{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:59:14Z","timestamp":1771477154488,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"One Health European Joint Programme","award":["773830"],"award-info":[{"award-number":["773830"]}]},{"DOI":"10.13039\/501100008751","name":"Bundesinstitut f\u00fcr Risikobewertung","doi-asserted-by":"publisher","award":["43-001"],"award-info":[{"award-number":["43-001"]}],"id":[{"id":"10.13039\/501100008751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008751","name":"Bundesinstitut f\u00fcr Risikobewertung","doi-asserted-by":"publisher","award":["43-002"],"award-info":[{"award-number":["43-002"]}],"id":[{"id":"10.13039\/501100008751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Resistance to carbapenems is a severe threat to human health. These last resort antimicrobials are indispensable for the treatment of severe human infections with multidrug-resistant Gram-negative bacteria. In accordance with their increasing medical impact, carbapenemase-producing Enterobacteriaceae (CPE) might be disseminated from colonized humans to non-human reservoirs (i.e., environment, animals, food). In Germany, the occurrence of CPE in livestock and food has been systematically monitored since 2016. In the 2019 monitoring, an OXA-48-producing E. coli (19-AB01443) was recovered from a fecal sample of a fattening pig. Phenotypic resistance was confirmed by broth microdilution and further characterized by PFGE, conjugation, and combined short-\/long-read whole genome sequencing. This is the first detection of this resistance determinant in samples from German meat production. Molecular characterization and whole-genome sequencing revealed that the blaOXA-48 gene was located on a common pOXA-48 plasmid-prototype. This plasmid-type seems to be globally distributed among various bacterial species, but it was frequently associated with clinical Klebsiella spp. isolates. Currently, the route of introduction of this plasmid\/isolate combination into the German pig production is unknown. We speculate that due to its strong correlation with human isolates a transmission from humans to livestock has occurred.<\/jats:p>","DOI":"10.3390\/microorganisms8060855","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:19:39Z","timestamp":1591676379000},"page":"855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Spill-Over from Public Health? First Detection of an OXA-48-Producing Escherichia coli in a German Pig Farm"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-9978","authenticated-orcid":false,"given":"Alexandra","family":"Irrgang","sequence":"first","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Pauly","sequence":"additional","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd-Alois","family":"Tenhagen","sequence":"additional","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Grobbel","sequence":"additional","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-2713","authenticated-orcid":false,"given":"Annemarie","family":"Kaesbohrer","sequence":"additional","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"},{"name":"Institute for Veterinary Public Health, University of Veterinary Medicine, 1210 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-4358","authenticated-orcid":false,"given":"Jens A.","family":"Hammerl","sequence":"additional","affiliation":[{"name":"Department Biological Safety, Unit Epidemiology, Zoonoses and Antimicrobial Resistance, German Federal Institute for Risk Assessment (Bundesinstitut f\u00fcr Risikobewertung, BfR), D-10589 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"ref_1","first-page":"289","article-title":"Bericht des Nationalen Referenzzentrums f\u00fcr gramnegative Krankenhauserreger, 2018","volume":"31","author":"Pfennigwerth","year":"2019","journal-title":"Epidemiol. 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