{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:44:41Z","timestamp":1768715081531,"version":"3.49.0"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine, University of Szeged","award":["SZTE \u00c1OK-KKA 2018\/270-62-2"],"award-info":[{"award-number":["SZTE \u00c1OK-KKA 2018\/270-62-2"]}]},{"name":"Hungary","award":["GINOP-2.3.2-15-2016-00038"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00038"]}]},{"name":"Hungary","award":["EFOP 3.6.3-VEKOP-16-2017-00009"],"award-info":[{"award-number":["EFOP 3.6.3-VEKOP-16-2017-00009"]}]},{"name":"Zamora, Spain","award":["Iniciativas Ropelanas"],"award-info":[{"award-number":["Iniciativas Ropelanas"]}]},{"name":"Zamora, Spain","award":["Asociaci\u00f3n Cultural Trevinca"],"award-info":[{"award-number":["Asociaci\u00f3n Cultural Trevinca"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Infections caused by Salmonella species and Staphylococcus aureus represent major health and food industry problems. Bacteria have developed many strategies to resist the antibacterial activity of antibiotics, leading to multidrug resistance (MDR). The over-expression of drug efflux pumps and the formation of biofilms based on quorum sensing (QS) can contribute the emergence of MDR. For this reason, the development of novel effective compounds to overcome resistance is urgently needed. This study focused on the antibacterial activity of nine symmetrical selenoesters (Se-esters) containing additional functional groups including oxygen esters, ketones, and nitriles against Gram-positive and Gram-negative bacteria. Firstly, the minimum inhibitory concentrations of the compounds were determined. Secondly, the interaction of compounds with reference antibiotics was examined. The efflux pump (EP) inhibitory properties of the compounds were assessed using real-time fluorimetry. Finally, the anti-biofilm and quorum sensing inhibiting effects of selenocompounds were determined. The methylketone and methyloxycarbonyl selenoesters were the more effective antibacterials compared to cyano selenoesters. The methyloxycarbonyl selenoesters (Se-E2 and Se-E3) showed significant biofilm and efflux pump inhibition, and a methyloxycarbonyl selenoester (Se-E1) exerted strong QS inhibiting effect. Based on results selenoesters could be promising compounds to overcome bacterial MDR.<\/jats:p>","DOI":"10.3390\/microorganisms8040566","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T09:19:50Z","timestamp":1586942390000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biofilm Eradication by Symmetrical Selenoesters for Food-Borne Pathogens"],"prefix":"10.3390","volume":"8","author":[{"given":"M\u00e1rta","family":"Nov\u00e9","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annam\u00e1ria","family":"Kincses","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Szalontai","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-4253","authenticated-orcid":false,"given":"Jessica M. A.","family":"Blair","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gonz\u00e1lez-Pr\u00e1dena","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Consejo Superior de Investigaciones Cient\u00edficas, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Benito-Lama","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Consejo Superior de Investigaciones Cient\u00edficas, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-1575","authenticated-orcid":false,"given":"Enrique","family":"Dom\u00ednguez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica General (IQOG-CSIC), Consejo Superior de Investigaciones Cient\u00edficas, Juan de la Cierva 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Spengler","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/1469-0691.12767","article-title":"Antibiotic resistance: A geopolitical issue","volume":"20","author":"Carlet","year":"2014","journal-title":"Clin. 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