{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:14:26Z","timestamp":1791929666313,"version":"4.3.4"},"reference-count":178,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["zoonoses research consortium PAC-Campylobacter to SM, SB and MMH IP7\/ 01KI1725D; Zoonoses research consortium \"PAC-Campy\""],"award-info":[{"award-number":["zoonoses research consortium PAC-Campylobacter to SM, SB and MMH IP7\/ 01KI1725D; Zoonoses research consortium \"PAC-Campy\""]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Human Campylobacter jejuni infections inducing campylobacteriosis including post-infectious sequelae such as Guillain-Barr\u00e9 syndrome and reactive arthritis are rising worldwide and progress into a global burden of high socioeconomic impact. Intestinal immunopathology underlying campylobacteriosis is a classical response of the innate immune system characterized by the accumulation of neutrophils and macrophages which cause tissue destruction, barrier defects and malabsorption leading to bloody diarrhea. Clinical studies revealed that enteritis and post-infectious morbidities of human C. jejuni infections are strongly dependent on the structure of pathogenic lipooligosaccharides (LOS) triggering the innate immune system via Toll-like-receptor (TLR)-4 signaling. Compared to humans, mice display an approximately 10,000 times weaker TLR-4 response and a pronounced colonization resistance (CR) against C. jejuni maintained by the murine gut microbiota. In consequence, investigations of campylobacteriosis have been hampered by the lack of experimental animal models. We here summarize recent progress made in the development of murine C. jejuni infection models that are based on the abolishment of CR by modulating the murine gut microbiota and by sensitization of mice to LOS. These advances support the major role of LOS driven innate immunity in pathogenesis of campylobacteriosis including post-infectious autoimmune diseases and promote the preclinical evaluation of novel pharmaceutical strategies for prophylaxis and treatment.<\/jats:p>","DOI":"10.3390\/microorganisms8040482","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T15:37:21Z","timestamp":1585755441000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis"],"prefix":"10.3390","volume":"8","author":[{"given":"Soraya","family":"Mousavi","sequence":"first","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9\u2014University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bereswill","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9\u2014University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-651X","authenticated-orcid":false,"given":"Markus M.","family":"Heimesaat","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology, Gastrointestinal Microbiology Research Group, Charit\u00e9\u2014University Medicine Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrmicro1718","article-title":"Campylobacter jejuni: Molecular biology and pathogenesis","volume":"5","author":"Young","year":"2007","journal-title":"Nat. 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