{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:00:35Z","timestamp":1790643635395,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Objectives: To determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI). Methods: Planned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) &gt; 48 h. COPD patients (n = 494) were compared to non-COPD patients (n = 2466). The diagnosis of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) was based on clinical, radiological and quantitative microbiological criteria. Results: No significant difference was found in VAP (12% versus 13%, p = 0.931), or VAT incidence (13% versus 10%, p = 0.093) between COPD and non-COPD patients. Among patients with VA-LRTI, Escherichia coli and Stenotrophomonas maltophilia were significantly more frequent in COPD patients as compared with non-COPD patients. However, COPD had no significant impact on multidrug-resistant bacteria incidence. Appropriate antibiotic treatment was not significantly associated with progression from VAT to VAP among COPD patients who developed VAT, unlike non-COPD patients. Among COPD patients, patients who developed VAT or VAP had significantly longer MV duration (17 days (9\u201330) or 15 (8\u201327) versus 7 (4\u201312), p &lt; 0.001) and intensive care unit (ICU) length of stay (24 (17\u201339) or 21 (14\u201340) versus 12 (8\u201319), p &lt; 0.001) than patients without VA-LRTI. ICU mortality was also higher in COPD patients who developed VAP (44%), but not VAT(38%), as compared to no VA-LRTI (26%, p = 0.006). These worse outcomes associated with VA-LRTI were similar among non-COPD patients. Conclusions: COPD had no significant impact on incidence or outcomes of patients who developed VAP or VAT.<\/jats:p>","DOI":"10.3390\/microorganisms8020165","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T10:36:02Z","timestamp":1579775762000},"page":"165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections"],"prefix":"10.3390","volume":"8","author":[{"given":"Anahita","family":"Rouz\u00e9","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Boddaert","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-4063","authenticated-orcid":false,"given":"Ignacio","family":"Martin-Loeches","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James\u2019s Hospital, St. James Street, Dublin 8, D08 NHY1 Dublin, Ireland"},{"name":"Hospital Clinic, IDIBAPS, Universidad de Barcelona, Ciberes, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Povoa","sequence":"additional","affiliation":[{"name":"Nova Medical School, New University of Lisbon, 1099-085 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"ICU, Hospital Universitari de Tarragona Joan XXIII, 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassima","family":"Ramdane","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Lille, University of Lille, EA 2694\u2014Sant\u00e9 Publique, Epid\u00e9miologie et Qualit\u00e9 des Soins, D\u00e9partement de Biostatistiques, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Salluh","sequence":"additional","affiliation":[{"name":"Institute for Research and Education, D\u2019Or, Rio de Janeiro 22281-100, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Houard","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-0357","authenticated-orcid":false,"given":"Saad","family":"Nseir","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: GOLD Executive Summary","volume":"187","author":"Vestbo","year":"2013","journal-title":"Am. 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