{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:24:55Z","timestamp":1790375095136,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Rosacea is a chronic inflammatory skin disorder of a not fully understood pathophysiology. Microbial factors, although not precisely characterized, are speculated to contribute to the development of the condition. The aim of the current review was to summarize the rosacea-associated alterations in the skin, blood, and gut microbiome, investigated using culture-independent, metagenomic techniques. A systematic review of the PubMed, Web of Science, and Scopus databases was performed, according to PRISMA (preferred reporting items for systematic review and meta-analyses) guidelines. Nine out of 185 papers were eligible for analysis. Skin microbiome was investigated in six studies, and in a total number of 115 rosacea patients. Blood microbiome was the subject of one piece of research, conducted in 10 patients with rosacea, and gut microbiome was studied in two papers, and in a total of 23 rosacea subjects. Although all of the studies showed significant alterations in the composition of the skin, blood, or gut microbiome in rosacea, the results were highly inconsistent, or even, in some cases, contradictory. Major limitations included the low number of participants, and different study populations (mainly Asians). Further studies are needed in order to reliably analyze the composition of microbiota in rosacea, and the potential application of microbiome modifications for the treatment of this dermatosis.<\/jats:p>","DOI":"10.3390\/microorganisms8111756","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T19:03:37Z","timestamp":1604862217000},"page":"1756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Diversity and Composition of the Skin, Blood and Gut Microbiome in Rosacea\u2014A Systematic Review of the Literature"],"prefix":"10.3390","volume":"8","author":[{"given":"Klaudia","family":"Tutka","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-0529","authenticated-orcid":false,"given":"Magdalena","family":"\u017bychowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-1754","authenticated-orcid":false,"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sinikumpu, S.P.P., Jokelainen, J.J., Haarala, A.K.K., Ker\u00e4nen, M.H.H., Kein\u00e4nen-Kiukaanniemi, S.S., and Huilaja, L. (2020). The high prevalence of skin disease in adults aged 70 or older. J. Am. Geriatr. Soc.","DOI":"10.1111\/jgs.16706"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/1346-8138.15301","article-title":"Epidemiological features of rosacea in Changsha, China: A population-based, cross-sectional study","volume":"47","author":"Li","year":"2020","journal-title":"J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/bjd.18420","article-title":"Recommendations for rosacea diagnosis, classification and management: Update from the global ROSacea Consensus 2019 panel","volume":"182","author":"Shaller","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/archderm.1994.01690030091015","article-title":"Rosacea: Pathophysiology and treatment","volume":"130","author":"Wilkin","year":"1994","journal-title":"Arch. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1046\/j.1468-3083.2000.00144.x","article-title":"What\u2019s going on in rosacea?","volume":"14","author":"Powell","year":"2000","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaad.2009.12.036","article-title":"Staphylococcus epidermidis: A possible role in the pustules of rosacea","volume":"64","author":"Whitfeld","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"Ursell","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40257-019-00467-1","article-title":"The microbiome and atopic dermatitis: A review","volume":"20","author":"Pothmann","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lee, Y.B.B., Byun, E.J.J., and Kim, H.S. (2019). Potential role of the microbiome in acne: A comprehensive review. J. Clin. Med., 8.","DOI":"10.3390\/jcm8070987"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s13671-017-0178-5","article-title":"The role of the skin and gut microbiome in psoriatic disease","volume":"6","author":"Yan","year":"2017","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00403-019-01965-2","article-title":"Identification of bacterial DNA in the peripheral blood of patients with active hidradenitis suppurativa","volume":"312","author":"Hispan","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.micpath.2014.04.002","article-title":"Microbiota of Demodex mites from rosacea patients and controls","volume":"71\u201372","author":"Murillo","year":"2014","journal-title":"Microb. Pathog."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/exd.13491","article-title":"Characterization of the facial microbiome in twins discordant for rosacea","volume":"27","author":"Zaidi","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s40257-019-00471-5","article-title":"Characterization and analysis of the skin microbiota in rosacea: A case-control study","volume":"21","author":"Rainer","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Thompson, K.G.G., Rainer, B.M.M., Antonescu, C.C., Florea, L.L., Mongodin, E.F.F., Kang, S.S., and Chien, A.L. (2020). Comparison of the skin microbiota in acne and rosacea. Exp. Dermatol.","DOI":"10.1111\/exd.14098"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wang, R.R., Farhat, M.M., Na, J.J., Li, R.R., and Wu, Y. (2020). Bacterial and fungal microbiome characterization in patients with rosacea and healthy controls. Br. J. Dermatol.","DOI":"10.1111\/bjd.19315"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Woo, Y.R.R., Lee, S.H.H., Cho, S.H.H., Lee, J.D.D., and Kim, H.S. (2020). Characterization and analysis of the skin microbiota in rosacea: Impact of systemic antibiotics. J. Clin. Med., 9.","DOI":"10.3390\/jcm9010185"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000496968","article-title":"Characterization of the blood microbiota in Korean females with rosacea","volume":"235","author":"Yun","year":"2019","journal-title":"Dermatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/exd.13398","article-title":"Rosacea and its association with enteral microbiota in Korean females","volume":"27","author":"Nam","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, Y.J., Lee, W.H., Ho, H.J., Tseng, C.H., and Wu, C.Y. (2020). An altered fecal microbial profiling in rosacea patients compared to matched controls. J. Formos. Med. Assoc.","DOI":"10.1016\/j.jfma.2020.04.034"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39491","DOI":"10.1038\/srep39491","article-title":"The balance of metagenomic elements shapes the skin microbiome in acne and health","volume":"6","author":"Barnard","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1600-0463.2012.02920.x","article-title":"No link between rosacea and Propionibacterium acnes","volume":"120","author":"Jahns","year":"2012","journal-title":"APMIS"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e120608","DOI":"10.1172\/jci.insight.120608","article-title":"First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis","volume":"3","author":"Myles","year":"2018","journal-title":"JCI Insight"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tan-Lim, C.S.C., Esteban-Ipac, N.A.R., Mantaring, J.B.V., Yen, E., Recto, M.S.T., Sison, O.T., and Alejandria, M.M. (2020). Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr. Allergy Immunol.","DOI":"10.1111\/pai.13305"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bjd.14930","article-title":"Rosacea and gastrointestinal disorders: A population-based cohort study","volume":"176","author":"Egeberg","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1440-1746.2002.02834.x","article-title":"Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody","volume":"17","author":"Ohkusa","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fimmu.2012.00154","article-title":"Effects of differences in Lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation","volume":"3","author":"Chilton","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jid.2016.01.016","article-title":"Skin microbiome surveys are strongly influenced by experimental design","volume":"136","author":"Meisel","year":"2016","journal-title":"J. Investig. Dermatol."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/8\/11\/1756\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:30:52Z","timestamp":1760178652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/8\/11\/1756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["microorganisms8111756"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms8111756","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]}}}