{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:14:22Z","timestamp":1792613662080,"version":"4.5.0"},"reference-count":167,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860634"],"award-info":[{"award-number":["81860634"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005147","name":"Applied Basic Research Key Project of Yunnan Province","doi-asserted-by":"publisher","award":["202001BB050029"],"award-info":[{"award-number":["202001BB050029"]}],"id":[{"id":"10.13039\/501100005147","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Science and Technology Projects of Yunnan Province","award":["202002AA100007"],"award-info":[{"award-number":["202002AA100007"]}]},{"name":"Project of Innovative Research Team of Yunnan Province","award":["202005AE160005"],"award-info":[{"award-number":["202005AE160005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>The genus Diaporthe and its anamorph Phomopsis are distributed worldwide in many ecosystems. They are regarded as potential sources for producing diverse bioactive metabolites. Most species are attributed to plant pathogens, non-pathogenic endophytes, or saprobes in terrestrial host plants. They colonize in the early parasitic tissue of plants, provide a variety of nutrients in the cycle of parasitism and saprophytism, and participate in the basic metabolic process of plants. In the past ten years, many studies have been focused on the discovery of new species and biological secondary metabolites from this genus. In this review, we summarize a total of 335 bioactive secondary metabolites isolated from 26 known species and various unidentified species of Diaporthe and Phomopsis during 2010\u20132019. Overall, there are 106 bioactive compounds derived from Diaporthe and 246 from Phomopsis, while 17 compounds are found in both of them. They are classified into polyketides, terpenoids, steroids, macrolides, ten-membered lactones, alkaloids, flavonoids, and fatty acids. Polyketides constitute the main chemical population, accounting for 64%. Meanwhile, their bioactivities mainly involve cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, anti-algae, phytotoxic, and enzyme inhibitory activities. Diaporthe and Phomopsis exhibit their potent talents in the discovery of small molecules for drug candidates.<\/jats:p>","DOI":"10.3390\/microorganisms9020217","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T11:49:40Z","timestamp":1611229780000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010\u20132019"],"prefix":"10.3390","volume":"9","author":[{"given":"Tang-Chang","family":"Xu","sequence":"first","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qiang","family":"Song","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ge","family":"Hou","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Si","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-7449","authenticated-orcid":false,"given":"Shao-Hua","family":"Wu","sequence":"additional","affiliation":[{"name":"Yunnan Institute of Microbiology, School of Life Sciences, Yunnan University, Kunming 650091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3767\/persoonia.2018.40.06","article-title":"Diaporthe diversity and pathogenicity revealed from a broad survey of grapevine diseases in Europe","volume":"40","author":"Guarnaccia","year":"2018","journal-title":"Persoonia"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dissanayake, A.J., Chen, Y.Y., and Liu, J.K.J. (2020). Unravelling Diaporthe species associated with woody hosts from karst formations (Guizhou) in China. J. Fungi, 6.","DOI":"10.3390\/jof6040251"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3767\/003158513X666844","article-title":"Diaporthe: A genus of endophytic, saprobic and plant pathogenic fungi","volume":"31","author":"Gomes","year":"2013","journal-title":"Persoonia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s13225-014-0297-2","article-title":"Insights into the genus Diaporthe: Phylogenetic species delimitation in the D. eres species complex","volume":"67","author":"Udayanga","year":"2014","journal-title":"Fungal Divers."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5598\/imafungus.2017.08.01.11","article-title":"Diaporthe is paraphyletic","volume":"8","author":"Gao","year":"2017","journal-title":"IMA Fungus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.funbio.2010.01.007","article-title":"Primers for mating-type diagnosis in Diaporthe and Phomopsis: Their use in teleomorph induction in vitro and biological species definition","volume":"114","author":"Santos","year":"2010","journal-title":"Fungal Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1094\/PDIS-09-19-1833-PDN","article-title":"First report of Phomopsis heveicola (anamorph of Diaporthe tulliensis) causing leaf blight of Coffee (Coffea arabica) in China","volume":"104","author":"Gong","year":"2020","journal-title":"Plant Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1139\/b94-204","article-title":"Nuclear ribosomal internal transcribed spacer phylogeny and host diversity in the coelomycete Phomopsis","volume":"72","author":"Rehner","year":"1994","journal-title":"Can. J. Bot."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3767\/003158511X603719","article-title":"Resolving the Diaporthe species occurring on soybean in Croatia","volume":"27","author":"Santos","year":"2011","journal-title":"Persoonia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.11646\/phytotaxa.422.2.3","article-title":"Three new species of Diaporthe from China based on morphological characters and DNA sequence data analyses","volume":"422","author":"Zhou","year":"2019","journal-title":"Phytotaxa"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Leon, M., Berbegal, M., Rodriguez-Reina, J.M., Elena, G., Abad-Campos, P., Ramon-Albalat, A., Olmo, D., Vicent, A., Luque, J., and Miarnau, X. (2020). Identification and characterization of Diaporthe spp. associated with twig cankers and shoot blight of almonds in Spain. Agronomy, 10.","DOI":"10.3390\/agronomy10081062"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5598\/imafungus.2015.06.01.09","article-title":"Recommendations of generic names in Diaporthales competing for protection or use","volume":"6","author":"Rossman","year":"2015","journal-title":"IMA Fungus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s13225-011-0126-9","article-title":"The genus Phomopsis: Biology, applications, species concepts and names of common phytopathogens","volume":"50","author":"Udayanga","year":"2011","journal-title":"Fungal Divers."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Santos, L., Alves, A., and Alves, R. (2017). Evaluating multi-locus phylogenies for species boundaries determination in the genus Diaporthe. PeerJ, 5.","DOI":"10.7717\/peerj.3120"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.femsle.2005.07.025","article-title":"Cytotoxic and antimicrobial metabolites from marine lignicolous fungi, Diaporthe sp.","volume":"251","author":"Lin","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.phytochem.2006.06.004","article-title":"Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae)","volume":"67","author":"Silva","year":"2006","journal-title":"Phytochemistry"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Niaz, S.I., Khan, D., Naz, R., Safdar, K., Ul Abidin, S.Z., Khan, I.U., Gul, R., Khan, W.U., Khan, M.A.U., and Lan, L. (2020). Antimicrobial and antioxidant chlorinated azaphilones from mangrove Diaporthe perseae sp. isolated from the stem of Chinese mangrove Pongamia pinnata. J. Asian Nat. Prod. Res.","DOI":"10.1080\/10286020.2020.1835872"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yang, Z.J., Zhang, Y.F., Wu, K., Xu, Y.X., Meng, X.G., Jiang, Z.T., Ge, M., and Shao, L. (2020). New azaphilones, phomopsones A-C with biological activities from an endophytic fungus Phomopsis sp. CGMCC No.5416. Fitoterapia, 145.","DOI":"10.1016\/j.fitote.2020.104573"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00449-019-02211-9","article-title":"Antioxidant compounds extracted from Diaporthe schini using supercritical CO2 plus cosolvent","volume":"43","author":"Kuhn","year":"2020","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Fan, M.M., Xiang, G., Chen, J.W., Gao, J., Xue, W.W., Wang, Y.X., Li, W.H., Zhou, L., Jiao, R.H., and Shen, Y. (2020). Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-\u03baB and NLRP3 inflammasome activation. Int. Immunopharmacol., 80.","DOI":"10.1016\/j.intimp.2019.106144"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1139\/v92-286","article-title":"Phytotoxic metabolites of Phomopsis convolvulus, a host-specific pathogen of field bindweed","volume":"70","author":"Tsantrizos","year":"1992","journal-title":"Can. J. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/np049591n","article-title":"Tenellones A and B from a Diaporthe sp.: Two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity","volume":"68","author":"Zhang","year":"2005","journal-title":"J. Nat. Prod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fitote.2013.09.004","article-title":"Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp.","volume":"91","author":"Yang","year":"2013","journal-title":"Fitoterapia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10600-013-0498-z","article-title":"A new xanthone derivative from the marine fungus Phomopsis sp. (No. SK7RN3G1)","volume":"49","author":"Yang","year":"2013","journal-title":"Chem. Nat. Compd."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s10600-015-1315-7","article-title":"Isolation of xanthones from the fermentation products of the endophytic fungus of Phomopsis amygdali","volume":"51","author":"Yuan","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s10600-015-1295-7","article-title":"Secondary metabolites of an endophytic fungus Phomopsis sp.","volume":"51","author":"Huang","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3987\/COM-14-13136","article-title":"Xanthones from the fermentation products of an endophytic fungus Phomopsis sp.","volume":"91","author":"Yuan","year":"2015","journal-title":"Heterocycles"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.14233\/ajchem.2014.16127","article-title":"A new xanthone from the fermentation products of endophytic fungus of Phomopsis species","volume":"26","author":"Yang","year":"2014","journal-title":"Asian J. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s10600-015-1314-8","article-title":"Xanthones from the fermentation products of the endophytic fungus of Phomopsis amygdali","volume":"51","author":"Hu","year":"2015","journal-title":"Chem. Nat. Compd."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10600-013-0497-0","article-title":"A new xanthone O-glycoside from the mangrove endophytic fungus Phomopsis sp.","volume":"49","author":"Huang","year":"2013","journal-title":"Chem. Nat. Compd."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12409","DOI":"10.1021\/jo402066b","article-title":"Pro-apoptotic and immunostimulatory tetrahydroxanthone dimers from the endophytic fungus Phomopsis longicolla","volume":"78","author":"Roensberg","year":"2013","journal-title":"J. Org. Chem."},{"key":"ref_32","first-page":"1735","article-title":"Isolation of a phomoxanthone A derivative, a new metabolite of tetrahydroxanthone, from a Phomopsis sp. isolated from the mangrove, Rhizhopora mucronata","volume":"8","author":"Shiono","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Meixiang, H., Jing, L., Lan, L., Sheng, Y., Jun, W., and Yongcheng, L.J.M.D. (2016). Phomopsichin A\u2013D; four new chromone derivatives from mangrove endophytic fungus Phomopsis sp. 33#. Mar. Drugs, 14.","DOI":"10.3390\/md14110215"},{"key":"ref_34","first-page":"494","article-title":"Identification, fermentation, and bioactivity against xanthomonas oryzae of antimicrobial metabolites isolated from Phomopsis longicolla S1B4","volume":"20","author":"Lim","year":"2010","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.3390\/md11124961","article-title":"New dimeric members of the phomoxanthone family: Phomolactonexanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp.","volume":"11","author":"Ding","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1002\/cjoc.201700375","article-title":"Three new chromone derivatives produced by Phomopsis sp. HNY29-2B from Acanthus ilicifolius linn","volume":"35","author":"Ding","year":"2017","journal-title":"Chin. J. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1007\/s10600-013-0433-3","article-title":"Two new cytosporones from the culture of endophytic Phomopsis sp.","volume":"48","author":"Wu","year":"2013","journal-title":"Chem. Nat. Compd."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.fitote.2018.11.004","article-title":"Xanthone-derived polyketides from the Thai mangrove endophytic fungus Phomopsis sp. xy21","volume":"131","author":"Hu","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s10600-014-0976-y","article-title":"A new isochroman derivative from the marine fungus Phomopsis sp. (No. Gx-4)","volume":"50","author":"Yang","year":"2014","journal-title":"Chem. Nat. Compd."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1002\/ejoc.201100158","article-title":"Three new antimicrobial metabolites from the endophytic fungus Phomopsis sp.","volume":"2011","author":"Ahmed","year":"2011","journal-title":"Eur. J. Org. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41429-019-0270-0","article-title":"Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416","volume":"73","author":"Yang","year":"2020","journal-title":"J. Antibiot."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10600-010-9514-8","article-title":"A new naphtho-\u03b3-pyrone from mangrove endophytic fungus ZSU-H26","volume":"46","author":"Huang","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1002\/ejoc.201000329","article-title":"Metabolites from the mangrove endophytic fungus Phomopsis sp. (#zsu-H76)","volume":"2010","author":"Yang","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10600-011-9820-9","article-title":"A new isochroman derivative from the marine fungus Phomopsis sp. (No. ZH-111)","volume":"47","author":"Yang","year":"2011","journal-title":"Chem. Nat. Compd."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1016\/j.tet.2017.02.019","article-title":"Polyketides from the endophytic fungus Phomopsis sp. sh917 by using the one strain\/many compounds strategy","volume":"73","author":"Tang","year":"2017","journal-title":"Tetrahedron"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.phytochem.2013.02.012","article-title":"Bioactive polyketides isolated from agar-supported fermentation of Phomopsis sp. CMU-LMA, taking advantage of the scale-up device, Platotex","volume":"93","author":"Adelin","year":"2013","journal-title":"Phytochemistry"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/hlca.201300367","article-title":"Chemical constituents of the endophytic fungus Phomopsis sp. A240 isolated from Taxus chinensis var. mairei","volume":"97","author":"Tao","year":"2014","journal-title":"Helv. Chim. Acta"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.phytol.2012.06.017","article-title":"Depsidones and other constituents from Phomopsis sp. CAFT69 and its host plant Endodesmia calophylloides with potent inhibitory effect on motility of zoospores of grapevine pathogen Plasmopara viticola","volume":"5","author":"Talontsi","year":"2012","journal-title":"Phytochem. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.3390\/molecules19056597","article-title":"Bioactive secondary metabolites from Phomopsis sp., an endophytic fungus from Senna spectabilis","volume":"19","author":"Chapla","year":"2014","journal-title":"Molecules"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.fitote.2014.05.001","article-title":"Phomopsidone A, a novel depsidone metabolite from the mangrove endophytic fungus Phomopsis sp. A123","volume":"96","author":"Zhang","year":"2014","journal-title":"Fitoterapia"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9112","DOI":"10.1016\/j.tet.2015.10.015","article-title":"Bioactive oxygen-bridged cyclooctadienes from endophytic fungus Phomopsis sp. BCC 45011","volume":"71","author":"Kornsakulkarn","year":"2015","journal-title":"Tetrahedron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.bioorg.2019.03.078","article-title":"Lithocarols A-F, six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508","volume":"87","author":"Xu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.phytol.2016.04.003","article-title":"Three new 3-methyl-2-arylbenzofurans from the fermentation products of an endophytic fungus Phomopsis sp. and their anti-TMV activity","volume":"21","author":"Du","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.phytol.2017.06.020","article-title":"Bioactive 2-pyrone metabolites from an endophytic Phomopsis asparagi SWUKJ5.2020 of Kadsura angustifolia","volume":"22","author":"Song","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fitote.2011.12.017","article-title":"Pyrenocines J-M: Four new pyrenocines from the endophytic fungus, Phomopsis sp.","volume":"83","author":"Hussain","year":"2012","journal-title":"Fitoterapia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.phytol.2013.02.003","article-title":"Phomonaphthalenone A: A novel dihydronaphthalenone with anti-HIV activity from Phomopsis sp. HCCB04730","volume":"6","author":"Yang","year":"2013","journal-title":"Phytochem. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1080\/14786419.2017.1300799","article-title":"A new biphenyl derivative from the mangrove endophytic fungus Phomopsis longicolla HL-2232","volume":"31","author":"Li","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/lam.12384","article-title":"Altersolanol A: A selective cytotoxic anthraquinone from a Phomopsis sp.","volume":"60","author":"Mishra","year":"2015","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10658-011-9743-0","article-title":"Phytotoxic polyketides produced by Phomopsis foeniculi, a strain isolated from diseased Bulgarian fennel","volume":"130","author":"Evidente","year":"2011","journal-title":"Eur. J. Plant Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.phytol.2012.08.003","article-title":"Anthraquinone derivatives from the mangrove-derived fungus Phomopsis sp. PSU-MA214","volume":"5","author":"Klaiklay","year":"2012","journal-title":"Phytochem. Lett."},{"key":"ref_61","first-page":"1905","article-title":"Antimicrobial chemical constituents from the endophytic fungus Phomopsis sp. from Notobasis syriaca","volume":"6","author":"Hussain","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/14786419.2016.1214833","article-title":"A new \u03b1-pyrone from the mangrove endophytic fungus Phomopsis sp. HNY29-2B","volume":"31","author":"Cai","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_63","first-page":"1907","article-title":"Phomosines H-J, novel highly substituted biaryl ethers, isolated from the endophytic fungus Phomopsis sp. from Ligustrum vulgare","volume":"6","author":"Krohn","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10600-019-02828-y","article-title":"Two new diphenyl ether derivatives from the fermentation products of the endophytic fungus Phomopsis asparagi","volume":"55","author":"Hu","year":"2019","journal-title":"Chem. Nat. Compd."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/10286020.2017.1421177","article-title":"Three new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii","volume":"21","author":"Gao","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41429-017-0006-y","article-title":"Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii","volume":"71","author":"Li","year":"2018","journal-title":"J. Antibiot."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s10600-019-02706-7","article-title":"Two new diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii","volume":"55","author":"Yang","year":"2019","journal-title":"Chem. Nat. Compd."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.phytol.2017.10.021","article-title":"Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii","volume":"22","author":"Yang","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s10600-019-02762-z","article-title":"Two new naphthalene derivatives from the fermentation products of an endophytic fungus Phomopsis sp.","volume":"55","author":"Li","year":"2019","journal-title":"Chem. Nat. Compd."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Xu, J.L., Liu, H.X., Chen, Y.C., Tan, H.B., Guo, H., Xu, L.Q., Li, S.N., Huang, Z.L., Li, H.H., and Gao, X.X. (2018). Highly substituted benzophenone aldehydes and eremophilane derivatives from the deep-Sea derived fungus Phomopsis lithocarpus FS508. Mar. Drugs, 16.","DOI":"10.3390\/md16090329"},{"key":"ref_71","first-page":"669","article-title":"Bioactiye metabolites produced by the endophytic fungus Phomopsis sp. YM355364","volume":"9","author":"Ma","year":"2014","journal-title":"Nat. Prod. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"42","DOI":"10.25135\/rnp.134.19.01.1243","article-title":"Histone deacetylase inhibitor induced lipase Inhibitors from endophytic Phomopsis sp. 0391","volume":"14","author":"Sheng","year":"2020","journal-title":"Rec. Nat. Prod."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.phytol.2017.10.002","article-title":"Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188","volume":"22","author":"Kongprapan","year":"2017","journal-title":"Phytochem. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cclet.2018.09.018","article-title":"Lithocarpinols A and B, a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508","volume":"30","author":"Xu","year":"2019","journal-title":"Chin. Chem. Lett."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s10600-010-9576-7","article-title":"A new indene derivative from the marine fungus Phomopsis sp. (No. GX7-4A)","volume":"46","author":"Chen","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tan, Q.W., Fang, P.H., Ni, J.C., Gao, F., and Chen, Q.J. (2017). Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity. Molecules, 22.","DOI":"10.3390\/molecules22122073"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ja.2017.125","article-title":"New eremophilane and dichlororesorcinol derivatives produced by endophytes isolated from Ficus ampelas","volume":"70","author":"Shiono","year":"2017","journal-title":"J. Antibiot."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/np900650c","article-title":"Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789","volume":"73","author":"Bunyapaiboonsri","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.3390\/molecules16043351","article-title":"Three new oblongolides from Phomopsis sp. XZ-01, an endophytic fungus from Camptotheca acuminate","volume":"16","author":"Lin","year":"2011","journal-title":"Molecules"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1021\/acs.jafc.7b04998","article-title":"Polyoxygenated cyclohexenoids with promising \u03b1-glycosidase inhibitory activity produced by Phomopsis sp. YE3250, an endophytic fungus derived from Paeonia delavayi","volume":"66","author":"Huang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/np300200j","article-title":"Phomentrioloxin: A phytotoxic pentasubstituted geranylcyclohexentriol produced by Phomopsis sp., a potential mycoherbicide for Carthamus lanatus Biocontrol","volume":"75","author":"Cimmino","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1021\/jf501141g","article-title":"Differential production of phytotoxins from Phomopsis sp. from grapevine plants showing esca symptoms","volume":"62","author":"Goddard","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1021\/acs.jnatprod.7b00889","article-title":"Protoilludane, illudalane, and botryane sesquiterpenoids from the endophytic fungus Phomopsis sp. TJ507A","volume":"81","author":"Xie","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1590\/S0100-40422012001100026","article-title":"Sesquiterpenes produced by endophytic fungus Phomopsis cassiae with antifungal and acetylcholinesterase inhibition activities","volume":"35","author":"Zanardi","year":"2012","journal-title":"Quim. Nova"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/np100632g","article-title":"Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from Phomopsis archeri","volume":"74","author":"Hemtasin","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/14786419.2015.1055742","article-title":"A new sesquiterpene from the entomogenous fungus Phomopsis amygdali","volume":"30","author":"Ma","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10600-018-2340-0","article-title":"Secondary metabolites of an endophytic fungus Phomopsis castaneae-mollissimae","volume":"54","author":"Qian","year":"2018","journal-title":"Chem. Nat. Compd."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1002\/ejoc.201402491","article-title":"Immunosuppressive diterpenes from Phomopsis sp. S12","volume":"2014","author":"Wei","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Xu, K., Zhang, X., Chen, J.W., Shen, Y., Jiang, N., Tan, R.X., Jiao, R.H., and Ge, H.M. (2019). Anti-inflammatory diterpenoids from an endophytic fungus Phomopsis sp. S12. Tetrahedron Lett., 60.","DOI":"10.1016\/j.tetlet.2019.151045"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ja.2013.70","article-title":"Stereochemical determination of a new and cytotoxic euphane triterpenoid from the plant endophytic fungus Phomopsis chimonanthi","volume":"66","author":"Zhang","year":"2013","journal-title":"J. Antibiot."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Peyrat, L.A., Eparvier, V., Eydoux, C., Guillemot, J.C., Litaudon, M., and Stien, D. (2017). Betulinic acid, the first lupane-type triterpenoid isolated from both a Phomopsis sp. and its host plant Diospyros carbonaria benoist. Chem. Biodivers., 14.","DOI":"10.1002\/cbdv.201600171"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/cbdv.201200415","article-title":"Two new steroids from an endophytic fungus Phomopsis sp.","volume":"10","author":"Wu","year":"2013","journal-title":"Chem. Biodivers."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1021\/acs.orglett.6b03557","article-title":"Phomopsterones A and B, two functionalized ergostane-type steroids from the endophytic fungus Phomopsis sp. TJ507A","volume":"19","author":"Hu","year":"2017","journal-title":"Org. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.phytochem.2011.08.010","article-title":"Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA","volume":"72","author":"Adelin","year":"2011","journal-title":"Phytochemistry"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1039\/C8QO00095F","article-title":"Lithocarpins A-D: Four tenellone-macrolide conjugated [4 + 2] hetero-adducts from the deep-sea derived fungus Phomopsis lithocarpus FS508","volume":"5","author":"Xu","year":"2018","journal-title":"Org. Chem. Front."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1021\/acs.orglett.6b00214","article-title":"Phomopchalasins A and B, two cytochalasans with polycyclic-fused skeletons from the endophytic fungus Phomopsis sp. shj2","volume":"18","author":"Yan","year":"2016","journal-title":"Org. Lett."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.phytol.2016.07.027","article-title":"Cytochalasins from mangrove endophytic fungi Phomopsis spp. xy21 and xy22","volume":"17","author":"Luo","year":"2016","journal-title":"Phytochem. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Jouda, J.B., Tamokou, J.D.D., Mbazoa, C.D., Douala-Meli, C., Sarkar, P., Bag, P.K., and Wandji, J. (2016). Antibacterial and cytotoxic cytochalasins from the endophytic fungus Phomopsis sp. harbored in Garcinia kola (Heckel) nut. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1454-9"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.5897\/AJMR11.272","article-title":"Antifungal metabolites from Phomopsis sp. By254, an endophytic fungus in Gossypium hirsutum","volume":"5","author":"Fu","year":"2011","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s10600-018-2390-3","article-title":"Chemical constituents of the endophytic fungus Phomopsis asparagi isolated from the plant Peperomia sui","volume":"54","author":"Chang","year":"2018","journal-title":"Chem. Nat. Compd."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Chen, S.C., Liu, Z.M., Tan, H.B., Chen, Y.C., Li, S.N., Li, H.H., Guo, H., Zhu, S., Liu, H.X., and Zhang, W.M. (2019). Tersone A-G, new pyridone alkaloids from the deep-sea fungus Phomopsis tersa. Mar. Drugs, 17.","DOI":"10.3390\/md17070394"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fitote.2017.10.013","article-title":"Phochrodines A-D, first naturally occurring new chromenopyridines from mangrove entophytic fungus Phomopsis sp. 33#","volume":"124","author":"Chen","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ja.2014.58","article-title":"Anticancer activity of new depsipeptide compound isolated from an endophytic fungus","volume":"67","author":"Verekar","year":"2014","journal-title":"J. Antibiot."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1021\/cr960025+","article-title":"Manipulation of modular polyketide syntheses","volume":"97","author":"Katz","year":"1997","journal-title":"Chem. Rev."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Le Pogam, P., and Boustie, J. (2016). Xanthones of lichen source: A 2016 update. Molecules, 21.","DOI":"10.3390\/molecules21030294"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fitote.2019.04.012","article-title":"The antitumor activity of naturally occurring chromones: A review","volume":"135","author":"Duan","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molstruc.2017.05.013","article-title":"Synthesis, structural characterisation and biological evolution of chromanones","volume":"1145","author":"Mayuri","year":"2017","journal-title":"J. Mol. Struct."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/adsc.201301038","article-title":"Catalytic asymmetric synthesis of chiral benzofuranones","volume":"356","author":"Li","year":"2014","journal-title":"Adv. Synth. Catal."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1039\/b416651p","article-title":"2-Pyrone natural products and mimetics: Isolation, characterisation and biological activity","volume":"22","author":"McGlacken","year":"2005","journal-title":"Nat. Prod. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.chemrestox.6b00256","article-title":"Formation and biological targets of quinones: Cytotoxic versus cytoprotective effects","volume":"30","author":"Bolton","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2174\/1389200023337388","article-title":"The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers","volume":"3","author":"Jones","year":"2002","journal-title":"Curr. Drug Metab."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1007\/s13197-017-2756-8","article-title":"Antidiabetic and antioxidant functionality associated with phenolic constituents from fruit parts of indigenous black jamun (Syzygium cumini L.) landraces","volume":"54","author":"Gajera","year":"2017","journal-title":"J. Food Sci. Technol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1021\/jo00123a011","article-title":"A short synthesis of natural (\u2212)-oblongolide via an intramolecular or a transannular diels-alder reaction","volume":"60","author":"Shing","year":"1995","journal-title":"J. Org. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1517\/13543784.2012.727395","article-title":"Terpenoids: Natural products for cancer therapy","volume":"21","author":"Huang","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4254\/wjh.v3.i9.228","article-title":"Terpenoids as potential chemopreventive and therapeutic agents in liver cancer","volume":"3","author":"Thoppil","year":"2011","journal-title":"World J. Hepatol."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Zielinska-Blajet, M., and Feder-Kubis, J. (2020). Monoterpenes and their derivatives-recent development in biological and medical applications. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197078"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Chen, D.L., Wang, B.W., Sun, Z.C., Yang, J.S., Xu, X.D., and Ma, G.X. (2020). Natural nitrogenous sesquiterpenoids and their bioactivity: A review. Molecules, 25.","DOI":"10.3390\/molecules25112485"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.tifs.2019.02.003","article-title":"Recent advances in the development of sesquiterpenoids in the treatment of type 2 diabetes","volume":"88","author":"Chen","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Su, Y.D., Su, J.H., Hwang, T.L., Wen, Z.H., Sheu, J.H., Wu, Y.C., and Sung, P.J. (2017). Briarane diterpenoids isolated from octocorals between 2014 and 2016. Mar. Drugs, 15.","DOI":"10.3390\/md15020044"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1055\/a-0832-2383","article-title":"Natural product triterpenoids and their semi-synthetic derivatives with potential anticancer activity","volume":"85","author":"Ren","year":"2019","journal-title":"Planta Med."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Rahman, S.U., Ismail, M., Khurram, M., Ullah, I., Rabbi, F., and Iriti, M. (2017). Bioactive steroids and saponins of the genus Trillium. Molecules, 22.","DOI":"10.3390\/molecules22122156"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Wang, M., Zhang, J., He, S., and Yan, X. (2017). A review study on macrolides isolated from cyanobacteria. Mar. Drugs, 15.","DOI":"10.3390\/md15050126"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ejmech.2017.06.005","article-title":"Drug development against tuberculosis: Impact of alkaloids","volume":"137","author":"Mishra","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_124","first-page":"12","article-title":"Bioactive flavonoids in medicinal plants: Structure, activity and biological fate","volume":"13","author":"Wang","year":"2018","journal-title":"Asian J. Pharm."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Luo, X., Yang, J., Chen, F., Lin, X., Chen, C., Zhou, X., Liu, S., and Liu, Y. (2018). Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Front. Chem., 6.","DOI":"10.3389\/fchem.2018.00282"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Liu, Y., Ruan, Q., Jiang, S., Qu, Y., Chen, J., Zhao, M., Yang, B., Liu, Y., Zhao, Z., and Cui, H. (2019). Cytochalasins and polyketides from the fungus Diaporthe sp. GZU-1021 and their anti-inflammatory activity. Fitoterapia, 137.","DOI":"10.1016\/j.fitote.2019.104187"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Niu, Z., Chen, Y., Guo, H., Li, S.N., Li, H.H., Liu, H.X., Liu, Z., and Zhang, W. (2019). Cytotoxic polyketides from a deep-sea sediment derived fungus Diaporthe phaseolorum FS431. Molecules, 24.","DOI":"10.3390\/molecules24173062"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"20128","DOI":"10.1039\/C7RA03032K","article-title":"Chroman-4-one and pyrano[4,3-b]chromenone derivatives from the mangrove endophytic fungus Diaporthe phaseolorum SKS019","volume":"7","author":"Cui","year":"2017","journal-title":"RSC Adv."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fitote.2018.04.009","article-title":"Dothiorelone derivatives from an endophyte Diaporthe pseudomangiferaea inhibit the activation of human lung fibroblasts MRC-5 cells","volume":"127","author":"Liu","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s11418-011-0518-x","article-title":"Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius","volume":"65","author":"Bungihan","year":"2011","journal-title":"J. Nat. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12223-018-0587-2","article-title":"Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds","volume":"63","author":"Savi","year":"2018","journal-title":"Folia Microbiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/ps.4712","article-title":"Isolation of a phytotoxic isocoumarin from Diaporthe eres-infected Hedera helix (English ivy) and synthesis of its phytotoxic analogs","volume":"74","author":"Meepagala","year":"2018","journal-title":"Pest Manag. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.bmcl.2018.04.018","article-title":"Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill","volume":"28","author":"Sharma","year":"2018","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1080\/14786419.2013.791819","article-title":"A new polyketide from Diaporthe sp. SXZ-19, an endophytic fungal strain of Camptotheca acuminate","volume":"27","author":"Liu","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/chir.22466","article-title":"Structure and absolute configuration of kongiidiazadione, a new phytotoxic 3-substituted-5-diazenylcyclopentendione produced by Diaporthe Kongii","volume":"27","author":"Evidente","year":"2015","journal-title":"Chirality"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.funbio.2016.05.007","article-title":"Production of antifungal and antiinsectan metabolites by the Picea endophyte Diaporthe maritima sp. nov","volume":"120","author":"Tanney","year":"2016","journal-title":"Fungal Biol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Riga, R., Happyana, N., Quentmeier, A., Zammarelli, C., Kayser, O., and Hakim, E.H. (2019). Secondary metabolites from Diaporthe lithocarpus isolated from Artocarpus heterophyllus. Nat. Prod. Res.","DOI":"10.1080\/14786419.2019.1672685"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/ps.5673","article-title":"Antifeedant, contact toxicity and oviposition deterrent effects of phyllostine acetate and phyllostine isolated from the endophytic fungus Diaporthe miriciae against Plutella xylostella larvae","volume":"76","author":"Ratnaweera","year":"2020","journal-title":"Pest Manag. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"160","DOI":"10.7454\/mss.v20i4.6703","article-title":"Antifungal activity of (+)-2,2\u2032-epicytoskyrin A and its membrane-disruptive action","volume":"20","author":"Wulansari","year":"2016","journal-title":"Makara J. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.fitote.2018.05.032","article-title":"Cytoskyrin C, an unusual asymmetric bisanthraquinone with cage-like skeleton from the endophytic fungus Diaporthe sp.","volume":"128","author":"Tian","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1590\/S1517-83822012000300045","article-title":"Chemical characterization of bioactive compounds from the endophytic fungus Diaporthe helianthi isolated from Luehea divaricata","volume":"43","author":"Specian","year":"2012","journal-title":"Braz. J. Microbiol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Reveglia, P., Pacetti, A., Masi, M., Cimmino, A., Carella, G., Marchi, G., Mugnai, L., and Evidente, A. (2019). Phytotoxic metabolites produced by Diaporthe eres involved in cane blight of grapevine in Italy. Nat. Prod. Res.","DOI":"10.1080\/14786419.2019.1679133"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Noriler, S.A., Savi, D.C., Ponomareva, L.V., Rodrigues, R., Rohr, J., Thorson, J.S., Glienke, C., and Shaaban, K.A. (2019). Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae. Fitoterapia, 138.","DOI":"10.1016\/j.fitote.2019.104273"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/jam.13132","article-title":"Chemical constituents and their antibacterial activity from the tropical endophytic fungus Diaporthe sp. F2934","volume":"120","author":"Sousa","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1016\/j.tetlet.2014.03.110","article-title":"Dihydroanthracenone metabolites from the endophytic fungus Diaporthe melonis isolated from Annona squamosa","volume":"55","author":"Ola","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.tetlet.2018.02.032","article-title":"Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.","volume":"59","author":"Nakashima","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1021\/acs.orglett.7b02748","article-title":"Diaporisoindoles A-C: Three isoprenylisoindole alkaloid derivatives from the mangrove endophytic fungus Diaporthe sp. SYSU-HQ3","volume":"19","author":"Cui","year":"2017","journal-title":"Org. Lett."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"11804","DOI":"10.1021\/acs.joc.8b01738","article-title":"Diaporindenes A-D: Four unusual 2,3-dihydro-1H-indene analogues with anti-inflammatory activities from the mangrove endophytic fungus Diaporthe sp. SYSU-HQ3","volume":"83","author":"Cui","year":"2018","journal-title":"J. Org. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/np500570h","article-title":"Gulypyrones A and B and phomentrioloxins B and C Produced by Diaporthe gulyae, a potential mycoherbicide for saffron thistle (Carthamus lanatus)","volume":"78","author":"Andolfi","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/acs.jnatprod.7b01053","article-title":"Isochromophilones A-F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011","volume":"81","author":"Luo","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"17559","DOI":"10.1039\/C4RA13136C","article-title":"Sesquiterpenoids isolated from an endophyte fungus Diaporthe sp.","volume":"5","author":"Chen","year":"2015","journal-title":"RSC Adv."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1021\/np501029s","article-title":"Secondary metabolites isolated from the amazonian endophytic fungus Diaporthe sp. SNB-GSS10","volume":"78","author":"Mandavid","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Liu, H., Chen, Y., Li, H., Li, S., Tan, H., Liu, Z., Li, D., Liu, H., and Zhang, W. (2019). Four new metabolites from the endophytic fungus Diaporthe lithocarpus A740. Fitoterapia, 137.","DOI":"10.1016\/j.fitote.2019.104260"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1021\/acs.jnatprod.5b00170","article-title":"Endophytic Diaporthe sp. LG23 produces a potent antibacterial tetracyclic triterpenoid","volume":"78","author":"Li","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/09168451.2015.1015953","article-title":"Relative and absolute structure of phomolide C","volume":"79","author":"Ito","year":"2015","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ja.2016.109","article-title":"Diapolic acid A-B from an endophytic fungus, Diaporthe terebinthifolii depicting antimicrobial and cytotoxic activity","volume":"70","author":"Yedukondalu","year":"2017","journal-title":"J. Antibiot."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s00436-017-5451-9","article-title":"18-Des-hydroxy cytochalasin: An antiparasitic compound of Diaporthe phaseolorum-92C, an endophytic fungus isolated from Combretum lanceolatum Pohl ex Eichler","volume":"116","author":"Brissow","year":"2017","journal-title":"Parasitol. Res."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Huang, X., Zhou, D., Liang, Y., Liu, X., Cao, F., Qin, Y., Mo, T., Xu, Z., Li, J., and Yang, R. (2019). Cytochalasins from endophytic Diaporthe sp. GDG-118. Nat. Prod. Res.","DOI":"10.1080\/14786419.2019.1700504"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ijch.201800158","article-title":"Natural products from Diaporthe arecae with anti-angiogenic activity","volume":"59","author":"Chang","year":"2019","journal-title":"Isr. J. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bmcl.2017.01.029","article-title":"Alkaloids from the mangrove endophytic fungus Diaporthe phaseolorum SKS019","volume":"27","author":"Cui","year":"2017","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1021\/acs.jnatprod.6b00662","article-title":"Detection of a toxic methylated derivative of phomopsin A produced by the legume-infesting fungus Diaporthe toxica","volume":"80","author":"Schloss","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s00284-012-0206-4","article-title":"3-Hydroxypropionic acid as an antibacterial agent from endophytic fungi Diaporthe phaseolorum","volume":"65","author":"Sebastianes","year":"2012","journal-title":"Curr. Microbiol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"41810","DOI":"10.1039\/C8RA08822E","article-title":"Potential antihyperlipidemic polyketones from endophytic Diaporthe sp. JC-J7 in Dendrobium nobile","volume":"8","author":"Hu","year":"2018","journal-title":"RSC Adv."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.4014\/jmb.1612.12009","article-title":"Endophytic Diaporthe sp. ED2 produces a novel anti-candidal ketone derivative","volume":"27","author":"Yenn","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1080\/00397911.2020.1731549","article-title":"Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one","volume":"50","author":"Hashem","year":"2020","journal-title":"Synth. Commun."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/cbdv.201400331","article-title":"Merosesquiterpenoids and ten-membered macrolides from a soft coral-derived Lophiostoma sp. fungus","volume":"12","author":"Zheng","year":"2015","journal-title":"Chem. Biodivers."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Jozwiak, M., Filipowska, A., Fiorino, F., and Struga, M. (2020). Anticancer activities of fatty acids and their heterocyclic derivatives. Eur. J. Pharmacol., 871.","DOI":"10.1016\/j.ejphar.2020.172937"}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/217\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:13:35Z","timestamp":1760159615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,21]]},"references-count":167,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["microorganisms9020217"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms9020217","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,21]]}}}