{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:07Z","timestamp":1790471527833,"version":"4.1.0"},"reference-count":163,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Research in Chlamydia trachomatis and Chlamydia pneumoniae has gained new traction due to recent advances in molecular biology, namely the widespread use of the metagenomic analysis and the development of a stable genomic transformation system, resulting in a better understanding of Chlamydia pathogenesis. C. trachomatis, the leading cause of bacterial sexually transmitted diseases, is responsible of cervicitis and urethritis, and C. pneumoniae, a widespread respiratory pathogen, has long been associated with several chronic inflammatory diseases with great impact on public health. The present review summarizes the current evidence regarding the complex interplay between C. trachomatis and host defense factors in the genital micro-environment as well as the key findings in chronic inflammatory diseases associated to C. pneumoniae.<\/jats:p>","DOI":"10.3390\/microorganisms7050140","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T11:21:22Z","timestamp":1558005682000},"page":"140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-0485","authenticated-orcid":false,"given":"Marisa","family":"Di Pietro","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Section of Microbiology, University of Rome \u201cSapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-8588","authenticated-orcid":false,"given":"Simone","family":"Filardo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Section of Microbiology, University of Rome \u201cSapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Romano","sequence":"additional","affiliation":[{"name":"Cardiology, Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sessa","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases, Section of Microbiology, University of Rome \u201cSapienza\u201d, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00404-012-2240-7","article-title":"Female genital Chlamydia trachomatis infection: Where are we heading?","volume":"285","author":"Mylonas","year":"2012","journal-title":"Arch. Ginecol. Obstet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.17219\/acem\/37035","article-title":"Infections caused by Chlamydophila pneumoniae","volume":"23","author":"Hober","year":"2014","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wang, Y., Kahane, S., Cutcliffe, L.T., Skilton, R.J., Lambden, P.R., and Clarke, I.N. (2011). Development of a transformation system for Chlamydia trachomatis: Restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002258"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Van de Wijgert, J.H., Borgdorff, H., Verhelst, R., Crucitti, T., Francis, S., Verstraelen, H., and Jespers, V. (2014). The vaginal microbiota: What have we learned after a decade of molecular characterization?. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105998"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/AOG.0000000000001932","article-title":"Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases","volume":"129","author":"Lewis","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"ref_6","unstructured":"GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390, 1211\u20131259."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/RMHP.S12710","article-title":"Public health policies and management strategies for genital Chlamydia trachomatis infection","volume":"4","author":"Shaw","year":"2011","journal-title":"Risk Manag. Healthc. Policy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/0956462415618837","article-title":"2015 European guideline on the management of Chlamydia trachomatis infections","volume":"27","author":"Lanjouw","year":"2016","journal-title":"Int. J. STD AIDS"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Buckner, L.R., Amedee, A.M., Albritton, H.L., Kozlowski, P.A., Lacour, N., McGowin, C.L., Schust, D.J., and Quayle, A.J. (2016). Chlamydia trachomatis infection of endocervical epithelial cells enhances early HIV transmission events. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146663"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00404-013-3122-3","article-title":"Chlamydia trachomatis infection: Implications for HPV status and cervical cancer","volume":"289","author":"Silva","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/infdis\/168.5.1231","article-title":"Evidence that Chlamydia pneumoniae causes pneumonia and bronchitis","volume":"168","author":"Grayston","year":"1993","journal-title":"J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1086\/515280","article-title":"Evidence of systemic dissemination of Chlamydia pneumoniae via macrophages in the mouse","volume":"177","author":"Moazed","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jnr.10519","article-title":"Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells","volume":"71","author":"MacIntyre","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1067\/mva.2003.200","article-title":"Chlamydia pneumoniae DNA in patients with symptomatic carotid atherosclerotic disease","volume":"37","author":"Sessa","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1016\/j.atherosclerosis.2007.04.052","article-title":"Measurement of Chlamydia pneumoniae bacterial load in peripheral blood mononuclear cells may be helpful to assess the state of Chlamydial infection in patients with carotid atherosclerotic disease","volume":"195","author":"Sessa","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00198-012-2217-1","article-title":"Chlamydia pneumoniae and osteoporosis-associated bone loss: A new risk factor?","volume":"24","author":"Schiavoni","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/039463200902200102","article-title":"Chlamydia pneumoniae and atherosclerosis: Current state and future prospectives","volume":"22","author":"Sessa","year":"2009","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_18","first-page":"367","article-title":"Chlamydia pneumoniae infection as a risk factor for accelerated atherosclerosis in hemodialysis patients","volume":"24","author":"Schiavoni","year":"2010","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.arcmed.2015.05.006","article-title":"Infection and atherosclerosis development","volume":"46","author":"Campbell","year":"2015","journal-title":"Arch. Med. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1615\/ForumImmunDisTher.2017020161","article-title":"Chlamydia pneumoniae infection and inflammatory diseases","volume":"7","author":"Porritt","year":"2016","journal-title":"Forum Immunopathol. Dis. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11926-015-0559-3","article-title":"Causality of Chlamydiae in Arthritis and Spondyloarthritis: A Plea for Increased Translational Research","volume":"18","author":"Zeidler","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/1744666X.2017.1233816","article-title":"Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis","volume":"13","author":"Carter","year":"2017","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Di Pietro, M., Filardo, S., Falasca, F., Turriziani, O., and Sessa, R. (2017). Infectious Agents in Atherosclerotic Cardiovascular Diseases through Oxidative Stress. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112459"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fnagi.2018.00302","article-title":"Chlamydia pneumoniae: An Etiologic Agent for Late-Onset Dementia","volume":"10","author":"Balin","year":"2018","journal-title":"Front. Aging. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The Chlamydial developmental cycle","volume":"29","author":"Abdelrahman","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"19781","DOI":"10.1073\/pnas.1212831109","article-title":"Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium","volume":"109","author":"Omsland","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Skipp, P.J., Hughes, C., McKenna, T., Edwards, R., Langridge, J., Thomson, N.R., and Clarke, I.N. (2016). Quantitative Proteomics of the Infectious and Replicative Forms of Chlamydia trachomatis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149011"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"a010256","DOI":"10.1101\/cshperspect.a010256","article-title":"Chlamydial intracellular survival strategies","volume":"3","author":"Bastidas","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"Elwell","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_30","first-page":"5404","article-title":"Conserved type III secretion system exerts important roles in Chlamydia trachomatis","volume":"7","author":"Dai","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.micinf.2015.08.004","article-title":"Host-pathogen reorganisation during host cell entry by Chlamydia trachomatis","volume":"17","author":"Nans","year":"2015","journal-title":"Microbes Infect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chom.2011.06.008","article-title":"The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence","volume":"10","author":"Jorgensen","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.micinf.2016.07.002","article-title":"Neutralizing anti-chlamydial activity of complement by Chlamydia-secreted protease CPAF","volume":"18","author":"Yang","year":"2016","journal-title":"Microbes Infect."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Wu, X., Lei, L., Gong, S., Chen, D., Flores, R., and Zhong, G. (2011). The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol. BMC Microbiol., 11.","DOI":"10.1186\/1471-2180-11-87"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.72.4.1843-1855.2004","article-title":"Chlamydial persistence: Beyond the biphasic paradigm","volume":"72","author":"Hogan","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1086\/652394","article-title":"Chlamydia trachomatis persistence in vitro: An overview","volume":"201","author":"Wyrick","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1128\/iai.65.11.4539-4547.1997","article-title":"Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins","volume":"65","author":"Raulston","year":"1997","journal-title":"Infect. Immun."},{"key":"ref_38","first-page":"277","article-title":"Analysis of gene expression in penicillin G induced persistence of Chlamydia pneumoniae","volume":"26","author":"Tramonti","year":"2012","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fcimb.2014.00044","article-title":"Commonly prescribed \u03b2-lactam antibiotics induce C. trachomatis persistence\/stress in culture at physiologically relevant concentrations","volume":"4","author":"Kintner","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.3389\/fmicb.2018.03101","article-title":"Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo","volume":"9","author":"Panzetta","year":"2018","journal-title":"Front Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1099\/mic.0.036566-0","article-title":"Interaction of herpes simplex virus type 2 (HSV-2) glycoprotein D with the host cell surface is sufficient to induce Chlamydia trachomatis persistence","volume":"156","author":"Vanover","year":"2010","journal-title":"Microbiology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/cmi.12060","article-title":"A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging","volume":"15","author":"Romano","year":"2013","journal-title":"Cell. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.micinf.2012.07.017","article-title":"Chlamydia muridarum enters a viable but non-infectious state in amoxicillin-treated BALB\/c mice","volume":"14","author":"Kintner","year":"2012","journal-title":"Microbes Infect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1128\/AAC.02097-13","article-title":"Induction of the Chlamydia muridarum stress\/persistence response increases azithromycin treatment failure in a murine model of infection","volume":"58","author":"Kintner","year":"2014","journal-title":"Antimicrob. Agents. Chemother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.atherosclerosis.2007.09.026","article-title":"Evidence for persistent Chlamydia pneumoniae infection of human coronary atheromas","volume":"199","author":"Borel","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fcimb.2014.00071","article-title":"Morphologic and molecular evaluation of Chlamydia trachomatis growth in human endocervix reveals distinct growth patterns","volume":"4","author":"Lewis","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jac\/dkh283","article-title":"Pre-exposure of infected human endometrial epithelial cells to penicillin in vitro renders Chlamydia trachomatis refractory to azithromycin","volume":"54","author":"Wyrick","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_48","first-page":"799","article-title":"Characteristics of the Chlamydia trachomatis species - immunopathology and infections","volume":"21","author":"Bober","year":"2012","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1139\/m94-093","article-title":"Expression of recombinant DNA introduced into Chlamydia trachomatis by electroporation","volume":"40","author":"Tam","year":"1994","journal-title":"Can. J. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Binet, R., and Maurelli, A.T. (2009). The Chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness. BMC Microbiol., 9.","DOI":"10.1186\/1471-2180-9-279"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Agaisse, H., and Derr\u00e9, I. (2013). A C. trachomatis cloning vector and the generation of C. trachomatis strains expressing fluorescent proteins under the control of a C. trachomatis promoter. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057090"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fcimb.2017.00079","article-title":"A Co-infection Model System and the Use of Chimeric Proteins to Study Chlamydia Inclusion Proteins Interaction","volume":"7","author":"Han","year":"2017","journal-title":"Front. Cell Infect Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wickstrum, J., Sammons, L.R., Restivo, K.N., and Hefty, P.S. (2013). Conditional gene expression in Chlamydia trachomatis using the tet system. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076743"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1073\/pnas.1102229108","article-title":"Generation of targeted Chlamydia trachomatis null mutants","volume":"108","author":"Kari","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1073\/pnas.1117884109","article-title":"Virulence determinants in the obligate intracellular pathogen Chlamydia trachomatis revealed by forward genetic approaches","volume":"109","author":"Nguyen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Johnson, C.M., and Fisher, D.J. (2013). Site-specific, insertional inactivation of incA in Chlamydia trachomatis using a group II intron. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083989"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2015.03.014","article-title":"Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia","volume":"17","author":"Kokes","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e01817-15","DOI":"10.1128\/mBio.01817-15","article-title":"Gene Deletion by Fluorescence-Reported Allelic Exchange Mutagenesis in Chlamydia trachomatis","volume":"7","author":"Mueller","year":"2016","journal-title":"mBio"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e00412-18","DOI":"10.1128\/mSphere.00412-18","article-title":"The Genetic Transformation of Chlamydia pneumoniae","volume":"3","author":"Shima","year":"2018","journal-title":"mSphere"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-319-31248-4_6","article-title":"Vaginal Microbiota","volume":"902","author":"Mendling","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"750479","DOI":"10.1155\/2008\/750479","article-title":"The human vaginal bacterial biota and bacterial vaginosis","volume":"2008","author":"Srinivasan","year":"2008","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMcp053720","article-title":"Clinical practice. Acute vulvovaginitis","volume":"355","author":"Eckert","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/infdis\/jiv338","article-title":"Influence of biofilm formation by Gardnerella vaginalis and other anaerobes on bacterial vaginosis","volume":"212","author":"Machado","year":"2015","journal-title":"J. Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.resmic.2017.02.005","article-title":"Candida and its dual lifestyle as a commensal and a pathogen","volume":"168","author":"Cauchie","year":"2017","journal-title":"Res. Microbiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1672109","DOI":"10.1155\/2019\/1672109","article-title":"Biofilm in Genital Ecosystem: A Potential Risk Factor for Chlamydia trachomatis Infection","volume":"2019","author":"Filardo","year":"2019","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejogrb.2005.11.036","article-title":"Hydrogen peroxide producing lactobacilli in women with vaginal infections","volume":"129","author":"Mijac","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.micinf.2008.07.032","article-title":"Adherence of clinically isolated lactobacilli to human cervical cells in competition with Neisseria gonorrhoeae","volume":"10","author":"Vielfort","year":"2008","journal-title":"Microbes Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fphys.2015.00081","article-title":"Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health","volume":"6","author":"Petrova","year":"2015","journal-title":"Front. Physiol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gong, Z., Luna, Y., Yu, P., and Fan, H. (2014). Lactobacilli inactivate Chlamydia trachomatis through lactic acid but not H2O2. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107758"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijmm.2014.04.006","article-title":"Effects of vaginal lactobacilli in Chlamydia trachomatis infection","volume":"304","author":"Mastromarino","year":"2014","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"29024","DOI":"10.1038\/srep29024","article-title":"Lactobacillus crispatus inhibits the infectivity of Chlamydia trachomatis elementary bodies, in vitro study","volume":"6","author":"Nardini","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.3389\/fmicb.2018.02630","article-title":"Lactobacillus crispatus BC5 Interferes with Chlamydia trachomatis Infectivity Through Integrin Modulation in Cervical Cells","volume":"9","author":"Parolin","year":"2018","journal-title":"Front Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ijmm.2015.07.005","article-title":"Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro","volume":"305","author":"Rizzo","year":"2015","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0166-3542(02)00214-0","article-title":"Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir","volume":"58","author":"Andersen","year":"2003","journal-title":"Antiviral Res."},{"key":"ref_75","first-page":"859","article-title":"Activated lactoferrin\u2019s ability to inhibit Candida growth and block yeast adhesion to the vaginal epithelial monolayer","volume":"49","author":"Naidu","year":"2004","journal-title":"J. Reprod. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.crvi.2014.08.003","article-title":"Potential lactoferrin activity against pathogenic viruses","volume":"337","author":"Redwan","year":"2014","journal-title":"C. R. Biol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Sessa, R., Di Pietro, M., Filardo, S., Bressan, A., Mastromarino, P., Biasucci, A.V., Rosa, L., Cutone, A., Berlutti, F., Paesano, R., and et., al. (2017). Lactobacilli-lactoferrin interplay in Chlamydia trachomatis infection. Pathog. Dis., 75.","DOI":"10.1093\/femspd\/ftx054"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1139\/bcb-2016-0049","article-title":"Effect of bovine lactoferrin on Chlamydia trachomatis infection and inflammation","volume":"95","author":"Sessa","year":"2017","journal-title":"Biochem. Cell. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijgo.2005.10.004","article-title":"Cervical inflammatory cytokines and other markers inthe cervical mucus of pregnant womenwith lower genital tract infection","volume":"92","author":"Sawada","year":"2006","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Spear, G.T., Kendrick, S.R., Chen, H.Y., Thomas, T.T., Bahk, M., Balderas, R., Ghosh, S., Aaron Weinberg, A., and Landay, A.L. (2011). Multiplex immunoassay of lower genital tract mucosal fluid from women attending an urban STD clinic shows broadly increased IL1\u00df and lactoferrin. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019560"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Filardo, S., Di Pietro, M., Tranquilli, G., Latino, M.A., Recine, N., Porpora, M., and Sessa, R. (2019). Selected immunological mediators and cervical microbial signatures in women with Chlamydia trachomatis infection. mSystems, In press.","DOI":"10.1128\/mSystems.00094-19"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0014-4800(02)00022-9","article-title":"Activity of Novispirin G-10, a novel antimicrobial peptide against Chlamydia trachomatis and vaginosis-associated bacteria","volume":"74","author":"Yasin","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1128\/AAC.49.3.1201-1202.2005","article-title":"Activity of cathelicidin peptides against Chlamydia spp.","volume":"49","author":"Donati","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1586\/14787210.2013.841450","article-title":"Host defense peptides: General overview and an update on their activity against Chlamydia spp.","volume":"11","author":"Favaroni","year":"2013","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/LGT.0000000000000315","article-title":"Cervicovaginal Levels of Human \u03b2-Defensin 1, 2, 3, and 4 of Reproductive-Aged Women With Chlamydia trachomatis Infection","volume":"21","author":"Bastos","year":"2017","journal-title":"J. Low Genit. Tract. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.micinf.2015.02.005","article-title":"Chlamydia-secreted protease CPAF degrades host antimicrobial peptides","volume":"17","author":"Tang","year":"2015","journal-title":"Microbes Infect."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1471-0528.2010.02840.x","article-title":"The vaginal microbiome: New information about genital tract flora using molecular based techniques","volume":"118","author":"Lamont","year":"2011","journal-title":"BJOG"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1126\/scitranslmed.3003605","article-title":"Temporal dynamics of the human vaginal microbiota","volume":"4","author":"Gajer","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-micro-092611-150157","article-title":"Vaginal microbiome: Rethinking health and disease","volume":"66","author":"Ma","year":"2012","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tim.2016.11.007","article-title":"Lactobacillus iners: Friend or Foe?","volume":"25","author":"Petrova","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1136\/sextrans-2013-051184.0110","article-title":"Association between Chlamydia trachomatis genital infection and the vaginal microbiome","volume":"89","author":"Ma","year":"2013","journal-title":"Sex. Transm. Infect."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3389\/fcimb.2017.00321","article-title":"Diversity of Cervical Microbiota in Asymptomatic Chlamydia trachomatis Genital Infection: A Pilot Study","volume":"7","author":"Filardo","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/cid\/ciw586","article-title":"The cervicovaginal microbiota in women notified for Chlamydia trachomatis infection: A case-control study at the sexually transmitted infection outpatient clinic in Amsterdam, The Netherlands","volume":"64","author":"Bruisten","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"11109","DOI":"10.1038\/s41598-018-29320-x","article-title":"Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection","volume":"8","author":"Balle","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_95","first-page":"34","article-title":"HPV\/Chlamydia trachomatis co-infection: Metagenomic analysis of cervical microbiota in asymptomatic women","volume":"41","author":"Filardo","year":"2018","journal-title":"New Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fmicb.2018.00600","article-title":"Insights Into Vaginal Bacterial Communities and Metabolic Profiles of Chlamydia trachomatis Infection: Positioning Between Eubiosis and Dysbiosis","volume":"9","author":"Parolin","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1136\/sextrans-2017-053133","article-title":"Lactobacillus iners-dominated vaginal microbiota is associated with increased susceptibility to Chlamydia trachomatis infection in Dutch women: A case-control study","volume":"94","author":"Ma","year":"2018","journal-title":"Sex. Transm. Infect."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2018.00001","article-title":"Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine\/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections","volume":"8","author":"Ziklo","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmi.2018.04.019","article-title":"The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: A systematic review and meta-analysis","volume":"25","author":"Tamarelle","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fcimb.2014.00072","article-title":"Influence of the tryptophan-indole-IFN\u03b3 axis on human genital Chlamydia trachomatis infection: Role of vaginal co-infections","volume":"4","author":"Aiyar","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.tim.2016.05.007","article-title":"Chlamydia trachomatis genital tract infections: When host immune response and the microbiome collide","volume":"24","author":"Ziklo","year":"2016","journal-title":"Trends Microbiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"240","DOI":"10.12998\/wjcc.v2.i7.240","article-title":"Infectious burden and atherosclerosis: A clinical issue","volume":"2","author":"Sessa","year":"2014","journal-title":"World J. Clin. Cases."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/imj.12580","article-title":"Detection of bacteria and analyses of Chlamydia trachomatis viability in patients with postvenereal reactive arthritis","volume":"44","author":"Pavlica","year":"2014","journal-title":"Intern. Med. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/ene.12477","article-title":"A study on the association between infectious burden and Alzheimer\u2019s disease","volume":"22","author":"Bu","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_105","unstructured":"Mendis, S., Puska, P., Norrving, B., and World Health Organization, World Heart Federation (2019, May 15). Global Atlas on Cardiovascular Disease Prevention and Control. Available online: http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241564373_eng.pdf."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(88)90741-6","article-title":"Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction","volume":"2","author":"Saikku","year":"1988","journal-title":"Lancet"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7326\/0003-4819-125-12-199612150-00008","article-title":"Isolation of Chlamydia pneumoniae from the coronary artery of a patient with coronary atherosclerosis. The Chlamydia pneumoniae\/Atherosclerosis Study Group","volume":"125","author":"Ramirez","year":"1996","journal-title":"Ann. Intern. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1086\/517270","article-title":"Isolation of Chlamydia pneumoniae from a carotid endarterectomy specimen","volume":"176","author":"Campbell","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s100960050481","article-title":"Isolation and continuous growth of Chlamydia pneumoniae from arterectomy specimens","volume":"19","author":"Apfalter","year":"2000","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2003.05.014","article-title":"Chlamydia pneumoniae infection is associated with coronary artery disease but not implicated in inducing plaque instability","volume":"95","author":"Romano","year":"2004","journal-title":"Int. J. Cardiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/205873920601900111","article-title":"Chlamydia pneumoniae in asymptomatic carotid atherosclerosis","volume":"19","author":"Sessa","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/CS20070298","article-title":"Role of Chlamydia pneumoniae in atherosclerosis","volume":"114","author":"Watson","year":"2008","journal-title":"Clin. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/1947-2714.109178","article-title":"Chlamydophila pneumoniae infection and cardiovascular disease","volume":"5","author":"Joshi","year":"2013","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0021-9150(03)00019-4","article-title":"Acute Chlamydia pneumoniae infection causes coronary endothelial dysfunction in pigs","volume":"167","author":"Liuba","year":"2000","journal-title":"Atherosclerosis"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cardiores.2004.09.031","article-title":"Chlamydia pneumoniae infections in mouse models: Relevance for atherosclerosis research","volume":"65","author":"Keller","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"ref_116","first-page":"509","article-title":"Resveratrol in Chlamydia pneumoniae-induced foam cell formation and interleukin-17A synthesis","volume":"27","author":"Schiavoni","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3390\/ijms16010724","article-title":"Chlamydia pneumoniae and oxidative stress in cardiovascular disease: State of the art and prevention strategies","volume":"16","author":"Filardo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/cmi.12341","article-title":"pneumoniae disrupts eNOS trafficking and impairs NO production in human aortic endothelial cells","volume":"17","author":"Mueller","year":"2015","journal-title":"Cell. Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"S473","DOI":"10.1086\/315612","article-title":"Growth in vascular cells and cytokine production by Chlamydia pneumoniae","volume":"181","author":"Gaydos","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"15105","DOI":"10.3390\/ijms140715105","article-title":"Chlamydia pneumoniae infection in atherosclerotic lesion development through oxidative stress: A brief overview","volume":"14","author":"Filardo","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cmet.2018.05.027","article-title":"Chlamydia pneumoniae hijacks a host autoregulatory IL-1\u03b2 loop to drive foam cell formation and accelerate atherosclerosis","volume":"28","author":"Tumurkhuu","year":"2018","journal-title":"Cell Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jacc.2018.01.072","article-title":"Chlamydia and lipids engage a common sigOfnaling pathway that promotes atherogenesis","volume":"71","author":"Chen","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"378658","DOI":"10.1155\/2015\/378658","article-title":"Chlamydia pneumoniae-mediated inflammation in atherosclerosis: A metaanalysis","volume":"2015","author":"Filardo","year":"2015","journal-title":"Mediators Inflamm."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fcimb.2014.00034","article-title":"Persistent C. pneumoniae infection in atherosclerotic lesions: Rethinking the clinical trials","volume":"4","author":"Campbell","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_125","first-page":"1537","article-title":"Helicobacter pylori infection and metabolic parameters: Is there an association in elderly population?","volume":"5","author":"Sotuneh","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e2034","DOI":"10.1002\/rmv.2034","article-title":"Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta-analysis","volume":"31","author":"Zuhair","year":"2019","journal-title":"Rev. Med. Virol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0002-9149(99)00653-0","article-title":"Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels","volume":"85","author":"Zhu","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_128","first-page":"3","article-title":"Association between bacterial infection and peripheral vascular disease: A review","volume":"25","year":"2016","journal-title":"Int. J. Angiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fcimb.2015.00086","article-title":"Chlamydia pneumoniae Clinical Isolate from Gingival Crevicular Fluid: A Potential Atherogenic Strain","volume":"5","author":"Filardo","year":"2015","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40168-015-0100-y","article-title":"In silico analyses of metagenomes from human atherosclerotic plaque samples","volume":"3","author":"Mitra","year":"2015","journal-title":"Microbiome"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.atherosclerosis.2017.06.016","article-title":"Bacterial profile in human atherosclerotic plaques","volume":"263","author":"Akrami","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/eji.201646879","article-title":"The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease","volume":"48","author":"Ascher","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.neuron.2014.12.064","article-title":"Immunotherapeutic approaches for Alzheimer\u2019s disease","volume":"85","author":"Wisniewski","year":"2015","journal-title":"Neuron"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s004300050071","article-title":"Identification and localization of Chlamydia pneumoniae in the Alzheimer\u2019s brain","volume":"187","author":"Balin","year":"1998","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00000441-200610000-00003","article-title":"Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype","volume":"332","author":"Hudson","year":"2006","journal-title":"Am. J. Med. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00415-006-0504-5","article-title":"Real time PCR for detection of Chlamydophila pneumoniae in peripheral blood mononuclear cells of patients with multiple sclerosis","volume":"254","author":"Sessa","year":"2007","journal-title":"J. Neurol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Hammond, C.J., Hallock, L.R., Howanski, R.J., Appelt, D.M., Little, C.S., and Balin, B.J. (2010). Immunohistological detection of Chlamydia pneumoniae in the Alzheimer\u2019s disease brain. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-121"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3233\/JAD-140621","article-title":"Bacterial infection and Alzheimer\u2019s disease: A meta-analysis","volume":"43","author":"Maheshwari","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0197-4580(03)00127-1","article-title":"Chlamydia pneumoniae induces alzheimer-like amyloid plaques in brains of BALB\/C mice","volume":"25","author":"Little","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fnagi.2014.00304","article-title":"Detection of bacterial antigens and Alzheimer\u2019s disease-like pathology in the central nervous system of BALB\/C mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae","volume":"6","author":"Little","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_141","first-page":"155","article-title":"Could past Chlamydial vascular infection promote the dissemination of Chlamydia pneumoniae to the brain?","volume":"27","author":"Filardo","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2202-9-13","article-title":"Apoptotic effects of Chlamydophila pneumoniae following infection of neuronal cells","volume":"9","author":"Appelt","year":"2008","journal-title":"BMC Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"501862","DOI":"10.4061\/2011\/501862","article-title":"Alzheimer\u2019s disease: APP, gamma secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and their relationships with herpes simplex, C. pneumoniae, other suspect pathogens, and the immune system","volume":"2011","author":"Carter","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","article-title":"A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer\u2019s disease","volume":"52","author":"Loeb","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_145","first-page":"224","article-title":"Reactive arthritis ascribed to Chlamydia pneumoniae. Report of a case","volume":"62","author":"Beaudreuil","year":"1995","journal-title":"Rev. Rhum. Engl. Ed."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/rheumatology\/35.11.1189","article-title":"Chlamydia pneumoniae--reactive arthritis and persistent infection","volume":"35","author":"Moling","year":"1996","journal-title":"Br. J. Rheumatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/rheumatology\/38.5.411","article-title":"Chlamydia pneumoniae as a triggering infection in reactive arthritis","volume":"38","author":"Hannu","year":"1999","journal-title":"Rheumatology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/00365549950163716","article-title":"Chlamydia pneumoniae as a trigger of reactive arthritis","volume":"31","author":"Melby","year":"1999","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1002\/1529-0131(199909)42:9<1889::AID-ANR13>3.0.CO;2-W","article-title":"Lower prevalence of Chlamydia pneumoniae DNA compared with Chlamydia trachomatis DNA in synovial tissue of arthritis patients","volume":"42","author":"Schumacher","year":"1999","journal-title":"Arthritis Rheum."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/mpat.2000.0360","article-title":"Chlamydia pneumoniae present in the human synovium are viable and metabolically active","volume":"29","author":"Schumacher","year":"2000","journal-title":"Microb. Pathog."},{"key":"ref_151","first-page":"845","article-title":"Cutaneous vasculitis and reactive arthritis following respiratory infection due to Chlamydia pneumoniae: Report of a case","volume":"20","author":"Cascina","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/art.24431","article-title":"Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis","volume":"60","author":"Carter","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00296-010-1460-z","article-title":"Detection of Chlamydophila pneumoniae in patients with arthritis: Significance and diagnostic value","volume":"31","author":"Contini","year":"2011","journal-title":"Rheumatol Int."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2169\/internalmedicine.51.6228","article-title":"The role of Chlamydia and Chlamydophila infections in reactive arthritis","volume":"51","author":"Rizzo","year":"2012","journal-title":"Intern Med."},{"key":"ref_155","first-page":"115","article-title":"Reactive arthritis: Incidence, triggering agents and clinical presentation","volume":"21","author":"Kvien","year":"1994","journal-title":"J. Rheumatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1574-695X.2006.00080.x","article-title":"Prior exposure to infection with Chlamydia pneumoniae can influence the T-cell-mediated response to Chlamydia trachomatis","volume":"47","author":"Telyatnikova","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2298\/MPNS1408222B","article-title":"Reiter\u2019s syndrome\u2014Disease of young men\u2014Analysis of 312 patients","volume":"67","author":"Pavlica","year":"2014","journal-title":"Med. Pregl."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1099\/jmm.0.46197-0","article-title":"Biofilm formation on intrauterine devices in relation to duration of use","volume":"54","author":"Pal","year":"2005","journal-title":"J. Med. Microbiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/13693780902856626","article-title":"Biofilm formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis","volume":"48","author":"Auler","year":"2010","journal-title":"Med. Mycol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1086\/315778","article-title":"Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping","volume":"182","author":"Dean","year":"2000","journal-title":"J. Infect. Dis."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/infdis\/jix155","article-title":"Demonstration of persistent infections and genome stability by whole-genome sequencing of repeat-positive, same-serovar Chlamydia trachomatis collected from the female genital tract","volume":"215","author":"Suchland","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/039463201302600227","article-title":"New insights into Chlamydiae persistence: An energy metabolism strategy?","volume":"26","author":"Filardo","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fcimb.2014.00073","article-title":"Membrane vesicle production by Chlamydia trachomatis as an adaptive response","volume":"4","author":"Frohlich","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/7\/5\/140\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:52:33Z","timestamp":1760187153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/7\/5\/140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":163,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["microorganisms7050140"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms7050140","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]}}}