{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:49Z","timestamp":1793060029859,"version":"4.5.0"},"reference-count":69,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP18\/00111"],"award-info":[{"award-number":["CP18\/00111"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01297"],"award-info":[{"award-number":["PI16\/01297"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CD18\/00091"],"award-info":[{"award-number":["CD18\/00091"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008743","name":"Ministerio de Educaci\u00f3n y Cultura","doi-asserted-by":"publisher","award":["FPU17\/01319"],"award-info":[{"award-number":["FPU17\/01319"]}],"id":[{"id":"10.13039\/501100008743","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The hepatitis E virus (HEV) is the major cause of acute hepatitis of viral origin worldwide. Despite its usual course as an asymptomatic self-limited hepatitis, there are highly susceptible populations, such as those with underlying immunosuppression, which could develop chronic hepatitis. In this situation, implementation of therapy is mandatory in the sense to facilitate viral clearance. Currently, there are no specific drugs approved for HEV infection, but ribavirin (RBV), the drug of choice, is used for off-label treatment. Here, we present two cases of chronic HEV infection in transplant patients, reviewing and discussing the therapeutic approach available in the literature. The use of RBV for the treatment of an HEV infection in organ transplant patients seems to be effective. The recommendation of 12 weeks of therapy is adequate in terms of efficacy. Nevertheless, there are important issues that urgently need to be assessed, such as optimal duration of therapy and drug dosage.<\/jats:p>","DOI":"10.3390\/microorganisms8010051","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T05:37:08Z","timestamp":1577425028000},"page":"51","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients"],"prefix":"10.3390","volume":"8","author":[{"given":"Antonio","family":"Rivero-Juarez","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Clinical Virology and Zoonoses research group, Hospital Universitario Reina Sof\u00eda de C\u00f3rdoba, Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, 14006 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolau","family":"Vallejo","sequence":"additional","affiliation":[{"name":"Digestive Unit, Complexo Hospitalario Universitario de Santiago, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5740-6675","authenticated-orcid":false,"given":"Pedro","family":"Lopez-Lopez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Clinical Virology and Zoonoses research group, Hospital Universitario Reina Sof\u00eda de C\u00f3rdoba, Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, 14006 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"D\u00edaz-Mareque","sequence":"additional","affiliation":[{"name":"Nephrology Unit, Complexo Hospitalario Universitario de Santiago, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Frias","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Clinical Virology and Zoonoses research group, Hospital Universitario Reina Sof\u00eda de C\u00f3rdoba, Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, 14006 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldara","family":"Vallejo","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Complexo Hospitalario Universitario de Santiago, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Caballero-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Clinical Virology and Zoonoses research group, Hospital Universitario Reina Sof\u00eda de C\u00f3rdoba, Instituto Maimonides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC), Universidad de C\u00f3rdoba, 14006 Cordoba, Spain"},{"name":"Animal Health Department, University of Cordoba-Agrifood Excellence International Campus (ceiA3), 15705 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Rodr\u00edguez-Velasco","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Complexo Hospitalario Universitario de Santiago, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Molina","sequence":"additional","affiliation":[{"name":"Digestive Unit, Complexo Hospitalario Universitario de Santiago, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Microbiology Unit, Complexo Hospitalario Universitario de Santiago, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41426-017-0009-6","article-title":"Origin and dispersal of Hepatitis E virus","volume":"7","author":"Forni","year":"2018","journal-title":"Emerg. 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