{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:26:08Z","timestamp":1792290368632,"version":"4.4.0"},"reference-count":90,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microorganisms"],"abstract":"<jats:p>Vector-borne parasitic infectious diseases are important causes of morbidity and mortality globally. Malaria is one of the most common vector-borne parasitic infection and is caused by five Plasmodium species, namely P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi. Epidemiologically, differences in the patterns of malaria cases, causative agent, disease severity, antimicrobial resistance, and mortality exist across diverse geographical regions. The world witnessed 229 million malaria cases which resulted in 409,000 deaths in 2019 alone. Although malaria cases are reported from 87 countries globally, Africa bears the brunt of these infections and deaths as nearly 94% of total malaria cases and deaths occur in this continent, particularly in sub-Saharan Africa. Most of the Middle East Region countries are malaria-free as no indigenous cases of infection have been described in recent years. However, imported cases of malaria continue to occur as some of these countries. Indeed, the six Gulf Cooperation Council (GCC) countries have large expatriate population originating from malaria endemic countries. In this review, the current status and epidemiology of malaria in the Middle East Region countries and other malaria-endemic countries that are home to a large migrant workforce being employed in Middle East Region countries are discussed.<\/jats:p>","DOI":"10.3390\/microorganisms9020338","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:08:12Z","timestamp":1613268492000},"page":"338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Current Status and the Epidemiology of Malaria in the Middle East Region and Beyond"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5668-1189","authenticated-orcid":false,"given":"Mohammad","family":"Al-Awadhi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-4781","authenticated-orcid":false,"given":"Suhail","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshaid","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Herricks, J.R., Hotez, P.J., Wanga, V., Coffeng, L.E., Haagsma, J.A., Bas\u00e1\u00f1ez, M.G., Buckle, G., Budke, C.M., Carabin, H., and F\u00e8vre, E.M. (2017). The global burden of disease study 2013: What does it mean for the NTDs?. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005424"},{"key":"ref_2","unstructured":"World Health Organization (2019). World Malaria Report, WHO. Available online: https:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2019\/en\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2214-109X(13)70032-9","article-title":"Domestic and donor financing for tuberculosis care and control in low-income and middle income countries: An analysis of trends, 2002\u20132011, 2002\u20132011, and requirements to meet 2015 targets","volume":"1","author":"Floyd","year":"2013","journal-title":"Lancet Glob. Health"},{"key":"ref_4","unstructured":"World Health Organization (2020). World Malaria Report, WHO. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240015791."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0972-9062.234620","article-title":"Epidemiology, drug resistance, and pathophysiology of Plasmodium vivax malaria","volume":"55","author":"Dayananda","year":"2018","journal-title":"J. Vector Borne Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/S0140-6736(13)60310-4","article-title":"The changing epidemiology of malaria elimination: New strategies for new challenges","volume":"382","author":"Cotter","year":"2013","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(14)60844-8","article-title":"Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Murray","year":"2014","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0140-6736(18)30324-6","article-title":"Malaria","volume":"391","author":"Ashley","year":"2018","journal-title":"Lancet"},{"key":"ref_9","first-page":"93","article-title":"Climate, environment and transmission of malaria","volume":"24","author":"Rossati","year":"2016","journal-title":"Infez. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0924-8579(02)00367-9","article-title":"Malaria: Still a threat to travellers","volume":"21","author":"Loutan","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00104","DOI":"10.1128\/CMR.00104-19","article-title":"Imported malaria in countries where malaria is not endemic: A comparison of semi-immune and nonimmune travelers","volume":"33","author":"Mischlinger","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2217\/fmb-2019-0212","article-title":"Update on the major imported protozoan infections in travelers and migrants","volume":"15","author":"Norman","year":"2020","journal-title":"Future Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.2147\/IDR.S279433","article-title":"Antimalarial drug resistance and novel targets for antimalarial drug discovery","volume":"13","author":"Shibeshi","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/1469-0691.12010","article-title":"Infectious diseases in the Arabian Peninsula and Egypt","volume":"18","author":"Shibl","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4269\/ajtmh.16-0339","article-title":"Burden of diarrhea in the Eastern Mediterranean Region, 1990\u20132013: Findings from the Global Burden of Disease Study 2013","volume":"95","author":"Khalil","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_16","first-page":"920","article-title":"Prevalence of S315T mutation within the katG gene in isoniazid-resistant clinical Mycobacterium tuberculosis isolates from Dubai and Beirut","volume":"6","author":"Ahmad","year":"2002","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0732-8893(02)00457-1","article-title":"Characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from Kuwait and Dubai","volume":"44","author":"Ahmad","year":"2002","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000081918","article-title":"Genotypic diversity among isoniazid-resistant isolates of Mycobacterium tuberculosis from Rashid Hospital in Dubai, United Arab Emirates","volume":"14","author":"Ahmad","year":"2005","journal-title":"Med. Princ. Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1080\/14787210.2018.1519393","article-title":"Prevalence of tuberculosis and multidrug resistant tuberculosis in the Middle East Region","volume":"16","author":"Ahmad","year":"2018","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000504625","article-title":"Cysticercosis, a potential public health concern in Kuwait: A new diagnostic method to screen Taenia solium taeniasis carriers in the expatriate population","volume":"29","author":"Iqbal","year":"2020","journal-title":"Med. Princ. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12936-020-03527-8","article-title":"Prevention of re-establishment of malaria: Historical perspective and future prospects","volume":"19","author":"Nasir","year":"2020","journal-title":"Malar. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2310\/7060.2004.17059","article-title":"Status of malaria in the Kingdom of Bahrain: A 10-year review","volume":"11","author":"Ismaeel","year":"2004","journal-title":"J. Travel Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1708-8305.2008.00285.x","article-title":"Epidemiology of imported malaria in Qatar","volume":"16","year":"2009","journal-title":"J. Travel Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e2018050","DOI":"10.4084\/mjhid.2018.050","article-title":"Epidemiology of malaria in the State of Qatar, 2008\u20132015","volume":"10","author":"Farag","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1038\/s41598-018-27229-z","article-title":"Genetic diversity and transmissibility of imported Plasmodium vivax in Qatar and three countries of origin","volume":"8","author":"Abdelraheem","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Iqbal, J., Al-Awadhi, M., and Ahmad, S. (2020). Decreasing trend of imported malaria cases but increasing influx of mixed P. falciparum and P. vivax infections in malaria-free Kuwait. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243617"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/jtm.12110","article-title":"Epidemiological and clinical characteristics of imported malaria in the United Arab Emirates","volume":"21","author":"Nilles","year":"2014","journal-title":"J. Travel Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1051\/parasite\/2017028","article-title":"An outbreak of locally acquired Plasmodium vivax malaria among migrant workers in Oman","volume":"24","author":"Simon","year":"2017","journal-title":"Parasite"},{"key":"ref_29","first-page":"591","article-title":"Epidemiological pattern of imported malaria in Jordan from 2007 to 2011","volume":"30","author":"Jamain","year":"2013","journal-title":"Trop. Biomed."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"World Health Organization (2015). Health Profile 2015, Lebanon, WHO. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/253773.","DOI":"10.30875\/e77f2f70-en"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4269\/ajtmh.19-0545","article-title":"Epidemiology of parasitic infections in the West Bank and Gaza Strip, Palestine","volume":"102","author":"Hamarsheh","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3201\/eid2404.171542","article-title":"Region-specific, life-threatening diseases among international travelers from Israel, 2004\u20132015","volume":"24","author":"Avni","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12936-020-03188-7","article-title":"Malaria situation in a clear area of Iran: An approach for the better understanding of the health service providers\u2019 readiness and challenges for malaria elimination in clear areas","volume":"19","author":"Azizi","year":"2020","journal-title":"Malar. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4274\/tpd.galenos.2019.6466","article-title":"Evaluation of malaria cases detected in Antalya Province between 2012 and 2017","volume":"44","author":"Ser","year":"2020","journal-title":"Turk. Parazitol. Derg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4274\/tpd.galenos.2020.6834","article-title":"Evaluation of imported malaria cases in Northern Cyprus between 2016 and 2019: First data series","volume":"44","year":"2020","journal-title":"Turk. Parazitol. Derg."},{"key":"ref_36","first-page":"617","article-title":"Reevaluation of malaria parasites in El-Fayoum Governorate, Egypt using rapid diagnostic tests (RDTS)","volume":"45","author":"Dahesh","year":"2015","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Al-Rumhi, A., Al-Hashami, Z., Al-Hamidhi, S., Gadalla, A., Naeem, R., Ranford-Cartwright, L., Pain, A., Sultan, A.A., and Babiker, H.A. (2020). Influx of diverse, drug resistant and transmissible Plasmodium falciparum into a malaria-free setting in Qatar. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05111-6"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Aabdien, M., Selim, N., Himatt, S., Hmissi, S., Merenkov, Z., AlKubaisi, N., Abdel-Rahman, M.E., Abdelmola, A., Khelfa, S., and Farag, E. (2020). Prevalence and trends of transfusion transmissible infections among blood donors in the State of Qatar, 2013\u20132017. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05344-5"},{"key":"ref_39","first-page":"319","article-title":"Secular trends in susceptibility patterns of Mycobacterium tuberculosis isolates in Kuwait, 1996\u20132005","volume":"12","author":"Mokaddas","year":"2008","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_40","first-page":"756","article-title":"Variations in the occurrence of specific rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis strains isolated from patients of different ethnic groups in Kuwait","volume":"135","author":"Ahmad","year":"2012","journal-title":"Indian J. Med. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40001-019-0397-2","article-title":"Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB","volume":"24","author":"Ahmad","year":"2019","journal-title":"Eur. J. Med. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0035-9203(85)90364-5","article-title":"Imported malaria in Kuwait","volume":"79","author":"Hira","year":"1985","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1016\/j.ijid.2008.05.840","article-title":"Imported malaria in Kuwait (1985\u20132007)","volume":"12","author":"Iqbal","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000026129","article-title":"Risk of introduction of drug-resistant malaria in a non-endemic country, Kuwait: A real threat?","volume":"9","author":"Iqbal","year":"2000","journal-title":"Med. Princ. Pract."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2310\/7060.2003.9291","article-title":"Imported malaria in Kuwait (1985\u20132000)","volume":"10","author":"Iqbal","year":"2003","journal-title":"J. Travel Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1128\/JCM.42.9.4237-4241.2004","article-title":"Persistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection","volume":"42","author":"Iqbal","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Coleman, M., Al-Zahrani, M.H., Coleman, M., Hemingway, J., Omar, A., Stanton, M.C., Thomsen, E.K., Alsheikh, A.A., Alhakeem, R.F., and McCall, P.J. (2014). A country on the verge of malaria elimination--the Kingdom of Saudi Arabia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0105980"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1186\/s12936-015-0858-1","article-title":"Progress toward malaria elimination in Jazan Province, Kingdom of Saudi Arabia: 2000\u20132014","volume":"14","author":"Sahly","year":"2015","journal-title":"Malar. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/s12936-016-1581-2","article-title":"The changing malaria landscape in Aseer region, Kingdom of Saudi Arabia: 2000\u20132015","volume":"15","author":"Alshahrani","year":"2016","journal-title":"Malar J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Al Zahrani, M.H., Omar, A.I., Abdoon, A.M.O., Ibrahim, A.A., Alhogail, A., Elmubarak, M., Elamin, Y.E., AlHelal, M.A., Alshahrani, A.M., and Abdelgader, T.M. (2018). Cross-border movement, economic development and malaria elimination in the Kingdom of Saudi Arabia. BMC Med., 16.","DOI":"10.1186\/s12916-018-1081-z"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.15537\/smj.2015.2.10874","article-title":"Molecular investigation of mixed malaria infections in southwest Saudi Arabia","volume":"36","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_52","first-page":"144","article-title":"Risk associated with malaria infection in Tihama Qahtan, Aseer Region, Kingdom of Saudi Arabia: 2006\u20132007","volume":"5","author":"Alshahrani","year":"2019","journal-title":"Malar. Control Elimin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3347\/kjp.2019.57.3.233","article-title":"Malaria prevalence in a low transmission area, Jazan District of southwestern Saudi Arabia","volume":"57","author":"Hawash","year":"2019","journal-title":"Korean J. Parasitol."},{"key":"ref_54","first-page":"1","article-title":"Evaluation of two malaria surveillance systems in Yemen using updated CDC guidelines: Lessons learned and future perspectives","volume":"56","author":"Anam","year":"2019","journal-title":"Inquiry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1186\/s12936-020-03431-1","article-title":"Uncomplicated falciparum malaria among schoolchildren in Bajil district of Hodeidah governorate, west of Yemen: Association with anaemia and underweight","volume":"19","author":"Alwajeeh","year":"2020","journal-title":"Malar. J."},{"key":"ref_56","first-page":"5625019","article-title":"The Current Insecticide Resistance in Main Malaria Vector Anopheles arabiensis in Yemen","volume":"2020","author":"Assada","year":"2020","journal-title":"J. Trop. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12936-017-1894-9","article-title":"Access to and use of long-lasting insecticidal nets and factors associated with non-use among communities in malaria-endemic areas of Al Hudaydah governorate in the Tihama region, west of Yemen","volume":"16","author":"Mahdy","year":"2017","journal-title":"Malar. J."},{"key":"ref_58","first-page":"270","article-title":"Epidemiology of malaria and predictions of retransmission in Babylon Governorate, Iraq","volume":"12","year":"2006","journal-title":"East Mediterr. Health J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s13149-015-0423-8","article-title":"A retrospective study on imported malaria in Jordan. 2. Malaria among non-military Jordanians","volume":"108","author":"Kanani","year":"2015","journal-title":"Bull. Soc. Pathol. Exot."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/cid\/cix560","article-title":"Plasmodium malariae in Israeli travelers: A nationwide study","volume":"65","author":"Yavne","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"523767","DOI":"10.1155\/2015\/523767","article-title":"Significant decline of malaria incidence in southwest of Iran (2001\u20132014)","volume":"2015","author":"Salmanzadeh","year":"2015","journal-title":"J. Trop. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5334\/aogh.2850","article-title":"Changing patterns in epidemiology of malaria between 2006 and 2018 in the south of Fars Province, southern Iran: The fall and rise of malaria","volume":"86","author":"Delam","year":"2020","journal-title":"Ann. Glob. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4274\/tpd.galenos.2018.5939","article-title":"The investigation of malaria cases in a central laboratory in Istanbul region for a period of fifteen years","volume":"43","author":"Akyar","year":"2019","journal-title":"Turk. Parazitol. Derg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4274\/tpd.galenos.2019.5265","article-title":"The epidemiology of malaria in Gaziantep between 2005 and 2015","volume":"43","year":"2019","journal-title":"Turk. Parazitol. Derg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/archdischild-2018-316459","article-title":"Return of vivax malaria in Cyprus","volume":"105","author":"Emms","year":"2020","journal-title":"Arch. Dis. Child."},{"key":"ref_66","first-page":"213","article-title":"Malariometric parasitological survey in El-Fayoum governorate, Egypt","volume":"39","author":"Dahesh","year":"2009","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/trstmh\/trz059","article-title":"Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan","volume":"113","author":"Bakhiet","year":"2019","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hussien, M., Abdel Hamid, M.M., Elamin, E.A., Hassan, A.O., Elaagip, A.H., Salama, A.H.A., Abdelraheem, M.H., and Mohamed, A.O. (2020). Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015\u20132017. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235401"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s40249-020-00773-5","article-title":"Malaria epidemiology and stratification of incidence in the malaria elimination setting in Harari Region, Eastern Ethiopia","volume":"9","author":"Esayas","year":"2020","journal-title":"Infect. Dis. Poverty."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13756-020-00846-y","article-title":"Artemether-lumefantrin treatment adherence among uncomplicated Plasmodium falciparum malaria patients, visiting public health facilities in AsgedeTsimbla district, Tigray, Ethiopia: A cross-sectional study","volume":"9","author":"Gebrekidan","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5144\/0256-4947.2014.153","article-title":"Toward malaria eradication in Saudi Arabia: Evidence from 4-year surveillance in Makkah","volume":"34","author":"Memish","year":"2014","journal-title":"Ann. Saudi Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12936-018-2438-7","article-title":"Imported and autochthonous malaria in West Saudi Arabia: Results from a reference hospital","volume":"17","author":"Soliman","year":"2018","journal-title":"Malar. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e003217","DOI":"10.1136\/bmjgh-2020-003217","article-title":"Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Africa: A systematic analysis of national trends","volume":"5","author":"Amimo","year":"2020","journal-title":"BMJ Glob. Health"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Tola, M., Ajibola, O., Idowu, E.T., Omidiji, O., Awolola, S.T., and Amambua-Ngwa, A. (2020). Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria. BMC Res. Notes, 13.","DOI":"10.1186\/s13104-020-05334-5"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/20477724.2019.1595904","article-title":"Malaria epidemiology and comparative reliability of diagnostic tools in Bannu; an endemic malaria focus in south of Khyber Pakhtunkhwa, Pakistan","volume":"113","author":"Jahan","year":"2019","journal-title":"Pathog. Glob. Health"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Karim, A.M., Hussain, I., Malik, S.K., Lee, J.H., Cho, I.H., Kim, Y.B., and Lee, S.H. (2016). Epidemiology and clinical burden of malaria in the war-torn area, Orakzai Agency in Pakistan. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0004399"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"453","DOI":"10.26719\/emhj.19.015","article-title":"Baseline survey for malaria prevalence in Khyber Pakhtunkhwa Province, Pakistan","volume":"26","author":"Qureshi","year":"2020","journal-title":"East. Mediterr. Health J."},{"key":"ref_78","first-page":"177","article-title":"Evaluation of asymptomatic malaria status in eastern of Afghanistan using high resolution melting analysis","volume":"15","author":"Mosawi","year":"2020","journal-title":"Iran J. Parasitol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.pt.2009.06.004","article-title":"Why is it important to study malaria epidemiology in India?","volume":"25","author":"Singh","year":"2009","journal-title":"Trends Parasitol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"136368","DOI":"10.1016\/j.scitotenv.2019.136368","article-title":"Malaria epidemics in India: Role of climatic condition and control measures","volume":"712","author":"Baghbanzadeh","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Haanshuus, C.G., Chandy, S., Manoharan, A., Vivek, R., Mathai, D., Xena, D., Singh, A., Langeland, N., Blomberg, B., and Vasanthan, G. (2016). A high malaria prevalence identified by PCR among patients with acute undifferentiated fever in India. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158816"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4269\/ajtmh.18-0005","article-title":"Malaria severity in Mangaluru City in the southwestern coastal region of India","volume":"100","author":"Dayanand","year":"2019","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00436-019-06540-2","article-title":"Clinical features and haematological parameters among malaria patients in Mangaluru city area in the southwestern coastal region of India","volume":"119","author":"Punnath","year":"2020","journal-title":"Parasitol. Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Siwal, N., Singh, U.S., Dash, M., Kar, S., Rani, S., Rawal, C., Singh, R., Anvikar, A.R., Pande, V., and Das, A. (2018). Malaria diagnosis by PCR revealed differential distribution of mono and mixed species infections by Plasmodium falciparum and P. vivax in India. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193046"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-3156.2010.02549.x","article-title":"High proportion of mixed-species Plasmodium infections in India revealed by PCR diagnostic assay","volume":"15","author":"Gupta","year":"2010","journal-title":"Trop. Med. Int. Health"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Sarker, A.R., and Sultana, M. (2020). Cost-effective analysis of childhood malaria vaccination in endemic hotspots of Bangladesh. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233902"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Hossain, M.S., Commons, R.J., Douglas, N.M., Thriemer, K., Alemayehu, B.H., Amaratunga, C., Anvikar, A.R., Ashley, E.A., Asih, P.B.S., and Carrara, V.I. (2020). The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. PLoS Med., 17.","DOI":"10.1371\/journal.pmed.1003393"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Fornace, K.M., Herman, L.S., Abidin, T.R., Chua, T.H., Daim, S., Lorenzo, P.J., Grignard, L., Nuin, N.A., Ying, L.T., and Grigg, M.J. (2018). Exposure and infection to Plasmodium knowlesi in case study communities in Northern Sabah, Malaysia and Palawan, The Philippines. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006432"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11068","DOI":"10.1038\/s41598-020-68082-3","article-title":"Plasmodium spp. mixed infection leading to severe malaria: A systematic review and meta-analysis","volume":"10","author":"Kotepui","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.actatropica.2018.01.006","article-title":"Molecular monitoring of dihydrofolatereductase (dhfr) and dihydropteroatesynthetase (dhps) associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates of Palawan, Philippines","volume":"180","author":"Bareng","year":"2018","journal-title":"Acta Trop."}],"container-title":["Microorganisms"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:21:38Z","timestamp":1760160098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2607\/9\/2\/338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["microorganisms9020338"],"URL":"https:\/\/doi.org\/10.3390\/microorganisms9020338","relation":{},"ISSN":["2076-2607"],"issn-type":[{"value":"2076-2607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,9]]}}}