{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:17:04Z","timestamp":1793647024089,"version":"4.5.1"},"reference-count":172,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:00:00Z","timestamp":1447286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is a Janus-faced molecule. On one hand, several toxic functions have been attributed to H2S and exposure to high levels of this gas is extremely hazardous to health. On the other hand, H2S delivery based clinical therapies are being developed to combat inflammation, visceral pain, oxidative stress related tissue injury, thrombosis and cancer. Since its discovery, H2S has been found to have pleiotropic effects on physiology and health. H2S is a gasotransmitter that exerts its effect on different systems, such as gastrointestinal, neuronal, cardiovascular, respiratory, renal, and hepatic systems. In the gastrointestinal tract, in addition to H2S production by mammalian cystathionine-\u03b2-synthase (CBS), cystathionine-\u03b3-lyase (CSE), H2S is also generated by the metabolic activity of resident gut microbes, mainly by colonic Sulfate-Reducing Bacteria (SRB) via a dissimilatory sulfate reduction (DSR) pathway. In the gut, H2S regulates functions such as inflammation, ischemia\/ reperfusion injury and motility. H2S derived from gut microbes has been found to be associated with gastrointestinal disorders such as ulcerative colitis, Crohn\u2019s disease and irritable bowel syndrome. This underscores  the importance of gut microbes and their production of H2S on host physiology  and pathophysiology.<\/jats:p>","DOI":"10.3390\/microorganisms3040866","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T03:52:35Z","timestamp":1447386755000},"page":"866-889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":260,"title":["Hydrogen Sulfide in Physiology and Diseases of the  Digestive Tract"],"prefix":"10.3390","volume":"3","author":[{"given":"Sudha","family":"Singh","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, the University of  New Mexico, Albuquerque, NM 87131, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Lin","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kfir, H., Rimbrot, S., and Markel, A. 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