{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:54:58Z","timestamp":1790787298963,"version":"4.1.0"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 106-2314-B-214-009-MY2 and 108-2314-B-214 -004"],"award-info":[{"award-number":["MOST 106-2314-B-214-009-MY2 and 108-2314-B-214 -004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004738","name":"E-Da Hospital","doi-asserted-by":"publisher","award":["EDPJ106075"],"award-info":[{"award-number":["EDPJ106075"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The genus Elizabethkingia has recently emerged as a cause of life-threatening infections in humans, particularly in immunocompromised patients. Several new species in the genus Elizabethkingia have been proposed in the last decade. Numerous studies have indicated that Elizabethkingia anophelis, rather than Elizabethkingia meningoseptica, is the most prevalent pathogen in this genus. Matrix-assisted laser desorption\/ionization\u2013time of flight mass spectrometry systems with an extended spectrum database could reliably identify E. anophelis and E. meningoseptica, but they are unable to distinguish the remaining species. Precise species identification relies on molecular techniques, such as housekeeping gene sequencing and whole-genome sequencing. These microorganisms are usually susceptible to minocycline but resistant to most \u03b2-lactams, \u03b2-lactam\/\u03b2-lactam inhibitors, carbapenems, and aminoglycosides. They often exhibit variable susceptibility to piperacillin, piperacillin-tazobactam, fluoroquinolones, and trimethoprim-sulfamethoxazole. Accordingly, treatment should be guided by antimicrobial susceptibility testing. Target gene mutations are markedly associated with fluoroquinolone resistance. Knowledge on the genomic characteristics provides valuable insights into in these emerging pathogens.<\/jats:p>","DOI":"10.3390\/microorganisms7090295","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T11:23:18Z","timestamp":1566991398000},"page":"295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Elizabethkingia Infections in Humans: From Genomics to Clinics"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-5350","authenticated-orcid":false,"given":"Jiun-Nong","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan"},{"name":"Department of Critical Care Medicine, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hsu","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung 824, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, Meiho University, Pingtung 912, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Han","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1099\/ijs.0.63541-0","article-title":"Transfer of Chryseobacterium meningosepticum and Chryseobacterium miricola to Elizabethkingia gen. nov. as Elizabethkingia meningoseptica comb. nov. and Elizabethkingia miricola comb. nov","volume":"55","author":"Kim","year":"2005","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10482-017-0926-3","article-title":"Revisiting the taxonomy of the genus Elizabethkingia using whole-genome sequencing, optical mapping, and MALDI-TOF, along with proposal of three novel Elizabethkingia species: Elizabethkingia bruuniana sp. nov., Elizabethkingia ursingii sp. nov., and Elizabethkingia occulta sp. nov","volume":"111","author":"Nicholson","year":"2018","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1099\/ijs.0.026393-0","article-title":"Elizabethkingia anophelis sp. nov., isolated from the midgut of the mosquito Anopheles gambiae","volume":"61","author":"Matthews","year":"2011","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1476-0711-10-16","article-title":"Biofilm formation and adherence characteristics of an Elizabethkingia meningoseptica isolate from Oreochromis mossambicus","volume":"10","author":"Jacobs","year":"2011","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3201\/eid2308.161565","article-title":"Detection of Elizabethkingia spp. in Culicoides biting midges, Australia","volume":"23","author":"Mee","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3201\/eid2312.170942","article-title":"Pathogenic Elizabethkingia miricola infection in cultured black-spotted frogs, China, 2016","volume":"23","author":"Hu","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/tbed.13101","article-title":"Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa)","volume":"66","author":"Lei","year":"2019","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3389\/fmicb.2017.02073","article-title":"Diets alter the gut microbiome of crocodile lizards","volume":"8","author":"Jiang","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid2201.150139","article-title":"Waterborne Elizabethkingia meningoseptica in adult critical care","volume":"22","author":"Moore","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3201\/eid2409.171843","article-title":"Elizabethkingia anophelis and association with tap water and handwashing, Singapore","volume":"24","author":"Yung","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0140-6736(13)61858-9","article-title":"First case of E anophelis outbreak in an intensive-care unit","volume":"382","author":"Teo","year":"2013","journal-title":"Lancet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcp\/31.3.241","article-title":"Studies on a group of previously unclassified bacteria associated with meningitis in infants","volume":"31","author":"King","year":"1959","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/S0140-6736(13)60318-9","article-title":"First case of Elizabethkingia anophelis meningitis in the Central African Republic","volume":"381","author":"Frank","year":"2013","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26045","DOI":"10.1038\/srep26045","article-title":"Elizabethkingia anophelis bacteremia is associated with clinically significant infections and high mortality","volume":"6","author":"Lau","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15483","DOI":"10.1038\/ncomms15483","article-title":"Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain","volume":"8","author":"Perrin","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_16","first-page":"1380","article-title":"Notes from the field: Investigation of Elizabethkingia anophelis cluster-Illinois, 2014\u20132016","volume":"65","author":"Navon","year":"2016","journal-title":"MMWR"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3201\/eid2501.171985","article-title":"Risk Factors for Elizabethkingia acquisition and clinical characteristics of patients, South Korea","volume":"25","author":"Choi","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1093\/jac\/dky197","article-title":"Clinical manifestations, molecular characteristics, antimicrobial susceptibility patterns and contributions of target gene mutation to fluoroquinolone resistance in Elizabethkingia anophelis","volume":"73","author":"Lin","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lin, J.-N., Lai, C.-H., Yang, C.-H., and Huang, Y.-H. (2018). Comparison of clinical manifestations, antimicrobial susceptibility patterns, and mutations of fluoroquinolone target genes between Elizabethkingia meningoseptica and Elizabethkingia anophelis isolated in Taiwan. J. Clin. Med., 7.","DOI":"10.3390\/jcm7120538"},{"key":"ref_20","unstructured":"(2017, April 17). Elizabethkingia, Available online: https:\/\/www.dhs.wisconsin.gov\/disease\/elizabethkingia.htm."},{"key":"ref_21","unstructured":"(2016, December 26). Recent Outbreaks, Elizabethkingia, CDC, Available online: https:\/\/www.cdc.gov\/elizabethkingia\/outbreaks\/."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Snesrud, E., McGann, P., Walsh, E., Ong, A., Maybank, R., Kwak, Y., Campbell, J., Jones, A., Vore, K., and Hinkle, M. (2018). Clinical and genomic features of the first cases of Elizabethkingia anophelis infection in New York, including the first case in a healthy infant without previous nosocomial exposure. J. Pediatr. Infect. Dis. Soc.","DOI":"10.1093\/jpids\/piy071"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Meier-Kolthoff, J.P., Auch, A.F., Klenk, H.-P., and G\u00f6ker, M. (2013). Genome sequence-based species delimitation with confidence intervals and improved distance functions. BMC Bioinformatics, 14.","DOI":"10.1186\/1471-2105-14-60"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6761","DOI":"10.1093\/nar\/gkv657","article-title":"Microbial species delineation using whole genome sequences","volume":"43","author":"Varghese","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_25","first-page":"827","article-title":"New perspectives in the classification of the Flavobacteria: Description of Chryseobacterium gen. nov., Bergeyella gen. nov., and Empedobacter nom. rev","volume":"44","author":"Vandamme","year":"1994","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1078\/072320203770865828","article-title":"Chryseobacterium miricola sp. nov., a novel species isolated from condensation water of space station Mir","volume":"26","author":"Li","year":"2003","journal-title":"Syst. Appl. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1099\/ijs.0.000236","article-title":"Elizabethkingia endophytica sp. nov., isolated from Zea mays and emended description of Elizabethkingia anophelis K\u00e4mpfer et al. 2011","volume":"65","author":"Busse","year":"2015","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1099\/ijsem.0.001390","article-title":"Taxonomic reassessment of the genus Elizabethkingia using whole-genome sequencing: Elizabethkingia endophytica K\u00e4mpfer et al. 2015 is a later subjective synonym of Elizabethkingia anophelis K\u00e4mpfer et al. 2011","volume":"66","author":"Doijad","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"13824","DOI":"10.1038\/s41598-017-14244-9","article-title":"Comparison of four automated microbiology systems with 16S rRNA gene sequencing for identification of Chryseobacterium and Elizabethkingia species","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/JCM.01637-16","article-title":"Relative prevalence and antimicrobial susceptibility of clinical isolates of Elizabethkingia species based on 16S rRNA gene sequencing","volume":"55","author":"Han","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cmi.2018.04.015","article-title":"Multicentre study evaluating matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of clinically isolated Elizabethkingia species and analysis of antimicrobial susceptibility","volume":"25","author":"Cheng","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/JCM.01228-07","article-title":"16S rRNA gene sequencing for bacterial identification in the diagnostic laboratory: Pluses, perils, and pitfalls","volume":"45","author":"Janda","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tim.2008.09.008","article-title":"The rpoB gene as a tool for clinical microbiologists","volume":"17","author":"Drancourt","year":"2009","journal-title":"Trends Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1099\/ijs.0.054353-0","article-title":"DNA-DNA hybridization study of strains of Chryseobacterium, Elizabethkingia and Empedobacter and of other usually indole-producing non-fermenters of CDC groups IIc, IIe, IIh and IIi, mostly from human clinical sources, and proposals of Chryseobacterium bernardetii sp. nov., Chryseobacterium carnis sp. nov., Chryseobacterium lactis sp. nov., Chryseobacterium nakagawai sp. nov. and Chryseobacterium taklimakanense comb. nov","volume":"63","author":"Holmes","year":"2013","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3886","DOI":"10.1128\/AEM.02953-09","article-title":"Diversity of 16S rRNA genes within individual prokaryotic genomes","volume":"76","author":"Pei","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1093\/molbev\/msh248","article-title":"Evolution of the RNA polymerase B\u2019 subunit gene (rpoB\u2019) in Halobacteriales: A complementary molecular marker to the SSU rRNA gene","volume":"21","author":"Walsh","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"40S","DOI":"10.1042\/bst021040s","article-title":"Comparative sequence analysis and predicted phylogeny of the DNA-dependent RNA polymerase beta subunits of Staphylococcus aureus and other eubacteria","volume":"21","author":"Rowland","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e01445","DOI":"10.1128\/JCM.01445-17","article-title":"Elizabethkingia anophelis is the dominant Elizabethkingia species found in blood cultures in Singapore","volume":"56","author":"Chew","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e01619","DOI":"10.1128\/JCM.01619-18","article-title":"A real-time multiplex PCR assay for detection of Elizabethkingia species, and differentiating between E. anophelis and E. meningoseptica","volume":"57","author":"Kelly","year":"2019","journal-title":"J. Clin. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1099\/ijs.0.64483-0","article-title":"DNA-DNA hybridization values and their relationship to whole-genome sequence similarities","volume":"57","author":"Goris","year":"2007","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19126","DOI":"10.1073\/pnas.0906412106","article-title":"Shifting the genomic gold standard for the prokaryotic species definition","volume":"106","author":"Richter","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1073\/pnas.0409727102","article-title":"Genomic insights that advance the species definition for prokaryotes","volume":"102","author":"Konstantinidis","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/s41598-019-38998-6","article-title":"Genomic features, comparative genomics, and antimicrobial susceptibility patterns of Elizabethkingia bruuniana","volume":"9","author":"Lin","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"14317","DOI":"10.1038\/s41598-017-14841-8","article-title":"Genomic features, phylogenetic relationships, and comparative genomics of Elizabethkingia anophelis strain EM361-97 isolated in Taiwan","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3201\/eid2302.161321","article-title":"Determination of Elizabethkingia diversity by MALDI-TOF mass spectrometry and whole-genome sequencing","volume":"23","author":"Eriksen","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e01408","DOI":"10.1128\/genomeA.01408-17","article-title":"Complete genome sequence of Elizabethkingia miricola strain EM798-26 isolated from the blood of a cancer patient","volume":"6","author":"Lin","year":"2018","journal-title":"Genome Announc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"30379","DOI":"10.1038\/srep30379","article-title":"Genomic epidemiology and global diversity of the emerging bacterial pathogen Elizabethkingia anophelis","volume":"6","author":"Breurec","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1442-200X.2012.03650.x","article-title":"Elizabethkingia meningoseptica: Emergent bacteria causing pneumonia in a critically ill child","volume":"55","author":"Pereira","year":"2013","journal-title":"Pediatr. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1128\/JCM.42.7.3353-3355.2004","article-title":"Clinical and microbiological analysis of bloodstream infections caused by Chryseobacterium meningosepticum in nonneonatal patients","volume":"42","author":"Lin","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1080\/00365540903089476","article-title":"Clinical and microbiological analysis of Elizabethkingia meningoseptica bacteremia in adult patients in Taiwan","volume":"41","author":"Lin","year":"2009","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_51","first-page":"137","article-title":"Chryseobacterium meningosepticum infection: Antibiotic susceptibility and risk factors for mortality","volume":"41","author":"Hung","year":"2008","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s10096-011-1223-0","article-title":"Clinical features, antimicrobial susceptibilities, and outcomes of Elizabethkingia meningoseptica (Chryseobacterium meningosepticum) bacteremia at a medical center in Taiwan, 1999\u20132006","volume":"30","author":"Hsu","year":"2011","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s10096-017-2942-7","article-title":"Risk factors and outcome of levofloxacin-resistant Elizabethkingia meningoseptica bacteraemia in adult patients in Taiwan","volume":"36","author":"Huang","year":"2017","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijantimicag.2017.05.018","article-title":"Comparison of the therapeutic efficacy of fluoroquinolone and non-fluoroquinolone treatment in patients with Elizabethkingia meningoseptica bacteraemia","volume":"51","author":"Huang","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_55","unstructured":"Chen, W.-C., Chen, Y.-W., Ko, H.-K., Yu, W.-K., and Yang, K.-Y. (2018). Comparisons of clinical features and outcomes between Elizabethkingia meningoseptica and other glucose non-fermenting Gram-negative bacilli bacteremia in adult ICU patients. J. Microbiol. Immunol. Infect."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jmii.2018.06.007","article-title":"Comparison of clinical characteristics of bacteremia from Elizabethkingia meningoseptica and other carbapenem-resistant, non-fermenting Gram-negative bacilli at a tertiary medical center","volume":"52","author":"Huang","year":"2019","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jhin.2015.07.008","article-title":"Infections due to Elizabethkingia meningoseptica in critically injured trauma patients: A seven-year study","volume":"92","author":"Rastogi","year":"2016","journal-title":"J. Hosp. Infect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ijantimicag.2010.06.033","article-title":"Biofilm production, use of intravascular indwelling catheters and inappropriate antimicrobial therapy as predictors of fatality in Chryseobacterium meningosepticum bacteraemia","volume":"36","author":"Lin","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00005792-199701000-00003","article-title":"Chryseobacterium meningosepticum: An emerging pathogen among immunocompromised adults. Report of 6 cases and literature review","volume":"76","author":"Bloch","year":"1997","journal-title":"Medicine (Baltimore)"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.diagmicrobio.2008.07.015","article-title":"Sepsis caused by Elizabethkingia miricola successfully treated with tigecycline and levofloxacin","volume":"62","author":"Green","year":"2008","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.diagmicrobio.2015.11.016","article-title":"BlaB-15, a new BlaB metallo-\u03b2-lactamase variant found in an Elizabethkingia miricola clinical isolate","volume":"85","author":"Colapietro","year":"2016","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijantimicag.2016.09.031","article-title":"Genome of the carbapenemase-producing clinical isolate Elizabethkingia miricola EM_CHUV and comparative genomics with Elizabethkingia meningoseptica and Elizabethkingia anophelis: Evidence for intrinsic multidrug resistance trait of emerging pathogens","volume":"49","author":"Opota","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zdziarski, P., Pa\u015bciak, M., Rogala, K., Korzeniowska-Kowal, A., and Gamian, A. (2017). Elizabethkingia miricola as an opportunistic oral pathogen associated with superinfectious complications in humoral immunodeficiency: A case report. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2886-7"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.diagmicrobio.2017.10.014","article-title":"rpoB gene sequencing highlights the prevalence of an E. miricola cluster over other Elizabethkingia species among UK cystic fibrosis patients","volume":"90","author":"Kenna","year":"2018","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3201\/eid2102.140623","article-title":"Evidence for Elizabethkingia anophelis transmission from mother to infant, Hong Kong","volume":"21","author":"Lau","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1128\/AAC.41.12.2738","article-title":"Reappraisal of the antimicrobial susceptibilities of Chryseobacterium and Flavobacterium species and methods for reliable susceptibility testing","volume":"41","author":"Fraser","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3201\/eid2507.180768","article-title":"Elizabethkingia bruuniana infections in humans, Taiwan, 2005\u20132017","volume":"25","author":"Lin","year":"2019","journal-title":"Emerg Infect Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jhin.2016.11.018","article-title":"Outbreak of Elizabethkingia meningoseptica sepsis with meningitis in a well-baby nursery","volume":"96","author":"Tai","year":"2017","journal-title":"J. Hosp. Infect."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e01137","DOI":"10.1128\/genomeA.01137-16","article-title":"Genome sequence of Elizabethkingia meningoseptica EM1, isolated from a patient with a bloodstream infection","volume":"4","author":"Chen","year":"2016","journal-title":"Genome Announc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e5608","DOI":"10.7717\/peerj.5608","article-title":"Molecular typing and profiling of topoisomerase mutations causing resistance to ciprofloxacin and levofloxacin in Elizabethkingia species","volume":"6","author":"Jian","year":"2018","journal-title":"Peer J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/gbe\/evv101","article-title":"Complete genome sequence and transcriptomic analysis of the novel pathogen Elizabethkingia anophelis in response to oxidative stress","volume":"7","author":"Li","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/jac\/dkz045","article-title":"Fluoroquinolone resistance in carbapenem-resistant Elizabethkingia anophelis: Phenotypic and genotypic characteristics of clinical isolates with topoisomerase mutations and comparative genomic analysis","volume":"74","author":"Jian","year":"2019","journal-title":"J. Antimicrob. 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