{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:03:02Z","timestamp":1778900582009,"version":"3.51.4"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.<\/jats:p>","DOI":"10.3390\/microorganisms8030435","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T07:29:07Z","timestamp":1584689347000},"page":"435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-5374","authenticated-orcid":false,"given":"Jos\u00e9 E.","family":"Villac\u00eds","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Pontificia Universidad Cat\u00f3lica del Ecuador,  Quito 170143, Ecuador"},{"name":"Centro de Referencia Nacional de Resistencia a los Antimicrobianos, Instituto Nacional de Investigaci\u00f3n en Salud P\u00fablica \u201cLeopoldo Izquieta P\u00e9rez\u201d,  Quito 170403, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas, Universidad Central del Ecuador,  Quito 170129, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-0267","authenticated-orcid":false,"given":"Hugo G.","family":"Castel\u00e1n-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Instituto de Investigaciones B\u00e1sicas y Aplicadas Universidad Aut\u00f3noma del Estado de Morelos,  Cuernavaca Morelos 62209, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-3477","authenticated-orcid":false,"given":"Sonia","family":"D\u00e1vila-Ramos","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Instituto de Investigaciones B\u00e1sicas y Aplicadas Universidad Aut\u00f3noma del Estado de Morelos,  Cuernavaca Morelos 62209, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Lazo","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Eugenio Espejo,  Quito 170136, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Wali","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Eugenio Espejo,  Quito 170136, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A.","family":"Bodero","sequence":"additional","affiliation":[{"name":"Ministerio de Salud P\u00fablica,  Quito 170702, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadira","family":"Toapanta","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Eugenio Espejo,  Quito 170136, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Hospital de Especialidades Eugenio Espejo,  Quito 170136, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1237-3552","authenticated-orcid":false,"given":"Lorena","family":"Montero","sequence":"additional","affiliation":[{"name":"Ministerio de Salud P\u00fablica,  Quito 170702, Ecuador"},{"name":"Universidad San Francisco de Quito, COCIBA, Instituto de Microbiolog\u00eda,  Quito 170901, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Campos","sequence":"additional","affiliation":[{"name":"Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud \u201dDr. Carlos G. Malbr\u00e1n,\u201d  Buenos Aires 1281, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo G.","family":"Galas","sequence":"additional","affiliation":[{"name":"Pan American Health Organization\/WHO,  Washington, DC 20037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-2460","authenticated-orcid":false,"given":"M\u00f3nica C.","family":"Gestal","sequence":"additional","affiliation":[{"name":"Louisiana State University (LSU), Health Science Center, Shreveport,  LA 71103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2014). Antimicrobial Resistance: Global Report on Surveillance 2014, The Organization. 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