{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:49Z","timestamp":1790775169223,"version":"4.1.0"},"reference-count":116,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["634674"],"award-info":[{"award-number":["634674"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Council of Reunion Island","award":["R97400235"],"award-info":[{"award-number":["R97400235"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Aging research aims at developing interventions that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to delay aging and\/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were recovered from the sponge, of which the Proteobacteria phylum was the most abundant. In addition, thirty isolates from S. hapalia were selected and cultivated for identification and secondary metabolites production. The selected isolates were affiliated to the genera Bacillus, Micromonospora, Rhodoccocus, Salinispora, Aspergillus, Chaetomium, Nigrospora and unidentified genera related to the family Thermoactinomycetaceae. Crude extracts from selected microbial cultures were found to be active against seven targets i.e., elastase, tyrosinase, catalase, sirtuin 1, Cyclin-dependent kinase 7 (CDK7), Fyn kinase and proteasome. These results highlight the potential of microorganisms associated with a marine sponge from Mayotte to produce anti-aging compounds. Future work will focus on the isolation and the characterization of bioactive molecules.<\/jats:p>","DOI":"10.3390\/microorganisms8091262","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T09:35:31Z","timestamp":1597916131000},"page":"1262","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process"],"prefix":"10.3390","volume":"8","author":[{"given":"Charifat","family":"Said Hassane","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie et Biotechnologie des Produits Naturels, Facult\u00e9 des Sciences et Technologies, Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-2154","authenticated-orcid":false,"given":"Mireille","family":"Fouillaud","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biotechnologie des Produits Naturels, Facult\u00e9 des Sciences et Technologies, Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3070-8726","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Le Goff","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universit\u00e9 Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-4847","authenticated-orcid":false,"given":"Aimilia 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Jerabek","sequence":"additional","affiliation":[{"name":"Crelux GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-9671","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Bignon","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universit\u00e9 Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"de Voogd","sequence":"additional","affiliation":[{"name":"Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands"},{"name":"Institute of Environmental Sciences, Leiden University, Einsteinweg 2, 2333 CC Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-6638","authenticated-orcid":false,"given":"Jamal","family":"Ouazzani","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universit\u00e9 Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-0704","authenticated-orcid":false,"given":"Anne","family":"Gauvin-Bialecki","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et Biotechnologie des Produits Naturels, Facult\u00e9 des Sciences et Technologies, Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La R\u00e9union, 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