-title":"Microbes Infect."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhouravleva, G.A., Bondarev, S.A., and Trubitsina, N.P. (2023). How Big Is the Yeast Prion Universe?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411651"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.00041-14","article-title":"Yeast Prions: Structure, Biology, and Prion-Handling Systems","volume":"79","author":"Wickner","year":"2015","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1242\/jcs.068403","article-title":"The Yeast CLC Protein Counteracts Vesicular Acidification during Iron Starvation","volume":"123","author":"Braun","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1046\/j.1365-2958.2003.03752.x","article-title":"A CLC-Type Chloride Channel Gene Is Required for Laccase Activity and Virulence in Cryptococcus Neoformans","volume":"50","author":"Zhu","year":"2003","journal-title":"Mol. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1128\/AEM.00218-12","article-title":"Expression of the Laccase Gene from a White Rot Fungus in Pichia Pastoris Can Enhance the Resistance of This Yeast to H2O2-Mediated Oxidative Stress by Stimulating the Glutathione-Based Antioxidative System","volume":"78","author":"Yang","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"fow043","DOI":"10.1093\/femsyr\/fow043","article-title":"MFS Transporters OfCandidaspecies and Their Role in Clinical Drug Resistance","volume":"16","author":"Redhu","year":"2016","journal-title":"FEMS Yeast Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Costa, C., Dias, P.J., Correia, I.S., and Teixeira, M.C. (2014). MFS Multidrug Transporters in Pathogenic Fungi: Do They Have Real Clinical Impact?. Front. Physiol., 5.","DOI":"10.3389\/fphys.2014.00197"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, L.-H., Tsai, H.-C., Yu, P.-L., and Chung, K.-R. (2017). A Major Facilitator Superfamily Transporter-Mediated Resistance to Oxidative Stress and Fungicides Requires Yap1, Skn7, and MAP Kinases in the Citrus Fungal Pathogen Alternaria Alternata. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169103"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00203-022-03394-8","article-title":"PHM6 and PHM7 Genes Are Essential for Phosphate Surplus in the Cells of Saccharomyces Cerevisiae","volume":"205","author":"Kulakovskaya","year":"2023","journal-title":"Arch. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mart\u00edn, J.F. (2023). Interaction of Calcium Responsive Proteins and Transcriptional Factors with the PHO Regulon in Yeasts and Fungi. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1225774"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.febslet.2010.01.020","article-title":"New Insights into the Function of Atg9","volume":"584","author":"Webber","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.devcel.2013.10.017","article-title":"Atg9 Interacts with DTRAF2\/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction","volume":"27","author":"Tang","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1128\/IAI.00069-18","article-title":"ATG Genes Influence the Virulence of Cryptococcus Neoformans through Contributions beyond Core Autophagy Functions","volume":"86","author":"Ding","year":"2018","journal-title":"Infect. Immun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41392-020-00249-w","article-title":"The Cross-Talk between Methylation and Phosphorylation in Lymphoid-Specific Helicase Drives Cancer Stem-like Properties","volume":"5","author":"Liu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1128\/mBio.01862-15","article-title":"Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus Neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation","volume":"7","author":"Geddes","year":"2016","journal-title":"MBio"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2215431120","DOI":"10.1073\/pnas.2215431120","article-title":"The Protein Methylation Network in Yeast: A Landmark in Completeness for a Eukaryotic Post-Translational Modification","volume":"120","author":"Hamey","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Caza, M., and Kronstad, J.W. (2019). The CAMP\/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus Neoformans. Front. Cell. Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00212"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1042\/EBC20230003","article-title":"Branched-Chain Amino Acid Biosynthesis in Fungi","volume":"67","author":"Steyer","year":"2023","journal-title":"Essays Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/mpp.12053","article-title":"Acetolactate Synthases MoIlv2 and MoIlv6 Are Required for Infection-Related Morphogenesis in Magnaporthe Oryzae","volume":"14","author":"Du","year":"2013","journal-title":"Mol. Plant Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/AAC.01809-12","article-title":"Identification and Evaluation of Novel Acetolactate Synthase Inhibitors as Antifungal Agents","volume":"57","author":"Richie","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/EBC20170106","article-title":"Coenzyme Q10 Deficiencies: Pathways in Yeast and Humans","volume":"62","author":"Awad","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbalip.2013.12.017","article-title":"Coenzyme Q Supplementation or Over-Expression of the Yeast Coq8 Putative Kinase Stabilizes Multi-Subunit Coq Polypeptide Complexes in Yeast Coq Null Mutants","volume":"1841","author":"He","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1365-2958.1999.01181.x","article-title":"Cardiolipin Synthase Expression Is Essential for Growth at Elevated Temperature and Is Regulated by Factors Affecting Mitochondrial Development","volume":"31","author":"Jiang","year":"1999","journal-title":"Mol. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"22387","DOI":"10.1074\/jbc.M909868199","article-title":"Absence of Cardiolipin in the Crd1 Null Mutant Results in Decreased Mitochondrial Membrane Potential and Reduced Mitochondrial Function","volume":"275","author":"Jiang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.bbrc.2017.04.145","article-title":"Human Alpha Beta Hydrolase Domain Containing Protein 11 and Its Yeast Homolog Are Lipid Hydrolases","volume":"487","author":"Arya","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2022.08.022","article-title":"Triacylglycerol Lipase Tgl4 Is a Stable Protein and Its Dephosphorylation Is Regulated in a Cell Cycle-Dependent Manner in Saccharomyces Cerevisiae","volume":"626","author":"Nakatsukasa","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"nwae398","DOI":"10.1093\/nsr\/nwae398","article-title":"The \u03b1\/\u03b2 Hydrolase Domain-Containing Protein 1 (ABHD1) Acts as a Lysolipid Lipase and Is Involved in Lipid Droplet Formation","volume":"11","author":"Bertrand","year":"2024","journal-title":"Natl. Sci. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Kovacs, M., Geltinger, F., Verwanger, T., Weiss, R., Richter, K., and Rinnerthaler, M. (2021). Lipid Droplets Protect Aging Mitochondria and Thus Promote Lifespan in Yeast Cells. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.774985"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Ren, Q., Brenner, R., Boothby, T.C., and Zhang, Z. (2020). Membrane and Lipid Metabolism Plays an Important Role in Desiccation Resistance in the Yeast Saccharomyces Cerevisiae. BMC Microbiol., 20.","DOI":"10.1186\/s12866-020-02025-w"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbrc.2022.02.016","article-title":"Involvement of Gtr1p in the Oxidative Stress Response in Yeast Saccharomyces Cerevisiae","volume":"598","author":"Sekiguchi","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.bbamcr.2016.05.020","article-title":"Role of the Mitochondrial Contact Site and Cristae Organizing System in Membrane Architecture and Dynamics","volume":"1864","author":"Rampelt","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e07739","DOI":"10.7554\/eLife.07739","article-title":"MICOS Coordinates with Respiratory Complexes and Lipids to Establish Mitochondrial Inner Membrane Architecture","volume":"4","author":"Friedman","year":"2015","journal-title":"Elife"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1128\/MCB.00578-15","article-title":"The Oxidation Status of Mic19 Regulates MICOS Assembly","volume":"35","author":"Sakowska","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41467-023-44057-6","article-title":"Mic19 Depletion Impairs Endoplasmic Reticulum-Mitochondrial Contacts and Mitochondrial Lipid Metabolism and Triggers Liver Disease","volume":"15","author":"Dong","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/prot.26776","article-title":"\u03b1\/\u03b2 Hydrolases: Toward Unraveling Entangled Classification","volume":"93","author":"Ozhelvaci","year":"2024","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5941\/MYCO.2013.41.2.67","article-title":"Lipolytic Enzymes Involved in the Virulence of Human Pathogenic Fungi","volume":"41","author":"Park","year":"2013","journal-title":"Mycobiology"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Djordjevic, J.T. (2010). Role of Phospholipases in Fungal Fitness, Pathogenicity, and Drug Development\u2014Lessons from Cryptococcus Neoformans. Front. Microbiol., 1.","DOI":"10.3389\/fmicb.2010.00125"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1194\/jlr.M087890","article-title":"Lysophospholipases Cooperate to Mediate Lipid Homeostasis and Lysophospholipid Signaling","volume":"60","author":"Wepy","year":"2019","journal-title":"J. Lipid Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tig.2007.03.017","article-title":"Evolution of Microbial Virulence: The Benefits of Stress","volume":"23","author":"Arnold","year":"2007","journal-title":"Trends Genet."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/8\/1800\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:28:34Z","timestamp":1787027314000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/14\/8\/1800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":73,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["microorganisms14081800"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms14081800","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]}}}