{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:04:19Z","timestamp":1760295859226,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["COOPB20237","201780I027"],"award-info":[{"award-number":["COOPB20237","201780I027"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Candida glabrata is one of the most prevalent pathogenic Candida species in dental plaque on tooth surfaces. Candida biofilms exhibit an enhanced resistance against most antifungal agents. Thus, the development of alternative more potent and effective antimicrobials is required to overcome this resistance. In this study, three novel fluorinated derivatives and nine selenoester compounds were screened as novel antifungal and antibiofilm agents against C. krusei, C. parapsilosis, and C. glabrata (N = 81 dental isolates). C. glabrata strains were susceptible only to fluorinated compounds while C. krusei, C. parapsilosis, and C. glabrata were susceptible to the action of the selenoesters. The evaluated symmetrical selenoester compounds presented very good antifungal activity against all the tested C. glabrata dental isolates (1\u20134 \u03bcg\/mL of minimum inhibitory concentration-MIC). The most active compound (Se-5) was able to inhibit and disperse C. glabrata biofilms. These results demonstrated that selenoesters may be novel and promising biocide agents against C. glabrata clinical dental isolates.<\/jats:p>","DOI":"10.3390\/microorganisms7120664","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T05:54:51Z","timestamp":1575870891000},"page":"664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Inhibition\u2013Disruption of Candida glabrata Biofilms: Symmetrical Selenoesters as Potential Anti-Biofilm Agents"],"prefix":"10.3390","volume":"7","author":[{"given":"Mar\u00eda L.","family":"De la Cruz-Claure","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda, Facultad de Ciencias de Bioqu\u00edmica, Qu\u00edmica Farmac\u00e9utica y Biolog\u00eda, Universidad Mayor, Real y Pontificia de San Francisco Xavier de Chuquisaca, Sucre, Bolivia Calle Dalence Casilla 497, Sucre 685041, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel A.","family":"C\u00e8spedes-Llave","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de Bioqu\u00edmica, Qu\u00edmica Farmac\u00e9utica y Biolog\u00eda, Universidad Mayor, Real y Pontificia de San Francisco Xavier de Chuquisaca, Sucre, Bolivia Calle Dalence Casilla 497, Sucre 685041, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda T.","family":"Ulloa","sequence":"additional","affiliation":[{"name":"Programa de Microbiolog\u00eda-Micolog\u00eda, Facultad de Medicina, Universidad de Chile (Av. Independencia 1027, Comuna Independencia), Santiago 7591538, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Benito-Lama","sequence":"additional","affiliation":[{"name":"Consejo Superior de Investigaciones Cient\u00edficas, Instituto de Qu\u00edmica Org\u00e1nica General, (IQOG-CSIC) c\/ Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-1575","authenticated-orcid":false,"given":"Enrique","family":"Dom\u00ednguez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Consejo Superior de Investigaciones Cient\u00edficas, Instituto de Qu\u00edmica Org\u00e1nica General, (IQOG-CSIC) c\/ Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5141-9595","authenticated-orcid":false,"given":"Agatha","family":"Bastida","sequence":"additional","affiliation":[{"name":"Consejo Superior de Investigaciones Cient\u00edficas, Instituto de Qu\u00edmica Org\u00e1nica General, (IQOG-CSIC) c\/ Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral Microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. 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