{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:26:32Z","timestamp":1789748792741,"version":"4.0.1"},"reference-count":162,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Candida albicans is an opportunistic pathogenic fungus considered to be a common member of the human microflora. Similar to some other opportunistic microbes, C. albicans can invade and benefit from its host when the immune status of that host is weakened. Most often this happens to immunocompromised individuals, leading to the infection of oral and vaginal mucosae or the systemic spread of the pathogen throughout the entire body. Oropharyngeal candidiasis (OPC) occurs in up to 90 percent of patients with acquired immunodeficiency syndrome (AIDS), making it the most frequent opportunistic infection for this group. Upon first signs of fungal invasion, a range of host signaling activates in order to eliminate the threat. Epithelial and myeloid type cells detect C. albicans mainly through receptor tyrosine kinases and pattern-recognition receptors. This review provides an overview of downstream signaling resulting in an adequate immune response through the activation of various transcription factors. The study discusses recent advances in research of the interleukin-17 (IL-17) producing innate cells, including natural T helper 17 (nTh17) cells, \u03b3\u03b4 T cells, invariant natural killer T (iNKT) cells and type 3 innate lymphoid cells (ILC3) that are involved in response to oral C. albicans infections.<\/jats:p>","DOI":"10.3390\/microorganisms8091340","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T09:29:28Z","timestamp":1599038968000},"page":"1340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis"],"prefix":"10.3390","volume":"8","author":[{"given":"Anna","family":"Pavlova","sequence":"first","affiliation":[{"name":"Integrated Immunology Programme, Division of Genetics, Department of Biology, Friedrich Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9873-9676","authenticated-orcid":false,"given":"Irshad","family":"Sharafutdinov","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen-Nuremberg, 91058 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1002\/eji.201344405","article-title":"The bacteriome-mycobiome interaction and antifungal host defense","volume":"44","author":"Oever","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bertolini, M., Ranjan, A., Thompson, A., Diaz, P.I., Sobue, T., Maas, K., and Dongari-Bagtzoglou, A. (2019). Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007717"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bartnicka, D., Gonzalez-Gonzalez, M., Sykut, J., Koziel, J., Ciaston, I., Adamowicz, K., Bras, G., Zawrotniak, M., Karkowska-Kuleta, J., and Satala, D. (2020). Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061984"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Passariello, C., di Nardo, F., Polimeni, A., di Nardo, D., and Testarelli, L. (2020). Probiotic Streptococcus salivarius Reduces Symptoms of Denture Stomatitis and Oral Colonization by Candida albicans. Appl. Sci., 10.","DOI":"10.1186\/ISRCTN14751782"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1439-0507.2007.01435.x","article-title":"Molecular epidemiology of Candida species isolated from clinical specimens of intensive care unit patients","volume":"51","author":"Marol","year":"2008","journal-title":"Mycoses"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(03)00801-6","article-title":"Epidemiology of Candida species infections in critically ill non-immunosuppressed patients","volume":"3","author":"Eggimann","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1099\/mic.0.000499","article-title":"Microbe Profile: Candida albicans: A shape-changing, opportunistic pathogenic fungus of humans","volume":"163","author":"Gow","year":"2017","journal-title":"Microbiol. SGM"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Southern, P., Horbul, J., Maher, D., and Davis, D.A. (2008). C. albicans Colonization of Human Mucosal Surfaces. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002067"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"ftw018","DOI":"10.1093\/femspd\/ftw018","article-title":"Pathogenesis of Candida albicans biofilm","volume":"74","author":"Tsui","year":"2016","journal-title":"Pathog. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fimmu.2017.00629","article-title":"Candida albicans Yeast, Pseudohyphal, and hyphal Morphogenesis Differentially affects immune recognition","volume":"8","author":"Mukaremera","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1128\/IAI.00744-09","article-title":"Influence of Mannan and Glucan on Complement Activation and C3 Binding by Candida albicans","volume":"78","author":"Boxx","year":"2010","journal-title":"Infect. Immun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e01874","DOI":"10.1128\/mBio.01874-14","article-title":"Candida albicans Hypha Formation and Mannan Masking of beta-Glucan Inhibit Macrophage Phagosome Maturation","volume":"5","author":"Bain","year":"2014","journal-title":"Mbio"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12275-016-5514-0","article-title":"Interaction of Candida albicans with host cells: Virulence factors, host defense, escape strategies, and the microbiota","volume":"54","author":"Hofs","year":"2016","journal-title":"J. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0002-9343(01)01130-5","article-title":"The epidemiology of Candida glabrata and Candida albicans fungemia in immunocompromised patients with cancer","volume":"112","author":"Bodey","year":"2002","journal-title":"Am. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2015.10.004","article-title":"The Global Burden of Fungal Diseases","volume":"30","author":"Vallabhaneni","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ghannoum, M.A., Jurevic, R.J., Mukherjee, P.K., Cui, F., Sikaroodi, M., Naqvi, A., and Gillevet, P.M. (2010). Characterization of the Oral Fungal Microbiome (Mycobiome) in Healthy Individuals. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1000713"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Dupuy, A.K., David, M.S., Li, L., Heider, T.N., Peterson, J.D., Montano, E.A., Dongari-Bagtzoglou, A., Diaz, P.I., and Strausbaugh, L.D. (2014). Redefining the Human Oral Mycobiome with Improved Practices in Amplicon-based Taxonomy: Discovery of Malassezia as a Prominent Commensal. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090899"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Metwalli, K.H., Khan, S.A., Krom, B.P., and Jabra-Rizk, M.A. (2013). Streptococcus mutans, Candida albicans, and the Human Mouth: A Sticky Situation. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003616"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/odi.12220","article-title":"Progress in understanding oral health and HIV\/AIDS","volume":"20","author":"Patton","year":"2014","journal-title":"Oral Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fmicb.2018.00980","article-title":"Oropharyngeal Candidosis in HIV-Infected Patients\u2014An Update","volume":"9","author":"Patil","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_21","unstructured":"UNAIDS (2019). UNAIDS (Joint United Nations Programme on HIV\/AIDS) Data 2019, UNAIDS."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MCC.0b013e32833e046e","article-title":"Pathogenesis of invasive candidiasis","volume":"16","author":"Kullberg","year":"2010","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1586\/14787210.2014.916210","article-title":"Pathogenicity mechanisms and host response during oral Candida albicans infections","volume":"12","author":"Hebecker","year":"2014","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20081463","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis","volume":"206","author":"Conti","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1128\/IAI.06146-11","article-title":"Interplay between Candida albicans and the Mammalian Innate Host Defense","volume":"80","author":"Cheng","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.4049\/jimmunol.1202671","article-title":"An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans","volume":"190","author":"Byrd","year":"2013","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Urban, C.F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., Brinkmann, V., Jungblut, P.R., and Zychlinsky, A. (2009). Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000639"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"eaat0797","DOI":"10.1126\/scitranslmed.aat0797","article-title":"A dysbiotic microbiome triggers T(H)17 cells to mediate oral mucosal immunopathology in mice and humans","volume":"10","author":"Dutzan","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nri2800","article-title":"Innate IL-17-producing cells: The sentinels of the immune system","volume":"10","author":"Cua","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"eaau4594","DOI":"10.1126\/sciimmunol.aau4594","article-title":"Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity","volume":"5","author":"Gaffen","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1084\/jem.20130877","article-title":"Oral-resident natural Th17 cells and gamma delta T cells control opportunistic Candida albicans infections","volume":"211","author":"Conti","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Rosati, D., Bruno, M., Jaeger, M., Oever, J.T., and Netea, M.G. (2020). Recurrent Vulvovaginal Candidiasis: An Immunological Perspective. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020144"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mengesha, B.G., and Conti, H.R. (2017). The Role of IL-17 in Protection against Mucosal Candida Infections. J. Fungi, 3.","DOI":"10.3390\/jof3040052"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/infdis\/jiz649","article-title":"The Interleukin (IL) 17R\/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status","volume":"221","author":"Peters","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.mib.2012.04.005","article-title":"Importance of the Candida albicans cell wall during commensalism and infection","volume":"15","author":"Gow","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1462-5822.2005.00505.x","article-title":"Immune recognition of fungal beta-glucans","volume":"7","author":"Brown","year":"2005","journal-title":"Cell. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gow, N.A.R., Latge, J.P., and Munro, C.A. (2017). The Fungal Cell Wall: Structure, Biosynthesis, and Function. Microbiol. Spectr., 5.","DOI":"10.1128\/microbiolspec.FUNK-0035-2016"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Swidergall, M. (2019). Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond. Pathogens, 8.","DOI":"10.3390\/pathogens8010040"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cyto.2017.10.013","article-title":"Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4\/CD14, and MyD88","volume":"106","author":"Pinheiro","year":"2018","journal-title":"Cytokine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1128\/EC.00093-14","article-title":"Interplay between Candida albicans and the Antimicrobial Peptide Armory","volume":"13","author":"Swidergall","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ni1408","article-title":"Dectin-1 is required for beta-glucan recognition and control of fungal infection","volume":"8","author":"Taylor","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.immuni.2013.05.017","article-title":"C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection","volume":"39","author":"Zhu","year":"2013","journal-title":"Immunity"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1084\/jem.20020470","article-title":"Dectin-1 is a major beta-glucan receptor on macrophages","volume":"196","author":"Brown","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.immuni.2010.05.001","article-title":"Dectin-2 Recognition of alpha-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans","volume":"32","author":"Saijo","year":"2010","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.immuni.2011.05.001","article-title":"Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense","volume":"34","author":"Osorio","year":"2011","journal-title":"Immunity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1084\/jem.20082818","article-title":"Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection","volume":"206","author":"Robinson","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity","volume":"442","author":"Gross","year":"2006","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/eji.200636830","article-title":"Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan","volume":"37","author":"Slack","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.4049\/jimmunol.178.5.3107","article-title":"Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells","volume":"178","author":"Goodridge","year":"2007","journal-title":"J. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-immunol-031210-101352","article-title":"Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis","volume":"30","author":"Sancho","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/cmi.2012.1","article-title":"Dectin-1 isoforms contribute to distinct Th1\/Th17 cell activation in mucosal candidiasis","volume":"9","author":"Carvalho","year":"2012","journal-title":"Cell. Mol. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1371\/journal.ppat.0010030","article-title":"Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display","volume":"1","author":"Hohl","year":"2005","journal-title":"PLoS Pathog."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1074\/jbc.M509824200","article-title":"Regulation of cytosolic phospholipase A(2) activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor","volume":"281","author":"Suram","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"30676","DOI":"10.1074\/jbc.M110.143800","article-title":"Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans","volume":"285","author":"Suram","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1471-4906(01)02154-8","article-title":"Prostaglandins as modulators of immunity","volume":"23","author":"Harris","year":"2002","journal-title":"Trends Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tips.2012.02.004","article-title":"Prostaglandins and chronic inflammation","volume":"33","author":"Aoki","year":"2012","journal-title":"Trends Pharmcol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1128\/IAI.69.5.2957-2963.2001","article-title":"Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins","volume":"69","author":"Noverr","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fcimb.2019.00359","article-title":"Fungal Symbionts Produce Prostaglandin E-2 to Promote Their Intestinal Colonization","volume":"9","author":"Tan","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.celrep.2019.03.033","article-title":"Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns","volume":"27","author":"Marquez","year":"2019","journal-title":"Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1084\/jem.180.6.2365","article-title":"Evidence for the involvement of interleukin-10 in the differential deactivation of murine peritoneal-macrophages by prostaglandin-e(2)","volume":"180","author":"Strassmann","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.3389\/fmicb.2016.01925","article-title":"Potential Antifungal Targets against a Candida Biofilm Based on an Enzyme in the Arachidonic Acid Cascade-A Review","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1086\/423854","article-title":"Induction of nuclear factor-kappa B and c-Jun\/activator protein-1 via Toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans","volume":"190","author":"Roeder","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_65","first-page":"38","article-title":"Both viable and killed Candida albicans cells induce in vitro production of TNF-alpha and IFN-gamma in murine cells through a TLR2-dependent signalling","volume":"18","author":"Murciano","year":"2007","journal-title":"Eur. Cytokine Netw."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e00266-19","DOI":"10.1128\/mBio.00266-19","article-title":"Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis","volume":"10","author":"Archambault","year":"2019","journal-title":"Mbio"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.micinf.2006.03.014","article-title":"TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae","volume":"8","author":"Gil","year":"2006","journal-title":"Microbes Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.micinf.2006.07.021","article-title":"Both TLR2 and TLR4 are involved in the recognition of Candida albicans. Reply to \u201cTLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae\u201d by Gil and Gozalbo, Microbes and Infection","volume":"8","author":"Netea","year":"2006","journal-title":"Microbes Infect."},{"key":"ref_69","first-page":"e00266-19","article-title":"A small secreted protein triggers a TLR2\/4-dependent inflammatory response during invasive Candida albicans infection","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.femsim.2004.12.005","article-title":"Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans","volume":"44","author":"Blasi","year":"2005","journal-title":"Fems. Immunol. Med. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.chom.2009.05.002","article-title":"An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans","volume":"5","author":"Hise","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e02221","DOI":"10.1128\/mBio.02221-18","article-title":"Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae","volume":"10","author":"Rogiers","year":"2019","journal-title":"Mbio"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1038\/s41467-018-06607-1","article-title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.tim.2015.09.006","article-title":"Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?","volume":"23","author":"Foo","year":"2015","journal-title":"Trends Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3389\/fimmu.2020.01471","article-title":"Candida and Complement: New Aspects in an Old Battle","volume":"11","author":"Harpf","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e00709-18","DOI":"10.1128\/IAI.00709-18","article-title":"Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients","volume":"86","author":"Angomas","year":"2018","journal-title":"Infect. Immun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.150.5.1804","article-title":"TSG-14, A tumor necrosis factor-inducible and il-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins","volume":"150","author":"Lee","year":"1993","journal-title":"J. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1182\/blood.V84.10.3483.3483","article-title":"Inducible expression of ptx3, a new member of the pentraxin family, in human mononuclear phagocytes","volume":"84","author":"Alles","year":"1994","journal-title":"Blood"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1074\/jbc.M110.190637","article-title":"Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System","volume":"286","author":"Ma","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"28263","DOI":"10.1074\/jbc.M109.009225","article-title":"Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition","volume":"284","author":"Ma","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s10096-014-2309-2","article-title":"The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections","volume":"34","author":"Jaeger","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/IAI.01335-13","article-title":"The Adaptor CARD9 Is Required for Adaptive but Not Innate Immunity to Oral Mucosal Candida albicans Infections","volume":"82","author":"Bishu","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"eaam8834","DOI":"10.1126\/sciimmunol.aam8834","article-title":"Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin","volume":"2","author":"Verma","year":"2017","journal-title":"Sci. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.chom.2010.08.002","article-title":"A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells","volume":"8","author":"Moyes","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"14194","DOI":"10.1073\/pnas.1117676109","article-title":"EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e00025-17","DOI":"10.1128\/mBio.00025-17","article-title":"The Aryl Hydrocarbon Receptor Governs Epithelial Cell Invasion during Oropharyngeal Candidiasis","volume":"8","author":"Solis","year":"2017","journal-title":"Mbio"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1111\/j.1600-6143.2008.02420.x","article-title":"The MAP Kinase Phosphatase-1 MKP-1\/DUSP1 Is a Regulator of Human Liver Response to Transplantation","volume":"8","author":"Boutros","year":"2008","journal-title":"Am. J. Transplant."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4049\/jimmunol.1800515","article-title":"IL-36 and IL-1\/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms","volume":"201","author":"Verma","year":"2018","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41564-017-0059-5","article-title":"EphA2 is an epithelial cell pattern recognition receptor for fungal beta-glucans","volume":"3","author":"Swidergall","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref_92","first-page":"3664","article-title":"Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling","volume":"117","author":"Weindl","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1073\/pnas.97.2.773","article-title":"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4049\/jimmunol.169.2.642","article-title":"Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis","volume":"169","author":"Starnes","year":"2002","journal-title":"J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.4049\/jimmunol.155.12.5483","article-title":"Human IL-17\u2014A novel cytokine derived from t-cells","volume":"155","author":"Yoo","year":"1995","journal-title":"J. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1074\/jbc.M008289200","article-title":"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1","volume":"276","author":"Lee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1093\/emboj\/20.19.5332","article-title":"IL-17s adopt a cystine knot fold: Structure and activity of a novel cytokine, IL-17F, and implications for receptor binding","volume":"20","author":"Hymowitz","year":"2001","journal-title":"EMBO J."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1128\/IAI.01389-13","article-title":"Interleukin-17-Induced Protein Lipocalin 2 Is Dispensable for Immunity to Oral Candidiasis","volume":"82","author":"Ferreira","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s10875-012-9664-5","article-title":"Additional Diverse Findings Expand the Clinical Presentation of DOCK8 Deficiency","volume":"32","author":"Sanal","year":"2012","journal-title":"J. Clin. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1128\/AAC.44.12.3310-3316.2000","article-title":"Salivary histatin 5 and human neutrophil defensin 1 kill Candida albicans via shared pathways","volume":"44","author":"Edgerton","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.4049\/jimmunol.1302265","article-title":"Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis","volume":"192","author":"Huppler","year":"2014","journal-title":"J. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/mi.2014.57","article-title":"IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils","volume":"8","author":"Gladiator","year":"2015","journal-title":"Mucosal Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/ni.1783","article-title":"Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation","volume":"10","author":"Marks","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/imr.12036","article-title":"Th17 cell development: From the cradle to the grave","volume":"252","author":"Zuniga","year":"2013","journal-title":"Immunol. Rev."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.4049\/jimmunol.0803828","article-title":"Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses","volume":"183","author":"Tanaka","year":"2009","journal-title":"J. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaut.2015.06.008","article-title":"Natural Th17 cells are critically regulated by functional medullary thymic microenvironments","volume":"63","author":"Jenkinson","year":"2015","journal-title":"J. Autoimmun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.4049\/jimmunol.1302089","article-title":"TLR-Induced Cytokines Promote Effective Proinflammatory Natural Th17 Cell Responses","volume":"192","author":"Massot","year":"2014","journal-title":"J. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.chom.2018.02.011","article-title":"Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection","volume":"23","author":"Wiesner","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev.iy.11.040193.003225","article-title":"GAMMA-DELTA Cells","volume":"11","author":"Haas","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"Gamma delta T Cells: First Line of Defense and Beyond","volume":"32","author":"Chien","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: Unique contributions of gamma delta T cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.it.2017.01.007","article-title":"Thymic Determinants of gamma delta T Cell Differentiation","volume":"38","author":"Sumaria","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/0022034520908839","article-title":"Development and Function of gamma delta T Cells in the Oral Mucosa","volume":"99","author":"Hovav","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1073\/pnas.1818812116","article-title":"Mutual interplay between IL-17-producing gamma delta T cells and microbiota orchestrates oral mucosal homeostasis","volume":"116","author":"Wilharm","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1182\/blood-2009-01-198028","article-title":"V delta 1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans","volume":"113","author":"Fenoglio","year":"2009","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"5953","DOI":"10.4049\/jimmunol.1403066","article-title":"Candida albicans Stimulates IL-23 Release by Human Dendritic Cells and Downstream IL-17 Secretion by V delta 1 T Cells","volume":"194","author":"Maher","year":"2015","journal-title":"J. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/343754a0","article-title":"Homing of a gamma-delta thymocyte subset with homogeneous t-cell receptors to mucosal epithelia","volume":"343","author":"Itohara","year":"1990","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00018-011-0701-y","article-title":"Dynamics of the interaction of gamma delta T cells with their neighbors in vivo","volume":"68","author":"Prinz","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2009.06.020","article-title":"Interleukin-17-Producing gamma delta T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals","volume":"31","author":"Martin","year":"2009","journal-title":"Immunity"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 Induce Innate IL-17 Production from gamma delta T Cells, Amplifying Th17 Responses and Autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Monin, L., Ushakov, D.S., Arnesen, H., Bah, N., Jandke, A., Munoz-Ruiz, M., Carvalho, J., Joseph, S., Almeida, B.C., and Green, M.J. (2020). Gamma delta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis. Mucosal Immunol.","DOI":"10.1038\/s41385-020-0305-7"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e98241","DOI":"10.1172\/jci.insight.98241","article-title":"Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection","volume":"3","author":"Ramani","year":"2018","journal-title":"JCI Insight"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.it.2016.04.007","article-title":"Skin Immunity to Candida albicans","volume":"37","author":"Kashem","year":"2016","journal-title":"Trends Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b(+) Dermal Dendritic Cells and Drive Protective Cutaneous Immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri3328","article-title":"Recognition of CD1d-restricted antigens by natural killer T cells","volume":"12","author":"Rossjohn","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20011786","article-title":"Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining","volume":"195","author":"Gumperz","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11287","DOI":"10.1073\/pnas.0801631105","article-title":"Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4(\u2212)NK1.1(\u2212) NKT cell population","volume":"105","author":"Coquet","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.1600643","article-title":"Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst gamma delta T, Innate Lymphoid, and Th Cells","volume":"197","author":"Lee","year":"2016","journal-title":"J. Immunol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"13116","DOI":"10.1038\/ncomms13116","article-title":"Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets","volume":"7","author":"Georgiev","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/ni.3437","article-title":"Innate-like functions of natural killer T cell subsets result from highly divergent gene programs","volume":"17","author":"Engel","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT cell family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20011908","article-title":"Distinct functional lineages of human V alpha-24 natural killer T cells","volume":"195","author":"Lee","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.4049\/jimmunol.1003043","article-title":"Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells","volume":"186","author":"Resende","year":"2011","journal-title":"J. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.chom.2011.09.011","article-title":"Innate Recognition of Cell Wall beta-Glucans Drives Invariant Natural Killer T Cell Responses against Fungi","volume":"10","author":"Cohen","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1038\/s41598-017-10309-x","article-title":"Activation of invariant natural killer T cells stimulated with microbial alpha-mannosyl glycolipids","volume":"7","author":"Shimamura","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"522","DOI":"10.7883\/yoken.65.522","article-title":"A Limited Role of iNKT Cells in Controlling Systemic Candida albicans Infections","volume":"65","author":"Tarumoto","year":"2012","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2014A proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells: A new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4049\/jimmunol.1202924","article-title":"Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection","volume":"190","author":"Gladiator","year":"2013","journal-title":"J. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Sparber, F., Dolowschiak, T., Mertens, S., Lauener, L., Clausen, B.E., Joller, N., Stoitzner, P., Tussiwand, R., and LeibundGut-Landmann, S. (2018). Langerin(+) DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007069"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"26860","DOI":"10.1038\/srep26860","article-title":"Exploring ecological modelling to investigate factors governing the colonization success in nosocomial environment of Candida albicans and other pathogenic yeasts","volume":"6","author":"Corte","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fmed.2018.00028","article-title":"Candida Biofilms: Threats, Challenges, and Promising Strategies","volume":"5","author":"Cavalheiro","year":"2018","journal-title":"Front. Med."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Alves, R., Barata-Antunes, C., Casal, M., Brown, A.J.P., van Dijck, P., and Paiva, S. (2020). Adapting to survive: How Candida overcomes host-imposed constraints during human colonization. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008478"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Sharafutdinov, I.S., Ozhegov, G.D., Sabirova, A.E., Novikova, V.V., Lisovskaya, S.A., Khabibrakhmanova, A.M., Kurbangalieva, A.R., Bogachev, M.I., and Kayumov, A.R. (2020). Increasing Susceptibility of Drug-Resistant Candida albicans to Fluconazole and Terbinafine by 2(5H)-Furanone Derivative. Molecules, 25.","DOI":"10.3390\/molecules25030642"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"eaau9894","DOI":"10.1126\/scisignal.aau9894","article-title":"Targeting of host cell receptor tyrosine kinases by intracellular pathogens","volume":"12","author":"Haqshenas","year":"2019","journal-title":"Sci. Signal."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.tim.2017.04.009","article-title":"The Role of ErbB Receptors in Infection","volume":"25","author":"Ho","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1099\/jgv.0.001235","article-title":"Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor beta signalling pathway","volume":"100","author":"Vrijens","year":"2019","journal-title":"J. Gen. Virol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/s41556-019-0352-z","article-title":"HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity","volume":"21","author":"Wu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrmicro.2017.126","article-title":"Listeria monocytogenes: Towards a complete picture of its physiology and pathogenesis","volume":"16","author":"Radoshevich","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/IAI.05403-11","article-title":"Neurotrophin Receptor TrkC Is an Entry Receptor for Trypanosoma cruzi in Neural, Glial, and Epithelial Cells","volume":"79","author":"Weinkauf","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/CMR.00011-10","article-title":"Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk","volume":"23","author":"Wroblewski","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/j.gastro.2015.09.004","article-title":"Pathobiology of Helicobacter pylori-Induced Gastric Cancer","volume":"150","author":"Amieva","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Sharafutdinov, I., Backert, S., and Tegtmeyer, N. (2020). Cortactin: A Major Cellular Target of the Gastric Carcinogen Helicobacter pylori. Cancers, 12.","DOI":"10.3390\/cancers12010159"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejim.2013.02.017","article-title":"Candida infection and cancer risk: A Danish nationwide cohort study","volume":"24","author":"Norgaard","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"63562","DOI":"10.18632\/oncotarget.18855","article-title":"Cancer risk in patients with candidiasis: A nationwide population-based cohort study","volume":"8","author":"Chung","year":"2017","journal-title":"Oncotarget"},{"key":"ref_157","first-page":"181","article-title":"Candida albicans and cancer: Can this yeast induce cancer development or progression?","volume":"42","author":"Rementeria","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Kazmierczak-Siedlecka, K., Dvorak, A., Folwarski, M., Daca, A., Przewlocka, K., and Makarewicz, W. (2020). Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis. Cancers, 12.","DOI":"10.3390\/cancers12051326"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00005-015-0344-z","article-title":"The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases","volume":"63","author":"Tabarkiewicz","year":"2015","journal-title":"Arch. Immunol. Et Ther. Exp."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/ijd.14695","article-title":"IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases: State of art","volume":"59","author":"Bernardini","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.autrev.2018.06.008","article-title":"IL-17 and IL-17-producing cells and liver diseases, with focus on autoimmune liver diseases","volume":"17","author":"Beringer","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/3908061","article-title":"The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases","volume":"2017","author":"Kuwabara","year":"2017","journal-title":"Mediat. Inflamm."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/8\/9\/1340\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:58Z","timestamp":1760177158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/8\/9\/1340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":162,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["microorganisms8091340"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms8091340","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]}}}