{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:10:49Z","timestamp":1792789849850,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant","award":["896201"],"award-info":[{"award-number":["896201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Periodontitis, an inflammatory condition that affects the structures surrounding the tooth eventually leading to tooth loss, is one of the two biggest threats to oral health. Beyond oral health, it is associated with systemic diseases and even with cancer risk. Obviously, periodontitis represents a major global health problem with significant social and economic impact. Recently, a new paradigm was proposed in the etiopathogenesis of periodontitis involving a herpesviral\u2013bacterial combination to promote long-term chronic inflammatory disease. Periodontitis as a risk factor for other systemic diseases can also be better explained based on viral\u2013bacterial etiology. Significant efforts have brought numerous advances in revealing the links between periodontitis and Epstein\u2013Barr virus (EBV), a gamma herpesvirus ubiquitous in the adult human population. The strong evidence from these studies may contribute to the advancement of periodontitis research and the ultimate control of the disease. Advancing the periodontitis research will require implementing suitable methods to establish EBV involvement in periodontitis. This review evaluates and summarizes the existing methods that allow the detection and diagnosis of EBV in periodontitis (also applicable in a more general way to other EBV-related diseases), and discusses the feasibility of the application of innovative emerging technologies.<\/jats:p>","DOI":"10.3390\/microorganisms9010072","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T19:55:25Z","timestamp":1609271725000},"page":"72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Detection of Epstein\u2013Barr Virus in Periodontitis: A Review of Methodological Approaches"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-3228","authenticated-orcid":false,"given":"Lilit","family":"Tonoyan","sequence":"first","affiliation":[{"name":"MICORALIS, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 C\u00f4te D\u2019Azur, 5 rue du 22i\u00e8me BCA, 06357 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Chevalier","sequence":"additional","affiliation":[{"name":"MICORALIS, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 C\u00f4te D\u2019Azur, 5 rue du 22i\u00e8me BCA, 06357 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Vincent-Bugnas","sequence":"additional","affiliation":[{"name":"MICORALIS, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 C\u00f4te D\u2019Azur, 5 rue du 22i\u00e8me BCA, 06357 Nice, France"},{"name":"P\u00f4le Odontologie, Centre Hospitalier Universitaire de Nice, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Marsault","sequence":"additional","affiliation":[{"name":"MICORALIS, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 C\u00f4te D\u2019Azur, 5 rue du 22i\u00e8me BCA, 06357 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Doglio","sequence":"additional","affiliation":[{"name":"MICORALIS, Facult\u00e9 de Chirurgie Dentaire, Universit\u00e9 C\u00f4te D\u2019Azur, 5 rue du 22i\u00e8me BCA, 06357 Nice, France"},{"name":"Unit\u00e9 de Th\u00e9rapie Cellulaire et G\u00e9nique (UTCG), Centre Hospitalier Universitaire de Nice, 06101 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus Report of Workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions: Classification and Case Definitions for Periodontitis","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. 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