{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:39:06Z","timestamp":1789213146953,"version":"build-2803163510"},"reference-count":84,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Corynebacterium species are commonly found in the conjunctiva of healthy adults and are recognized as non-pathogenic bacteria. In recent years, however, Corynebacterium species have been reported to be potentially pathogenic in various tissues. We investigated Corynebacterium species on the ocular surface and reviewed various species of Corynebacterium in terms of their antimicrobial susceptibility and the underlying molecular resistance mechanisms. We identified a risk for Corynebacterium-related ocular infections in patients with poor immunity, such as patients with diabetes or long-term users of topical steroids, and in those with corneal epithelial damage due to trauma, contact lens wear, lagophthalmos, and trichiasis. The predominant strain in the conjunctiva was C. macginleyi, and the species associated with keratitis and conjunctivitis were C. macginleyi, C. propinquum, C. mastitidis, C. pseudodiphtheriticum, C. accolens, C. striatum, C. xerosis, and C. bovis. Overall, Corynebacterium species present on the ocular surface were resistant to quinolones, whereas those in the nasal cavity were more susceptible. The prevalence of fluoroquinolone-resistant Corynebacterium has not changed in the past 10 years; however, Corynebacterium species remain susceptible to third-generation cephems. In conclusion, the use of third-generation cephems should be a reasonable and pragmatic approach for treatment of ocular infections caused by Corynebacterium species.<\/jats:p>","DOI":"10.3390\/microorganisms9020254","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T12:20:26Z","timestamp":1611750026000},"page":"254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Current Evidence for Corynebacterium on the Ocular Surface"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-3480","authenticated-orcid":false,"given":"Takanori","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-5776","authenticated-orcid":false,"given":"Koji","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-8046","authenticated-orcid":false,"given":"Hideto","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Sotozono","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10384-008-0517-y","article-title":"Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: A prospective randomized multicenter study","volume":"52","author":"Inoue","year":"2008","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_2","unstructured":"Davis, C.P. (1996). Normal flora. Medical Microbiology, University of Texas Medical Branch at Galveston. [4th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CMR.10.1.125","article-title":"Clinical microbiology of coryneform bacteria","volume":"10","author":"Funke","year":"1997","journal-title":"Clin. Microbiol Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.3389\/fmicb.2017.01937","article-title":"Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species","volume":"8","author":"Oliveira","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/eye.2016.143","article-title":"Risk factors for aerobic bacterial conjunctival flora in preoperative cataract patients","volume":"30","author":"Hoshi","year":"2016","journal-title":"Eye"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Petrillo, F., Pignataro, D., Lavano, M.A., Santella, B., Folliero, V., Zannella, C., Astarita, C., Gagliano, C., Franci, G., and Avitabile, T. (2020). Current Evidence on the Ocular Surface Microbiota and Related Diseases. Microorganisms, 8.","DOI":"10.3390\/microorganisms8071033"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1128\/JCM.36.12.3670-3673.1998","article-title":"Corynebacterium macginleyi has to date been isolated exclusively from conjunctival swabs","volume":"36","author":"Funke","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/JCM.01741-07","article-title":"High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi","volume":"46","author":"Eguchi","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/bjophthalmol-2015-306749","article-title":"Corynebacterium spp as causative agents of microbial keratitis","volume":"100","author":"Das","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.oret.2016.11.007","article-title":"Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes","volume":"1","author":"Kuriyan","year":"2017","journal-title":"Ophthalmol. Retin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1128\/jcm.34.5.1290-1292.1996","article-title":"Endocarditis of native aortic and mitral valves due to Corynebacterium accolens: Report of a case and application of phenotypic and genotypic techniques for identification","volume":"34","author":"Claeys","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1128\/JCM.02160-06","article-title":"Corynebacterium accolens isolated from breast abscess: Possible association with granulomatous mastitis","volume":"45","author":"Ang","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/JCM.00818-09","article-title":"Corynebacterium accolens-associated pelvic osteomyelitis","volume":"48","author":"Wong","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/ICO.0000000000000787","article-title":"Corynebacterium propinquum Keratitis Identified Using MALDI-TOF","volume":"35","author":"Badenoch","year":"2016","journal-title":"Cornea"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/bjophthalmol-2015-306641","article-title":"Corneal inlay implantation complicated by infectious keratitis","volume":"100","author":"Duignan","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1128\/JCM.00899-15","article-title":"Contact Lens-Related Infectious Keratitis with White Plaque Formation Caused by Corynebacterium propinquum","volume":"53","author":"Todokoro","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ruoff, K.L., Toutain-Kidd, C.M., Srinivasan, M., Lalitha, P., Acharya, N.R., Zegans, M.E., and Schwartzman, J.D. (2010). Corynebacterium macginleyi isolated from a corneal ulcer. Infect. Dis. Rep., 2.","DOI":"10.4081\/idr.2010.e3"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1128\/JCM.01289-10","article-title":"Corynebacterium macginleyi conjunctivitis in Canada","volume":"48","author":"Alsuwaidi","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1128\/JCM.01212-07","article-title":"Suture-related keratitis caused by Corynebacterium macginleyi","volume":"45","author":"Suzuki","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0732-8893(02)00438-8","article-title":"Corynebacterium macginleyi isolation from conjunctival swab in Italy","volume":"44","author":"Giammanco","year":"2002","journal-title":"Diagn Microbiol. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1046\/j.1442-9071.2000.00268.x","article-title":"Corynebacterium pseudodiphtheriticum keratitis and conjunctivitis: A case report","volume":"28","author":"Li","year":"2000","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Deguchi, H., Kitazawa, K., Kayukawa, K., Kondoh, E., Fukumoto, A., Yamasaki, T., Kinoshita, S., and Sotozono, C. (2018). The trend of resistance to antibiotics for ocular infection of Staphylococcus aureus, coagulase-negative staphylococci, and Corynebacterium compared with 10-years previous: A retrospective observational study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203705"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/ICO.0000000000002445","article-title":"Corynebacterium Species of the Conjunctiva and Nose: Dominant Species and Species-Related Differences of Antibiotic Susceptibility Profiles","volume":"11","author":"Hoshi","year":"2020","journal-title":"Cornea"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1099\/00207713-45-1-128","article-title":"Genomic diversity and phylogenetic relationships among lipid-requiring diphtheroids from humans and characterization of Corynebacterium macginleyi sp. nov","volume":"45","author":"Riegel","year":"1995","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00003226-199101000-00018","article-title":"Corynebacterium striatus keratitis","volume":"10","author":"Heidemann","year":"1991","journal-title":"Cornea"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0002-9394(89)90114-1","article-title":"Diphtheroids as ocular pathogens","volume":"108","author":"Rubinfeld","year":"1989","journal-title":"Am. J. Ophthalmol."},{"key":"ref_27","first-page":"1105","article-title":"A Case of lnfectious Keratitis Caused by Corynebacterium","volume":"26","author":"Inata","year":"2009","journal-title":"J. Eye"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/bjo.84.12.1420","article-title":"Corynebacterium macginleyi: A conjunctiva specific pathogen","volume":"84","author":"Joussen","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1016\/j.jcrs.2004.04.056","article-title":"Postoperative Corynebacterium macginleyi endophthalmitis","volume":"30","author":"Ferrer","year":"2004","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.37201\/req\/070.2019","article-title":"Decreased painful visual acuity. Corynebacterium macginleyi blebitis-endophthalmitis infection","volume":"33","year":"2020","journal-title":"Rev. Esp. Quim."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1097\/IJG.0000000000001051","article-title":"Corynebacterium macginleyi-associated Blebitis: A Case Report","volume":"27","author":"Qin","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Eguchi, H. (2013). Ocular infections caused by Corynebacterium species. Infection Control, IntechOpen.","DOI":"10.5772\/56214"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/00365540210147778","article-title":"Corynebacterium macginleyi isolated from urine in a patient with a permanent bladder catheter","volume":"34","author":"Villanueva","year":"2002","journal-title":"Scand. J. Infect. Dis"},{"key":"ref_34","first-page":"89","article-title":"A rare case of sepsis due to Corynebacterium macginleyi from central venous catheter in an elderly woman","volume":"35","author":"Mosele","year":"2012","journal-title":"New Microbiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10096-002-0870-6","article-title":"Highly resistant Corynebacterium macginleyi as cause of intravenous catheter-related infection","volume":"22","author":"Dobler","year":"2003","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijid.2007.07.004","article-title":"Septicemia caused by Corynebacterium macginleyi: A rare form of extraocular infection","volume":"12","author":"Regueiro","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0723-2020(11)80360-7","article-title":"Corynebacterium accolens sp. nov., a Gram-Positive Rod Exhibiting Satellitism, from Clinical Material","volume":"14","author":"Neubauer","year":"1991","journal-title":"Syst. Appl. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-6968.1993.tb06519.x","article-title":"Proposal of Corynebacterium propinquum sp. nov. for Corynebacterium group ANF-3 strains","volume":"113","author":"Riegel","year":"1993","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1099\/ijs.0.046979-0","article-title":"Emendation of the description of the species Corynebacterium propinquum to include strains which produce urease","volume":"63","author":"Bernard","year":"2013","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41479-018-0054-5","article-title":"Corynebacteria as a cause of pulmonary infection: A case series and literature review","volume":"10","author":"Yang","year":"2018","journal-title":"Pneumonia (Nathan)"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jiac.2013.10.013","article-title":"Corynebacterium propinquum as the first cause of infective endocarditis in childhood","volume":"20","author":"Kawasaki","year":"2014","journal-title":"J. Infect. Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Neemuchwala, A., Soares, D., Ravirajan, V., Marchand-Austin, A., Kus, J.V., and Patel, S.N. (2018). In Vitro Antibiotic Susceptibility Pattern of Non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016. Antimicrob. Agents Chemother., 62.","DOI":"10.1128\/AAC.01776-17"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1574-6968.1988.tb02755.x","article-title":"Corynebacterium amycolatum sp. nov. a new mycolic acid-less Corynebacterium species from human skin","volume":"49","author":"Collins","year":"1988","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/01676830.2017.1337172","article-title":"Orbital implant infection by Corynebacterium amycolatum","volume":"36","author":"Toribio","year":"2017","journal-title":"Orbit"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"13862","DOI":"10.1038\/s41598-017-14383-z","article-title":"RNase 7 participates in cutaneous innate control of Corynebacterium amycolatum","volume":"7","author":"Walter","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1093\/jac\/20.6.922","article-title":"Corynebacterium jeikeium (group JK) resistance to ciprofloxacin emerging during therapy","volume":"20","author":"Murphy","year":"1987","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/mdr.2010.0032","article-title":"High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species","volume":"16","author":"Esteban","year":"2010","journal-title":"Microb. Drug Resist."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1007\/BF01967505","article-title":"In vitro susceptibility of Corynebacterium group D2 and Corynebacterium jeikeium to twelve antibiotics","volume":"9","author":"Philippon","year":"1990","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/AAC.39.1.208","article-title":"Antimicrobial susceptibilities of Corynebacterium species and other non-spore-forming gram-positive bacilli to 18 antimicrobial agents","volume":"39","author":"Soriano","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1099\/00207713-47-4-1082","article-title":"Corynebacterium mastitidis sp. nov., isolated from milk of sheep with subclinical mastitis","volume":"47","author":"Collins","year":"1997","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1800046","DOI":"10.1002\/bies.201800046","article-title":"Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease","volume":"40","author":"Caspi","year":"2018","journal-title":"Bioessays"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1099\/ijsem.0.001059","article-title":"Corynebacterium lowii sp. nov. and Corynebacterium oculi sp. nov., derived from human clinical disease and an emended description of Corynebacterium mastitidis","volume":"66","author":"Bernard","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10384-011-0052-0","article-title":"Infectious keratitis caused by fluoroquinolone-resistant Corynebacterium","volume":"55","author":"Fukumoto","year":"2011","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_54","first-page":"1683","article-title":"Quinolone-resistant Corynebacterium Keratitis Successfully Treated with 1.5% Levofloxacin Ophthalmic Solution","volume":"31","author":"Sano","year":"2014","journal-title":"J. Eye"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/jac\/39.6.707","article-title":"Comparison of disc diffusion and agar dilution methods for antibiotic susceptibility testing of Campylobacter jejuni subsp. jejuni and Campylobacter coli","volume":"39","author":"Gaudreau","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1093\/jac\/dky276","article-title":"Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: The NordicAST CPE study","volume":"73","author":"Haldorsen","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1442-9071.2006.01143.x","article-title":"Bacteria commonly isolated from keratitis specimens retain antibiotic susceptibility to fluoroquinolones and gentamicin plus cephalothin","volume":"34","author":"Ly","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bjophthalmol-2015-306910","article-title":"Clinical features, microbiological profile and treatment outcome of patients with Corynebacterium endophthalmitis: Review of a decade from a tertiary eye care centre in southern India","volume":"100","author":"Joseph","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4103\/0301-4738.71678","article-title":"Etiology and antibacterial susceptibility pattern of community-acquired bacterial ocular infections in a tertiary eye care hospital in south India","volume":"58","author":"Bharathi","year":"2010","journal-title":"Indian J. Ophthalmol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ceo.13364","article-title":"Keratitis antimicrobial resistance surveillance program, Sydney, Australia: 2016 Annual Report","volume":"47","author":"Watson","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_61","first-page":"619","article-title":"Five Cases with Ocular Surface Infections in which Multidrug Resistant Coryneform Bacteria was Detected by the Disk Diffusion Method","volume":"37","author":"Hagihara","year":"2020","journal-title":"J. Eye"},{"key":"ref_62","first-page":"1341","article-title":"A case of corneal ulcer due to Corynebacterium speciesc resistant to multiple antibiotics","volume":"58","author":"Kishimoto","year":"2004","journal-title":"Jpn. J. Clin. Ophthalmol."},{"key":"ref_63","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/AAC.00996-10","article-title":"Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance","volume":"55","author":"Swick","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2958.2004.04158.x","article-title":"Interactions underlying assembly of the Escherichia coli AcrAB\u2013TolC multidrug efflux system","volume":"53","author":"Eswaran","year":"2004","journal-title":"Mol. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1128\/AAC.44.12.3322-3327.2000","article-title":"Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa","volume":"44","author":"Masuda","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3201\/eid0702.010239","article-title":"Emerging mechanisms of fluoroquinolone resistance","volume":"7","author":"Hooper","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1086\/514923","article-title":"Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance","volume":"27","author":"Hooper","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1099\/mic.0.26867-0","article-title":"Identification of a topoisomerase IV in actinobacteria: Purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489","volume":"150","author":"Schmutz","year":"2004","journal-title":"Microbiology (Reading)"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Hooper, D.C., and Jacoby, G.A. (2016). Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance. Cold Spring Harb. Perspect Med., 6.","DOI":"10.1101\/cshperspect.a025320"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nsmb.1892","article-title":"Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance","volume":"17","author":"Wohlkonig","year":"2010","journal-title":"Nat. Struct Mol. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1128\/AAC.49.5.1714-1719.2005","article-title":"Relationship between mutations in the gyrA gene and quinolone resistance in clinical isolates of Corynebacterium striatum and Corynebacterium amycolatum","volume":"49","author":"Sierra","year":"2005","journal-title":"Antimicrob. Agent Chemother."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1038\/s41598-017-10081-y","article-title":"Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital","volume":"7","author":"Alibi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s10482-019-01353-w","article-title":"Novel mutations in the QRDR region gyrA gene in multidrug-resistance Corynebacterium spp. isolates from intravenous sites","volume":"113","author":"Ramos","year":"2020","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1128\/JCM.00760-15","article-title":"Antimicrobial Treatment Options for Granulomatous Mastitis Caused by Corynebacterium Species","volume":"53","author":"Dobinson","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1016.e7","DOI":"10.1016\/j.cmi.2017.12.024","article-title":"Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients","volume":"24","author":"Nudel","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1128\/JCM.01532-10","article-title":"Pacemaker lead endocarditis due to multidrug-resistant Corynebacterium striatum detected with sonication of the device","volume":"48","author":"Oliva","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_78","first-page":"67","article-title":"A case of fatal sepsis due to multidrug-resistant Corynebacterium striatum","volume":"20","author":"Chatzopoulou","year":"2016","journal-title":"Hippokratia"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Goldner, N.K., Bulow, C., Cho, K., Wallace, M., Hsu, F.F., Patti, G.J., Burnham, C.A., Schlesinger, P., and Dantas, G. (2018). Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum. mSphere, 3.","DOI":"10.1128\/mSphereDirect.00371-18"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ramos, J.N., Souza, C., Faria, Y.V., da Silva, E.C., Veras, J.F.C., Baio, P.V.P., Seabra, S.H., de Oliveira Moreira, L., Hirata J\u00fanior, R., and Mattos-Guaraldi, A.L. (2019). Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4294-7"},{"key":"ref_81","first-page":"315","article-title":"Comparative Study Between Topical Gatifloxacin 0.5% and Moxifloxacin 0.5% as a Prophylactic Measure Before Intraocular Surgery","volume":"35","author":"Gabr","year":"2019","journal-title":"J. Ocul. Pharmacol. Ther. Off. J. Assoc. Ocul. Pharmacol. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1097\/ICO.0000000000002375","article-title":"In Vitro Antimicrobial Activity of a New Ophthalmic Solution Containing Hexamidine Diisethionate 0.05% (Keratosept)","volume":"39","author":"Pinna","year":"2020","journal-title":"Cornea"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.survophthal.2016.10.009","article-title":"Therapeutic agents and biocides for ocular infections by free-living amoebae of Acanthamoeba genus","volume":"62","author":"Foronda","year":"2017","journal-title":"Surv. Ophthalmol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1167\/iovs.16-20853","article-title":"Conjunctival Bacteria Flora of Glaucoma Patients During Long-Term Administration of Prostaglandin Analog Drops","volume":"58","author":"Ohtani","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/254\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:16:05Z","timestamp":1760159765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,27]]},"references-count":84,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["microorganisms9020254"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms9020254","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,27]]}}}