{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:42:12Z","timestamp":1792806132347,"version":"4.5.0"},"reference-count":114,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,5]],"date-time":"2019-05-05T00:00:00Z","timestamp":1557014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology","award":["NRF-2018M3A9F3020956"],"award-info":[{"award-number":["NRF-2018M3A9F3020956"]}]},{"name":"Hallym University Research Fund 2016","award":["(HURF-2016-60)."],"award-info":[{"award-number":["(HURF-2016-60)."]}],"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Hallym University Research Fund.","award":["Hallym University Research Fund."],"award-info":[{"award-number":["Hallym University Research Fund."]}],"id":[{"id":"https:\/\/ror.org\/03sbhge02","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Hepatocellular carcinoma (HCC), one of the leading causes of death worldwide, has a causal nexus with liver injury, inflammation, and regeneration that accumulates over decades. Observations from recent studies have accounted for the involvement of the gut\u2013liver axis in the pathophysiological mechanism responsible for HCC. The human intestine nurtures a diversified colony of microorganisms residing in the host ecosystem. The intestinal barrier is critical for conserving the normal physiology of the gut microbiome. Therefore, a rupture of this barrier or dysbiosis can cause the intestinal microbiome to serve as the main source of portal-vein endotoxins, such as lipopolysaccharide, in the progression of hepatic diseases. Indeed, increased bacterial translocation is a key sign of HCC. Considering the limited number of clinical studies on HCC with respect to the microbiome, we focus on clinical as well as animal studies involving the gut microbiota, with the current understandings of the mechanism by which the intestinal dysbiosis promotes hepatocarcinogenesis. Future research might offer mechanistic insights into the specific phyla targeting the leaky gut, as well as microbial dysbiosis, and their metabolites, which represent key pathways that drive HCC-promoting microbiome-mediated liver inflammation and fibrosis, thereby restoring the gut barrier function.<\/jats:p>","DOI":"10.3390\/microorganisms7050121","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T03:57:07Z","timestamp":1557719827000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Role of Gut Microbiota in Hepatocarcinogenesis"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-1143","authenticated-orcid":false,"given":"Haripriya","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Soo","family":"Youn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jea","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9206-9245","authenticated-orcid":false,"given":"Ki Tae","family":"Suk","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45846","DOI":"10.1038\/srep45846","article-title":"International incidence and mortality trends of liver cancer: A global profile","volume":"7","author":"Wong","year":"2017","journal-title":"Sci. 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