{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:35:03Z","timestamp":1769600103071,"version":"3.49.0"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Key Research and Development Programme of Guangdong Province","award":["2019A1515011534"],"award-info":[{"award-number":["2019A1515011534"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972707"],"award-info":[{"award-number":["31972707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Guangdong Province","award":["2019A1515011534"],"award-info":[{"award-number":["2019A1515011534"]}]},{"name":"Major Scientific Research Projects (Characteristic Innovation) of Guangdong Province","award":["2017KTSCX018"],"award-info":[{"award-number":["2017KTSCX018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Toxoplasma gondii (T. gondii) infection in female mammals during pregnancy can result in poor pregnancy. Similarly, it can result in male reproductive disorders in male mammals. Although the testes and uterus have very different biological makeup, they are still both attacked by T. gondii resulting in reproductive dysfunctions. We hypothesized that there are significant common genes in the testes and uterus that interact with T. gondii. Finding out and studying these genes is vital to understand the infection mechanism of T. gondii and the induced disease pathogenesis. To achieve this goal, we built a mice model of acute infection with T. gondii and the testes and uterus of the mice were sequenced by RNA-Seq. A total of 291 and 679 significantly differently expressed genes (DEGs) were obtained from the testes and the uterus, respectively. In the Gene Ontology (GO) analysis, part of the DEGs in the testes and uterus were related to 35 GO functions. When compared with the KEGG database, seven pathways affecting both the testes and uterus during the course of T. gondii infection were identified. In addition, Toxoplasmosis can significantly affect the expression of Nlrp5 and Insc leading to negative outcomes in the host. On the other hand, the host regulates Gbp7, Gbp2b, and Ifit3 to defend against T. gondii infection.<\/jats:p>","DOI":"10.3390\/microorganisms8081136","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:16:49Z","timestamp":1595931409000},"page":"1136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced by Toxoplasma gondii in Mice"],"prefix":"10.3390","volume":"8","author":[{"given":"Junjie","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, Guangdong, China"},{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8267-8282","authenticated-orcid":false,"given":"Tanghui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-3454","authenticated-orcid":false,"given":"Yasser S.","family":"Mahmmod","sequence":"additional","affiliation":[{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, Guangdong, China"},{"name":"Infectious Diseases, Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Sharkia, Egypt"},{"name":"Veterinary Sciences Division, Al Ain Men\u2019s College, Higher Colleges of Technology, Al Ain 17155, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zipeng","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiexing","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowen","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Agriculture, South China Agricultural University, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Guo","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou 510642, Guangdong, China"},{"name":"Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs, South China Agricultural University, Guangzhou 510642, Guangdong, China"},{"name":"Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/cid\/cis508","article-title":"Foodborne toxoplasmosis","volume":"55","author":"Jones","year":"2012","journal-title":"Clin. 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