{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:38:55Z","timestamp":1790509135186,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T00:00:00Z","timestamp":1611964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","award":["Alberta Sepsis Network"],"award-info":[{"award-number":["Alberta Sepsis Network"]}],"id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007582","name":"Alberta Health Services","doi-asserted-by":"publisher","award":["Centre for Antimicrobial Resistance (CAR) operation fund"],"award-info":[{"award-number":["Centre for Antimicrobial Resistance (CAR) operation fund"]}],"id":[{"id":"10.13039\/100007582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>USA300 is a predominant and highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain that is a leading cause of skin and soft tissue infections. We established a murine intradermal infection model capable of demonstrating dermatopathological differences between USA300 and other MRSA strains. In this model, USA300 induced dermonecrosis, uniformly presenting as extensive open lesions with a histologically documented profound inflammatory cell infiltrate extending below the subcutis. In contrast, USA400 and a colonizing control strain M92 caused only localized non-ulcerated skin infections associated with a mild focal inflammatory infiltrate. It was also determined that the dermonecrosis induced by USA300 was associated with significantly increased neutrophil recruitment, inhibition of an antibacterial response, and increased production of cytokines\/chemokines associated with disease severity. These results suggest that induction of severe skin lesions by USA300 is related to over-activation of neutrophils, inhibition of host antibacterial responses, and selective alteration of host cytokine\/chemokine profiles.<\/jats:p>","DOI":"10.3390\/microorganisms9020287","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T21:15:51Z","timestamp":1612041351000},"page":"287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Murine Skin Infection Model Capable of Differentiating the Dermatopathology of Community-Associated MRSA Strain USA300 from Other MRSA Strains"],"prefix":"10.3390","volume":"9","author":[{"given":"Jack","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Conly","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Centre for Antimicrobial Resistance, Alberta Health Services, Alberta Precision Laboratories, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn","family":"McClure","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Centre for Antimicrobial Resistance, Alberta Health Services, Alberta Precision Laboratories, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u04e7rn","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Medicine, University of Western Ontario, London, ON N6A5C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1078-6011","authenticated-orcid":false,"given":"Kunyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Department of Medicine, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"Centre for Antimicrobial Resistance, Alberta Health Services, Alberta Precision Laboratories, University of Calgary, Calgary, AB T2N4N1, Canada"},{"name":"The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"David, M.Z., Cadilla, A., Boyle-Vavra, S., and Daum, R.S. 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